JP2019147767A - Cosmetics and skin external preparations - Google Patents

Abstract

To suppress temporal discoloration of cosmetics or skin external preparations containing: component (a) a C16-22 polyunsaturated fatty acid; and component (b) a vitamin E.SOLUTION: The present invention provides cosmetics or skin external preparations containing following components (a), (b) and (c): (a) a C16-22 polyunsaturated fatty acid, (b) a vitamin E, and (c) Lonicera japonica extract.SELECTED DRAWING: None

Description

  The present technology relates to a cosmetic, an external preparation for skin, and an agent for suppressing discoloration of a composition containing (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and (b) vitamin E.

Free fatty acids having 18 to 22 carbon atoms and having an unsaturated number of 2 or more in the molecular structure are often used in cosmetics or skin preparations for various purposes such as whitening.
For example, Patent Document 1 discloses a cosmetic containing, as an active ingredient, a free fatty acid having 18 to 22 carbon atoms and an unsaturated number in the molecular structure of 2 or more, a salt thereof, or an ester with a monohydric or dihydric alcohol. It is disclosed.
Patent Document 2 discloses an oil-soluble extract extracted from licorice, a free fatty acid having 18 to 22 carbon atoms and having 2 or more unsaturated bonds in its molecular structure, its salt and its ester. Whitening cosmetics characterized by blending one or two or more components selected from the group are disclosed.

JP 63-284109 A JP-A-5-194176

As shown in Table 1 below, the present inventors have noticed that a cosmetic ingredient in which a polyunsaturated fatty acid having 16 to 22 carbon atoms and vitamin E are mixed is discolored over time. (See Test Examples 1 to 3).
In general, polyunsaturated fatty acids having 16 to 22 carbon atoms are known to be components that are susceptible to deterioration due to oxidation or the like and that are unstable over time. Vitamin E is widely used as a fat-soluble vitamin in foods, pharmaceuticals, cosmetics and the like, and is also widely used as an antioxidant.
Normally, it is considered that the degradation of the polyunsaturated fatty acid is suppressed by vitamin E's antioxidant action. However, in actuality, discoloration occurred in the composition in which these were mixed.
In products such as cosmetics and external preparations for skin, it is desirable to use a component (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and a component (b) vitamin E, while discoloration is caused by the appearance of the product. In the case of a product that is not preferable and is subject to discoloration, the application may be limited.

  Therefore, the main object of the present technology is to suppress discoloration of a cosmetic or skin external preparation containing component (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and component (b) vitamin E.

In order to suppress discoloration of the composition containing the component (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and the component (b) vitamin E, The combination of was examined.
As shown in the following [Table 2], when using any one of peonies extract, rosemary extract and green tea extract, compared with one comparative example product to which these plant extracts are not added, the above components Discoloration of the composition containing (a) and the component (b) became strong. (See Comparative Examples 2 to 4). However, the present inventors have found that the honeysuckle extract can suppress discoloration of the composition containing the components (a) and (b), and completed the present invention.

That is, the present technology is as follows.
The present technology comprises the following components (a), (b) and (c);
(A) C16-C22 polyunsaturated fatty acid (b) Vitamin E (c) Cosmetic or skin external preparation containing honeysuckle extract.

Moreover, this technique uses the honeysuckle extract as an active ingredient, the following component (a) and component (b);
(A) 1 type, or 2 or more types selected from polyunsaturated fatty acids having 16 to 22 carbon atoms (b) 1 type or 2 or more types selected from vitamin Es,
It is an agent which suppresses discoloration of the composition containing this.

The component (a) may be linoleic acid or may contain it.
Vitamin E may be sufficient as the said component (b), and this may be included.
The content mass ratio (a) / (b) of the component (a) and the component (b) may be 0.1 to 10,000.
The content ratio of the “component (a) + component (b)” and the component (c) [(a) + (b)] / (c) may be 0.1 to 12000.
The discoloration due to the component (a) and the component (b) may be suppressed.

According to the present technology, discoloration of a cosmetic or skin external preparation containing component (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and component (b) vitamin E can be suppressed.
In addition, the effect described here is not necessarily limited, and may be any effect described in the present technology.

<Cosmetic or external preparation for skin>
The present technology is a composition containing component (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms, component (b) vitamin E, and component (c) honeysuckle extract. The composition is preferably a cosmetic and a skin external preparation.
By using the component (c) honeysuckle extract, discoloration caused by the component (a) and the component (b) can be suppressed, and a composition containing these components (a) and (b) Discoloration and discoloration of cosmetics or external preparations for skin can be suppressed.
In addition, the present technology includes a composition, a cosmetic, or a skin external application that includes the component (a), the component (b), and the component (c) and suppresses discoloration due to the component (a) and the component (b). An agent can be provided.

In general, for example, light (particularly ultraviolet rays), temperature (particularly heat, high temperature), pH, and the like are promoted as a cause of promoting “discoloration”, and discoloration with time is regarded as a problem.
Usually, cosmetics or external preparations for skin are often packaged after production and stored for a certain period of time, and are required to be stable over time even if exposed to various temperature environments and light during that time. In particular, since the appearance is an important quality for cosmetics and external preparations for skin, the product can suppress discoloration over time due to the component (a) and the component (b) when the user opens or during use. It becomes important.
In the present technology, it is advantageous that discoloration over time due to the component (a) and the component (b) can be suppressed for a long time at room temperature. According to the following [Example], it is possible to suppress at least 3 years at room temperature. I think it is possible.

Further, “discoloration” can be determined by leaving the color difference: 50 ° C. and 5 ° C. respectively, and comparing ΔE of the colorimetric values after a certain period.
This color difference is preferably less than ΔE6, more preferably less than ΔE5.5, and even more preferably ΔE5.0 or less. It can be determined that the smaller the color difference ΔE, the less the degree of discoloration.

<Long-chain polyunsaturated fatty acid>
The polyunsaturated fatty acid having 16 to 22 carbon atoms, which is component (a) used in the present technology, has 2 or 3 or more unsaturated bonds in its molecular structure. The component (a) is considered to cause discoloration when used in combination with the component (b) vitamin E described below.
The component (a) polyunsaturated fatty acid may be a free fatty acid or a salt thereof (generally usable salt), and one or more of them can be selected. The polyunsaturated fatty acid is preferably in the form of a free fatty acid, and preferably has two unsaturated bonds.
Moreover, carbon number of the polyunsaturated fatty acid is preferably 18-22.
The component (a) may be a commercially available product, and is preferably a separated purified product or a synthesized product.

