JP7254447B2 - Cosmetics and external skin preparations - Google Patents

Description

TECHNICAL FIELD The present technology relates to cosmetics, external skin preparations, and agents for suppressing discoloration of compositions containing (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and (b) vitamin E.

Free fatty acids having 18 to 22 carbon atoms and 2 or more unsaturations in the molecular structure are often used in cosmetics or external preparations for skin for various purposes such as whitening.
For example, Patent Document 1 discloses a cosmetic containing a free fatty acid having 18 to 22 carbon atoms and 2 or more unsaturations in the molecular structure, a salt thereof, or an ester with a monohydric or dihydric alcohol as an active ingredient. disclosed.
In addition, Patent Document 2 discloses an oil-soluble extract extracted from licorice, a free fatty acid having 18 to 22 carbon atoms and having 2 or more unsaturated bonds in its molecular structure, a salt thereof, and an ester thereof. A whitening cosmetic is disclosed which is characterized by blending one or two or more components selected from the group consisting of:

JP-A-63-284109 JP-A-5-194176

The inventors of the present invention have noticed that, as shown in [Table 1] below, the color of a cosmetic composition containing a mixture of a polyunsaturated fatty acid having 16 to 22 carbon atoms and vitamin E changes over time. (See Test Examples 1 to 3).
Polyunsaturated fatty acids having 16 to 22 carbon atoms are generally known to be susceptible to deterioration due to oxidation and the like and unstable over time. In addition, vitamin E is widely used as a fat-soluble vitamin in foods, pharmaceuticals, cosmetics, and the like, and is also widely used as an antioxidant.
Normally, it is considered that the deterioration of the polyunsaturated fatty acids is suppressed by vitamin E due to its antioxidant action. However, discoloration actually occurred in the composition in which these were mixed.
While it is desirable to use component (a) polyunsaturated fatty acids having 16 to 22 carbon atoms and component (b) vitamin E in combination with cosmetics and skin preparations for external use, discoloration is a problem in the appearance of the product. Products that are objectionable and discoloration may limit their use.

Therefore, the main object of the present technology is to suppress the discoloration of cosmetics or external preparations for skin containing component (a) polyunsaturated fatty acids having 16 to 22 carbon atoms and component (b) vitamin E.

In order to suppress discoloration of a composition containing component (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms and component (b) vitamin E, the present inventors combined this composition with various plant extracts. considered a combination of
As shown in [Table 2] below, even when any of the peony extract, rosemary extract and green tea extract is used, when compared with the comparative example in which these plant extracts are not added, the component (a ) and the composition containing component (b) was severely discolored. (See Comparative Examples 2-4). However, the present inventors have accidentally found that a sage extract can suppress the discoloration of the composition containing the components (a) and (b), and completed the present invention.

That is, the present technology is as follows.
The present technology comprises the following components (a), (b) and (c);
A cosmetic or external preparation for skin containing (a) a polyunsaturated fatty acid having 16 to 22 carbon atoms, (b) vitamin E, and (c) a sage extract.

In addition, the present technology uses a sage extract as an active ingredient, the following components (a) and (b);
(a) one or more selected from polyunsaturated fatty acids having 16 to 22 carbon atoms (b) one or more selected from vitamin E,
It is an agent that suppresses the discoloration of the composition containing.

The component (a) may be or contain linoleic acid.
The component (b) may be vitamin E or may contain this.
The content ratio (a)/(b) of the component (a) and the component (b) may be 0.1 to 10,000.
The content mass ratio [(a)+(b)]/(c) of "component (a)+component (b)" and component (c) may be 0.1 to 12,000.
It may be to suppress discoloration caused by the components (a) and (b).

According to the present technology, it is possible to suppress the discoloration of cosmetics or external skin preparations containing component (a) polyunsaturated fatty acids having 16 to 22 carbon atoms and component (b) vitamin E.
Note that the effects described here are not necessarily limited, and may be any of the effects described in the present technology.

<Cosmetics or external preparations for skin>
The present technology is a composition containing component (a) polyunsaturated fatty acid having 16 to 22 carbon atoms, component (b) vitamin E, and component (c) sage extract. The composition is desirably a cosmetic or external skin preparation.
Discoloration caused by the components (a) and (b) can be suppressed by using the component (c) sage extract, and a composition containing these components (a) and (b) discoloration of cosmetics or external preparations for skin can be suppressed.
In addition, the present technology includes a composition, a cosmetic, or an external skin application that contains the component (a), the component (b), and the component (c) and suppresses discoloration caused by the component (a) and the component (b). agent can be provided.

In general, factors that promote "discoloration" are, for example, light (particularly ultraviolet rays), temperature (particularly heat and high temperature), pH, and the like, and discoloration over time is regarded as a problem.
Cosmetics or topical skin preparations are usually packaged and stored for a certain period of time after production, and are required to be stable over time even when exposed to various temperature environments and light during that time. In particular, appearance is an important quality for cosmetics and topical skin preparations, so it is expected that the product can suppress discoloration over time due to the components (a) and (b) when the product is opened by the user or during the period of use. important.
In the present technology, it is advantageous that discoloration over time due to the components (a) and (b) can be suppressed at room temperature for a long period of time. think possible.

Further, "discoloration" can be judged by comparing ΔE of colorimetric values after standing at a color difference of 50° C. and 5° C. respectively for a certain period of time.
This color difference is preferably less than ΔE6, more preferably less than ΔE5.5, more preferably less than ΔE5.0. It can be judged that the smaller the ΔE of this color difference, the smaller the degree of discoloration.

<Long-chain polyunsaturated fatty acid>
The polyunsaturated fatty acid having 16 to 22 carbon atoms, which is the component (a) used in the present technology, has 2 or 3 or more unsaturated bonds in its molecular structure. The component (a) is considered to cause discoloration when used in combination with the component (b) vitamin E described later.
The component (a) polyunsaturated fatty acid may be either a free fatty acid or a salt thereof (generally usable salt), and one or more of these may be selected. The polyunsaturated fatty acid is preferably in the form of a free fatty acid, and preferably has two unsaturated bonds.
Also, the polyunsaturated fatty acid preferably has 18 to 22 carbon atoms.
A commercially available product may be used as the component (a), and it is preferable to use a separated and purified product or a synthetic product.

