JP2019503997A5 - - Google Patents
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- Publication number
- JP2019503997A5 JP2019503997A5 JP2018529067A JP2018529067A JP2019503997A5 JP 2019503997 A5 JP2019503997 A5 JP 2019503997A5 JP 2018529067 A JP2018529067 A JP 2018529067A JP 2018529067 A JP2018529067 A JP 2018529067A JP 2019503997 A5 JP2019503997 A5 JP 2019503997A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- formoterol
- mometasone
- compound
- propellant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 93
- 239000008194 pharmaceutical composition Substances 0.000 claims 90
- -1 mometasone compound Chemical class 0.000 claims 68
- 229960002848 formoterol Drugs 0.000 claims 52
- 229960001664 mometasone Drugs 0.000 claims 42
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 claims 39
- 239000003380 propellant Substances 0.000 claims 39
- 239000004094 surface-active agent Substances 0.000 claims 30
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 25
- 229960002744 mometasone furoate Drugs 0.000 claims 18
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 18
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 12
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 12
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 12
- 239000005642 Oleic acid Substances 0.000 claims 12
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 12
- 239000012535 impurity Substances 0.000 claims 12
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 12
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 10
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims 9
- 229960003610 formoterol fumarate dihydrate Drugs 0.000 claims 9
- 229940071648 metered dose inhaler Drugs 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 238000003860 storage Methods 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 230000015556 catabolic process Effects 0.000 claims 4
- 238000006731 degradation reaction Methods 0.000 claims 4
- 239000000787 lecithin Substances 0.000 claims 4
- 229940067606 lecithin Drugs 0.000 claims 4
- 235000010445 lecithin Nutrition 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 3
- 238000012387 aerosolization Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 238000001556 precipitation Methods 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 229920002943 EPDM rubber Polymers 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229920005557 bromobutyl Polymers 0.000 claims 1
- 229920005556 chlorobutyl Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 239000013536 elastomeric material Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1521462.0 | 2015-12-04 | ||
| GB1521462.0A GB2545025A (en) | 2015-12-04 | 2015-12-04 | Pharmaceutical composition |
| PCT/GB2016/053804 WO2017093755A1 (en) | 2015-12-04 | 2016-12-02 | Pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019231998A Division JP6993398B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019503997A JP2019503997A (ja) | 2019-02-14 |
| JP2019503997A5 true JP2019503997A5 (https=) | 2020-01-16 |
| JP6993335B2 JP6993335B2 (ja) | 2022-01-13 |
Family
ID=55234449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529067A Active JP6993335B2 (ja) | 2015-12-04 | 2016-12-02 | 薬学的組成物 |
| JP2019231998A Active JP6993398B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019231998A Active JP6993398B2 (ja) | 2015-12-04 | 2019-12-23 | 薬学的組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US20180264007A1 (https=) |
| EP (3) | EP3563832A1 (https=) |
| JP (2) | JP6993335B2 (https=) |
| CN (2) | CN113908164A (https=) |
| AU (3) | AU2016364005B2 (https=) |
| CA (1) | CA3007046C (https=) |
| ES (1) | ES2796343T3 (https=) |
| GB (1) | GB2545025A (https=) |
| MX (1) | MX375784B (https=) |
| WO (1) | WO2017093755A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| CN114712337A (zh) * | 2016-09-19 | 2022-07-08 | 墨西哥氟石股份公司 | 药物组合物 |
| MX2019003103A (es) * | 2016-09-19 | 2019-08-01 | Mexichem Fluor Sa De Cv | Composicion farmaceutica. |
| GB2573297A (en) * | 2018-04-30 | 2019-11-06 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| AU2019282562A1 (en) * | 2018-06-04 | 2021-01-21 | Lupin Inc. | Stable pharmaceutical compositions for pressurized metered dose inhalers |
| GB202001537D0 (en) | 2020-02-05 | 2020-03-18 | Consort Medical Plc | Pressurised dispensing container |