  The component (a) can be expected to have an action of disappearing / preventing skin dryness by ultraviolet rays and pigmentation such as spots and freckles. For this reason, the said component (a) can be used as an emollient active component and a whitening component. And it can be set as the composition (for example, cosmetics, skin external preparation, etc.) for emollient or whitening by containing the said component (a).

Representative examples of the free fatty acid include linoleic acid, α-linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid, arachidonic acid, eicosadienoic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). ) And the like, and one or more of them can be selected from these.
Examples of the salt of the free fatty acid include metal salts such as sodium salt and potassium salt; amino acid salts such as arginine salt and lysine salt; amine salts such as triethanolamine salt and monoethanolamine salt. 1 type, or 2 or more types can be selected.

  In the present technology, when an ester of the polyunsaturated fatty acid is contained in the composition, the ester derivative may be decomposed depending on temperature, pH, time, or the like to generate free polyunsaturated fatty acid. According to the present technology, discoloration due to this free polyunsaturated fatty acid and vitamin E can be suppressed.

Among the components (a), linoleic acid or a salt thereof is considered to easily cause discoloration when mixed with component (b) vitamin E, and linoleic acid also has a whitening action and an emollient action. There is little smell.
For this reason, among the component (a), linoleic acid or a salt thereof (hereinafter also referred to as linoleic acid) is preferable, and the component (a) containing linoleic acid (preferably linoleic acid) is preferable. . In the present technology, it is possible to include the component (a) other than linoleic acids as long as the efficacy is not impaired.
The emollient action of the present technology refers to the action of softening the skin and the moisturizing action of the skin.

The content or use amount of the component (a) used in the present technology is preferably 0.0001% by mass to 5% by mass, more preferably 0.001% by mass to 3% by mass in terms of free fatty acid in the composition. Preferably, 0.01% by mass to 1% by mass is more preferable.
Moreover, 0.0001 mass%-5 mass% are preferable in the said composition, cosmetics, or skin external preparations, and, as for content or usage-amount of linoleic acid used by this technique, 0.001 mass%-3 % By mass is more preferable, and 0.01% by mass to 1% by mass is more preferable.

As component (b) vitamin E used in the present technology, tocopherol (for example, α-, β-, γ-, δ-tocopherol) and tocotrienol (for example, α-, β-, γ-, δ-tocotrienol, etc.) Vitamin E derivatives such as vitamin E acetate, vitamin E nicotinate, α-tocopherol 2-L-ascorbic acid diester (preferably vitamin E ester); salts thereof (generally usable) Salt) and the like, and one or more of them can be selected.
The component (b) may be a commercially available product and may be naturally derived or a synthetic product. In the case of natural origin, a separated and purified product is preferred.

  In general, synthetic vitamin E is a raw material produced by chemical synthesis (for example, dl-α-tocopherol).

In general, naturally derived vitamin E is extracted from vegetable oil or production oil of microorganisms (for example, algae). Of these, vegetable oil-derived vitamin E is preferred because it is widely used in cosmetics and the like. Examples of the plant include soybean, sunflower seed, wheat germ, rapeseed and the like. Examples of algae include euglena, chlorella, and spirulina.
Moreover, as naturally-derived vitamin E, for example, organic acid (for example, acetic acid, succinic acid, etc.) after extraction and the like stabilized (for example, vitamin E derivatives containing acetic acid d-α-tocophenol, etc.) and What is not used as a derivative after extraction (vitamin E containing d-α-tocopherol and the like) and the like.

  In general, vitamin E derived from vegetable oil or vitamin E derived from algae includes α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol, and is one or a mixture of two or more selected from these. Usually, among these, two, three or four are often contained.

  The composition ratio of vegetable oil-derived vitamin E that is generally marketed is as follows: α-tocopherol 5-20% by mass, β-tocopherol 0-10% by mass, γ-tocopherol 30-90% by mass, δ-tocopherol 5-60% by mass %and so on. This commercially available vegetable oil-derived vitamin E is also called natural vitamin E as another name.

  It is considered that the component (b) vitamin E is likely to cause discoloration over time by mixing with the component (a) polyunsaturated fatty acid. Vitamin E has an antioxidant action and a blood circulation promoting action, and is often used from the viewpoint of cost and safety.

Of the components (b), vitamin E is preferred. Vitamin E may be synthetic vitamin E or naturally derived vitamin E. In the present technology, it is possible to include the component (b) other than vitamin E as long as the efficacy is not impaired.
Of the vitamin E, tocopherol is preferred. The tocopherol may be a synthetic tocopherol or a natural tocopherol.
Of these, natural tocopherol is preferable in that it is a mixture selected from α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol. Moreover, if it is a mixture, a synthetic tocopherol may be sufficient.

The content or amount of the component (b) used in the present technology is preferably 0.00001% by mass to 5% by mass, more preferably 0.0001% by mass to 3% by mass in the composition. 001 mass%-1 mass% are still more preferable.
In addition, the content or use amount of vitamin E used in the present technology is preferably 0.00001% by mass to 5% by mass, more preferably 0.0001% by mass to 3% by mass in the composition. 001 mass%-1 mass% are still more preferable.

The honeysuckle extract of the component (c) used in the present technology is an extract of the family Caprifoliaceae, Lonicera, Lonicera japonica, and related plants. The honeysuckle family (Caprifolaceae), honeysuckle genus (Lonicera), honeysuckle (Lonicera japonica) and its related plants include Lonicera hypoglaca (Licera hydraca), Lonella hypoglaca (Licera), Lonicera hydraca (Licera). and dastystyla, Lonicera confusa, Lonicera mcrantha, and the like.
Honeysuckle is a shrub native to Japan, East Asia, etc., and the flowers have a fragrance. The herbal medicine “Kinginka” is a dried honeysuckle pod, and the herbal medicine “Nindou” is a dried honeysuckle foliage.

Although any part may be used as a part used for the extraction of the plant, for example, flowers, flower buds, leaves, stems and roots may be used, and one or more selected from these may be used. Can do. Among these, the flower is preferable and the floret is more preferable from the viewpoint of discoloration suppression of the present technology.
As the plant extraction site, those subjected to appropriate treatment such as drying, pulverization, cutting or shredding can be used, and it is desirable to perform extraction after the treatment.

