JP2019099465A - Skin lotion composition - Google Patents

Abstract

To provide a skin lotion composition having excellent sense of use.SOLUTION: There is provided a skin lotion composition having improved sticky feeling after application or after drying by blending a liposomal retinol, glycerin and a polyethylene glycol having an average molecular weight of 2000 to 4200 in spite of blending retinol capable of imparting a sufficient moist feeling to the skin.SELECTED DRAWING: None

Description

  The present invention relates to a moisturizing composition with a good feeling of use and high moisturizing effect. More specifically, the present invention relates to a moisturizing cosmetic lotion composition that reduces the feeling of stickiness of the skin after application and drying.

  Lotions are often used for the purpose of providing a refreshing feeling or moisturizing the skin. However, unlike emulsion-type preparations such as emulsions and creams, since a large amount of oil components can not be blended, there is a drawback that it is difficult to obtain moist feeling of the skin after coating and drying. For this reason, development of the technique which can be mix | blended with the lotion which has a transparent or semi-transparent appearance, and provides skin | skin with sufficient moist feeling after applying and drying a lotion was desired.

  Various proposals have been made for this problem. For example, a technique using the formation of a complex (liposome) in which a poorly water-soluble substance is combined with a phospholipid in water (patent document 1), a technique using a combination of trimethylglycine and dipotassium glycyrrhizinate (patent document 2), etc. It can be mentioned. However, it has not yet come to realize a sufficiently moist and sticky feeling and refreshing feeling on the skin upon application and after drying.

JP 2007-197328 A Unexamined-Japanese-Patent No. 2004-352641

  The present inventors have found that a lotion containing liposomal retinol can impart a sufficiently moist feeling to the skin upon application and after drying, but a sticky feeling is generated on the skin upon application and after application and drying. It turns out that there are issues with usability.

    The present invention has been made in view of the above problems, and the main object of the present invention is the skin upon application and after application and drying although it is blended with retinol to a degree sufficient to impart moistness to the skin. In the above, the present invention provides a cosmetic composition that does not feel sticky.

  The present inventors combined use of polyethylene glycol having a molecular weight distribution with an average molecular weight of 2000 to 4200 in addition to liposomal retinol and glycerin to the skin upon application of the lotion composition and after application and drying. It has been found that it is possible to give a moist and sufficient moisturizing feeling even though it does not give a sticky feeling, and the present invention has been completed.

That is, this invention provides the lotion composition of following 1-4.
Item 1.
The lotion composition containing the following A, B, and C component.
A Liposome B including retinol Glycerin C Polyethylene glycol having an average molecular weight of 2,000 to 4,200.
Item 2. The cosmetic composition according to item 1, containing 0.01 to 0.15% by mass of retinol based on the total amount of the composition.
Item 3.
Item 3. The lotion composition according to any one of Items 1 to 2, which contains polyethylene glycol in an amount of 0.1 to 2% by mass based on the total amount of the composition.
Item 4.
The cosmetic composition according to any one of Items 1 to 3, further containing trimethylglycine.

  It is possible to provide a lotion composition capable of reducing the sticky feeling upon application or after drying although the moisturizing property to feel moist after drying is imparted.

  Hereinafter, the present invention will be described in detail.

  The lotion composition of the present invention relates to a lotion composition comprising a liposome containing retinol, glycerin and polyethylene glycol having a molecular weight distribution with an average molecular weight of 2000 to 4200.

  The lotion composition of the present invention contains "a liposome including γ-oryzanol". Here, the liposome is referred to as a lipid vesicle formed by a lipid bilayer membrane, and can usually be formed by hydration of a phospholipid-based lipid with a sufficient amount of water. Liposomes are generally classified based on the number of lipid bilayers and are classified into multilamellar liposomes (MLV) and unilamellar liposomes. Monolamellar liposomes are further classified into SUV (small unilamella vesicle), LUV (large unilamella vesicle), GUV (giant unilamella vesicle) and the like according to their size. Although any of these can be used, the liposome most suitable for the present invention is MLV. The size (outer diameter) of the liposome which can be preferably used in the present invention is 10 to 1000 nm, more preferably 20 to 600 nm, and most preferably 30 to 200 nm.