The component (a) can be expected to have an effect of eliminating/preventing drying of the skin caused by ultraviolet rays and pigmentation such as age spots and freckles. Therefore, the component (a) can be used as an emollient component or a whitening component. By containing the component (a), an emollient or whitening composition (for example, a cosmetic, an external preparation for skin, etc.) can be obtained.

Typical examples of the free fatty acids include linoleic acid, α-linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid, arachidonic acid, eicosadienoic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). ) and the like, and one or more of these can be selected.
Examples of the salt of the free fatty acid include metal salts such as sodium salts and potassium salts; amino acid salts such as arginine salts and lysine salts; amine salts such as triethanolamine salts and monoethanolamine salts; 1 or 2 or more can be selected from.

In the present technology, when the composition contains an ester of the polyunsaturated fatty acid, the ester derivative may be decomposed due to temperature, pH, time, etc. to generate a free polyunsaturated fatty acid. , according to the present technology, discoloration due to the free polyunsaturated fatty acids and vitamin E can be suppressed.

Among the components (a), linoleic acid or a salt thereof is considered to easily cause discoloration when mixed with the component (b) vitamin E, and linoleic acid also has a whitening effect and an emollient effect. , less odor.
For this reason, of the component (a), linoleic acid or a salt thereof (hereinafter also referred to as linoleic acid) is preferable, and the component (a) containing linoleic acids (preferably linoleic acid) is preferable. . In addition, in the present technology, it is possible to include the component (a) other than linoleic acids as long as the efficacy is not impaired.
The emollient action of the present technology refers to the action of softening the skin and the action of moisturizing the skin.

The content or amount of component (a) used in the present technology is preferably 0.0001% by mass to 5% by mass in terms of free fatty acid in the composition, and more preferably 0.001% by mass to 3% by mass. Preferably, 0.01% by mass to 1% by mass is more preferable.
In addition, the content or amount of linoleic acids used in the present technology is preferably 0.0001% by mass to 5% by mass, more preferably 0.001% by mass to 3% by mass, in the composition, cosmetic or external preparation for skin. % by mass is more preferred, and 0.01% by mass to 1% by mass is even more preferred.

As the component (b) vitamin E used in the present technology, tocopherol (eg, α-, β-, γ-, δ-tocopherol) and tocotrienol (eg, α-, β-, γ-, δ-tocotrienol, etc.) ), etc.; vitamin E derivatives (preferably vitamin E esters) such as vitamin E acetate, vitamin E nicotinate, α-tocopherol 2-L-ascorbic acid phosphate diester; salts thereof (generally available salt) and the like, and one or more of them can be selected.
A commercially available product may be used for the component (b), and it may be a naturally-derived product or a synthetic product. In the case of natural origin, isolated and purified products are preferred.

Synthetic vitamin E is generally produced by chemical synthesis of raw materials (for example, dl-α-tocopherol, etc.).

In general, naturally-derived vitamin E is extracted from vegetable oils or oils produced by microorganisms (for example, algae). Of these, vitamin E derived from vegetable oil is preferred because it is widely used in cosmetics and the like. Examples of such plants include soybean, sunflower seed, wheat germ, and rapeseed. Examples of algae include euglena, chlorella, spirulina, and the like.
In addition, as naturally-derived vitamin E, for example, those stabilized by adding an organic acid (eg, acetic acid, succinic acid, etc.) after extraction (eg, vitamin E derivatives containing d-α-tocopherol acetate, etc.) and Examples include those not converted to derivatives after extraction (vitamin E including d-α-tocopherol, etc.).

In general, the vegetable oil-derived vitamin E or the algae-derived vitamin E includes α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol, and is one or a mixture of two or more selected from these. Two, three or four of these are usually contained in many cases.

The composition ratio of commonly commercially available vegetable oil-derived vitamin E is 5 to 20% by mass of α-tocopherol, 0 to 10% by mass of β-tocopherol, 30 to 90% by mass of γ-tocopherol, and 5 to 60% by mass of δ-tocopherol. %and so on. This commercially available vegetable oil-derived vitamin E is also called natural vitamin E as another name.

It is considered that the component (b) vitamin E is likely to cause discoloration over time when mixed with the component (a) polyunsaturated fatty acid. In addition, vitamin E has an antioxidant effect and a blood circulation promoting effect, and is often used from the viewpoints of cost, safety, and the like.

Among the components (b), vitamin E is preferred. Vitamin E may be synthetic vitamin E or naturally derived vitamin E. In addition, in the present technology, it is possible to include the component (b) other than vitamin E as long as the efficacy is not impaired.
Among said vitamin E, tocopherol is preferred. The tocopherol may be synthetic tocopherol or natural tocopherol.
Of these, natural tocopherol is preferred in that it is a mixture selected from α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol. Synthetic tocopherols may also be used as long as they are mixtures.

The content or usage amount of component (b) used in the present technology is preferably 0.00001% by mass to 5% by mass, more preferably 0.0001% by mass to 3% by mass, and 0.0001% by mass to 5% by mass. 001% by mass to 1% by mass is more preferable.
In addition, the content or usage amount of vitamin E used in the present technology is preferably 0.00001% by mass to 5% by mass, more preferably 0.0001% by mass to 3% by mass, and 0.0001% by mass to 5% by mass. 001% by mass to 1% by mass is more preferable.

The sage extract of component (c) used in the present technology is an extract of Lamiaceae, genus Salvia, sage (Salvia officinalis) and related plants. The Labiatae (Lamiaceae) genus Salvia, sage (Salvia officinalis) and related plants include Salvia miltiorrhiza, clary sage (Salvia sclarea), Salvia japonica, Salvia ple, Chia (Salvia hispanica), Spanish sage (Salvia lavandulifolia), Salvia triloba, and the like. Sage is a perennial herb native to the Mediterranean coastal region, and is one of representative herbs, and is cultivated as a fragrance and for medicinal purposes.