  The method for extracting the plant is not particularly limited. The extraction may be performed using an extraction solvent for the honeysuckle under a certain temperature (low temperature, room temperature or warming), for a predetermined period of time, such as by immersion.

Although it does not specifically limit as said extraction solvent, For example, water, an organic solvent, etc. are mentioned, From this, 1 type (s) or 2 or more types can be selected. Also, carbon dioxide, water, etc. in a supercritical state can be used.
Examples of the organic solvent include one or more selected from alcohols; ketones such as acetone; ethers such as ethyl ether; esters such as ethyl acetate; hydrocarbons such as hexane and benzene. Can be used.

Examples of the alcohols include lower monohydric alcohols (eg, methanol, ethanol, etc.); liquid polyhydric alcohols (eg, 1,3-butylene glycol, propylene glycol, glycerin, etc.) and the like.
The alcohols are preferably monohydric alcohols and dihydric alcohols, and the alcohols preferably have about 1 to 5 carbon atoms.

Of the extraction solvents, water and / or alcohols (preferably having 1 to 4 carbon atoms) are preferable. As the alcohols, one or more selected from methanol, ethanol, propylene glycol, and 1,3-butylene glycol (1,3-BG) are preferable.
Among these extraction solvents, more preferably one or a mixture of two or more selected from water, ethanol and 1,3-butylene glycol, more preferably water, ethanol, 1,3-butylene glycol. Ethanol water mixed solution, 1,3-butylene glycol water mixed solution, and still more preferably ethanol water mixed solution.
In the case of an alcohol aqueous solution, the alcohol concentration (V / V) is preferably 0 to 100% by volume, and more preferably 20 to 80% by volume.

As an example of a preferable extraction method of the honeysuckle extract, the honeysuckle is extracted with the extraction solvent at room temperature (for example, about 1 to 30 ° C.) or warming (for example, about 30 to 100 ° C.) for 5 minutes to 7 days. The method of performing is mentioned. As the extraction solvent at this time, any of water, alcohols, and water-alcohol mixed liquids is preferable, and alcohols and water-alcohol mixed liquids are more preferable.
The extraction may be either room temperature extraction or warm extraction. It is preferable that the extraction is performed at room temperature (preferably 10 to 30 ° C.) for 1 to 7 days. Moreover, it is preferable that it is 1 to 12 hours by heating (40-90 degreeC) extraction.

  The honeysuckle extract of the present technology may be used as an active ingredient as it is, or may be appropriately treated by a known separation and purification method in order to remove impurities or other impurities within a range that does not impair the effect. May be. For example, if necessary, it can also be used after performing purification treatment such as removal of the extraction solvent, filtration, deodorization of ion exchange resin, decolorization and the like. In addition, a highly active fraction can be used by using a separation means such as liquid chromatography.

  The honeysuckle extract of the present technology can be used as an extract alone or by mixing the extract obtained by different extraction methods, or by diluting, concentrating or drying the extract. It is also possible to prepare and use it in the form of a shape.

  And as shown in the postscript Example, the component (c) honeysuckle extract of this technique is (a) 1 type, or 2 or more types chosen from a C16-C22 polyunsaturated fatty acid, (b) vitamin It has the effect of suppressing discoloration caused by including one or more selected from E. That is, the discoloration inhibitor of the composition containing the said component (a) and the component (b) which contains the said component (c) as an active ingredient can be provided. In addition, it is preferable from the result of an after-mentioned [Example] that the composition containing the said component (a) and a component (b) is cosmetics or a skin external preparation.

  Moreover, the component (c) honeysuckle extract of this technique can be used for the method of suppressing discoloration by the said component (a) and a component (b). Moreover, the component (c) honeysuckle extract for suppressing discoloration of the composition containing the component (a) and the component (b) can be provided. Moreover, in order to manufacture the agent or composition which can suppress the discoloration by the said component (a) and a component (b), a component (c) honeysuckle extract can be used.

The content or use amount of the component (c) used in the present technology is preferably 0.00001% by mass to 5% by mass, more preferably 0.00005% by mass to 1% by mass, as the pure extract in the composition. Preferably, 0.0001% by mass to 0.5% by mass is more preferable.
In addition, the content or use amount of the extracts of the honeysuckle family (Caprifolaceae), honeysuckle (Lonicera), honeysuckle (Lonicera japonica) and related plants (preferably extracts of flowers and florets) used in the present technology is In the composition, 0.00001% by mass to 5% by mass is preferable as a pure extract, more preferably 0.00005% by mass to 1% by mass, and further preferably 0.0001% by mass to 0.5% by mass.

The pH in the composition, cosmetics, external preparation for skin, or discoloration suppressing method of the present technology is not particularly limited, and can be appropriately adjusted with a pH adjuster.
The pH (20 ° C.) of the present technology is preferably 3.0 to 9.0, and more preferably 4.0 to 8.0. By adjusting to the said pH, since the said component (c) honeysuckle extract is easy to suppress the discoloration by the said component (a) and a component (b), it is advantageous.
Moreover, pH (20 degreeC) after mixing the said component (a)-component (c) becomes like this. Preferably it adjusts to 3.0-9.0, More preferably, it is 4.0-8.0, This is preferable in that discoloration over time can be easily suppressed.
Moreover, since the said component (a) and a component (b) are easy to produce discoloration in water presence, it is preferable to use a component (c) honeysuckle extract for the composition containing water for discoloration suppression.

The content (use) mass ratio (a) / (c) of the component (a) and the component (c) used in the present technology is preferably 0.1 to 1000, more preferably 0.3 to 500, and more. Preferably it is 0.5-100.
The content ratio (b) / (c) of the component (b) and the component (c) used in the present technology is preferably 0.003 to 10,000, more preferably 0.01 to 1000, and more. Preferably it is 0.1-100.

  The content mass ratio (a) / (b) of the component (a) polyunsaturated fatty acid and the component (b) vitamin E used in the present technology is preferably 0.1 to 10,000, more preferably 0. .3-1000, more preferably 0.5-500. By setting it as such a range, the effect of the said component (a) and a component (b) can be exhibited further more favorably.

  The content (use) mass ratio [(a) + (b)] / (c) of “component (a) + component (b)” and component (c) used in the present technology is preferably 0.1 to 0.1%. 12000, More preferably, it is 0.3-6000, More preferably, it is 0.5-3000. By setting it as such a range, discoloration can be suppressed more satisfactorily while the effects of the component (a) and the component (b) are exhibited more satisfactorily.

  Examples of the composition (preferably a cosmetic or skin external preparation) that is subject to discoloration suppression according to the present technology include a skin external preparation, a cosmetic, a whitening agent, a deodorant agent, and a detergent. Among these, a composition used for skin care that expects an emollient effect is preferred.

  In addition, compositions, cosmetics or external preparations for skin containing components (a) to (c) of the present technology are usually used in cosmetics and quasi-drugs as long as they do not impair the effects of the present technology. Ingredients used in various preparations such as external preparations for skin products and pharmaceuticals can be added. Examples of the component include water, oil agent, surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, UV protection agent, clathrate compound, antibacterial agent, perfume , Deodorant, salt, pH adjuster, freshener, animal / microbe-derived extract, plant extract, blood circulation promoter, astringent, antiseborrheic agent, whitening agent, anti-inflammatory agent, active oxygen scavenger, cell Activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like can be mentioned. One or two or more can be appropriately selected from these and used.

The composition, cosmetics or skin external preparation containing the component (a) to the component (c) of the present technology can be obtained by a known production method.
Specific examples of the cosmetics and skin external preparations of the present technology include, for example, basic cosmetics such as milky lotion, cream, lotion, beauty essence, pack, all-in-one gel, sunscreen, cleaning, makeup base, BB cream, Makeup cosmetics such as foundation, blusher and lipstick, hair nourishing agents, hair tonics, shampoos, rinses and other hair cosmetics, dispersions, ointments, solutions, aerosols, patches, poultices, liniments, etc. It may be. Cosmetics for use on the skin and external preparations for skin that are expected to have a whitening effect, an emollient effect, and the like are preferred.

Moreover, the discoloration inhibitor containing the component (c) of the present technology can be obtained by a known production method.
As a use of the discoloration inhibitor or discoloration suppression method of the present technology, it can be used for cosmetics; quasi-drugs, external preparations for pharmaceuticals, etc .; oral preparations, injections, etc., and particularly applied to the skin. Such cosmetics and external preparations for skin are suitable.
Moreover, as a form which mix | blends the discoloration inhibitor of this technique, skin external preparations, such as cosmetics, a quasi-drug, and a pharmaceutical, etc. are mentioned, for example. When the discoloration inhibitor of the present technology is blended in these forms, an appropriately acceptable component may be contained. Moreover, the discoloration inhibitor of this technique can also be contained when manufacturing these.

  Hereinafter, the present invention (present technique) will be described more specifically with reference to examples and test examples, but the present invention (present technique) is not limited to these examples and the like. Hereinafter, unless otherwise specified, the content is indicated by mass% with respect to the system containing the component.

<Sample preparation>
As linoleic acid, a commercially available product (manufactured by Wako Pure Chemical Industries, Ltd.), a free fatty acid linoleic acid, was purchased and used.
As vitamin E, a commercially available product (manufactured by Eisai Co., Ltd.), a naturally derived vitamin E (plant-derived), was purchased and used. The commercially available product is plant-derived vitamin E, which contains at least α-tocopherol, γ-tocopherol and δ-tocopherol.
Each plant extract used the following honeysuckle extract, rosemary extract, peonies extract, and green tea extract.

<Production Example 1. Preparation of Honeysuckle Extract>
Caprifoliaceae Lonicera and Lonicera japonica crushed 10 g of pulverized 10 g of 80% by volume ethanol aqueous solution (EtOH 8: water 2 (Vol / Vol)) was added for warm extraction. After filtering the extract, the solvent was distilled off to dryness to obtain a honeysuckle extract as a pure extract.

<Production Example 2. Preparation of rosemary extract>
100 mL of 50 volume% 1,3-butylene glycol aqueous solution was added to 10 g of dried leaves of Lamiaceae rosemary (scientific name: Rosmarinus officinalis), followed by extraction at room temperature (10-30 ° C.) for 7 days, and then the filtrate. The solution was aged by standing at about 5 ° C. for 7 days, and then filtered. The solvent of the filtrate was distilled off to dryness to obtain a rosemary extract as a pure extract.
<Production Example 3. Preparation of peony extract>
Shred 10 g of the roots of the genus Peonies (scientific name: Paeonia lactiflora), add 100 mL of 50 volume% 1,3-butylene glycol aqueous solution to this, and stir while heating (about 50-70 ° C.) for 4 hours. After extraction, it was filtered. The filtrate was allowed to stand at about 5 ° C. for 7 days for aging and then filtered. The solvent of the filtrate was distilled off to dryness to obtain a peony extract as a pure extract.
<Production Example 4. Preparation of green tea plant extract>
10 g of dried leaves of Camellia genus Camellia (scientific name: Camellia sinensis) are cut into small pieces, 200 mL of a 50% by volume aqueous ethanol solution is added, and extraction is performed for 2 days while stirring at room temperature (10 to 30 ° C.). After filtering the liquid, the solvent was distilled off to dryness to obtain a green tea extract as a pure extract.

<Color difference measurement method>
Glass bottles containing samples for 50 ° C. and 5 ° C. were prepared. The sample was dispensed into each glass bottle, and the lid was left as it was without replacing the air in the glass bottle. The glass bottle with the sample was put in a thermostat at 50 ° C. and 5 ° C., respectively, and left still for a certain period.
Each sample that has been allowed to stand for a certain period of time is transferred to a glass cell for measurement, and L *, a *, b * values are measured using a Nippon Denshoku color difference meter SE-2000, and ΔL = L ^* ( 5 ° C.) − L ^* (50 ° C.), Δa = a ^* (5 ° C.) − A ^* (50 ° C.), Δb = b ^* (5 ° C.) − B ^* (50 ° C.).
Next, ΔE was calculated according to the following equation, and the discoloration of the sample was evaluated based on the value of ΔE.
ΔE = ((ΔL) ² + (Δa) ² + (Δb) ² ) ^1/2
L ^* is “lightness index” (L axis = 0 to 100), a ^* and b ^* are “chromaticness index” (a axis = −120 to +120, b axis = −120 to +120)

<Test Example 1: Stability over time (discoloration) test>
Samples of Test Examples 1 to 3 were prepared by mixing the components shown in Table 1. The pH (20 ° C.) of the sample at the time of manufacture was 6.5, and the samples of Test Examples 1 to 3 were measured by the above color difference measurement method and stored for 5 days and stored at 50 ° C. for 4 days. The color difference ΔE from the product was determined.

  In the test example 2 sample of natural vitamin E alone and the test example 3 sample of linoleic acid alone, in which linoleic acid and natural vitamin E were not used in combination, the color difference was less than 1 and no discoloration occurred. However, in the sample of Test Example 1 in which linoleic acid and naturally occurring vitamin E are used in combination, the color difference ΔE is 4 times as long as the test starts only on the 4th day compared to the samples of Test Example 2 and Test Example 3 respectively. Furthermore, since the color change (yellowing) was slightly confirmed even with the naked eye, the color change was expected to further progress with time.

  By adding linoleic acid and vitamin E, it was completely unexpected that the color difference increased synergistically even on the fourth day, and the present inventors have examined the mechanism, and this mechanism is still Although it is unknown, it is considered to be a discoloration caused by polyunsaturated fatty acids and vitamin Es.

However, in products such as cosmetics and external preparations for skin, discoloration is not preferable, and on the other hand, it is possible to reduce the content of either polyunsaturated fatty acids or vitamin Es. It is a component often used in preparations and external preparations for skin, and it is desired to use it in as much content as possible.
Therefore, it has become necessary to search for a component that can suppress discoloration of a composition containing these, without worrying about the contents of polyunsaturated fatty acids and vitamin Es.

[Example 1: Lotion]
Therefore, as shown in Table 2, the present inventors blended various plant extracts in a lotion containing linoleic acid and naturally occurring vitamin E, and left the discoloration over time for about 5 weeks. Evaluation was made using the color difference ΔE between the 5 ° C. storage product and the 50 ° C. storage product. The pH (20 ° C.) of the lotion at the time of manufacture was 5.1. As Comparative Examples 2 to 4, a lotion containing a peony extract, a rosemary extract and a green tea extract instead of the honeysuckle extract was evaluated.

<Evaluation of ΔE at 50 ° C. and 5 ° C.>
Less than 6 ○: Almost no discoloration 6 or more and less than 7.5 △: Discoloration 7.5 or more ×: Strong discoloration

Manufacturing method 1. 1. Components (1) to (4) and components (10) to (13) are combined and mixed uniformly. Components (5) to (9), (14) and (15) are mixed uniformly.
While stirring 3.1, 2 was gradually added, and stirring was continued for 5 minutes after completion of the addition to obtain a skin lotion.

Even in the lotion that is an actual product, in Comparative Example 1 in which no plant extract was added, discoloration occurred over time, and good temporal stability important for cosmetics and skin external preparations was not recognized. .
And even if it mix | blends any of a peony extract, a rosemary extract, and a green tea extract with a lotion, compared with the lotion of the comparative example 1 which does not add these plant extracts, discoloration becomes strong on the contrary. Oops. These plant extracts are well known to have an antioxidant effect, but it was thought that this discoloration could not be suppressed only by a plant extract having an antioxidant effect. For this reason, since there is no index as a discoloration suppressing component, it was considered that it must be derived empirically, and various components were used.

  The present inventors have found that the discoloration of a composition containing linoleic acid and naturally occurring vitamin E can be suppressed in a honeysuckle extract by chance. Moreover, in the color difference evaluation, it has reached a level where there is no or almost no discoloration, which can be said to be a particularly remarkable effect. Moreover, since the discoloration inhibitory effect was recognized in the practical product containing components other than linoleic acid and naturally occurring vitamin E, it is considered that it can be applied to a wide range of products such as cosmetics, external preparations for skin, and other compositions.

[Example 3: lotion]
(Manufacturing method)
A. The following components (6) to (12) are mixed and dissolved.
B. The following components (1) to (5) and (13) are mixed and dissolved.
C. A was added to B and mixed to obtain a skin lotion.

(Ingredient) (%)
1. Glycerin 5.0
2. 1,3-butylene glycol 5.0
3. Lactic acid 0.05
4). Sodium lactate 0.1
5. Honeysuckle extract (Note 1) 0.001
6). Polyoxyethylene (60 mol) hydrogenated castor oil 1.2
7). Polyoxyethylene (40 mol) hydrogenated castor oil 0.5
8). Ethanol 8.0
9. Linoleic acid 0.1
10. Synthetic vitamin E (Note 2) 0.001
11. Methyl paraoxybenzoate 0.1
12 Fragrance 0.1
13. Purified water remaining amount (Note 1) Honeysuckle extract of Production Example 1 (Note 2) Vitamin E Eisai (Eisai Food Chemical Co., Ltd.)

  The lotion of Example 3 had no discoloration and good temporal stability.

[Example 4: Oil-in-water emulsified lotion]
(Production method)
A: Components (1) to (6) are heated and dissolved at 70 ° C.
B: Components (7) to (9) are heated and dissolved at 70 ° C. and then added to A to emulsify.
C: The B is cooled to room temperature.
D: The C is subjected to high pressure treatment (treatment pressure 200 MPa) with a microfluidizer.
E: Components (10) to (15) were uniformly mixed with D to obtain an oil-in-water emulsion lotion.

(Ingredient) (%)
1. Linoleic acid 0.0001
2. Hydrogenated soybean phospholipid 2.0
3. Cholesterol 0.8
4). Isostearic acid 3.0
5. Natural vitamin E (Note 3) 0.1
6). Tetra-2-ethylhexanoic acid pentaerythrityl 1.0
7). Glycerin 8.0
8). Dipropylene glycol 8.0
9. Purified water remaining amount 10. Honeysuckle extract (Note 4) 0.01
11. Glycosyl trehalose 5.0
12 Sodium pyrrolidonecarboxylate 1.0
13. Ethanol 5.0
14 Methyl paraoxybenzoate 0.2
15. Fragrance 0.2
(Note 3) Emix 70L (Eisai Food Chemical Co., Ltd.)
(Note 4) 100 mL of 1,3-butylene glycol) is added to 10 g of pulverized florets of Caprifoliaceae (Lonicera) and Lonicera japonica, and extracted at room temperature (10-30 ° C.) for 5 days. Thereafter, the extract was filtered and the solvent was distilled off to obtain a honeysuckle extract.

  The lotion of Example 4 had no discoloration and good temporal stability.

[Example 5: Cosmetic liquid]
(Manufacturing method)
A. The following components (1) to (10) are mixed and dissolved.
B. The following components (11) to (17) are mixed and dissolved.
C. B was added to A and mixed to obtain a serum.

(Ingredient) (%)
1. Dipropylene glycol 5.0
2. 1,3-butylene glycol 8.0
3. Acrylic acid / alkyl methacrylate (C10-30)
Cross polymer (Note 5) 0.2
4). Xanthan gum 0.2
5. Purified water remaining amount 6. Sodium hydroxide 2% aqueous solution 2.0
7). Honeysuckle extract (Note 6) 0.005
8). Sodium hyaluronate 0.01
9. Hydrolyzed elastin 0.01
10. Hydrolyzed collagen 0.1
11. Polyoxyethylene (60 mol) hydrogenated castor oil 0.5
12 Isostearic acid 0.2
13. Linoleic acid 0.001
14 Naturally derived vitamin E (Note 3) 0.01
15. Methyl paraoxybenzoate 0.1
16. Ethanol 2.0
17. Perfume 0.02
(Note 5) CARBOPOL 1382 (manufactured by LUBRIZOL ADVANCED MATERIALS)
(Note 6) 200 g of purified water was added to 10 g of pulverized flowers of Caprifoliaceae, Lonicera and Lonicera japonica, and the mixture was stirred for 4 hours while heating (50-60 ° C). It was. Thereafter, the extract was filtered and the solvent was distilled off to obtain a honeysuckle extract.

  The cosmetic liquid of Example 5 had no discoloration and good temporal stability.

[Example 6: Cosmetic liquid]
(Production method)
A: Components (1) to (6) are dissolved by heating at 70 ° C.
B: After heating components (7) to (19) at 70 ° C., the above A was added to emulsify and cooled to room temperature to obtain an oil-in-water cosmetic liquid.

(Ingredient) (%)
1. Linoleic acid 0.1
2. Ceramide 3 (Note 7) 0.1
3. Glyceryl triethylhexanoate 3.0
4). Sorbitan sesquioleate 1.5
5. Dimethylpolysiloxane (Note 8) 2.0
6). dl-α-tocopherol (Note 9) 0.02
7). Glycerin 3.0
8.1,3-Butylene glycol 5.0
9. 1,2-pentanediol 2.0
10. Xanthan gum 0.05
11. Purified water remaining amount 12. Phosphoric acid 0.1
13. Sodium monohydrogen phosphate 0.1
14 Honeysuckle extract (Note 10) 0.00001
15. Carboxymethylcellulose 2.0
16. Xanthan gum 0.1
17. Sodium hyaluronate 0.05
18. Edetic acid disodium 0.02
19. Fragrance 0.5
(Note 7) CERAMIDE3 (Nikko Chemicals)
(Note 8) KF-96-10CS (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 9) Made by DSM Nutrition Japan Co., Ltd. (Note 10) A 50% ethanol aqueous solution (EtOH 7: Water 3) was added to 50 g of pulverized florets of Caprifoliaceae (Lonicera) and Honeysuckle (Lonicera Japan). Vol / Vol)) 500 mL was added, and extraction was performed at room temperature (10 to 30 ° C.) for 5 days. Thereafter, the extract was filtered and the solvent was distilled off to obtain a honeysuckle extract.

  The cosmetic liquid of Example 6 had no discoloration and good temporal stability.

[Example 7: Oil-in-water emulsion]
(Manufacturing method)
A. Components (1) to (5) are uniformly dissolved and mixed at 70 ° C.
B. Components (6) to (14) are uniformly dissolved and mixed at 80 ° C.
C. B is added to A and emulsified at 70 ° C.
D. Components (15) to (19) were added to C and mixed, and then cooled to 40 ° C. to obtain an oil-in-water emulsion.

(Ingredient) (%)
1.1,3-Butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Purified water remaining amount 4. Honeysuckle extract (Note 11) 0.5
5. Sodium hydroxide 2% aqueous solution 0.2
6). N-myristoyl-L-glutamic acid 0.2
7). Polyoxyethylene (10 mol) hydrogenated castor oil 0.2
8). Macadamia nut oil fatty acid phytosteryl 1.0
9. Tri (caprylic acid / caprylic acid) glyceryl 0.2
10. Linoleic acid 0.1
11. Natural vitamin E (Note 3) 1.0
12 N-stearoyl phytosphingosine 0.1
13. Tocopherol acetate 0.01
14 Stearyl alcohol 0.5
15.1,2-Pentanediol 0.1
16. Carboxyvinyl polymer (Note 12) 0.15
17. (Na-acrylate / acryloyldimethyltaurine Na)
Copolymer (Note 13) 2.0
18. Ethanol 5.0
19. Fragrance 0.1
(Note 11) The pulverized product of the fruit of the honeysuckle family (Caprifoliaceae), Lonicera, and Black-headed Squid (Hascup) (Lonicera caerulea) is added to 100 g of a 20% by volume ethanol aqueous solution (EtOH 2: water 8 (Vol / Vol)). ) 500 mL was added and extraction was performed at room temperature (10-30 ° C.) for 5 days. Thereafter, the extract was filtered and the solvent was distilled off to obtain a honeysuckle extract.
(Note 12) CARBOPOL 941 (manufactured by LUBRIZOL ADVANCED MATERIALS)
(Note 13) SIMULGEL EG (manufactured by SEPIC)

  The emulsion of Example 7 had no discoloration and good temporal stability.

[Example 8: Latex]
(Manufacturing method)
A: Components (1) to (8) are dissolved by heating at 70 ° C.
B: Components (9) to (15) are heated at 70 ° C. and then added to A to emulsify.
C: After cooling B to room temperature, components (16) to (18) were added to obtain an oil-in-water emulsion.

