JP2019196345A - 炎症緩和用薬物を調製するためのニッケル錯体の使用方法 - Google Patents
炎症緩和用薬物を調製するためのニッケル錯体の使用方法 Download PDFInfo
- Publication number
- JP2019196345A JP2019196345A JP2018102793A JP2018102793A JP2019196345A JP 2019196345 A JP2019196345 A JP 2019196345A JP 2018102793 A JP2018102793 A JP 2018102793A JP 2018102793 A JP2018102793 A JP 2018102793A JP 2019196345 A JP2019196345 A JP 2019196345A
- Authority
- JP
- Japan
- Prior art keywords
- nickel complex
- preparing
- inflammation
- drug
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (9)
- 構造式(I)及び構造式(II)の少なくとも1つを含むニッケル錯体を有しており、Lは溶媒分子である、炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 膀胱炎を緩和する請求項1記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 酸化活性物質によって引き起こされる炎症反応を緩和する、請求項1記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 体液中の酸化活性物質の含有量を低減する、請求項1記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 前記酸化活性物質は、スーパーオキシドアニオン(O2 −)、過酸化水素(H2O2)、一重項酸素(1O2)、次亜塩素酸(HOCl)、一酸化窒素(NO)、および二酸化窒素(NO2)の少なくとも一つを含む、請求項3又は4記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 前記ニッケル錯体の含有量は、0.15mg/kg〜15mg/kgである、請求項1〜4のいずれか記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 前記ニッケル錯体の含有量は、0.5mg/kg〜2.5mg/kgである、請求項6記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 前記ニッケル錯体の含有量は、1.5mg/kgである、請求項7記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
- 静脈内、経皮、腹腔内、経口投与又は膀胱洗浄のための、請求項1〜4のいずれか記載の炎症緩和用薬物を調製するためのニッケル錯体の使用方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW107115858A TWI710371B (zh) | 2018-05-10 | 2018-05-10 | 鎳錯合物用於製備緩解膀胱發炎的藥物之用途 |
TW107115858 | 2018-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019196345A true JP2019196345A (ja) | 2019-11-14 |
JP6675439B2 JP6675439B2 (ja) | 2020-04-01 |
Family
ID=68465015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018102793A Active JP6675439B2 (ja) | 2018-05-10 | 2018-05-11 | 炎症緩和用薬物を調製するためのニッケル錯体の使用方法 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20190343874A1 (ja) |
JP (1) | JP6675439B2 (ja) |
TW (1) | TWI710371B (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230277554A1 (en) * | 2020-10-08 | 2023-09-07 | Matthew Lee | Composition containing nickel-superoxide dismutase and the like useful for haircare |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040052489A (ko) * | 2001-03-06 | 2004-06-23 | 셀러지 파마세우티칼스, 인크 | 비뇨생식기 장애 치료용 화합물 및 그 방법 |
TWI449699B (zh) * | 2012-05-22 | 2014-08-21 | Univ Nat Taiwan Normal | 新穎鎳錯合物及其衍生物與其製法及其做為抗氧化劑之應用 |
US9358239B2 (en) * | 2012-06-08 | 2016-06-07 | National Taiwan Normal University | NiSOD-like compound and its derivatives for suppressing abnormal protein aggregation, recovering cell viability, increasing mature neuron number and neurite outgrowth length and protecting dopaminergic cells by reducing oxidative stress or reactive oxygen species in brain tissues |
-
2018
- 2018-05-10 TW TW107115858A patent/TWI710371B/zh active
- 2018-05-11 JP JP2018102793A patent/JP6675439B2/ja active Active
- 2018-07-03 US US16/026,869 patent/US20190343874A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20190343874A1 (en) | 2019-11-14 |
TW201946618A (zh) | 2019-12-16 |
JP6675439B2 (ja) | 2020-04-01 |
TWI710371B (zh) | 2020-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Pluta et al. | Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage | |
Pritchard et al. | Effects of amiodarone on thyroid function in patients with ischaemic heart disease. | |
Liu et al. | Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts | |
Holland et al. | Use of ethylene diamine tetra acetic acid in hypercalcemic patients. | |
Ward et al. | Invited review: Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia | |
US20190282595A1 (en) | Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide | |
CN104010643A (zh) | 用于减少体脂肪和脂肪细胞的方法和组合物 | |
ES2359719T3 (es) | Composición farmacéutica comprendiendo quinuclidin-3'-il 1-fenil-1,2,3,4-tetrahidroisoquinolin-2-carboxilato para el tratamiento de la cistitis instersticial y/o la prostatitis no bacteriana. | |
JP5866279B2 (ja) | 脱毛防止又は育毛促進のための組成物 | |
CN106187793A (zh) | 5‑氨基酮戊酸及其衍生物的盐化合物和应用 | |
Sakai et al. | IV infusion of a drag-reducing polymer extracted from aloe vera prolonged survival time in a rat model of acute myocardial ischaemia | |
JP2011230055A5 (ja) | ||
JP6675439B2 (ja) | 炎症緩和用薬物を調製するためのニッケル錯体の使用方法 | |
CN107929314A (zh) | 一种含氢生理盐水及其制备方法和用途 | |
Effros | Microcirculation: current physiologic, medical, and surgical concepts | |
Poznyak et al. | Ozone dosage is the key factor of its effect in biological systems | |
WO2021073249A1 (zh) | β-NMN在制备脓毒症器官损伤的治疗、预防药物中的应用 | |
CN115813833A (zh) | 一种抑菌抗炎生发精华液及其制备方法 | |
WO2006020912A2 (en) | Treatments for congestive heart failure | |
CN101152180A (zh) | 一种含有米力农的药物组合物 | |
Strauch et al. | Cooling to 10 C and treatment with cyclosporine A improve cerebral recovery following prolonged hypothermic circulatory arrest in a chronic porcine model | |
US20230355871A1 (en) | Minimally Invasive and Semi-Automated Myocardial Injection Device | |
Redaelli et al. | How to obtain severe hypoglycemia without causing brain or cardiac damage | |
Appelgren et al. | Capillary flow and capillary transport in dog skeletal muscle in an experimental shock model (laparatomy and exteriorisation of the small intestine) | |
Wyska et al. | Pharmacokinetic modelling of pentoxifylline and lisofylline after oral and intravenous administration in mice |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180614 |
|
A80 | Written request to apply exceptions to lack of novelty of invention |
Free format text: JAPANESE INTERMEDIATE CODE: A80 Effective date: 20180606 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20181019 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191112 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200207 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200225 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200310 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6675439 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |