JP2019069927A - Oral composition - Google Patents

Abstract

To provide a formulation technique that can prevent discoloration while containing hinokitiol, allantoin and water.SOLUTION: An oral composition contains hinokitiol, allantoin and water, as well as a phosphocholine group-containing polymer, to prevent discoloration.SELECTED DRAWING: None

Description

  The present invention relates to an oral composition which is inhibited from discoloring while containing hinokitiol, allantoin and / or a derivative thereof (hereinafter sometimes referred to as "allantoins"), and water.

  Phosphocholine group-containing polymers such as 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer have high affinity to living bodies, and further have effects such as moisture retention, prevention of adhesion of microorganisms to the oral cavity, prevention of gingivitis, etc. Have also been reported and used in oral compositions (see, for example, Patent Documents 1 to 3).

  Allantoins are known to activate cell functions and have anti-inflammatory, hemostatic, bactericidal, anti-ulcer effects and the like, and are used in oral compositions (for example, Patent Document 4) reference).

  In addition, a bactericidal agent for reducing the number of pathogens of caries and periodontal diseases is used in the composition for oral cavity. Although various bactericidal agents used in oral compositions are known, hinokitiol is widely used in oral compositions because it exhibits low toxicity and a broad antibacterial spectrum. Hinokitiol suffers from instability problems such as discoloration and content reduction. Various proposals have been made to maintain the stability of hinokitiol.

  For example, Patent Document 5 describes that a water-soluble inorganic salt such as sodium chloride is blended with a composition for oral cavity containing hinokitiol. As a technique for obtaining even better storage stability, in Patent Document 6, 0.02 to 1% by mass of an edetate salt and 0.2 to 10% by weight of ethanol with respect to an oral composition containing hinokitiol And blending 3 to 200 times as much water as ethanol by mass ratio with ethanol is described. However, in the formulation technology of Patent Document 6, there are cases in which the formulation can not be adapted to the recent diversifying liquid oral composition formulations because the formulation is limited. Therefore, development of a new formulation technology for stabilizing hinokitiol in oral compositions is desired.

JP, 2006-219450, A JP, 2011-153101, A JP, 2015-853, A JP, 2011-168557, A JP-A-4-198121 JP, 2010-150155, A

  The present inventors examined formulation stability of an oral composition containing hinokitiol, and encountered a new problem that when hinokitiol coexists with allantoins, significant discoloration occurs. That is, it has become clear that the oral composition containing hinokitiol and allantoin in water has a unique problem of the problem of discoloration.

  Therefore, an object of the present invention is to provide a formulation technology that can suppress discoloration while containing hinokitiol, allantoins and water.

  The inventors of the present invention conducted intensive studies to solve the above-mentioned problems. As a result, in the composition for oral cavity, the composition for oral cavity containing phosphocholine group-containing polymer together with hinokitiol, allantoins and water suppresses discoloration. I found out what I could do. The present invention has been completed by further studies based on such findings.

That is, the present invention provides the invention of the aspects listed below.
Item 1. An oral composition comprising (A) hinokitiol, (B) at least one member selected from the group consisting of allantoin, and (C) a phosphocholine group-containing polymer, and (D) water.
Item 2. The composition for oral cavity as described in item 1 or 2 above, wherein the component (C) is a 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer.
Item 3. A discoloration inhibitor used to inhibit discoloration in an oral composition comprising (A) hinokitiol, (B) allantoin and at least one member selected from the group consisting of (D) water, ,
(C) A discoloration inhibitor comprising a phosphocholine group-containing polymer as an active ingredient.
Item 4. A method for suppressing discoloration in an oral composition comprising at least one member selected from the group consisting of (A) hinokitiol, (B) allantoin and derivatives thereof and (D) water,
A method for suppressing discoloration by incorporating a (C) phosphocholine group-containing polymer into the composition for oral cavity together with the (A) component, the (B) component and the (D) component.

  According to the composition for oral cavity of the present invention, while containing hinokitiol, allantoins and water, it is possible to suppress the color change and to have excellent formulation stability, so that a good appearance can be maintained during storage, While being able to become a favorable appearance also at the time of use, attenuation of the effect by hinokitiol can be suppressed.

1. Oral Composition The oral composition of the present invention comprises (A) hinokitiol (hereinafter sometimes referred to as component (A)), (B) allantoin and / or a derivative thereof (hereinafter, component (B)) It may be described), (C) phosphocholine group-containing polymer (hereinafter, may be described as (C) component), (D) water (hereinafter, may be described as (D) component) And containing. Hereinafter, the composition for oral cavity of this invention is explained in full detail.