  The term "including" in the present invention means a state in which a substance to be included in a lipid vesicle (liposome) mainly formed of a lipid bilayer membrane is present. It is preferable that the liposome is enclosed in a space surrounded by the liposome membrane, but it may be present together with the components of the liposome membrane, or may be present between multiple membranes constituting the multilamellar liposome. The liposome may be present in a form attached to or bound to the surface of the outermost membrane of lipid bilayers constituting the liposome, or may be present in all or part of them. In the present application, the “liposome containing γ-oryzanol” may be expressed as “liposomalized γ-oryzanol” or simply “γ-oryzanol liposome”.

  The phospholipids constituting the γ-oryzanol liposome used in the present invention are lecithin and derivatives thereof. As lecithin, for example, egg yolk lecithin, soybean lecithin, rapeseed lecithin, corn lecithin, sunflower lecithin, peanut lecithin etc. can be used singly or in combination of two or more types, but it is not limited thereto. In the present invention, it is more preferable to use a hydrogenated product of these derivatives. Lecithin is also referred to as phosphatidylcholine or 1,2-diacylglycerol 3-phosphocholine, and generally, fatty acids are attached to the 1- and 2-positions of glycerol. In the present invention, it is preferable to use a lecithin in which an unsaturated fatty acid having 12 to 24 carbon atoms is bonded to one or both of the 1- and 2-positions in addition to the above-mentioned lecithins. It is particularly preferable to use a lecithin in which a saturated fatty acid of 24 to 24 and an unsaturated fatty acid having 12 to 24 carbon atoms are bonded to the 2-position. Here, the saturated fatty acid and the unsaturated fatty acid may be linear or branched. As a preferable unsaturated fatty acid, a C16-C18 unsaturated fatty acid can be used. In particular, lecithin having a large amount of oleic acid and linoleic acid bound at the 2-position is preferable. Specifically, egg yolk lecithin, soya lecithin and hydrogenated products thereof are preferable.

  Retinol liposomes can be produced by conventional methods. For example, a desired amount of lecithin and optionally a desired amount of sterol are dissolved in a suitable organic solvent such as ethanol, the solvent is removed under reduced pressure, and a membrane lipid is prepared, to which a solution containing retinol is added Then, for example, the dispersion liquid of retinol liposomes can be obtained by preparing a liposome dispersion liquid by stirring at about 1000 to 3000 rpm for about 2 to 5 minutes.

  Also, separately from this method, the desired amount of lecithin and optionally the desired amount of sterol are dissolved in a small amount of ethanol, dispersed in an aqueous solution or buffer and preemulsified, and then dispersed under high pressure to A dispersion of retinol liposomes can also be obtained by forming an overlay and preparing a liposome dispersion.

  The liposomes of the present invention may contain sterols. Sterols include animal-derived sterols such as cholesterol, lanosterol, dihydrolanosterol, desmosterol and dihydrocholesterol; Sterols (phytosterols) derived from microorganisms; sterols derived from microorganisms such as timosterol, ergosterol and the like, and the like, and can be used singly or in combination of two or more. Among these, cholesterol or phytosterol is preferable.

  The molar ratio of phospholipid to sterol in the liposome is preferably about 55:45 to 95: 5, more preferably about 60:40 to 90:10, and most preferably about 75:25 to 85:15. When the molar ratio is in these ranges, the stability of the lipid bilayer membrane constituting the liposome is improved. In addition, content of a phospholipid or sterol can be measured by a known method. For example, the content of phospholipids can be quantified by the Fiske-Subbarow method, the content of sterols can be quantified by HPLC, the colorimetric method, or the like.