Any part may be used as the part of the plant to be extracted, and examples thereof include whole plants, leaves, stems, roots, flowers and seeds, and one or more selected from these. can be used. Among these, leaves are preferable in terms of suppressing discoloration in the present technology.
The part of the plant to be extracted may be dried, pulverized, cut, shredded, or otherwise appropriately treated, and it is desirable to perform the extraction after the treatment.

A method for extracting the plant is not particularly limited. The extraction may be performed by immersing the sage under a constant temperature (low temperature, room temperature, or heating) for a predetermined period of time using an extraction solvent.

Examples of the extraction solvent include, but are not limited to, water, organic solvents, and the like, and one or more of these can be selected. Alternatively, supercritical carbon dioxide, water, or the like can be used.
Examples of the organic solvent include alcohols; ketones such as acetone; ethers such as ethyl ether; esters such as ethyl acetate; and hydrocarbons such as hexane and benzene. can be used.

Examples of the alcohols include lower monohydric alcohols (eg, methanol, ethanol, etc.); liquid polyhydric alcohols (eg, 1,3-butylene glycol, propylene glycol, glycerin, etc.).
The alcohols are preferably monohydric alcohols and dihydric alcohols, and the alcohols preferably have about 1 to 5 carbon atoms.

Among the extraction solvents, water and/or alcohols (preferably having 1 to 4 carbon atoms) are preferred. As the alcohol, one or more selected from methanol, ethanol, propylene glycol and 1,3-butylene glycol (1,3-BG) is preferable.
Among these extraction solvents, more preferably one selected from water, ethanol and 1,3-butylene glycol or a mixture of two or more, more preferably water, ethanol and 1,3-butylene glycol. , ethanol water mixed solution, 1,3-butylene glycol water mixed solution, more preferably 1,3-butylene glycol water mixed solution.
In the case of extraction with an alcohol-water mixed solution, the alcohol concentration (V/V) is preferably 0 to 100% by volume, more preferably 20 to 80% by volume.

As an example of a preferred extraction method for the sage extract, the sage is extracted with the extraction solvent at room temperature (for example, about 1 to 30° C.) or heated (for example, about 30 to 100° C.) for 5 minutes to 7 days. There is a method of performing At this time, the extraction solvent is preferably water, alcohols, or a water-alcohol mixture, more preferably a 1,3-butylene glycol aqueous mixture.
The extraction may be either room temperature extraction or heated extraction. Room temperature (preferably 10 to 30° C.) extraction is preferably for 1 to 7 days. Moreover, it is preferable that the heating (40 to 90° C.) extraction takes 1 to 12 hours.

The sage extract of the present technology may be used as it is as an active ingredient, or may be appropriately treated by a known separation and purification method in order to remove impurities such as contaminants within a range that does not impair the effect, or to enhance the effect. You may For example, if necessary, it can be used after purification treatment such as removal of the extraction solvent, filtration, deodorization of the ion-exchange resin or the like, decoloration, and the like. In addition, fractions with high activity can be used by separation means such as liquid chromatography.

The sage extract of the present technology can be used as it is by mixing the extracts obtained by different extraction methods, or by diluting, concentrating, or drying the extract to obtain a liquid, powder, or paste. It can also be used after being prepared in a form.

Then, as shown in the examples below, the component (c) sage extract of the present technology includes (a) one or more selected from polyunsaturated fatty acids having 16 to 22 carbon atoms, (b) vitamins It has the effect of suppressing discoloration caused by including one or more selected from E group. That is, it is possible to provide a discoloration inhibitor for a composition containing the component (a) and the component (b), which contains the component (c) as an active ingredient. In addition, the composition containing the component (a) and the component (b) is preferably a cosmetic or an external preparation for skin, according to the results of [Examples] described later.

In addition, the component (c) sage extract of the present technology can be used in a method for suppressing discoloration caused by the components (a) and (b). Further, it is possible to provide a component (c) sage extract for suppressing discoloration of the composition containing the components (a) and (b). In addition, component (c) sage extract can be used to produce an agent or composition capable of suppressing discoloration caused by components (a) and (b).

The content or usage amount of component (c) used in the present technology is preferably 0.00001% by mass to 5% by mass, more preferably 0.00005% by mass to 1% by mass, as a pure extract component in the composition. Preferably, 0.0001% by mass to 0.5% by mass is more preferable.
In addition, the content or amount of the extract (preferably leaf extract) of Lamiaceae genus Salvia, sage (Salvia officinalis) and its related plants used in the present technology is In the composition, the extract content is preferably 0.00001% by mass to 5% by mass, more preferably 0.00005% by mass to 1% by mass, and even more preferably 0.0001% by mass to 0.5% by mass.

The pH in the composition, cosmetic or external preparation for skin, or method for suppressing discoloration of the present technology is not particularly limited, and can be appropriately adjusted with a pH adjuster.
The pH (20° C.) of the present technology is preferably 3.0-9.0, more preferably 4.0-8.0. By adjusting the pH to this level, the component (c) sage extract easily suppresses the discoloration caused by the components (a) and (b), which is advantageous.
Further, the pH (20° C.) after mixing the components (a) to (c) is preferably adjusted to 3.0 to 9.0, more preferably 4.0 to 8.0. This is preferable in that discoloration over time can be easily suppressed.
In addition, since the components (a) and (b) tend to discolor in the presence of water, it is preferable to use the component (c) sage extract in the composition containing water to suppress discoloration.

The content (use) mass ratio (a)/(c) of the component (a) and the component (c) used in the present technology is preferably 0.1 to 1000, more preferably 0.3 to 500, and more It is preferably 0.5-100.
The content (use) mass ratio (b) / (c) of the component (b) and the component (c) used in the present technology is preferably 0,003 to 10000, more preferably 0.01 to 1000, and more It is preferably 0.1-100.

The content ratio (a) / (b) of the component (a) polyunsaturated fatty acid and the component (b) vitamin E used in the present technology is preferably 0.1 to 10000, more preferably 0 0.3 to 1000, more preferably 0.5 to 500. By setting the amount in such a range, the effects of the components (a) and (b) can be exhibited more satisfactorily.

