JP2019501167A5 - - Google Patents
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- JP2019501167A5 JP2019501167A5 JP2018532323A JP2018532323A JP2019501167A5 JP 2019501167 A5 JP2019501167 A5 JP 2019501167A5 JP 2018532323 A JP2018532323 A JP 2018532323A JP 2018532323 A JP2018532323 A JP 2018532323A JP 2019501167 A5 JP2019501167 A5 JP 2019501167A5
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- JP
- Japan
- Prior art keywords
- disease
- amyloidosis
- compound
- protein
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 150000001875 compounds Chemical class 0.000 claims description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 27
- 201000010099 disease Diseases 0.000 claims description 22
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 206010002022 amyloidosis Diseases 0.000 claims description 15
- 208000022256 primary systemic amyloidosis Diseases 0.000 claims description 15
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 claims description 13
- 102000029797 Prion Human genes 0.000 claims description 12
- 108091000054 Prion Proteins 0.000 claims description 12
- 208000024777 Prion disease Diseases 0.000 claims description 12
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims description 10
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 10
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims description 10
- 102000014461 Ataxins Human genes 0.000 claims description 10
- 108010078286 Ataxins Proteins 0.000 claims description 10
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 10
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 10
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 10
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 10
- 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 claims description 10
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 10
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 10
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 10
- 229910052794 bromium Inorganic materials 0.000 claims description 10
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 10
- 230000004845 protein aggregation Effects 0.000 claims description 10
- 208000037956 transmissible mink encephalopathy Diseases 0.000 claims description 10
- -1 ANF Proteins 0.000 claims description 8
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims description 8
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims description 8
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 8
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 8
- 208000037957 feline spongiform encephalopathy Diseases 0.000 claims description 8
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 150000002367 halogens Chemical class 0.000 claims description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 208000018737 Parkinson disease Diseases 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000001768 cations Chemical group 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- 239000000460 chlorine Substances 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 6
- 208000023769 AA amyloidosis Diseases 0.000 claims description 5
- 208000023761 AL amyloidosis Diseases 0.000 claims description 5
- 208000024827 Alzheimer disease Diseases 0.000 claims description 5
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims description 5
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims description 5
- 208000014644 Brain disease Diseases 0.000 claims description 5
- 241000283707 Capra Species 0.000 claims description 5
- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 5
- 241000282994 Cervidae Species 0.000 claims description 5
- 102000012192 Cystatin C Human genes 0.000 claims description 5
- 108010061642 Cystatin C Proteins 0.000 claims description 5
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 5
- 208000032274 Encephalopathy Diseases 0.000 claims description 5
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 claims description 5
- 208000007487 Familial Cerebral Amyloid Angiopathy Diseases 0.000 claims description 5
- 102000008946 Fibrinogen Human genes 0.000 claims description 5
- 108010049003 Fibrinogen Proteins 0.000 claims description 5
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 5
- 102000004878 Gelsolin Human genes 0.000 claims description 5
- 108090001064 Gelsolin Proteins 0.000 claims description 5
- 206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 claims description 5
- 208000023105 Huntington disease Diseases 0.000 claims description 5
- 108060003951 Immunoglobulin Proteins 0.000 claims description 5
- 102000004877 Insulin Human genes 0.000 claims description 5