  The retinol liposome prepared by the above method is obtained as a dispersion. The contents of retinol and lecithin in the preferred retinol liposome dispersion are as follows. The content of retinol is preferably about 0.01 to 0.5% by mass, more preferably about 0.03 to 0.2% by mass, and still more preferably about 0.05 to 0.15% by mass. The content of lecithin is preferably about 1 to 80% by mass, more preferably about 3 to 65% by mass, and still more preferably about 5 to 50% by mass. In addition, the liposome containing the retinol can be made to be contained in the lotion composition of this invention by mix | blending said retinol liposome dispersion liquid. Let retinol liposome dispersion be a compounding quantity adjusted so that content of retinol may become the range of 0.01-0.15 mass% with respect to the composition whole quantity. As content of (gamma)-oryzanol with respect to the composition whole quantity, 0.03-0.15 mass% is more preferable, and 0.05-0.1 mass% is the most preferable.

  The glycerin used in the present invention is contained in an amount of 1 to 15% by mass based on the total amount of the composition. More preferably, it is 3 to 12% by mass, and most preferably 4 to 10% by mass.

  Polyethylene glycol having a molecular weight of more than about 1000 is manufactured as a mixture having a distribution of molecular weights because it is difficult to separate single molecules. Thus, the polyethylene glycol used in the present invention has a molecular weight distribution with an average molecular weight of 2000 to 4200. The average molecular weight of polyethylene glycol can be measured using a known method. Examples include gradient HPLC using an ODS column and gel permeation chromatography. Various average molecular weights of polyethylene glycol are commercially available depending on production methods and purification methods. In the present invention, although those having an average molecular weight of 2000 to 4200 can be used, 2800 to 3800 are preferable, 3000 to 3600 are more preferable, 3100 to 3500 are more preferable, and 3100 to 3400 are most preferable. The polyethylene glycol is preferably contained in an amount of 0.1 to 2% by mass with respect to the total amount of the composition, more preferably 0.5 to 1.5% by mass, and most preferably 0.7 to 1.3% by mass.

  In the present invention, it is more preferable to contain trimethylglycine. The content of trimethylglycine is preferably 0.1 to 15% by mass, more preferably 0.5 to 10% by mass, and still more preferably 0.5 to 5% by mass, based on the total amount of the composition part. And 0.5 to 3% by mass is the most preferable.

  In the lotion composition of the present invention, in addition to the above-described compounds, components that can be used in the composition for external use to the skin can be generally blended as long as the effects of the present invention are not impaired. For example, surfactants, fatliquor, silicones, moisturizers, polymers, UV absorbers, sequestering agents, solvents, pH adjusters, vitamins, antioxidants, antioxidant aids, preservatives, perfumes Etc.

  As surfactant, an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and a nonionic surfactant are mentioned. Of these, nonionic surfactants are preferred. One or more of these can be blended.

  As anionic surfactants, polyoxyethylene alkyl ether phosphoric acid, polyoxyethylene polyoxypropylene alkyl ether phosphoric acid, polyoxyethylene sterol ether phosphoric acid, polyoxyethylene polyoxypropylene sterol ether phosphoric acid, polyoxyethylene alkyl ether Acetic acid, polyoxyethylene polyoxypropylene alkyl ether acetic acid, etc. may be mentioned.