The content (use) mass ratio of "component (a) + component (b)" and component (c) used in the present technology [(a) + (b)] / (c) is preferably 0.1 to 12000, more preferably 0.3-6000, more preferably 0.5-3000. By setting the amount in such a range, discoloration can be suppressed more satisfactorily while exhibiting the efficacy of the components (a) and (b) more satisfactorily.

Compositions (preferably cosmetics or topical skin preparations) targeted for discoloration suppression by the present technology include, for example, topical skin preparations, cosmetics, whitening agents, deodorants, detergents, and the like. Among these, compositions used for skin care in which an emollient effect is expected are preferred.

In addition, the composition, cosmetic, or topical skin preparation containing the components (a) to (c) of the present technology usually contains cosmetics and quasi-drugs within a range that does not impair the effects of the present technology, if necessary. Ingredients used in various formulations such as skin preparations for external use such as cosmetics and pharmaceuticals can be added. Such components include, for example, water, oils, surfactants, metallic soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, UV protection agents, clathrate compounds, antibacterial agents, and fragrances. , deodorants, salts, pH adjusters, cooling agents, extracts derived from animals and microorganisms, plant extracts, blood circulation promoters, astringents, antiseborrheic agents, whitening agents, anti-inflammatory agents, active oxygen scavenging agents, cells Activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like. One or more of these can be appropriately selected and used.

Compositions, cosmetics, or external preparations for skin containing components (a) to (c) of the present technology can be obtained by known methods.
Specific examples of cosmetics and external skin agents of the present technology include, for example, basic cosmetics such as milky lotions, creams, lotions, serums, packs, all-in-one gels, sunscreens, and cleansers, makeup bases, BB creams, Makeup cosmetics such as foundations, blushes and lipsticks, hair cosmetics such as hair tonics, shampoos and rinses, dispersions, ointments, liquids, aerosols, patches, poultices, liniments, etc. may be Cosmetics and external preparations for skin that are expected to have a whitening effect, an emollient effect, and the like are preferred.

Moreover, the discoloration inhibitor containing the component (c) of the present technology can be obtained by a known production method.
As applications of the discoloration inhibitor or method for inhibiting discoloration of the present technology, it can be used for cosmetics; skin preparations for external use such as quasi-drugs and pharmaceuticals; oral preparations and injections; It is suitable for use in cosmetics and external skin preparations such as
Examples of forms in which the discoloration inhibitor of the present technology is blended include cosmetics, quasi-drugs, and skin preparations for external use such as pharmaceuticals. When blending the discoloration inhibitor of the present technology in these forms, it may contain an appropriately acceptable component. In addition, the discoloration inhibitor of the present technology can also be included when these are produced.

EXAMPLES Hereinafter, the present invention (the present technology) will be described in more detail with reference to examples, test examples, and the like, but the present invention (the present technology) is not limited to these examples. Unless otherwise specified, the content is expressed in % by mass relative to the system containing the component.

<Sample preparation>
As linoleic acid, linoleic acid, which is a free fatty acid commercially available (manufactured by Wako Pure Chemical Industries, Ltd.), was purchased and used.
As vitamin E, commercially available natural vitamin E (plant-derived) (manufactured by Eisai Co., Ltd.) was purchased and used. The commercial product is a plant-derived vitamin E containing at least α-tocopherol, γ-tocopherol and δ-tocopherol.
For each plant extract, the following sage extract, rosemary extract, peony extract, and green tea extract were used.

<Production Example 1. Preparation of sage extract>
Lamiaceae Salvia, sage (Salvia officinalis) 10 g of pulverized leaves, 50% by volume 1,3-butylene glycol aqueous solution (1,3-butylene glycol 1: water 1 (Vol / Vol) ) was added and extracted at room temperature (10-30° C.) for 1 week. After filtering the extract, the solvent was evaporated to dryness to obtain a sage extract as a pure extract.

<Production Example 2. Preparation of rosemary extract>
Add 100 mL of a 50% by volume 1,3-butylene glycol aqueous solution to 10 g of dried leaves of the Labiatae genus Rosemary (scientific name: Rosmarinus officinalis), extract at room temperature (10 to 30 ° C.) for 7 days, and then filtrate. was allowed to stand at about 5°C for 7 days for maturation, and then filtered. The filtrate was evaporated to dryness to obtain a rosemary extract as a pure extract.
<Production Example 3. Preparation of peony extract>
10 g of Peony peony (scientific name: Paeonia lactiflora) root is finely chopped, 100 mL of 50% by volume 1,3-butylene glycol aqueous solution is added, and the mixture is heated (about 50 to 70° C.) and stirred for 4 hours. After extraction, it was filtered. The filtrate was allowed to stand at about 5°C for 7 days for aging, and then filtered. The filtrate was evaporated to dryness to obtain a peony extract as a pure extract.
<Production Example 4. Preparation of green tea plant extract>
10 g of dried leaves of Camellia genus Camellia (scientific name: Camellia sinensis) of the family Theaceae are finely chopped, 200 mL of a 50 vol% ethanol aqueous solution is added, and the mixture is extracted for 2 days while stirring at room temperature (10 to 30 ° C.), and then extracted. After filtering the liquid, the solvent was evaporated to dryness to obtain a green tea extract as a pure extract.

<Color difference measurement method>
Glass bottles were prepared for containing samples for 50°C and 5°C. The sample was dispensed into each glass bottle, and the glass bottle was capped as it was without replacing the air in the glass bottle. The sample-filled glass bottles were placed in thermostats at 50° C. and 5° C., respectively, and allowed to stand still for a certain period of time.
Each sample left still for a certain period of time is transferred to a measurement glass cell, and the L*, a*, b* values are measured using a Nippon Denki color difference meter SE-2000, and from the colorimetric values, ΔL = L ^* ( 5° C.)−L ^* (50° C.), Δa=a ^* (5° C.)−a ^* (50° C.), and Δb=b ^* (5° C.)−b ^* (50° C.) were calculated.
Next, ΔE was calculated according to the following formula, and the discoloration of the sample was evaluated based on the value of ΔE.
ΔE=((ΔL) ² +(Δa) ² +(Δb) ² ) ^1/2
L ^* is the "lightness index" (L axis = 0 to 100), a ^* and b ^* are the "chromaticness index" (a axis = -120 to +120, b axis = -120 to +120)

<Test Example 1: Stability (discoloration) test over time>
Each component shown in Table 1 was mixed to prepare samples of Test Examples 1 to 3. The pH (20°C) of the sample at the time of production was 6.5, and the samples of Test Examples 1 to 3 were measured by the above-described color difference measurement method, and after standing for 4 days, stored at 5°C and stored at 50°C. A color difference ΔE from the product was obtained.