| FR3107039B1 (fr) * | 2020-02-07 | 2022-03-18 | Aptar France Sas | Valve doseuse avec chambre de dosage améliorée |
| IL295269A (en) * | 2020-02-20 | 2022-10-01 | Chiesi Farm Spa | Inhalers with a measured dose under pressure that include the composition of pharmacy buffers |
| CN115813935A (zh) * | 2021-09-16 | 2023-03-21 | 上海上药信谊药厂有限公司 | 药物组合物、气雾剂及其制备方法和气雾剂产生系统 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE9700138A (et) * | 1994-12-22 | 1997-12-15 | Astra Aktiebolag | Aerosoolravimvormid |
| GB9904919D0 (en) * | 1999-03-03 | 1999-04-28 | Novartis Ag | Organic compounds |
| US6432415B1 (en) * | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| AU2001278115A1 (en) * | 2000-08-04 | 2002-02-18 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
| AR036358A1 (es) | 2001-08-28 | 2004-09-01 | Schering Corp | Un inhalador de dosis medidas que contiene una formulacion de suspension en aerosol para inhalacion, un proceso para la produccion de la formulacion, el producto y el uso de una formulacion para la manufactura de un medicamento de asma |
| GB0207906D0 (en) * | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
| GB0323684D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| BRPI0721256A2 (pt) * | 2007-02-09 | 2013-03-12 | Schering Corp | aerossàis de fÁrmaco farmacÊuticos estÁveis |
| US8236786B2 (en) * | 2008-08-07 | 2012-08-07 | Pulmagen Therapeutics (Inflammation) Limited | Respiratory disease treatment |
| NZ590774A (en) * | 2008-08-07 | 2012-09-28 | Pulmagen Therapeutics Inflammation Ltd | Substantially pure 5R enantiomers of pioglitazone and rosiglitazone for treating inflammatory respiratory diseases |
| US20120252824A1 (en) * | 2009-06-16 | 2012-10-04 | John Brew | Drug Combinations and Uses in Treating a Coughing Condition |
| WO2011067364A1 (en) * | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Novel compounds |
| EP2515855B3 (en) * | 2009-12-23 | 2023-05-03 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
| CN102416179B (zh) * | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
| GB201108039D0 (en) * | 2011-05-13 | 2011-06-29 | Mexichem Amanco Holding Sa | Compositions |
| GB201117621D0 (en) * | 2011-10-12 | 2011-11-23 | Mexichem Amanco Holding Sa | Compositions |
| GB201117619D0 (en) * | 2011-10-12 | 2011-11-23 | Mexichem Amanco Holding Sa | Compositions |
| WO2014016548A2 (en) * | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| RS57687B1 (sr) * | 2013-12-30 | 2018-11-30 | Chiesi Farm Spa | Pod pritiskom stabilan aerosolni rastvor kompozicije glikopironijum bromida i kombinacije formoterola |
| ES2796177T5 (es) * | 2015-12-04 | 2024-10-29 | Mexichem Fluor Sa De Cv | Composición farmacéutica |
| GB2545025A (en) | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| WO2018051133A1 (en) * | 2016-09-19 | 2018-03-22 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
-
2015
- 2015-12-04 GB GB1521462.0A patent/GB2545025A/en not_active Withdrawn
-
2016
- 2016-12-02 JP JP2018529067A patent/JP6993335B2/ja active Active
- 2016-12-02 EP EP19178833.0A patent/EP3563832A1/en active Pending
- 2016-12-02 CA CA3007046A patent/CA3007046C/en active Active
- 2016-12-02 MX MX2018006799A patent/MX375784B/es active IP Right Grant
- 2016-12-02 AU AU2016364005A patent/AU2016364005B2/en active Active
- 2016-12-02 ES ES16823027T patent/ES2796343T3/es active Active
- 2016-12-02 CN CN202111072725.8A patent/CN113908164A/zh active Pending
- 2016-12-02 EP EP19178815.7A patent/EP3563831A1/en not_active Withdrawn
- 2016-12-02 US US15/781,060 patent/US20180264007A1/en not_active Abandoned
- 2016-12-02 WO PCT/GB2016/053804 patent/WO2017093755A1/en not_active Ceased
- 2016-12-02 CN CN201680071093.4A patent/CN108289842B/zh active Active
- 2016-12-02 EP EP16823027.4A patent/EP3383367B1/en active Active
-
2019
- 2019-03-05 AU AU2019201521A patent/AU2019201521B2/en active Active
- 2019-03-05 AU AU2019201520A patent/AU2019201520C1/en active Active
- 2019-09-09 US US16/565,226 patent/US20190388438A1/en not_active Abandoned
- 2019-09-09 US US16/565,217 patent/US20200000826A1/en not_active Abandoned
- 2019-12-23 JP JP2019231998A patent/JP6993398B2/ja active Active
-
2022
- 2022-09-14 US US17/944,637 patent/US20230029180A1/en active Pending
- 2022-09-14 US US17/944,666 patent/US20230029174A1/en active Pending
- 2022-10-19 US US17/969,250 patent/US20230051849A1/en active Pending
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