  As the nonionic surfactant, polyoxyethylene (average addition mole number 20 to 50 moles) lauryl ether, polyoxyethylene (average addition mole number 20 to 50 moles) oleyl ether, polyoxyethylene (average addition mole number 10 to 50) Mol) cetyl ether, polyoxyethylene (average addition mole number 20 to 40 mol) stearyl ether, polyoxyethylene (average addition mole number 10 to 30 mol) behenyl ether, polyoxyethylene (average addition mole number 20 to 40 mol) Octyl phenyl ether, polyoxyethylene (average addition mole number 10 to 50 moles) 2-octyldodecyl ether, polyoxyethylene (average addition mole number 10 to 50 moles) decyl tetradecyl ether, polyoxyethylene (average addition mole number 10 ~ 50 moles) phytostero Ether, polyoxyethylene (average addition mol number 20 to 100 mol) hardened castor oil derivative, polyoxyethylene (average addition mol number 5 to 30 mol) polyoxypropylene (average addition mol number 5 to 30 mol) 2-decyltetra Ether type nonionic surfactants such as decyl ether, polyoxyethylene (average addition mole number 10 to 50 mol) polyoxypropylene (average addition mole number 2 to 30 mol) cetyl ether; polyoxyethylene (average addition mole number 20 to 20) 40 moles) sorbitan monolaurate, polyoxyethylene (average added mole number 20 to 60 moles) sorbitan monopalmitate, polyoxyethylene (average added mole number 40 to 60 moles) monostearate, polyoxyethylene (average added mole) 10 to 60 moles) sorbitan monoisostearate Polyoxyethylene (average addition mole number 20 to 40 moles) sorbitan monooleate, polyoxyethylene (average addition mole number 10 to 80 moles) glyceryl monoisostearate, polyoxyethylene (average addition mole number 10 to 30 moles) Glyceryl monostearate, sorbitan monooleate, sorbitan sesquiolate, sorbitan trioleate, sorbitan monoisostearate, sorbitan sesquiisostearate, glyceryl monooleate, glyceryl monoisostearate, glyceryl diisostearate, glyceryl monoesterate, Diglycerin monooleate, diglycerindiolate, diglycerin monoisostearate, diglycerin diisostearate, decaglyceryl monolaurate, decaglycerin pentaoleate Ester type nonionic surfactants such as caglycerin pentaisostearate, decaglycerin dekaolate, decaglycerin deca isostearate, sucrose monostearate, sucrose monopalmitate, sucrose monomyristate, sucrose monooleate; Alkyl glucoside type nonionic surfactants, such as oxyethylene (average added mole number of 20-30 mol) methyl glucoside, etc. are mentioned.

  As fatliquor, fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils and the like can be mentioned. One or more of these can be blended.

  As fats and oils, avocado oil, flaxseed oil, camellia oil, almond oil, sasanka oil, macadamia nut oil, corn oil, coking oil, grape oil, grape seed oil, medium oil, jojoba oil, olive oil, sunflower oil, rapeseed oil , Cinnamon oil, egg yolk oil, sesame oil, wheat germ oil, sasanqua oil, castor oil, castor oil, safflower oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, tea seed oil, kaaya oil, rice germ oil, rice bran oil, cocoa butter, coconut oil And evening primrose oil, shea butter, hydrogenated coconut oil, palm oil, palm kernel oil, magnolia kernel oil, hydrogenated castor oil and the like. One or more of these can be blended.

  Examples of the waxes include lanolin acetate, liquid lanolin, sugar cane, reduced lanolin, POE lanolin alcohol ether and the like. One or more of these can be blended. One or more of these can be blended.

  Examples of hydrocarbons include liquid paraffin, ozokerite, squalene, paraffin, squalane, paraffin, isoparaffin, octane, decane, dodecane, isododecane, hexadecane, isohexadecane and the like. One or more of these can be blended.

  Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behen (behenin) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, Examples thereof include icosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid and the like. One or more of these can be blended.

  Examples of higher alcohols include straight alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearylglycerin ether (batyl alcohol), 2-decyltetradecinol, lanolin Examples thereof include branched chain alcohols such as alcohol, cholesterol, phytosterol, hexyl dodecanol, isostearyl alcohol and octyl dodecanol. One or more of these can be blended.

  As synthetic ester oils, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, decyl dimethyl octanoate, cetyl lactate, myristyl lactate , Lanolin acetate, isocetyl stearate, isocetyl isostearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, di-2 -Heptylundecanoate glycerine, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, tetra-2 Ethylhexylhexyl pentaneerythritol, Glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glycerol trimyristate, glycerol tri-2-heptylundecanoate, castor oil Fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, adipic acid di-2-heptylundecyl Ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, seba Phosphate diisopropyl, 2-ethylhexyl succinate, trioctanoate glycerin triisopalmitate glycerin, lanolin fatty acid isopropyl, hexyl laurate. One or more of these can be blended.

