JP2019503984A5 - - Google Patents
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- Publication number
- JP2019503984A5 JP2019503984A5 JP2018521955A JP2018521955A JP2019503984A5 JP 2019503984 A5 JP2019503984 A5 JP 2019503984A5 JP 2018521955 A JP2018521955 A JP 2018521955A JP 2018521955 A JP2018521955 A JP 2018521955A JP 2019503984 A5 JP2019503984 A5 JP 2019503984A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- dkk2
- subject
- antibody
- humanized anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 50
- 206010028980 Neoplasm Diseases 0.000 claims description 47
- 201000011510 cancer Diseases 0.000 claims description 43
- 102100030091 Dickkopf-related protein 2 Human genes 0.000 claims description 30
- 101710099523 Dickkopf-related protein 2 Proteins 0.000 claims description 30
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 239000012472 biological sample Substances 0.000 claims description 16
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 14
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 14
- 201000002528 pancreatic cancer Diseases 0.000 claims description 14
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 14
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 12
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 12
- 230000003472 neutralizing effect Effects 0.000 claims description 10
- 206010009944 Colon cancer Diseases 0.000 claims description 9
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 9
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 9
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims description 9
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 9
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 9
- 201000004101 esophageal cancer Diseases 0.000 claims description 9
- 206010017758 gastric cancer Diseases 0.000 claims description 9
- 201000002313 intestinal cancer Diseases 0.000 claims description 9
- 201000011549 stomach cancer Diseases 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 7
- 102100034540 Adenomatous polyposis coli protein Human genes 0.000 claims description 6
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 6
- 239000002955 immunomodulating agent Substances 0.000 claims description 6
- 230000002062 proliferating effect Effects 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 230000021633 leukocyte mediated immunity Effects 0.000 claims description 4
- 230000001394 metastastic effect Effects 0.000 claims description 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 230000008685 targeting Effects 0.000 claims description 4
- 230000004071 biological effect Effects 0.000 claims description 3
- 108020004999 messenger RNA Proteins 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 101150108150 DKK2 gene Proteins 0.000 claims description 2
- 201000006107 Familial adenomatous polyposis Diseases 0.000 claims description 2
- 101100223943 Homo sapiens DKK2 gene Proteins 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 230000005809 anti-tumor immunity Effects 0.000 claims description 2
- 229940022399 cancer vaccine Drugs 0.000 claims description 2
- 238000009566 cancer vaccine Methods 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 208000029664 classic familial adenomatous polyposis Diseases 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 229940032219 immunotherapy vaccine Drugs 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 23
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000000699 topical effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562247410P | 2015-10-28 | 2015-10-28 | |
| US62/247,410 | 2015-10-28 | ||
| PCT/US2016/057814 WO2017074774A1 (en) | 2015-10-28 | 2016-10-20 | Humanized anti-dkk2 antibody and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019503984A JP2019503984A (ja) | 2019-02-14 |
| JP2019503984A5 true JP2019503984A5 (cg-RX-API-DMAC7.html) | 2019-11-28 |
| JP6921067B2 JP6921067B2 (ja) | 2021-08-18 |
Family