(Ingredient) (%)
1. Linoleic acid 0.6
2. α-Linolenic acid (Note 14) 0.4
3. Hydrogenated soybean phospholipid 1.2
4). δ-tocopherol (Note 15) 0.003
5. α-Tocopherol (Note 16) 0.002
6.1,3-Butylene glycol 16.0
7). Isotridecyl isononanoate 1.0
8). Triethylhexanoin 1.0
9. Purified water remaining amount 10. Citric acid 0.1
11. Sodium citrate 0.1
12 Sodium hydroxide appropriate amount13. Honeysuckle extract (Note 17) 0.0001
14 Hydroxyproline 0.01
15. Phenoxyethanol 0.5
16. Ethanol 8
17. Carboxyvinyl polymer (Note 12) 0.2
18. Xanthan gum 0.2
(Note 14) Wako Pure Chemical Industries, Ltd. (Note 15) Sigma-Aldrich, Inc. (Note 16) Sigma-Aldrich, Inc. 100 g of ethanol was added to 10 g of pulverized stem and extracted at room temperature (10 to 30 ° C.) for 2 days. The extract was filtered, and the solvent was distilled off to obtain a honeysuckle extract.

  The emulsion of Example 8 had little discoloration and good temporal stability.

[Example 9: Cream]
(Manufacturing method)
A: Components (1) to (10) are dissolved by heating at 70 ° C.
B: After heating components (11) to (17) at 70 ° C., the A is added and emulsified.
C: The B was cooled to room temperature, and (18) to (20) were added and mixed to obtain an oil-in-water cream.

(Ingredient) (%)
1. Linoleic acid 1.0
2. Docosahexaenoic acid (DHA) (Note 18) 1.0
3. Polyoxyethylene (20) sorbitan monooleate 2.0
4). Polyoxyethylene alkyl ether phosphoric acid (Note 19) 0.3
5. Propylene glycol dicaprate 1.7
6). Squalane 3.5
7). Cetostearyl alcohol 3.0
8). Vaseline 2.0
9. Jojoba oil 1.0
10. Synthetic vitamin E (Note 2) 3.0
11.1,3-butylene glycol 2.0
12 Glycerin 10.0
13. Carboxyvinyl polymer (Note 20) 0.3
14 Carrageenan 0.1
15. Sodium hydroxide appropriate amount 16. Purified water remaining amount 17. Honeysuckle extract (Note 1) 1.0
18. Methyl paraoxybenzoate 0.3
19. Ethanol 7.0
20. Fragrance 0.2
(Note 18) Wako Pure Chemical Industries, Ltd. (Note 19) NIKKOL-DDP10 (Nikko Chemicals)
(Note 20) Hibiswako 105 (manufactured by Wako Pure Chemical Industries, Ltd.)

  The cream of Example 9 had little discoloration and good temporal stability.

[Example 10: Sunscreen fee]
(Manufacturing method)
A. Ingredients (10) to (12) are dispersed by a three roll.
B. The A and components (1) to (9) are heated to 70 ° C.
C. Ingredients (13)-(18) are warmed to 70 ° C.
D. B is added to C and emulsified.
E. The D was cooled to room temperature and cooled to obtain a creamy oil-in-water emulsion type sunscreen.

(Ingredient) (%)
1. Cetostearyl alcohol 1.0
2. Liquid paraffin 3.0
3. Polyoxyethylene (20) sorbitan monooleate 2.0
4). Polyoxyethylene (60 mol) hydrogenated castor oil 1.0
5. Polyoxyethylene alkyl ether phosphoric acid (Note 19) 0.1
6). Acrylic-silicone graft copolymer solution (Note 21) 1.0
7). Octyl paramethoxycinnamate 10.0
8). Natural vitamin E (Note 3) 0.001
9. Linoleic acid 0.05
10. Myristic acid (3%) methyl hydrogen polysiloxane (15%) treated zinc oxide (particle size 20 nm) 10.0
11. Decamethylcyclopentasiloxane 15.0
12 (Dimethicone / Phenyl dimethicone) Crosspolymer mixture (Solid content 15%) (Note 22) 10.0
13. Stearoyl methyl taurine sodium 2.0
14 (Sodium acrylate / acryloyldimethyltaurine sodium) copolymer (Note 13) 4.0
15.1,3-Butylene glycol 8.0
16. Polyethylene glycol (Note 23) 5.0
17. Purified water remaining amount 18. Honeysuckle extract (Note 1) 0.4
(Note 21) KP545L (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 22) KSG-18 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 23) PEG400 (manufactured by Sanyo Chemical Industries)

  The sunscreen of Example 10 had no discoloration and good stability over time.

[Example 11: Liquid foundation]
(Manufacturing method)
A: Disperse components (15) to (22) with three rollers.
B: Components (1) to (9) are heated at 90 ° C. and uniformly mixed.
C: (10) heated to about 90 ° C. was added to B and emulsified, and then cooled and (11) to (14) were added.
D: Mix A with C. E: Fill the container with D to obtain an oil-in-water liquid foundation.

(Ingredient) (%)
1. Polyoxyethylene (60) hydrogenated castor oil 0.5
2. Tetraoleic acid polyoxyethylene (20) sorbit 1.0
3. (Dimethicone / Vinyl Dimethicone)
Cross polymer mixture (5% solids) (Note 24) 10.0
4). Methyl trimethicone 5.0
5. Octyl methoxycinnamate 3.0
6). Bisethylhexyloxyphenol Methoxyphenyltriazine (Note 25) 5.0
7). Acrylic-silicone graft copolymer solution (Note 26) 5.0
8). Linoleic acid 0.1
9. Natural vitamin E (Note 3) 0.00001
10. Purified water remaining amount 11. (Sodium acrylate / acryloyldimethyltaurine sodium) copolymer (Note 13) 1.0
12 Phenoxyethanol 0.3
13.1,3-Butylene glycol 10.0
14 Honeysuckle extract (Note 1) 0.0001
15. Alkyl acrylate polymer emulsion (Note 27) 3.0
16. Triethanolamine 3.5
17. Black iron oxide 0.2
18. Bengala 1.3
19. Titanium oxide 8.0
20. Yellow iron oxide 0.5
21. Sericite 5.0
22. Red No. 202 0.2
(Note 24) KSG-15 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 25) TINOSORB S (manufactured by BASF)
(Note 26) KP-541 (Shin-Etsu Chemical Co., Ltd.)
(Note 27) Ultrazol V-280C (manufactured by Aika Industries)

  The liquid foundation of Example 11 had no discoloration and good stability over time.