  Examples of silicones include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. It can be mentioned. One or more of these can be blended.

  As a moisturizer, for example, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol having an average molecular weight of 3,000 or less, propylene glycol, dipropylene glycol, 1,3-butylene glycol, isoprene glycol, 1,2-butanediol, 1 And glycols such as 2-pentanediol, 1,2-propanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol; glycerins such as glycerin, diglycerin and polyglycerin; Sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, saccharides such as maltose, xylitose and derivatives thereof; starch-decomposing sugar reducing alcohol etc. Sugar alcohol; soybean protein hydrolyzate, wheat protein hydrolyzate, silk protein hydrolyzate, casein hydrolyzate, egg yolk membrane hydrolyzate, cationized protein hydrolyzate, silylated polypeptide, acylated polypeptide etc Protein hydrolysates and derivatives thereof; polyoxyalkylene glyceryl ethers such as polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether; Polyoxyalkylene diglyceryl ether such as oxypropylene diglyceryl ether; Polyoxyal such as polyoxyethylene polyoxypropylene hexylene glycol ether Polyethylene glycol, polyoxyalkylene alkyl glucoside such as polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, etc .; polyoxyalkylene sorbitol ether such as polyoxypropylene sorbitol ether; polyoxyalkylene alkyl ether such as polyoxyethylene polyoxypropylene butyl ether Dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters such as bisethoxydiglycol succinate, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, chondroitin sulfate, hyaluronic acid and / or derivatives thereof, mucoitin sulfate , Collagen derivatives, cholesteryl-12-hydroxystearate, sodium lactate, bile salts, seawater, deep sea water, Tosan derivatives, PCA soda, diglycerin (EO) PO adducts and the like can be mentioned. One or more of these can be blended.

  Examples of the polymers include natural water-soluble polymers, semi-synthetic water-soluble polymers, synthetic water-soluble polymers and inorganic water-based polymers. One or more of these can be blended.

  Examples of natural water-soluble polymers include arabia gum, tragacanth gum, galactan, guar gum, carob gum, caraya gum, carrageenan, amylopectin, pullulan, agarose, sodium pectate, sodium alginate, agartenite, quince seed (marmero), alge colloid (Kashou extract ), Plant-based polymers such as starch (rice, corn, potato, wheat), amylose, etc., microbial-based polymers such as xanthan gum, dextran, succinoglucan, pullulan, animal-based polymers such as casein, albumin, gelatin It can be mentioned.

  Examples of semi-synthetic water-soluble polymers include starch-based polymers such as carboxymethyl starch and methyl hydroxypropyl starch, methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose sodium Examples include cellulose-based polymers such as (CMC), crystalline cellulose and cellulose powder, and alginic acid-based polymers such as sodium alginate and alginic acid propylene glycol ester.

  Examples of synthetic water-soluble polymers include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, copolymer polymers such as polyoxyethylene polyoxypropylene copolymer, and polyacryl And acrylic polymers such as sodium acid, polyethyl acrylate and polyacrylamide, polyethylene imine, polyethylene glycol, cationized polymers and the like.

  Examples of the inorganic water-based polymer include bentonite, magnesium aluminum silicate (bee gum), laponite, hectorite, silicic anhydride and the like.

