JP2019072472A - 凝塊ベース生体材料組成物およびその方法 - Google Patents
凝塊ベース生体材料組成物およびその方法 Download PDFInfo
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Abstract
Description
本出願は2017年9月27日出願の米国仮特許出願第62/563,685号の利益を主張し、すべての目的のために参照としてその全体が本明細書に組み込まれる。
Claims (20)
- 組織の再生を助けるための組成物であって、
血液流体を含む凝塊と、
外因性組み換えタンパク質と、
セラミック粒子、コラーゲンファイバ、またはその両方と、を含む、組成物。 - 組織の再生を助けるための組成物であって、
セラミック粒子、コラーゲンファイバ、およびそれらの混合物のうちの一つ以上を含む足場と、
足場を通って分散される血液流体を含む凝塊と、
外因性組み換えタンパク質と、を含む組成物。 - 前記凝塊が、血小板、赤血球、白血球、血漿、骨髄間質、間葉系幹細胞、骨前駆細胞、骨髄造血細胞、赤血球生成細胞、およびそれらの組み合わせのうちの一つ以上を含む、請求項1に記載の組成物。
- 前記凝塊が生存細胞を含む、請求項1に記載の組成物。
- 前記凝塊が凝固した骨髄穿刺液を含む、請求項1に記載の組成物。
- 前記凝塊が凝固した血液を含む、請求項1に記載の組成物。
- 前記組み換えタンパク質が骨形成タンパク質を含む、請求項1に記載の組成物。
- 前記組み換えタンパク質が、BMP−2、BMP−4、BMP−6、BMP−7、それらのヘテロ二量体、およびそれらの組み合わせからなる群から選択される、請求項1に記載の組成物。
- 前記セラミック粒子が生理活性ガラス、リン酸三カルシウム、およびそれらの混合物からなる群から選択される、請求項1に記載の組成物。
- 前記セラミック粒子が生理活性ガラス粒子を含む、請求項1に記載の組成物。
- 前記セラミック粒子がリン酸三カルシウム粒子を含む、請求項1に記載の組成物。
- 前記セラミック粒子が、約1〜1000μmの範囲の粒子サイズを有する、請求項1に記載の組成物。
- 前記セラミック粒子が、約100〜500μmの孔サイズを有し、全体の気孔率が約60〜80%である、請求項1に記載の組成物。
- 組織の再生を助けるための移植可能組成物を調製する方法であって、
試料を採取するのに抗凝血剤を使用することなく患者から血液流体の試料を取得することと、
均質混合物を形成するため、前記試料を外因性組み換えタンパク質およびセラミック粒子、コラーゲンファイバ、またはその両方と混合させることと、
前記移植可能組成物を形成するのに凝固剤を追加することなく、均質混合物を自然に凝固させることを可能にすることと、を含む方法。 - 前記組み換えタンパク質およびセラミック粒子、コラーゲンファイバ、または両方が、前記試料が凝固する前に前記試料と混合される、請求項14に記載の方法。
- 前記血液流体の試料が前記患者から回収された骨髄穿刺液である、請求項14に記載の方法。
- 前記血液流体の試料が前記患者から回収された末梢血である、請求項14に記載の方法。
- 前記移植可能組成物が、前記試料を取得した同一患者に投与される、請求項14に記載の方法。
- 哺乳動物における骨や創傷の治癒を促進させる方法であって、
血液流体、外因性組み換えタンパク質、およびセラミック粒子、コラーゲンファイバ、または両方を含む凝塊の混合物を含む組成物を提供することと、
標的修復部位における組織の修復または再生を促進させるよう、前記組成物を前記標的修復部位内に投与することと、を含む方法。 - 前記標的修復部位が、前記脊椎における損傷または欠損であり、再生されている前記組織が骨である、請求項19に記載の方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762563685P | 2017-09-27 | 2017-09-27 | |
US62/563,685 | 2017-09-27 | ||
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US16/124,315 US20190091372A1 (en) | 2017-09-27 | 2018-09-07 | Coagulum-based biomaterial compositions and methods thereof |
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JP2007050272A (ja) * | 2001-02-28 | 2007-03-01 | Clevland Clinic Foundation | 複合型骨髄移植材、その調製法およびキット |
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US8877221B2 (en) * | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
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US20160159869A1 (en) | 2014-12-09 | 2016-06-09 | Northwestern University | Bmp-2-binding peptide amphiphile nanofibers |
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