JP2020510418A5 - - Google Patents

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Publication number
JP2020510418A5
JP2020510418A5 JP2019545322A JP2019545322A JP2020510418A5 JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5 JP 2019545322 A JP2019545322 A JP 2019545322A JP 2019545322 A JP2019545322 A JP 2019545322A JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5
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JP
Japan
Prior art keywords
seq
tfr
animal
polypeptide
apical domain
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JP2019545322A
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English (en)
Japanese (ja)
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JP7669113B2 (ja
JP2020510418A (ja
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Priority claimed from PCT/US2018/018302 external-priority patent/WO2018152285A1/en
Publication of JP2020510418A publication Critical patent/JP2020510418A/ja
Publication of JP2020510418A5 publication Critical patent/JP2020510418A5/ja
Priority to JP2023085382A priority Critical patent/JP2023116513A/ja
Priority to JP2025036281A priority patent/JP2025087857A/ja
Application granted granted Critical
Publication of JP7669113B2 publication Critical patent/JP7669113B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2019545322A 2017-02-17 2018-02-15 トランスフェリン受容体トランスジェニックモデル Active JP7669113B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023085382A JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US62/460,692 2017-02-17
US201762543559P 2017-08-10 2017-08-10
US201762543658P 2017-08-10 2017-08-10
US62/543,559 2017-08-10
US62/543,658 2017-08-10
US201762583314P 2017-11-08 2017-11-08
US62/583,314 2017-11-08
PCT/US2018/018302 WO2018152285A1 (en) 2017-02-17 2018-02-15 Transferrin receptor transgenic models

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023085382A Division JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル

Publications (3)

Publication Number Publication Date
JP2020510418A JP2020510418A (ja) 2020-04-09
JP2020510418A5 true JP2020510418A5 (OSRAM) 2021-03-11
JP7669113B2 JP7669113B2 (ja) 2025-04-28

Family

ID=61628463

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019545322A Active JP7669113B2 (ja) 2017-02-17 2018-02-15 トランスフェリン受容体トランスジェニックモデル
JP2023085382A Pending JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A Pending JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023085382A Pending JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A Pending JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Country Status (9)

Country Link
EP (2) EP4628586A2 (OSRAM)
JP (3) JP7669113B2 (OSRAM)
KR (1) KR102637590B1 (OSRAM)
CN (1) CN110382526B (OSRAM)
AU (1) AU2018221704B2 (OSRAM)
CA (1) CA3053370A1 (OSRAM)
IL (1) IL268659A (OSRAM)
SG (1) SG11201907419PA (OSRAM)
WO (1) WO2018152285A1 (OSRAM)

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SG11202002730XA (en) 2017-10-02 2020-04-29 Denali Therapeutics Inc Fusion proteins comprising enzyme replacement therapy enzymes
AU2019288212A1 (en) 2018-06-18 2020-12-03 Denali Therapeutics Inc. Fusion proteins comprising progranulin
WO2021133907A1 (en) 2019-12-23 2021-07-01 Denali Therapeutics Inc. Progranulin variants
CN112243953B (zh) * 2020-07-15 2022-02-11 吉林医药学院 TfR1肺组织特异性敲除小鼠模型及其构建方法和应用
CR20230178A (es) 2020-10-14 2023-07-26 Denali Therapeutics Inc Proteínas de fusión que comprenden enzimas sulfoglucosamina sulfohidrolasa y métodos de estas
CN112501124A (zh) * 2020-11-27 2021-03-16 领诺(上海)医药科技有限公司 稳定表达人转铁蛋白受体1细胞株的制备方法及其应用
WO2023284850A1 (en) * 2021-07-16 2023-01-19 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric tfr1
KR20240119118A (ko) 2021-12-17 2024-08-06 데날리 테라퓨틱스 인크. 알파-l-이두 로니다제 효소를 포함하는 융합 단백질 및 이의 방법
TW202340235A (zh) 2021-12-17 2023-10-16 美商戴納立製藥公司 多肽工程、文庫及工程cd98重鏈以及轉鐵蛋白受體結合多肽
WO2023192288A1 (en) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Monovalent anti-trem2 binding molecules and methods of use thereof
WO2024026488A2 (en) * 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a modified transferrin receptor locus
EP4658684A1 (en) 2023-01-30 2025-12-10 ISAR Bioscience GmbH Human anti-trem2 antibody for treating neurodegenerative disorders
CN116784280B (zh) * 2023-08-10 2025-08-19 广东药康生物科技有限公司 一种tfrc人源化小鼠模型的构建方法及其应用
WO2025137213A1 (en) 2023-12-20 2025-06-26 Denali Therapeutics Inc. Fusion proteins comprising acid alpha-glucosidase enzymes and methods thereof

Family Cites Families (16)

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US5898094A (en) 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
US6175057B1 (en) 1997-10-08 2001-01-16 The Regents Of The University Of California Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
WO2004094647A2 (en) * 2003-04-18 2004-11-04 Cytovia, Inc. Methods of treating diseases responsive to induction of apoptosis and screening assays
US20090263900A1 (en) 2008-04-14 2009-10-22 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
EP2564695B1 (en) 2009-07-08 2015-04-15 Kymab Limited Animal models and therapeutic molecules
EP2660318A1 (en) 2010-02-09 2013-11-06 Sangamo BioSciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
US8476485B2 (en) 2010-06-24 2013-07-02 Academia Sinica Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
US9232775B2 (en) 2012-08-03 2016-01-12 Industry-Academic Cooperation Foundation, Yonsei University Genetically engineered mouse model for autism spectrum disorder having deletion of Shank2 gene and use thereof
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US20160050895A1 (en) 2013-03-13 2016-02-25 Australian Nuclear Science And Technology Organization Transgenic non-human organisms with non-functional tspo genes
IL242088B2 (en) * 2013-05-20 2023-12-01 Genentech Inc Anti-transferrin receptor antibodies and methods of use
WO2015040402A1 (en) 2013-09-18 2015-03-26 Kymab Limited Methods. cells & organisms
CN103897033A (zh) * 2014-03-31 2014-07-02 中国药科大学 转铁蛋白受体TfR特异性结合肽及其应用
US10508151B2 (en) * 2014-11-19 2019-12-17 Genentech, Inc. Anti-transferrin receptor antibodies and methods of use
EP3313890A1 (en) * 2015-06-24 2018-05-02 H. Hoffnabb-La Roche Ag Trispecific antibodies specific for her2 and a blood brain barrier receptor and methods of use
WO2018152375A2 (en) * 2017-02-17 2018-08-23 Denali Therapeutics Inc. Engineered polypeptides

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