  Examples of UV absorbers include paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, 4- [N, N-di (2-hydroxypropyl) Benzoic acid ultraviolet light absorbers such as ethyl amino] benzoate, anthranilic acid ultraviolet light absorbers such as homomentyl-N-acetyl anthranilate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, p-tert-butyl salicylate Salicylic acid ultraviolet absorbers such as phenyl and homomentyl salicylate, benzyl cinnamate, 2-ethoxyethyl paramethoxycinnamate, octyl paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate Cinnamate UV absorbers such as paramethoxycinnamic acid isopropyl and diisopropylcinnamic acid ester mixture, urocanic acid, urocanic acid UV absorbers such as urocanic acid ethyl, hydroxymethoxy benzophenone, hydroxymethoxy benzophenone sulfonic acid, sodium hydroxymethoxy benzophenone sulfonate Benzophenone UV absorbers such as dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, dihydroxybenzophenone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxy-dibenzoylmethane, 2,4,6-trianilino-p -(Carbo-2'-ethylhexyl-1'-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-) Butylphenyl) benzotriazole.

  As a metal sequestering agent, for example, alanine, ethylenediamine hydroxyethyl triacetate trisodium, disodium edetate, trisodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, sodium metaphosphate, gluconic acid, tartaric acid, Succinic acid, edetic acid, phytic acid and the like can be mentioned.

  As the solvent, for example, lower alcohols such as methanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol etc., ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, Etc., trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol, tetrahydric alcohols such as pentaerythritol, pentahydric alcohols such as xylitol, and hexavalents such as sorbitol and mannitol. Alcohol, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycose Polyalcohol polymers such as polyglycerin, dihydric alcohol alkyl ethers such as ethylene glycol monomethyl ether, dihydric alcohol alkyl ethers such as diethylene glycol monomethyl ether and diethylene glycol monoethyl ether, ethylene glycol monomethyl ether acetate Examples thereof include dihydric alcohol ether esters, glycerin monoalkyl ethers such as xyl alcohol, cerakyl alcohol and batyl alcohol.

  Examples of pH adjusters include citric acid, lactic acid, acetic acid, hydrochloric acid, potassium hydroxide, sodium hydroxide, sodium lactate, sodium citrate, sodium lactate and the like. These can be used alone or in combination, and can be used not only for adjusting pH value but also for buffering pH value adjustment.

  Examples of vitamins include vitamin Bs such as VB2, VB6, VB12; vitamin Cs such as ascorbic acid and erythorbic acid; α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β -Vitamin Es such as tocotrienol, γ-tocotrienol, δ-tocotrienol and the like; pantothenic acid and derivatives thereof and the like.

  Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.

  Examples of antiseptics include organic acids such as benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid, parahydroxybenzoate and derivatives thereof, phenols such as isopropylmethylphenol, phenoxyethanol, 1,2-hexanediol And 1,2-pentanediol.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In addition, unless there is particular notice below, "%" shows the "mass%."

Evaluation of feeling of use at the time of application and after application and drying With respect to the lotion composition of the formulation in Table 1, hydrogenated lecithin, propylene glycol, cholesterol, water and retinol are mixed in advance, and liposome dispersion is obtained using a conventional method (Table 1) The part indicated by I) was prepared. Separately, the liposome dispersion was added to a composition obtained by uniformly mixing other components using a conventional method, and the cosmetic composition was prepared by making the composition uniform. With respect to the obtained cosmetic composition, the evaluation of stickiness after drying was conducted by 12 expert panels. Evaluation was relative evaluation which judges the use feeling of two subjects relatively. The polyethylene glycols of Table 1 used are polyethylene glycols having an average molecular weight of about 3400, and HCO-60 is polyoxyethylene (average added mole number: 60) hydrogenated castor oil.

As a result of the evaluation, it was evaluated by eight evaluators (about 67%) that the lotion composition containing polyethylene glycol having an average molecular weight of about 3400 had an improved tackiness after coating and drying.

Claims (4)

The lotion composition containing the following A, B, and C component.
A Liposome B including retinol Glycerin C Polyethylene glycol having an average molecular weight of 2000 to 4200 The lotion composition of Claim 1 which contains retinol 0.01-0.15 mass% with respect to composition whole quantity. The lotion composition of any one of Claim 1 or 2 which contains 0.1-2 mass% of polyethyleneglycol with respect to composition whole quantity. Furthermore, the lotion composition in any one of Claims 1-3 containing a trimethyl glycine.