In Test Example 2 sample of natural vitamin E alone and Test Example 3 sample of linoleic acid alone, in which linoleic acid and naturally-derived vitamin E were not used in combination, the color difference was less than 1 and no discoloration occurred. However, in the sample of Test Example 1, in which linoleic acid and naturally-derived vitamin E were used in combination, the color difference ΔE was four times as large as that of the sample of Test Example 2 and the sample of Test Example 3, even in a short period of only 4 days after the start of the test. and 9 times or more, and a slight discoloration (yellowing) was confirmed even with the naked eye, so it was expected that the discoloration would further progress over time.

It is completely unexpected that the combination of linoleic acid and vitamin E synergistically increased the color difference even on the fourth day. Although it is unknown, it is believed that the discoloration is caused by polyunsaturated fatty acids and vitamin E.

However, discoloration is undesirable in products such as cosmetics and skin preparations. It is a component that is often used in cosmetics and external preparations for skin, and we would like to use it in as free a content as possible.
Therefore, it has become necessary to search for a component capable of suppressing the discoloration of compositions containing these without worrying about the content of polyunsaturated fatty acids and vitamin E.

[Example 1: Lotion]
Therefore, as shown in Table 2, the present inventors blended various plant extracts in a lotion containing linoleic acid and naturally-derived vitamin E, and allowed the discoloration over time to stand for about 5 weeks. Evaluation was made using the color difference ΔE between the product stored at 5°C and the product stored at 50°C. The pH of the lotion (20°C) at the time of production was 5.1. As Comparative Examples 2 to 4, lotions containing peony extract, rosemary extract and green tea extract instead of sage extract were evaluated.

<Evaluation of ΔE at 50°C and 5°C>
Less than 6 ○: Almost no discoloration 6 or more and less than 7.5 △: Discoloration 7.5 or more ×: Strong discoloration

Manufacturing method 1. Components (1) to (4) and components (10) to (13) are uniformly mixed together2. Components (5) to (9), (14) and (15) are uniformly mixed.
3. Add 2 gradually while stirring 1, and stir for 5 minutes after completion of the addition to obtain a lotion.

Even in the lotion, which is an actual product, Comparative Example 1, in which no plant extract was added, caused discoloration over time, and good stability over time, which is important for cosmetics and topical skin preparations, was not observed. .
Even if any of the peony extract, the rosemary extract and the green tea extract is added to the lotion, the discoloration is rather strong compared to the lotion of Comparative Example 1 in which these plant extracts are not added. Oops. Although these plant extracts are well known to have anti-oxidative activity, we thought that the discoloration could not be suppressed simply by plant extracts having anti-oxidative activity. For this reason, since there is no index for discoloration-suppressing components, it was thought that there was no choice but to derive them empirically, and various components were used.

The present inventors have accidentally discovered that sage extract can inhibit discoloration of compositions containing linoleic acid and naturally occurring vitamin E. Moreover, in the color difference evaluation, it reached a level where there was no discoloration or almost no discoloration, which can be said to be a particularly remarkable effect. In addition, since discoloration-suppressing effects were observed in practical products containing ingredients other than linoleic acid and naturally-derived vitamin E, we believe that it can be applied to a wide range of products such as cosmetics, external skin preparations, and other compositions.

[Example 2: Lotion]
(Manufacturing method)
A. The following components (6) to (12) are mixed and dissolved.
B. The following components (1) to (5) and (13) are mixed and dissolved.
C. A was added to B and mixed to obtain a lotion.

(Component) (%)
1. Glycerin 5.0
2.1,3-butylene glycol 5.0
3. Lactic acid 0.05
4. Sodium lactate 0.1
5. Sage extract (Note 1) 0.001
6. Polyoxyethylene (60 mol) hydrogenated castor oil 1.2
7. Polyoxyethylene (40 mol) hydrogenated castor oil 0.5
8. Ethanol 8.0
9. Linoleic acid 0.1
10. Synthetic vitamin E (Note 2) 0.001
11. Methyl paraoxybenzoate 0.1
12. Perfume 0.1
13. Remaining amount of purified water (Note 1) Sage extract of Production Example 1 (Note 2) Vitamin E Eisai (Eisai Food & Chemical Co., Ltd.)

The lotion of Example 2 did not discolor and had good stability over time.

[Example 3: Oil-in-water emulsified lotion]
(Production method)
A: Components (1) to (6) are dissolved by heating to 70°C.
B: Components (7) to (9) are dissolved by heating to 70° C., then added to A and emulsified.
C: Cool the B to room temperature.
D: The above C is subjected to high pressure treatment (treatment pressure 200 MPa) with a microfluidizer.
E: Components (10) to (15) were uniformly mixed with D to obtain an oil-in-water emulsified lotion.

(Component) (%)
1. Linoleic acid 0.0001
2. Hydrogenated soybean phospholipid 2.0
3. Cholesterol 0.8
4. Isostearic acid 3.0
5. Natural vitamin E (Note 3) 0.1
6. Pentaerythrityl tetra-2-ethylhexanoate 1.0
7. Glycerin 8.0
8. Dipropylene glycol 8.0
9. Remaining purified water 10. Sage extract (Note 4) 0.01
11. Glycosyltrehalose 5.0
12. Sodium pyrrolidonecarboxylate 1.0
13. Ethanol 5.0
14. Methyl paraoxybenzoate 0.2
15. Perfume 0.2
(Note 3) Emix 70L (manufactured by Eisai Food and Chemical Co., Ltd.)
(Note 4) Add 100 mL of 90% by volume ethanol aqueous solution (EtOH 9: water 1 (Vol / Vol)) to 10 g of ground whole grass of Lamiaceae, genus Salvia, and sage (Salvia officinalis). The mixture was stirred while being heated (50° C. to 80° C.) and extracted for 8 hours. After that, the extract was filtered and the solvent was distilled off to obtain a sage extract.