(A) Hinokitiol The composition for oral cavity of the present invention contains hinokitiol as the component (A). Hinokitiol is a known drug known to have low toxicity and bactericidal activity showing a broad antibacterial spectrum.

  In the present invention, hinokitiol may be of natural origin or chemically synthesized. Moreover, the hinokitiol used by this invention can also use the hinokitiol containing essential oil obtained from the tree whether it is a purified product or a crudely purified product, for example.

  The content of the component (A) in the composition for oral cavity of the present invention is appropriately set according to the formulation form and application of the composition for oral cavity, but from the viewpoint of exhibiting excellent bactericidal action, 0.001 to 0.5% by weight, preferably 0.005 to 0.3% by weight, more preferably 0.01 to 0.2% by weight can be mentioned.

(B) Allantoin The composition for oral cavity of the present invention contains, as the component (B), at least one selected from the group consisting of allantoin and its derivative.

  Allantoin is a compound also referred to as 5-ureidohydantoin, and is a known drug known to have anti-inflammatory action, cell activating action, hemostatic action, bactericidal action, anti-ulcer action and the like.

  The derivative of allantoin is not particularly limited as long as it is pharmaceutically acceptable, and specific examples include allantoin chlorohydroxyaluminum, allantoin hydroxyaluminum and the like. These allantoin derivatives may be used alone or in combination of two or more.

  In the composition for oral cavity of the present invention, as the component (B), one kind of allantoin and its derivative may be selected and used, or two or more kinds may be used in combination. Among these (B) components, allantoin is preferably mentioned from the viewpoint of obtaining excellent stability.

  In the composition for oral cavity of the present invention, the content of the component (B) may be appropriately set according to the medicinal effect to be prepared for the composition for oral cavity, the formulation form of the composition for oral cavity, etc. 0.001 to 2% by weight, preferably 0.005 to 0.5% by weight, and more preferably 0.01 to 0.3% by weight.

(C) Phosphocholine Group-Containing Polymer The composition for oral cavity of the present invention contains a phosphocholine group-containing polymer as the component (C). The phosphocholine group-containing polymer can suppress the color change by coexisting with the (A) component and the (B) component.

  The phosphocholine group-containing polymer is a polymer obtained by polymerizing a monomer containing a phosphocholine group (hereinafter sometimes referred to as "phosphocholine group-containing monomer"), and is a known component having a moisturizing effect and the like. .

  In the phosphocholine group-containing polymer, the type of the phosphocholine group-containing monomer is not particularly limited, and examples thereof include monomers having a phosphocholine group and a vinyl group. More specifically, examples of the phosphocholine group-containing monomer include 2-methacryloyloxyethyl phosphoryl choline and 2-methacryloyloxyethyl phosphoryl ethanolamine. In the phosphocholine group-containing polymer, the phosphocholine group-containing monomer may be contained singly or in combination of two or more. Among these phosphocholine group-containing monomers, 2-methacryloyloxyethyl phosphoryl choline is preferably mentioned from the viewpoint of further improving the color change suppressing effect.

  The phosphocholine group-containing polymer used in the present invention may be a homopolymer consisting of one kind of phosphocholine group-containing monomer, or a copolymer consisting of two or more kinds of monomers. Good.

  When the phosphocholine group-containing polymer is a copolymer, it may be a copolymer composed of two or more types of phosphocholine group-containing monomers, and at least one type of a phosphocholine group-containing monomer and at least one type of monomer. The copolymer which consists of monomers other than a phosphocholine group containing monomer may be sufficient.

  The types of monomers other than the phosphocholine group-containing monomer contained in the phosphocholine group-containing polymer are pharmaceutically acceptable and particularly limited as far as they are radically polymerizable with a single amount of phosphocholine group-containing monomer. Although it does not restrict | limit, the monomer which has a vinyl group is mentioned, for example. As monomers other than the phosphocholine group-containing monomer, specifically, methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) acrylate, 2- Alkyl (meth) acrylates such as ethyl hexyl (meth) acrylate; benzyl (meth) acrylate, phenoxyethyl (meth) acrylate, cyclohexyl (meth) acrylate, polypropylene glycol mono (meth) acrylate, polytetramethylene glycol mono (meth) acrylate, Polypropylene glycol di (meth) acrylate, polytetramethylene glycol mono (meth) acrylate, polypropylene glycol polyethylene glycol mono (meth) acrylate, methacryl Sodium 2-hydroxy-3-methacryloyloxy propyl trimethyl ammonium, and the like. In the phosphocholine group-containing polymer, monomers other than the phosphocholine group-containing monomer may be contained singly or in combination of two or more. Among monomers other than these phosphocholine group-containing monomers, alkyl (meth) acrylate, 2-hydroxy-3-, preferably from the viewpoint of further improving the color change suppressing effect while exhibiting the moisturizing action effectively. Methacryloyloxypropyltrimethylammonium, more preferably an alkyl (meth) acrylate having 1 to 18 carbon atoms, more preferably an alkyl (meth) acrylate having 3 to 5 carbon atoms of an alkyl group, particularly preferably butyl (meth) ) Acrylates. In the present specification, "(meth) acrylate" indicates methacrylate and / or acrylate.