- 108090001061 Insulin Proteins 0.000 claims description 5
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 5
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 5
- 102000016943 Muramidase Human genes 0.000 claims description 5
- 108010014251 Muramidase Proteins 0.000 claims description 5
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 5
- 241000772415 Neovison vison Species 0.000 claims description 5
- 241001494479 Pecora Species 0.000 claims description 5
- 108010071690 Prealbumin Proteins 0.000 claims description 5
- 102000054727 Serum Amyloid A Human genes 0.000 claims description 5
- 108700028909 Serum Amyloid A Proteins 0.000 claims description 5
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 5
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 5
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 5
- 102100040347 TAR DNA-binding protein 43 Human genes 0.000 claims description 5
- 101710150875 TAR DNA-binding protein 43 Proteins 0.000 claims description 5
- 241000933173 Tragelaphus angasii Species 0.000 claims description 5
- 102000009190 Transthyretin Human genes 0.000 claims description 5
- 108090000185 alpha-Synuclein Proteins 0.000 claims description 5
- 102000003802 alpha-Synuclein Human genes 0.000 claims description 5
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 5
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 5
- 230000001684 chronic effect Effects 0.000 claims description 5
- 201000006061 fatal familial insomnia Diseases 0.000 claims description 5
- 229940012952 fibrinogen Drugs 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 5
- 102000018358 immunoglobulin Human genes 0.000 claims description 5
- 239000012678 infectious agent Substances 0.000 claims description 5
- 229940125396 insulin Drugs 0.000 claims description 5
- 229960000274 lysozyme Drugs 0.000 claims description 5
- 235000010335 lysozyme Nutrition 0.000 claims description 5
- 239000004325 lysozyme Substances 0.000 claims description 5
- 230000002981 neuropathic effect Effects 0.000 claims description 5
- 208000008864 scrapie Diseases 0.000 claims description 5
- 208000011580 syndromic disease Diseases 0.000 claims description 5
- 102000013498 tau Proteins Human genes 0.000 claims description 5
- 108010026424 tau Proteins Proteins 0.000 claims description 5
- 201000007905 transthyretin amyloidosis Diseases 0.000 claims description 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 241000283690 Bos taurus Species 0.000 claims description 3
- 241000282326 Felis catus Species 0.000 claims description 3
- 206010023497 kuru Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 241000283904 Tragelaphus strepsiceros Species 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 2
- 229960001231 choline Drugs 0.000 claims description 2
- 230000006806 disease prevention Effects 0.000 claims description 2
- 229940031098 ethanolamine Drugs 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 229910052744 lithium Inorganic materials 0.000 claims description 2
- 229960003646 lysine Drugs 0.000 claims description 2
- 229960003194 meglumine Drugs 0.000 claims description 2
- 229960005141 piperazine Drugs 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 2
- 229960000281 trometamol Drugs 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 108010040003 polyglutamine Proteins 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940002612 prodrug Drugs 0.000 description 3
- 239000000651 prodrug Substances 0.000 description 3
- 206010061818 Disease progression Diseases 0.000 description 2
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 2
- 230000005750 disease progression Effects 0.000 description 2
- 210000000003 hoof Anatomy 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 229960002036 phenytoin Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- RCQIIBJSUWYYFU-UHFFFAOYSA-N 5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1h-pyrazole Chemical compound BrC1=CC=CC(C=2NN=C(C=2)C=2C=C3OCOC3=CC=2)=C1 RCQIIBJSUWYYFU-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- XWLUWCNOOVRFPX-UHFFFAOYSA-N Fosphenytoin Chemical compound O=C1N(COP(O)(=O)O)C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 XWLUWCNOOVRFPX-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000034799 Tauopathies Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000003941 amyloidogenesis Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- JIKSKOXEWAHMRJ-UHFFFAOYSA-N chloromethyl dihydrogen phosphate Chemical class OP(O)(=O)OCCl JIKSKOXEWAHMRJ-UHFFFAOYSA-N 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000011979 disease modifying therapy Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229940126359 emrusolmin Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 229960000693 fosphenytoin Drugs 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 208000007153 proteostasis deficiencies Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15199972 | 2015-12-14 | ||