The lotion of Example 3 did not discolor and had good stability over time.

[Example 4: Essence]
(Manufacturing method)
A. The following components (1) to (10) are mixed and dissolved.
B. The following components (11) to (17) are mixed and dissolved.
C. B was added to A and mixed to obtain a beauty essence.

(Component) (%)
1. Dipropylene glycol 5.0
2.1,3-butylene glycol 8.0
3. Alkyl acrylate/methacrylate (C10-30)
Crosspolymer (Note 5) 0.2
4. Xanthan gum 0.2
5. Remaining amount of purified water 6. 2% aqueous sodium hydroxide solution 2.0
7. Sage extract (Note 6) 0.005
8. Sodium hyaluronate 0.01
9. Hydrolyzed elastin 0.01
10. Hydrolyzed collagen 0.1
11. Polyoxyethylene (60 mol) hydrogenated castor oil 0.5
12. Isostearic acid 0.2
13. Linoleic acid 0.001
14. Naturally derived vitamin E (Note 3) 0.01
15. Methyl paraoxybenzoate 0.1
16. Ethanol 2.0
17. Perfume 0.02
(Note 5) CARBOPOL1382 (manufactured by LUBRIZOL ADVANCED MATERIALS)
(Note 6) Add 200 mL of purified water to 10 g of pulverized flowers of Lamiaceae, genus Salvia, and sage (Salvia officinalis), stir while heating (50 to 60 ° C.), and perform extraction for 4 hours. rice field. After that, the extract was filtered and the solvent was distilled off to obtain a sage extract.

The beauty essence of Example 4 did not discolor and had good stability over time.

[Example 5: Essence]
(Production method)
A: Components (1) to (6) are dissolved by heating at 70°C.
B: After heating components (7) to (19) at 70° C., A was added to emulsify and cooled to room temperature to obtain an oil-in-water beauty essence.

(Component) (%)
1. Linoleic acid 0.1
2. Ceramide 3 (Note 7) 0.1
3. Glyceryl triethylhexanoate 3.0
4. Sorbitan sesquioleate 1.5
5. Dimethylpolysiloxane (Note 8) 2.0
6. dl-α-tocopherol (Note 9) 0.02
7. Glycerin 3.0
8.1,3-butylene glycol 5.0
9.1,2-pentanediol 2.0
10. Xanthan gum 0.05
11. Remaining purified water 12. Phosphoric acid 0.1
13. Sodium monohydrogen phosphate 0.1
14. Sage extract (Note 10) 0.00001
15. Carboxymethylcellulose 2.0
16. Xanthan gum 0.1
17. Sodium hyaluronate 0.05
18. Disodium edetate 0.02
19. Perfume 0.5
(Note 7) CERAMIDE3 (manufactured by Nikko Chemicals)
(Note 8) KF-96-10CS (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 9) DSM Nutrition Japan Co., Ltd. (Note 10) To 10 g of pulverized leaves of Lamiaceae, Salvia, clary sage (Salvia sclarea), 50% by volume ethanol aqueous solution (EtOH 1: water 1 ( Vol/Vol)) was added and extraction was carried out at room temperature (10 to 30° C.) for 5 days. After that, the extract was filtered and the solvent was distilled off to obtain a sage extract.

The beauty essence of Example 5 did not discolor and had good stability over time.

[Example 6: Oil-in-water emulsion]
(Manufacturing method)
A. Components (1) to (5) are uniformly dissolved and mixed at 70°C.
B. Components (6) to (14) are uniformly dissolved and mixed at 80°C.
C. B is added to A and emulsified at 70°C.
D. After adding and mixing the components (15) to (19) to C, the mixture was cooled to 40° C. to obtain an oil-in-water emulsion.

(Component) (%)
1.1,3-butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Remaining amount of purified water 4. Sage extract (Note 11) 0.5
5. 2% aqueous sodium hydroxide solution 0.2
6. N-myristoyl-L-glutamic acid 0.2
7. Polyoxyethylene (10 mol) hydrogenated castor oil 0.2
8. Macadamia nut oil fatty acid phytosteryl 1.0
9. Tri(caprylic/caprylic)glyceryl 0.2
10. Linoleic acid 0.1
11. Natural vitamin E (Note 3) 1.0
12. N-stearoyl phytosphingosine 0.1
13. Tocopherol acetate 0.01
14. Stearyl alcohol 0.5
15.1,2-pentanediol 0.1
16. Carboxyvinyl polymer (Note 12) 0.15
17. (Sodium acrylate/Na acryloyldimethyltaurate)
Copolymer (Note 13) 2.0
18. Ethanol 5.0
19. Perfume 0.1
(Note 11) Add 400 mL of a 50% by volume ethanol aqueous solution (EtOH 1: water 1 (Vol/Vol)) to 10 g of pulverized seeds of Lamiaceae, genus Salvia, and Chia (Salvia hispanica) at room temperature. The extraction was carried out at (10-30°C) for 7 days. After that, the extract was filtered and the solvent was distilled off to obtain a sage extract.
(Note 12) CARBOPOL941 (manufactured by LUBRIZOL ADVANCED MATERIALS)
(Note 13) SIMULGEL EG (manufactured by SEPIC)

The milky lotion of Example 6 did not discolor and had good stability over time.

[Example 7: Emulsion]
(Manufacturing method)
A: Components (1) to (8) are dissolved by heating at 70°C.
B: Components (9) to (15) are heated at 70° C., then added to A and emulsified.
C: After B was cooled to room temperature, components (16) to (18) were added to obtain an oil-in-water beauty essence.