  Specific examples of the phosphocholine group-containing polymer used in the present invention include polymethacryloyloxyethyl phosphorylcholine homopolymer, 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer (polyquaternium-51), 2-methacryloyloxy Ethylene phosphorylcholine / butyl methacrylate / sodium methacrylate copolymer (polyquaternium-65), 2-methacryloyloxyethyl phosphorylcholine, 2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer (polyquaternium-64), 2-methacryloyloxy Ethyl phosphoryl choline / stearyl methacrylate copolymer (polyquaternium-61) etc. are mentioned. In addition, in the said description regarding a phosphocholine group containing polymer, the name in parenthesis shows a cosmetic component display name.

  In the composition for oral cavity of the present invention, as the component (C), one type of phosphocholine group-containing polymer may be used, or two or more types of phosphocholine group-containing polymers may be used in combination.

  Among these (C) components, 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer and polymethacryloyloxyethyl are preferable, from the viewpoint of further improving the color change suppressing effect while exhibiting the moisturizing action effectively. Phosphoryl choline homopolymer, 2-methacryloyloxyethyl phosphorylcholine. 2-hydroxy-3-methacryloyloxypropyl trimethyl ammonium copolymer; more preferably 2-methacryloyloxyethyl phosphorylcholine butyl methacrylate copolymer, 2-methacryloyloxyethyl. Phosphorylcholine • 2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer; particularly preferably 2-methacryloyloxyethyl phosphorylcholine • methacryl Butyl copolymer.

  In the composition for the oral cavity of the present invention, the content of the component (C) is not particularly limited, but from the viewpoint of further improving the discoloration suppression effect, for example, 0.05% by weight in total of the component (C) Or more, preferably 0.05 to 0.5% by weight, more preferably 0.05 to 0.3% by weight, and still more preferably 0.05 to 0.25% by weight.

  In the composition for the oral cavity of the present invention, the ratio of the component (C) to the component (A) is determined according to the content of each of the component (A) and the component (B), but the coloration suppressing effect is further improved. From the viewpoint of, for example, the total amount of the component (C) is 0.1 parts by weight or more, preferably 0.1 to 500 parts by weight, more preferably 0.15 to 60 parts by weight, per 1 part by weight of the component (A) More preferably, it is from 0.25 to 25 parts by weight.

(D) The oral composition of the water present invention contains water as a base. The components (A) and (B) tend to cause discoloration when stored in the presence of water, but according to the composition for oral cavity of the present invention, such discoloration is effectively suppressed. can do.

  In the composition for oral cavity of the present invention, the content of the component (D) is appropriately set according to the form of the formulation etc., but it is, for example, 1 to 95% by weight, preferably 3 to 90% by weight, more preferably Is 5 to 85% by weight.

Other Components The composition for oral cavity of the present invention contains, in addition to the components described above, components generally used in the technical field according to the formulation form of the composition for oral cavity as long as the effects of the present invention are not impaired. It may be done. Such components include, for example, preservatives, bactericides, antibacterial agents, anti-inflammatory agents, abrasives, glucosyl transferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, anti-calculus agents, dentinaceous agent Mineralizer, antihistamine, local anesthetic, circulation enhancer, thickener, wetting agent, excipient, flavor, sweetener, refreshing agent, pigment, deodorant, surfactant, solvent, pH adjuster, etc. Can be mentioned.

  The preservative, bactericidal agent and antibacterial agent may be any component other than the above-mentioned component (A), for example, benzoic acids, salicylic acids, sorbic acids, parabens, decarinium chloride, chlorhexidine chloride, chlorhexidine gluconate, isopropyl Methylphenol, triclosan, lysozyme chloride, chlorhexidine hydrochloride, potassium iodide and the like can be mentioned.

