JP2019507775A5 - - Google Patents
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- Publication number
- JP2019507775A5 JP2019507775A5 JP2018546897A JP2018546897A JP2019507775A5 JP 2019507775 A5 JP2019507775 A5 JP 2019507775A5 JP 2018546897 A JP2018546897 A JP 2018546897A JP 2018546897 A JP2018546897 A JP 2018546897A JP 2019507775 A5 JP2019507775 A5 JP 2019507775A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical composition
- subject
- composition according
- rheumatoid arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 12
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 8
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 8
- 206010003246 arthritis Diseases 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229940071643 prefilled syringe Drugs 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022170275A JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305253.3 | 2016-03-07 | ||
| EP16305253.3A EP3216461A1 (en) | 2016-03-07 | 2016-03-07 | Compositions and methods for treating rheumatoid arthritis |
| EP16170664.3 | 2016-05-20 | ||
| EP16170664 | 2016-05-20 | ||
| EP16306111.2 | 2016-09-05 | ||
| EP16306111 | 2016-09-05 | ||
| PCT/US2017/021149 WO2017155990A1 (en) | 2016-03-07 | 2017-03-07 | Compositions and methods for treating rheumatoid arthritis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022170275A Division JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507775A JP2019507775A (ja) | 2019-03-22 |
| JP2019507775A5 true JP2019507775A5 (https=) | 2020-04-09 |
| JP7166925B2 JP7166925B2 (ja) | 2022-11-08 |
Family
ID=58387910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546897A Active JP7166925B2 (ja) | 2016-03-07 | 2017-03-07 | 関節リウマチを処置するための組成物及び方法 |
| JP2022170275A Active JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022170275A Active JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20190100585A1 (https=) |
| EP (1) | EP3426295A1 (https=) |
| JP (2) | JP7166925B2 (https=) |
| KR (3) | KR20260049875A (https=) |
| CN (1) | CN109069642A (https=) |
| AU (2) | AU2017229364A1 (https=) |
| BR (1) | BR112018067851A2 (https=) |
| CA (1) | CA3016880A1 (https=) |
| CL (1) | CL2018002559A1 (https=) |
| CR (1) | CR20180465A (https=) |
| EA (1) | EA201892005A1 (https=) |
| IL (2) | IL261515B2 (https=) |
| MX (2) | MX2018010815A (https=) |
| PH (1) | PH12018501894A1 (https=) |
| SG (2) | SG10202012182YA (https=) |
| TN (1) | TN2018000312A1 (https=) |
| TW (3) | TW202419103A (https=) |
| WO (1) | WO2017155990A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| RU2020121415A (ru) * | 2017-11-30 | 2021-12-30 | Био-Тера Солюшнз, Лтд. | Жидкий препарат гуманизированного антитела для лечения заболеваний, опосредованных ил-6 |
| SG11202101674QA (en) * | 2018-08-29 | 2021-03-30 | Regeneron Pharma | Methods and compositions for treating subjects having rheumatoid arthritis |
| MA54861A (fr) * | 2019-01-31 | 2021-12-08 | Regeneron Pharma | Anticorps anti-récepteur de l'il6 pour traiter l'arthrite idiopathique juvénile |
| SG11202111742QA (en) | 2019-04-24 | 2021-11-29 | Sanofi Biotechnology | Methods of diagnosis and treatment of rheumatoid arthritis |
| CA3142710A1 (en) * | 2019-06-04 | 2020-12-10 | Sanofi Biotechnology | Compositions and methods for treating pain in subjects with rheumatoid arthritis |
| WO2023020563A1 (en) * | 2021-08-18 | 2023-02-23 | Bio-Thera Solutions, Ltd. | Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases |
| WO2026047197A1 (en) | 2024-08-30 | 2026-03-05 | Sanofi Biotechnology | Differential biomarkers for anti-interleukin-6 and anti-tumor necrosis factor-α treatment response in rheumatoid arthritis |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215534A (en) | 1991-12-02 | 1993-06-01 | Lawrence De Harde | Safety syringe system |
| CA2817619A1 (en) * | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| GB0718684D0 (en) * | 2007-09-24 | 2007-10-31 | Roche Products Ltd | Treatment method |
| JO3417B1 (ar) * | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| US9427531B2 (en) | 2010-06-28 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
| TWI589299B (zh) * | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| US9248242B2 (en) | 2012-04-20 | 2016-02-02 | Safety Syringes, Inc. | Anti-needle stick safety device for injection device |
| US20140155827A1 (en) | 2012-12-03 | 2014-06-05 | Mylan, Inc. | Medicament information system and method |
| MX377190B (es) * | 2013-11-22 | 2025-03-07 | Sanofi Biotechnology | Uso de un anticuerpo anti-il6r para el tratamiento de la artritis reumatoide. |
-
2017
- 2017-03-07 CA CA3016880A patent/CA3016880A1/en active Pending
- 2017-03-07 SG SG10202012182YA patent/SG10202012182YA/en unknown
- 2017-03-07 IL IL261515A patent/IL261515B2/en unknown
- 2017-03-07 TW TW112135625A patent/TW202419103A/zh unknown
- 2017-03-07 US US16/082,841 patent/US20190100585A1/en active Pending
- 2017-03-07 IL IL308539A patent/IL308539A/en unknown
- 2017-03-07 KR KR1020267009842A patent/KR20260049875A/ko active Pending
- 2017-03-07 AU AU2017229364A patent/AU2017229364A1/en not_active Abandoned
- 2017-03-07 CR CR20180465A patent/CR20180465A/es unknown
- 2017-03-07 SG SG11201807614SA patent/SG11201807614SA/en unknown
- 2017-03-07 KR KR1020187028624A patent/KR20180114955A/ko not_active Ceased
- 2017-03-07 BR BR112018067851A patent/BR112018067851A2/pt not_active Application Discontinuation
- 2017-03-07 TN TNP/2018/000312A patent/TN2018000312A1/en unknown
- 2017-03-07 EA EA201892005A patent/EA201892005A1/ru unknown
- 2017-03-07 CN CN201780028050.2A patent/CN109069642A/zh active Pending
- 2017-03-07 TW TW110146922A patent/TWI819435B/zh active
- 2017-03-07 EP EP17712604.2A patent/EP3426295A1/en active Pending
- 2017-03-07 TW TW106107363A patent/TWI747885B/zh active
- 2017-03-07 JP JP2018546897A patent/JP7166925B2/ja active Active
- 2017-03-07 WO PCT/US2017/021149 patent/WO2017155990A1/en not_active Ceased
- 2017-03-07 KR KR1020237019726A patent/KR20230093522A/ko not_active Ceased
- 2017-03-07 MX MX2018010815A patent/MX2018010815A/es unknown
-
2018
- 2018-09-05 PH PH12018501894A patent/PH12018501894A1/en unknown
- 2018-09-07 CL CL2018002559A patent/CL2018002559A1/es unknown
- 2018-09-07 MX MX2023014841A patent/MX2023014841A/es unknown
-
2022
- 2022-10-25 JP JP2022170275A patent/JP7745529B2/ja active Active
-
2024
- 2024-05-07 AU AU2024203011A patent/AU2024203011A1/en active Pending
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