ID=58630689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521955A Active JP6921067B2 (ja) | 2015-10-28 | 2016-10-20 | ヒト化抗Ｄｋｋ２抗体およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11267875B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3368567B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6921067B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180085723A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108463247B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016344459B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3003252C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3368567T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL258924A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2018119317A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017074774A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6921067B2 (ja) | 2015-10-28 | 2021-08-18 | イエール ユニバーシティ | ヒト化抗Ｄｋｋ２抗体およびその使用方法 |
| CN112839960B (zh) | 2018-08-10 | 2024-09-06 | 中外制药株式会社 | 抗cd137抗原结合分子及其应用 |
| US12275781B2 (en) | 2019-02-01 | 2025-04-15 | Board Of Regents, The University Of Texas System | Monoclonal antibodies against MHC-bound human dickkopf-1 peptides and uses thereof |
| EP3693063A1 (en) * | 2019-02-06 | 2020-08-12 | Diaccurate | Methods and compositions for treating cancer |
| CN114286689A (zh) * | 2019-07-10 | 2022-04-05 | 耶鲁大学 | 使用人源化的抗dkk2抗体的组合物和方法 |
| TWI895351B (zh) * | 2020-02-12 | 2025-09-01 | 日商中外製藥股份有限公司 | 用於癌症之治療的抗cd137抗原結合分子 |
| CN112592402B (zh) * | 2020-12-02 | 2022-04-26 | 杭州奕安济世生物药业有限公司 | 抗dkk2抗体、包含该抗dkk2抗体的组合物及其用途 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| EP1291360A1 (en) | 1991-12-13 | 2003-03-12 | Xoma Corporation | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| DE69333807T2 (de) | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6133232A (en) | 1996-06-20 | 2000-10-17 | The Regents Of The University Of California | Endoderm, cardiac and neural inducing factors |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| US7057017B2 (en) * | 1997-04-16 | 2006-06-06 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| ATE472609T1 (de) | 2001-04-26 | 2010-07-15 | Amgen Mountain View Inc | Kombinatorische bibliotheken von monomerdomänen |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| US20040038860A1 (en) * | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| AU2002357932A1 (en) | 2001-12-18 | 2003-06-30 | Whitehead Institute For Biomedical Research | Fusion partner cells and uses thereof |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| CA2536238C (en) | 2003-08-18 | 2015-04-07 | Medimmune, Inc. | Humanization of antibodies |
| WO2005035575A2 (en) | 2003-08-22 | 2005-04-21 | Medimmune, Inc. | Humanization of antibodies |
| AR060017A1 (es) | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
| KR100781753B1 (ko) * | 2006-05-24 | 2007-12-04 | 연세대학교 산학협력단 | Ｄｋｋ2를 포함하는 혈관신생을 촉진시키는 방법 |
| CA2800311A1 (en) * | 2010-05-11 | 2011-11-17 | Aveo Pharmaceuticals, Inc. | Anti-fgfr2 antibodies |
| WO2012103787A1 (en) * | 2011-02-01 | 2012-08-09 | The University Of Hongkong | Use of anti-dkk1 monoclonal antibody for treatment of liver cancer |
| JP6758832B2 (ja) * | 2012-12-21 | 2020-09-30 | アベオ ファーマシューティカルズ， インコーポレイテッド | 抗ｇｄｆ１５抗体 |
| KR101508052B1 (ko) * | 2013-05-20 | 2015-04-08 | 울산대학교 산학협력단 | 생물학적 활성을 가진 인간 Ｄｋｋ２ 재조합 단백질의 수용성 발현 및 정제방법 |
| US10398765B2 (en) * | 2014-07-03 | 2019-09-03 | Yale University | Dickkopf2 (Dkk2) inhibition suppresses tumor formation |
| US11078278B2 (en) * | 2015-05-29 | 2021-08-03 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
| JP6921067B2 (ja) | 2015-10-28 | 2021-08-18 | イエール ユニバーシティ | ヒト化抗Ｄｋｋ２抗体およびその使用方法 |
-
2016
- 2016-10-20 JP JP2018521955A patent/JP6921067B2/ja active Active
- 2016-10-20 CA CA3003252A patent/CA3003252C/en active Active
- 2016-10-20 AU AU2016344459A patent/AU2016344459B2/en active Active
- 2016-10-20 CN CN201680075535.2A patent/CN108463247B/zh active Active
- 2016-10-20 DK DK16860530.1T patent/DK3368567T3/da active
- 2016-10-20 KR KR1020187013788A patent/KR20180085723A/ko not_active Ceased
- 2016-10-20 US US15/771,965 patent/US11267875B2/en active Active
- 2016-10-20 RU RU2018119317A patent/RU2018119317A/ru not_active Application Discontinuation
- 2016-10-20 WO PCT/US2016/057814 patent/WO2017074774A1/en not_active Ceased
- 2016-10-20 EP EP16860530.1A patent/EP3368567B1/en active Active
-
2018
- 2018-04-25 IL IL258924A patent/IL258924A/en unknown
-
2022
- 2022-02-07 US US17/666,018 patent/US20220162294A1/en not_active Abandoned
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