| EP15199972.9 | 2015-12-14 | ||
| PCT/EP2016/081084 WO2017102893A1 (en) | 2015-12-14 | 2016-12-14 | Water-soluble derivatives of 3,5-diphenyl-diazole compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501167A JP2019501167A (ja) | 2019-01-17 |
| JP2019501167A5 true JP2019501167A5 (enExample) | 2019-02-28 |
| JP6898931B2 JP6898931B2 (ja) | 2021-07-07 |
Family
ID=54850017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532323A Active JP6898931B2 (ja) | 2015-12-14 | 2016-12-14 | ３，５−ジフェニル−ジアゾール化合物の水溶性誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10308671B2 (enExample) |
| EP (1) | EP3390412B1 (enExample) |
| JP (1) | JP6898931B2 (enExample) |
| KR (1) | KR102671166B1 (enExample) |
| CN (1) | CN108473516B (enExample) |
| AU (1) | AU2016372408B2 (enExample) |
| BR (1) | BR112018011994B1 (enExample) |
| CA (1) | CA3008334C (enExample) |
| CL (1) | CL2018001570A1 (enExample) |
| DK (1) | DK3390412T3 (enExample) |
| ES (1) | ES2873510T3 (enExample) |
| HU (1) | HUE054815T2 (enExample) |
| IL (1) | IL260011B (enExample) |
| MX (1) | MX379522B (enExample) |
| NZ (1) | NZ742979A (enExample) |
| PH (1) | PH12018501276A1 (enExample) |
| PL (1) | PL3390412T3 (enExample) |
| PT (1) | PT3390412T (enExample) |
| RU (1) | RU2764131C2 (enExample) |
| WO (1) | WO2017102893A1 (enExample) |
| ZA (1) | ZA201803865B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH713150A2 (fr) * | 2016-11-23 | 2018-05-31 | Eta Sa Mft Horlogere Suisse | Mécanisme régulateur à résonateur rotatif à guidage flexible entretenu par un échappement libre à ancre. |
| US10368502B2 (en) | 2017-09-25 | 2019-08-06 | Multiple Energy Technologies Llc | Bioceramic and carbon-based hydroponic systems, methods and devices |
| EP4368184A3 (en) | 2019-11-19 | 2024-07-31 | Modag GmbH | Novel compounds for the diagnosis, treatment and prevention of diseases associated with the aggregation of alpha-synuclein |
| US20250161273A1 (en) * | 2022-03-01 | 2025-05-22 | Modag Gmbh | Pharmaceutical composition comprising diphenyldiazole derivatives and methods of use |
| CN115337301A (zh) * | 2022-07-22 | 2022-11-15 | 汕头大学医学院第一附属医院 | Anle138b在制备改善饮食诱导胰岛素抵抗药物中的应用 |
| CN116399983B (zh) * | 2023-06-09 | 2023-08-15 | 天津辰欣药物研究有限公司 | 一种利用gc-ms法检测二叔丁基氯甲基磷酸酯残留量的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| NZ564326A (en) * | 2005-06-16 | 2010-01-29 | Cv Therapeutics Inc | Prodrugs of A2B adenosine receptor antagonists |
| EP2272822A4 (en) * | 2008-03-31 | 2012-01-18 | Renascience Co Ltd | PLASMINOG ACTIVATOR-1 HEMMER |
| EP2687513B1 (en) * | 2008-06-09 | 2020-12-02 | Ludwig-Maximilians-Universität München | Drugs for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases |
| JP6069661B2 (ja) * | 2010-06-24 | 2017-02-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用 |
| SMT201700306T1 (it) * | 2012-06-08 | 2017-07-18 | Theravance Biopharma R&D Ip Llc | Inibitori di neprilisina |
-
2016
- 2016-12-14 KR KR1020187020192A patent/KR102671166B1/ko active Active
- 2016-12-14 EP EP16809425.8A patent/EP3390412B1/en active Active
- 2016-12-14 CA CA3008334A patent/CA3008334C/en active Active
- 2016-12-14 BR BR112018011994-6A patent/BR112018011994B1/pt active IP Right Grant
- 2016-12-14 ES ES16809425T patent/ES2873510T3/es active Active
- 2016-12-14 HU HUE16809425A patent/HUE054815T2/hu unknown
- 2016-12-14 WO PCT/EP2016/081084 patent/WO2017102893A1/en not_active Ceased
- 2016-12-14 RU RU2018125590A patent/RU2764131C2/ru active
- 2016-12-14 MX MX2018006877A patent/MX379522B/es unknown
- 2016-12-14 CN CN201680073089.1A patent/CN108473516B/zh active Active
- 2016-12-14 DK DK16809425.8T patent/DK3390412T3/da active
- 2016-12-14 US US16/062,258 patent/US10308671B2/en active Active
- 2016-12-14 JP JP2018532323A patent/JP6898931B2/ja active Active
- 2016-12-14 PL PL16809425T patent/PL3390412T3/pl unknown
- 2016-12-14 AU AU2016372408A patent/AU2016372408B2/en active Active
- 2016-12-14 NZ NZ742979A patent/NZ742979A/en unknown
- 2016-12-14 PT PT168094258T patent/PT3390412T/pt unknown
-
2018
- 2018-06-11 ZA ZA2018/03865A patent/ZA201803865B/en unknown
- 2018-06-13 IL IL260011A patent/IL260011B/en unknown
- 2018-06-13 CL CL2018001570A patent/CL2018001570A1/es unknown
- 2018-06-14 PH PH12018501276A patent/PH12018501276A1/en unknown
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