(Component) (%)
1. Linoleic acid 0.6
2. α-Linolenic acid (Note 14) 0.4
3. Hydrogenated soybean phospholipid 1.2
4. δ-tocopherol (Note 15) 0.003
5. α-Tocopherol (Note 16) 0.002
6.1,3-butylene glycol 16.0
7. Isotridecyl isononanoate 1.0
8. Triethylhexanoin 1.0
9. Remaining purified water 10. Citric acid 0.1
11. Sodium citrate 0.1
12. Sodium hydroxide appropriate amount 13. Sage extract (note 17) 0.0001
14. Hydroxyproline 0.01
15. Phenoxyethanol 0.5
16. Ethanol 8.0
17. Carboxyvinyl polymer (Note 12) 0.2
18. Xanthan gum 0.2
(Note 14) Manufactured by Wako Pure Chemical Industries, Ltd. (Note 15) Manufactured by Sigma-Aldrich (Note 16) Manufactured by Sigma-Aldrich (Note 17) Lamiaceae, Salvia, Spanish sage (Salvia lavandulifolia) leaves 200 mL of a 20% by volume ethanol aqueous solution (EtOH 1:water 4 (Vol/Vol)) was added to 10 g of the pulverized product of No. 2, and extraction was performed at room temperature (10 to 30° C.) for 5 days. After that, the extract was filtered and the solvent was distilled off to obtain a sage extract.

The milky lotion of Example 7 was less discolored and had good stability over time.

[Example 8: Cream]
(Manufacturing method)
A: Components (1) to (10) are dissolved by heating at 70°C.
B: After heating components (11) to (17) at 70° C., the above A is added and emulsified.
C: B was cooled to room temperature, and (18) to (20) were added and mixed to obtain an oil-in-water cream.

(Component) (%)
1. Linoleic acid 1.0
2. Docosahexaenoic acid (DHA) (Note 18) 1.0
3. Polyoxyethylene (20) sorbitan monooleate 2.0
4. Polyoxyethylene alkyl ether phosphate (Note 19) 0.3
5. Propylene glycol dicaprate 1.7
6. Squalane 3.5
7. Cetostearyl alcohol 3.0
8. Vaseline 2.0
9. Jojoba oil 1.0
10. Synthetic vitamin E (Note 2) 3.0
11.1,3-butylene glycol 2.0
12. Glycerin 10.0
13. Carboxyvinyl polymer (Note 20) 0.3
14. Carrageenan 0.1
15. Sodium hydroxide appropriate amount 16. Remaining purified water 17. Sage extract (Note 1) 1.0
18. Methyl paraoxybenzoate 0.3
19. Ethanol 7.0
20. Perfume 0.2
(Note 18) Manufactured by Wako Pure Chemical Industries, Ltd. (Note 19) NIKKOL-DDP10 (manufactured by Nikko Chemicals)
(Note 20) Hivis Wako 105 (manufactured by Wako Pure Chemical Industries, Ltd.)

The cream of Example 8 had little discoloration and good stability over time.

[Example 9: Sunscreen agent]
(Manufacturing method)
A. Components (10) to (12) are dispersed using three rolls.
B. A and components (1) to (9) are heated to 70°C.
C. Ingredients (13)-(18) are warmed to 70°C.
D. Add B to C and emulsify.
E. D was cooled to room temperature and cooled to obtain a creamy oil-in-water emulsified milk sunscreen.

(Component) (%)
1. Cetostearyl alcohol 1.0
2. Liquid paraffin 3.0
3. Polyoxyethylene (20) sorbitan monooleate 2.0
4. Polyoxyethylene (60 mol) hydrogenated castor oil 1.0
5. Polyoxyethylene alkyl ether phosphate (Note 19) 0.1
6. Acrylic-silicone graft copolymer solution (Note 21) 1.0
7. Octyl p-methoxycinnamate 10.0
8. Natural vitamin E (Note 3) 0.001
9. Linoleic acid 0.05
10. Myristic acid (3%) methylhydrogenpolysiloxane (15%) treated zinc oxide (particle size 20 nm) 10.0
11. Decamethylcyclopentasiloxane 15.0
12. (Dimethicone/phenyl dimethicone) crosspolymer mixture (solid content 15%) (Note 22) 10.0
13. Stearoyl methyl taurate sodium 2.0
14. (sodium acrylate/sodium acryloyldimethyltaurate) copolymer (Note 13) 4.0
15.1,3-butylene glycol 8.0
16. Polyethylene glycol (Note 23) 5.0
17. Remaining purified water 18. Sage extract (Note 1) 0.4
(Note 21) KP545L (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 22) KSG-18 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 23) PEG400 (manufactured by Sanyo Chemical Industries, Ltd.)

The sunscreen of Example 9 did not discolor and had good stability over time.

[Example 10: Liquid foundation]
(Manufacturing method)
A: Components (15) to (22) are dispersed using three rollers.
B: Components (1) to (9) are heated at 90°C and uniformly mixed.
C: (10) heated to about 90° C. was added to B above, emulsified, cooled, and (11) to (14) were added.
D: Mixing A with C E: Filling D into a container to obtain an oil-in-water liquid foundation.

(Component) (%)
1. Polyoxyethylene (60) hydrogenated castor oil 0.5
2. Polyoxyethylene (20) sorbitol tetraoleate 1.0
3. (dimethicone/vinyl dimethicone)
Crosspolymer mixture (5% solids) (Note 24) 10.0
4. Methyl trimethicone 5.0
5. Octyl methoxycinnamate 3.0
6. Bisethylhexyloxyphenol Methoxyphenyltriazine (Note 25) 5.0
7. Acrylic-silicone graft copolymer solution (Note 26) 5.0
8. Linoleic acid 0.1
9. Natural vitamin E (Note 3) 0.00001
10. Remaining purified water 11. (sodium acrylate/sodium acryloyldimethyltaurate) copolymer (Note 19) 1.0
12. Phenoxyethanol 0.3
13.1,3-butylene glycol 10.0
14. Sage extract (Note 1) 0.0001
15. Alkyl acrylate polymer emulsion (Note 27) 3.0
16. Triethanolamine 3.5
17. Black iron oxide 0.2
18. Bengara 1.3
19. Titanium oxide 8.0
20. Yellow iron oxide 0.5
21. Sericite 5.0
22. Red No. 202 0.2
(Note 24) KSG-15 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 25) TINOSORBS (manufactured by BASF)
(Note 26) KP-541 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 27) Ultrasol V-280C (manufactured by Aica Kogyo Co., Ltd.)

