JP2019506897A5 - - Google Patents
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- JP2019506897A5 JP2019506897A5 JP2018555851A JP2018555851A JP2019506897A5 JP 2019506897 A5 JP2019506897 A5 JP 2019506897A5 JP 2018555851 A JP2018555851 A JP 2018555851A JP 2018555851 A JP2018555851 A JP 2018555851A JP 2019506897 A5 JP2019506897 A5 JP 2019506897A5
- Authority
- JP
- Japan
- Prior art keywords
- transgenic mouse
- mouse
- human
- crbn
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 101000941994 Homo sapiens Protein cereblon Proteins 0.000 claims 33
- 102000055425 human CRBN Human genes 0.000 claims 33
- 238000011830 transgenic mouse model Methods 0.000 claims 31
- 239000012634 fragment Substances 0.000 claims 18
- 239000000090 biomarker Substances 0.000 claims 11
- 238000010172 mouse model Methods 0.000 claims 9
- 108020004705 Codon Proteins 0.000 claims 8
- 241000699666 Mus <mouse, genus> Species 0.000 claims 8
- 102000001708 Protein Isoforms Human genes 0.000 claims 8
- 108010029485 Protein Isoforms Proteins 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 230000002068 genetic effect Effects 0.000 claims 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 238000009395 breeding Methods 0.000 claims 3
- 230000001488 breeding effect Effects 0.000 claims 3
- 101150013999 CRBN gene Proteins 0.000 claims 2
- 101000599038 Homo sapiens DNA-binding protein Ikaros Proteins 0.000 claims 2
- 101000599042 Homo sapiens Zinc finger protein Aiolos Proteins 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000055354 human IKZF1 Human genes 0.000 claims 2
- 102000044015 human IKZF3 Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 101100275694 Mus musculus Crbn gene Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 description 1
- 238000010459 TALEN Methods 0.000 description 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 description 1
- -1 ZFN Proteins 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022020184A JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662280633P | 2016-01-19 | 2016-01-19 | |
| US62/280,633 | 2016-01-19 | ||
| PCT/US2017/013909 WO2017127414A1 (en) | 2016-01-19 | 2017-01-18 | Transgenic mouse expressing human cereblon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022020184A Division JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506897A JP2019506897A (ja) | 2019-03-14 |
| JP2019506897A5 true JP2019506897A5 (OSRAM) | 2020-03-05 |
Family
ID=59362645
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555851A Pending JP2019506897A (ja) | 2016-01-19 | 2017-01-18 | ヒトのセレブロンを発現するトランスジェニックマウス |
| JP2022020184A Active JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022020184A Active JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11963520B2 (OSRAM) |
| EP (1) | EP3405790B1 (OSRAM) |
| JP (2) | JP2019506897A (OSRAM) |
| WO (1) | WO2017127414A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| WO2018144832A1 (en) | 2017-02-03 | 2018-08-09 | Celgene Corporation | Methods for measuring small molecule affinity to cereblon |
| JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| WO2020067199A1 (ja) * | 2018-09-27 | 2020-04-02 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| WO2021091946A1 (en) | 2019-11-05 | 2021-05-14 | Celgene Corporation | Combination therapy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide |
| CN112980882A (zh) * | 2021-03-15 | 2021-06-18 | 上海科技大学 | Crbn基因在构建GSPT1敏感模型中的用途 |
| WO2025164957A1 (ko) * | 2024-01-31 | 2025-08-07 | 남부대학교산학협력단 | 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| EP0972445B1 (en) * | 1997-02-28 | 2006-07-05 | Kirin Beer Kabushiki Kaisha | Chimeric mice that express a human antibody |
| US6875904B2 (en) * | 2000-09-20 | 2005-04-05 | The Ohio State University Research Foundation | Animal model for identifying agents that inhibit or enhance CTLA4 signaling |
| AUPR446701A0 (en) * | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| KR20050084317A (ko) * | 2002-12-16 | 2005-08-26 | 제넨테크, 인크. | 인간 ｃｄ２０ 및(또는) ｃｄ１６을 발현하는 트랜스제닉마우스 |
| US8110720B2 (en) | 2006-12-22 | 2012-02-07 | Genentech, Inc | Transgenic mice expressing humanized VEGF |
| EP2436387B1 (en) | 2009-05-25 | 2018-07-25 | Celgene Corporation | Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex |
| CN103688176A (zh) | 2011-04-29 | 2014-03-26 | 细胞基因公司 | 利用cereblon作为预报因子治疗癌和炎性疾病的方法 |
| US9587281B2 (en) * | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| WO2014028445A2 (en) | 2012-08-14 | 2014-02-20 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| KR20140100731A (ko) * | 2013-02-07 | 2014-08-18 | 광주과학기술원 | Ｃｒｂ ｎ ｋｏ 마우스의 제조방법 및 이의 용도 |
| US20160282354A1 (en) * | 2013-11-08 | 2016-09-29 | The Broad Institute, Inc. | Compositions and methods for selecting a treatment for b-cell neoplasias |
| WO2015127351A1 (en) | 2014-02-24 | 2015-08-27 | Celgene Corporation | Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders |
| US10092555B2 (en) | 2014-06-27 | 2018-10-09 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
| WO2018144832A1 (en) | 2017-02-03 | 2018-08-09 | Celgene Corporation | Methods for measuring small molecule affinity to cereblon |
-
2017
- 2017-01-18 EP EP17741841.5A patent/EP3405790B1/en active Active
- 2017-01-18 US US16/070,769 patent/US11963520B2/en active Active
- 2017-01-18 JP JP2018555851A patent/JP2019506897A/ja active Pending
- 2017-01-18 WO PCT/US2017/013909 patent/WO2017127414A1/en not_active Ceased
-
2022
- 2022-02-14 JP JP2022020184A patent/JP7350911B2/ja active Active
-
2024
- 2024-03-19 US US18/609,867 patent/US20240389562A1/en active Pending
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