JP2019502748A - プロバイオティック組成物及びその使用 - Google Patents
プロバイオティック組成物及びその使用 Download PDFInfo
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- JP2019502748A JP2019502748A JP2018542116A JP2018542116A JP2019502748A JP 2019502748 A JP2019502748 A JP 2019502748A JP 2018542116 A JP2018542116 A JP 2018542116A JP 2018542116 A JP2018542116 A JP 2018542116A JP 2019502748 A JP2019502748 A JP 2019502748A
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- composition
- bacillus
- species
- bacteria
- biofilm
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Abstract
Description
本願は、すべての目的のために参照することによりその全体が本明細書に組み込まれる、2015年10月30日に出願され、「プロバイオティック組成物及びその使用」と題された米国仮特許出願第62/248,710号の利益を主張する。
本明細書に開示される組成物において、塩素が消毒剤として使用される。本明細書に開示される組成物において、1種以上の消毒剤が使用され得る。本明細書に開示されるもののような、当業者に公知の任意の消毒剤が、本開示の組成物において使用され得る。例えば、消毒剤は、二酸化塩素、アルコール又は過酸化水素であり得る。
Claims (17)
- 環境中の病原体を低減させるため、又は環境中のバイオフィルムを低減させるための組成物であって、
a)安定化剤及び少なくとも1つのBacillus属の菌種;又は
b)安定化剤、少なくとも1つのBacillus属の菌種、及びプロテアーゼ若しくはアミラーゼ;又は
c)安定化剤、少なくとも1つのBacillus属の菌種、及び消毒剤;又は
d)安定化剤、少なくとも1つのBacillus属の菌種、消毒剤、及びプロテアーゼ若しくはアミラーゼ;又は
e)安定化剤、少なくとも1つのBacillus属の菌種、及び1種以上の界面活性剤;又は
f)安定化剤、少なくとも1つのBacillus属の菌種、1種以上の界面活性剤、及び消毒剤;又は
g)安定化剤、少なくとも1つのBacillus属の菌種、1種以上の界面活性剤、及びプロテアーゼ若しくはアミラーゼ;又は
h)安定化剤、少なくとも1つのBacillus属の菌種、1種以上の界面活性剤、プロテアーゼ若しくはアミラーゼ、及び消毒剤
を含む、組成物。 - 1種以上の界面活性剤が、組成物の0.5%〜1.0%、1%〜10%、10%〜20%、20%〜30%、30%〜40%、40%〜50%、50%〜60%、60%〜70%、70%〜80%、80%〜90%、又は90%〜99%の全体積である、請求項1に記載の組成物。
- 安定化剤が、組成物の0.1%〜0.2%、0.2%〜0.3%、0.3%〜0.4%、0.4%〜0.5%、0.5%〜0.6%、0.6%〜0,7%、0.7%〜0.8%、0.8%〜0.9%、0.9%〜1.0%、1.0%〜2.0%、2%〜5%、5%〜10%、10%〜20%、20%〜30%、30%〜40%又は40%〜50%の全体積である、請求項1に記載の組成物。
- プロテアーゼが、組成物の0.1%〜0.2%、0.2%〜0.3%、0.3%〜0.4%、0.4%〜0.5%、0.5%〜0.6%、0.6%〜0,7%、0.7%〜0.8%、0.8%〜0.9%、0.9%〜1.0%、1.0%〜2.0%、2.0%〜3.0%、3.0%〜4.0%、4.0%〜5.0%、5%〜10%、10%〜20%、20%〜30%、30%〜40%又は40%〜50%の全体積である、請求項1に記載の組成物。
- アミラーゼが、組成物の0.01%〜0.02%、0.02%〜0.03%、0.03%〜0.04%、0.04%〜0.05%、0.05%〜0.06%、0.06%〜0.07%、0.07%〜0.08%、0.08%〜0.09%、0.09%〜0.1%、0.1%〜1.0%、1.0%〜2.0%、2.0%〜3.0%、3.0%〜4.0%、4.0%〜5.0%、5%〜10%、10%〜20%、20%〜30%、30%〜40%又は40%〜50%の全体積である、請求項1に記載の組成物。