The liquid foundation of Example 10 did not discolor and had good stability over time.

[Example 11: Impregnation mask]
(Manufacturing method)
A: Components (1) to (6) are dissolved by heating to 70°C.
B: Components (7) to (11) are dissolved by heating to 70° C., then added to A and emulsified.
C: B was cooled to room temperature, and (12) to (14) were added and mixed to obtain an oil-in-water emulsion.
D: A nonwoven fabric (material: cellulose) was impregnated with C to obtain an impregnated mask.
(Component) (%)
1. Dipropylene glycol 10.0
2. Polyoxyethylene (40) hydrogenated castor oil 0.5
3. Methyl paraoxybenzoate 0.1
4. Squalane 0.5
5. Linoleic acid 0.04
6. Natural vitamin E (Note 3) 0.01
7. Glycerin 10.0
8. Remaining amount of purified water 9 . Hot spring water 1.0
10. Sodium hydroxide appropriate amount 11. Sage extract (Note 1) 0.0001
12. Carboxyvinyl polymer (Note 20) 0.1
13. Xanthan gum 0.05
14. Perfume 0.2

The impregnated mask of Example 11 did not discolor and had good stability over time.

[Example 12: Hand cream]
(Manufacturing method)
A: Components (1) to (12) and (24) are mixed and dissolved at 70°C.
B: Components (13) to (23) are mixed and dissolved at 70°C.
C: Add A to B while stirring to emulsify.
D: C was cooled to room temperature to obtain a hand cream.

(Component) (%)
1. Polyethylene glycol monostearate 2.0
2. Glyceryl monostearate 3.0
3. Cetostearyl alcohol 2.0
4. behenyl alcohol 3.0
5. Liquid paraffin 4.0
6. Vaseline 10.0
7. Di(octyldodecyl/phytosteryl/behenyl) lauroyl glutamate (Note 28) 2.0
8. Oleyl oleate 1.0
9. Coenzyme Q10 0.2
10. Linoleic acid 0.04
11. Natural vitamin E (Note 3) 0.01
12. Retinol palmitate 0.3
13. Methyl paraoxybenzoate 0.2
14. Concentrated glycerin 5.0
15.1,3-butylene glycol 10.0
16. Sodium monohydrogen phosphate 0.1
17. Sodium dihydrogen phosphate 0.1
18. Disodium edetate 0.1
19. Sodium hydroxide appropriate amount 20. Remaining purified water 21. Sage extract (Note 1) 0.0001
22. Royal jelly extract 0.1
23. Magnesium ascorbyl phosphate 0.5
24. Perfume 0.2
(Note 28) Eldew PS-304 (manufactured by Ajinomoto Co., Inc.)

The hand cream of Example 12 had good stability over time without discoloration.

[Example 13: Lotion]
(Manufacturing method)
A. The following components (6) to (12) are mixed and dissolved.
B. The following components (1) to (5) and (13) are mixed and dissolved.
C. A was added to B and mixed to obtain a lotion.

(Component) (%)
1. Glycerin 5.0
2.1,3-butylene glycol 5.0
3. Lactic acid 0.05
4. Sodium lactate 0.1
5. Sage extract (Note 1) 0.001
6. Polyoxyethylene (60 mol) hydrogenated castor oil 1.2
7. Polyoxyethylene (40 mol) hydrogenated castor oil 0.5
8. Ethanol 8.0
9. α-Linolenic acid (Note 14) 0.1
10. Synthetic vitamin E (Note 2) 0.001
11. Methyl paraoxybenzoate 0.1
12. Perfume 0.1
13. Remaining amount of purified water

The lotion of Example 13 did not discolor and had good stability over time.

[Example 14: Oil-in-water emulsion]
(Manufacturing method)
A. Components (1) to (5) are uniformly dissolved and mixed at 70°C.
B. Components (6) to (14) are uniformly dissolved and mixed at 80°C.
C. B is added to A and emulsified at 70°C.
D. After adding and mixing the components (15) to (19) to C, the mixture was cooled to 40° C. to obtain an oil-in-water emulsion.

(Component) (%)
1.1,3-butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Remaining amount of purified water 4. Sage extract (Note 11) 0.5
5. 2 wt% sodium hydroxide solution 0.2
6. N-myristoyl-L-glutamic acid 0.2
7. Polyoxyethylene (10 mol) hydrogenated castor oil 0.2
8. Macadamia nut oil fatty acid phytosteryl 1.0
9. Tri(caprylic/caprylic)glyceryl 0.2
10. Docosahexaenoic acid (DHA) (Note 18) 0.1
11. Natural vitamin E (Note 3) 1.0
12. N-stearoyl phytosphingosine 0.1
13. Tocopherol acetate 0.01
14. Stearyl alcohol 0.5
15.1,2-pentanediol 0.1
16. Carboxyvinyl polymer (Note 12) 0.15
17. (Sodium acrylate/Na acryloyldimethyltaurate)
Copolymer (Note 13) 2.0
18. Ethanol 5.0
19. Perfume 0.1

The milky lotion of Example 14 did not discolor and had good stability over time.

Claims (3)

Component (a) and component (b) using component (c) sage extract;
A method for suppressing discoloration of a composition containing one or more selected from (a) linoleic acid (b) vitamin E, wherein "component (a) + component (b)" in the composition and component (c) in an amount such that the content mass ratio [(a)+(b)]/(c) is 0.1 to 12000. A method for suppressing discoloration. 2. The method of inhibiting discoloration according to claim 1, wherein said component (b) is vitamin E. A method for suppressing discoloration according to claim 1 or 2, wherein the content ratio (a)/(b) of the component (a) and the component (b) is 0.1 to 10,000.