[Example 12: Impregnation mask]
(Manufacturing method)
A: Components (1) to (6) are heated and dissolved at 70 ° C.
B: Components (7) to (11) are heated and dissolved at 70 ° C., and then added to A to emulsify.
C: Said B was cooled to room temperature, (12)-(14) was added and mixed, and the oil-in-water type emulsion was obtained.
D: The above C was impregnated into a nonwoven fabric (material: cellulose) to obtain an impregnation mask.
(Ingredient) (%)
1. Dipropylene glycol 10.0
2. Polyoxyethylene (40) hydrogenated castor oil 0.5
3. Methyl paraoxybenzoate 0.1
4). Squalane 0.5
5. Linoleic acid 0.04
6). Natural vitamin E (Note 3) 0.01
7). Glycerin 10.0
8). Purified water remaining amount 9. Hot spring water 1.0
10. Sodium hydroxide appropriate amount11. Honeysuckle extract (Note 1) 0.0001
12 Carboxyvinyl polymer (Note 20) 0.1
13. Xanthan gum 0.05
14 Fragrance 0.2

  The impregnation mask of Example 12 had no discoloration and good temporal stability.

[Example 13: Hand cream]
(Manufacturing method)
A: Components (1) to (12) and (24) are mixed and dissolved at 70 ° C.
B: Components (13) to (23) are mixed and dissolved at 70 ° C.
C: A is added to B and emulsified while stirring.
D: C was cooled to room temperature to obtain a hand cream.

(Ingredient) (%)
1. Polyethylene glycol monostearate 2.0
2. Glycerol monostearate 3.0
3. Cetostearyl alcohol 2.0
4). Behenyl alcohol 3.0
5. Liquid paraffin 4.0
6). Vaseline 10.0
7). Lauroylglutamate di (octyldodecyl / phytosteryl / behenyl) (Note 28) 2.0
8). Oleyl oleate 1.0
9. Coenzyme Q10 0.2
10. Linoleic acid 0.04
11. Natural vitamin E (Note 3) 0.01
12 Retinol palmitate 0.3
13. Methyl paraoxybenzoate 0.2
14 Concentrated glycerin 5.0
15.1,3-Butylene glycol 10.0
16. Sodium monohydrogen phosphate 0.1
17. Sodium dihydrogen phosphate 0.1
18. Edetic acid disodium 0.1
19. Sodium hydroxide adequate amount20. Purified water remaining amount 21. Honeysuckle extract (Note 1) 0.0001
22. Royal jelly extract 0.1
23. Magnesium ascorbate phosphate 0.5
24. Fragrance 0.2
(Note 28) El Dew PS-304 (Ajinomoto Co., Inc.)

  The hand cream of Example 13 had no discoloration and good temporal stability.

[Example 14: lotion]
(Manufacturing method)
A. The following components (6) to (12) are mixed and dissolved.
B. The following components (1) to (5) and (13) are mixed and dissolved.
C. A was added to B and mixed to obtain a skin lotion.

(Ingredient) (%)
1. Glycerin 5.0
2. 1,3-butylene glycol 5.0
3. Lactic acid 0.05
4). Sodium lactate 0.1
5. Honeysuckle extract (Note 1) 0.001
6). Polyoxyethylene (60 mol) hydrogenated castor oil 1.2
7). Polyoxyethylene (40 mol) hydrogenated castor oil 0.5
8). Ethanol 8.0
9. α-Linolenic acid (Note 14) 0.1
10. Synthetic vitamin E (Note 2) 0.001
11. Methyl paraoxybenzoate 0.1
12 Fragrance 0.1
13. Purified water remaining

  The lotion of Example 14 had no discoloration and good temporal stability.

[Example 15: Oil-in-water emulsion]
(Manufacturing method)
A. Components (1) to (5) are uniformly dissolved and mixed at 70 ° C.
B. Components (6) to (14) are uniformly dissolved and mixed at 80 ° C.
C. B is added to A and emulsified at 70 ° C.
D. Components (15) to (19) were added to C and mixed, and then cooled to 40 ° C. to obtain an oil-in-water emulsion.

(Ingredient) (%)
1.1,3-Butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Purified water remaining amount 4. Honeysuckle extract (Note 11) 0.5
5. Sodium hydroxide 2% solution 0.2
6). N-myristoyl-L-glutamic acid 0.2
7). Polyoxyethylene (10 mol) hydrogenated castor oil 0.2
8). Macadamia nut oil fatty acid phytosteryl 1.0
9. Tri (caprylic acid / caprylic acid) glyceryl 0.2
10. Docosahexaenoic acid (DHA) (Note 18) 0.1
11. Natural vitamin E (Note 3) 1.0
12 N-stearoyl phytosphingosine 0.1
13. Tocopherol acetate 0.01
14 Stearyl alcohol 0.5
15.1,2-Pentanediol 0.1
16. Carboxyvinyl polymer (Note 12) 0.15
17. (Na-acrylate / acryloyldimethyltaurine Na)
Copolymer (Note 13) 2.0
18. Ethanol 5.0
19. Fragrance 0.1

The emulsion of Example 15 had no discoloration and good temporal stability.

Claims (8)

The following components (a), (b) and (c);
(A) C16-22 polyunsaturated fatty acid (b) Vitamin E (c) Cosmetic or skin external preparation containing honeysuckle extract.   The cosmetic or external preparation for skin according to claim 1, wherein the component (a) is linoleic acid.   The cosmetic or skin external preparation according to claim 1 or 2, wherein the component (b) is vitamin E.   The cosmetic or skin external preparation according to any one of claims 1 to 3, wherein a content mass ratio (a) / (b) of the component (a) and the component (b) is 0.1 to 10,000.   The content ratio [(a) + (b)] / (c) of the “component (a) + component (b)” and the component (c) is 0.1 to 12000. 5. The cosmetic or skin external preparation according to claim 1.   The cosmetic or external preparation for skin according to any one of claims 1 to 5, which suppresses discoloration due to the component (a) and the component (b). The following ingredient (a) and ingredient (b) which use a honeysuckle extract as an active ingredient;
(A) One type or two or more types selected from polyunsaturated fatty acids having 16 to 22 carbon atoms (b) An agent for suppressing discoloration of a composition containing one or more types selected from vitamin Es. The method to suppress discoloration by the following component (a) and component (b) using a honeysuckle extract.
(A) One or more selected from polyunsaturated fatty acids having 16 to 22 carbon atoms (b) One or more selected from vitamin E