- 少なくとも1つのBacillus属の菌種が、組成物の0.01%〜0.02%、0.02%〜0.03%、0.03%〜0.04%、0.04%〜0.05%、0.05%〜0.06%、0.06%〜0.07%、0.07%〜0.08%、0.08%〜0.09%、0.09%〜1.0%、1.0%〜2.0%、2.0%〜3.0%、3.0%〜4.0%、4.0%〜5.0%、5.0%〜6.0%、6.0%〜7.0%、7.0%〜8.0%、8.0%〜9.0%、9.0%〜10.0%、10.0%〜15.0%、15.0%〜20.0%又は20.0%〜25.0%の全体積である、請求項1に記載の組成物。
- 消毒剤が、組成物の0.000001%〜0.000010%、0.00001%〜0.00010%、0.0001%〜0.0010%、0.0010%〜0.010%、0.010%〜0.1%、0.10%〜1.0%、1.0%〜10%の全体積である、請求項1に記載の組成物。
- 少なくとも1つのBacillus属の菌種が、Bacillus subtilis、Bacillus licheniformis、Bacillus pumilus、Bacillus coagulans、Bacillus amyloliquefaciens、Bacillus magaterium又はBacillus mojavensisである、請求項1に記載の組成物。
- 環境が、表面、空気、空間、哺乳動物の呼吸器系、哺乳動物の胃腸管、又は水溶液である、請求項1に記載の組成物。
- a)安定化剤が、安息香酸ナトリウム、硝酸塩、亜硝酸塩、クエン酸、硝酸ナトリウム、安息香酸、二酸化イオウ、酢、塩化ベンザルコニウム、安息香酸、ベンジルアルコール、パラベン、酒石酸、イソチアゾリノン、二酸化イオウ、プロピレングリコール、ポリエチレングリコール(PEG)、グリセリン、グリセロール、酸化エチレンのオリゴマー若しくはポリマー、メトキシポリエチレングリコール、酸化ポリエチレン、ポリオキシエチレン、単純ポリオール、1,2-ジヒドロキシプロパン、1,2-プロパンジオール、メチルグリコール、トリメチルグリコール、若しくは上記のいずれかの誘導体であり;又は
b)消毒剤が、塩素、二酸化塩素、アルコール、過酸化水素、次亜塩素酸ナトリウム、酸化性物質、第四級アンモニウム、クロルヘキシジン、グルタルアルデヒド、フェノール、マツ油、若しくは上記のいずれかの誘導体であり;又は
c)界面活性剤が、石鹸、洗剤、湿潤剤、乳化剤、発泡剤若しくは分散剤である、
請求項1に記載の組成物。 - 病原体が、病原性細菌、ウイルス又は真菌である、請求項1に記載の組成物。
- バイオフィルムが病原体を含み、病原体が病原性細菌、ウイルス又は真菌である、請求項1に記載の組成物。
- a)ふき取り布、スポンジ若しくはクロス上に存在するか;又は
b)スプレー、ミスト、霧、粒子のコロイド状懸濁液、半固体形態若しくはエアロゾルスプレーであるか;又は
c)フォームである、
請求項1に記載の組成物。 - a) A1+、A2+、B1+、CF+、C+、CO+、AC-C、AC-L、HC+、PBフォーム、A1+ふき取り布、CO+ ふき取り布、M+、M+2、M+2s、W+、P+、W+2、W+2s、AC-S、D+t128、J+、D+h100、Tingle若しくはCPD+;又は
b)水溶液中に希釈されたA1+、A2+、B1+、CF+、C+、CO+、AC-C、AC-L、HC+、PBフォーム、M+、M+2、M+2s、W+、P+、W+2、W+2s、AC-S、D+t128、J+、D+h100、Tingle若しくはCPD+
である、
請求項1に記載の組成物。 - a)低減が、ATPを測定することにより、RLUでATPを測定することにより、若しくは面積当たりのCFUで細胞数を測定することにより、決定されるか;又は
b)低減が、0.1%〜1%、1%〜10%、10%〜20%、20%〜30%、30%〜40%、40%〜50%、50%〜60%、60%〜70%、70%〜80%、80%〜90%、若しくは90%〜100%である、
請求項1に記載の組成物。 - 請求項1〜8、10及び13〜14のいずれか1項に記載の組成物により環境を処理する工程を含む、環境中の病原体を低減させる方法。
- 請求項1〜8、10及び13〜14のいずれか1項に記載の組成物により環境を処理する工程を含む、環境中のバイオフィルムを低減させる方法。
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