  The anti-inflammatory agent may be any component other than the above-mentioned component (B), for example, dipotassium glycyrrhizinate, glycyrrhetinic acid, methyl glycyrrhizinate, stearyl glycyrrhizinate, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinate Monoglucuronide, tranexamic acid, epsilon aminocaproic acid, azulene, sodium chloride, vitamins and the like can be mentioned.

  Examples of the abrasive include anhydrous silicic acid, hydrous silicic acid, aluminum oxide, aluminum hydroxide, calcium hydrogen phosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, crystalline cellulose, polyethylene powder, carbon particles and the like.

  As a GTase inhibitor, for example, an extract of a plant belonging to the genus Pinus vulgare L., an extract of Vitis vines, a dextranase, mutanase, tastein, tannins, ellagic acid, polyphenol, oolong tea extract, green tea extract, There are Semburi, Taisou, fennel, glaze, gentiana, senso, long-bowl, Huangren, etc.

  Examples of the plaque inhibitor include zinc citrate and gluconic acid.

  Examples of the hypersensitivity suppressor include potassium nitrate, strontium chloride and the like.

  As an anti-calculus agent, for example, polyphosphates, zeolite, ethane hydroxy diphosphonate and the like can be mentioned.

  Examples of the tooth strengthening / remineralizing agent include fluorine, sodium fluoride, sodium fluorophosphate and stannous fluoride.

  Examples of antihistamines include diphenhydramine, diphenhydramine hydrochloride and the like.

  The local anesthetic includes, for example, procaine, tetracaine, bupipakine, mepipacain, chlorprocaine, proparacaine, meprilcain or salts thereof, orthokine, oxesazein, oxypolyentoxydecane, roto extract, percamine pase, tesitdectin and the like.

  Examples of the blood circulation promoting agent include nonylic acid allirylamide, nicotinic acid benzyl ester, capsaicin, pepper extract and the like.

  As the thickener, for example, polysaccharides such as pullulan, pullulan derivatives, starch and the like; hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, carboxymethyl cellulose, carboxymethyl cellulose salts (sodium carboxymethylcellulose, potassium carboxymethylcellulose etc.) , Methylcellulose, ethylcellulose, polyacrylic acid, polyacrylate (sodium polyacrylate, acrylic acid / acrylic acid octyl ester copolymer, etc.), methacrylic acid copolymers (methacrylic acid and n-butyl acrylate) Polymers, polymers of methacrylic acid and methyl methacrylate, polymers of methacrylic acid and ethyl acrylate, etc.) Polymeric substances; Synthetic polymeric substances such as carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, etc .; Lectin, alginic acid, alginate (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, alginate Natural polymeric substances such as triisopropanolamine, ammonium alginate, butylamine alginic acid, diamylamine alginic acid sodium, chondroitin sulfate sodium, agar, chitosan, carrageenan, etc .; amino acid type polymeric substances such as collagen, gelatin; gum arabic, karaya gum, tragacanth gum, Xanthan gum, locust bean gum, guar gum, tamarind gum, gellan gum, etc. System polymer material, and the like.

  As the humectant, for example, glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactol, erythritol and the like can be mentioned.

  Examples of the excipient include lactose, sucrose, mannitol, starch, dextrin, crystalline cellulose, silica (light anhydrous silicic acid etc.) and the like.

  Examples of the fragrant include natural fragrant (such as fennel oil), synthetic fragrant, and blended fragrants thereof.

  As the sweetening agent, saccharin sodium, stevioside, stevia extract, aspartame, xylitol, starch syrup, honey, sorbitol, maltitol, mannitol, erythritol, saccharides (lactose, sucrose, fructose, glucose, etc.) and the like can be mentioned.

  Examples of the refreshing agent include menthol, erythritol, camphor, borneol, geraniol, essential oils containing these, and the like.

  The dyes include, for example, natural dyes, synthetic dyes, and mixtures thereof.

  Examples of the deodorant include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, burdock powder, green tea, roasted rice bran extract and the like.

  As the surfactant, for example, sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristryl sarcosinate, sodium dodecyl benzene sulfonate, hydrogenated coconut fatty acid monoglyceride Anionic surfactants such as sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoylglutarate, sodium N-methyl-N-acyl taurine, etc .; polyoxyethylene hydrogenated castor oil, Sugar fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan mo Nonionic surfactants such as stearate, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, polyglycerin fatty acid ester; coconut oil fatty acid amidopropyl betaine, lauryl Dimethylaminoacetic acid betaine, lauryldimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, N-alkyl-1-hydroxyethylimidazoline Amphoteric surfactants such as betaine sodium; lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, benzethonium chloride, benzalkonium chloride , Cationic surfactants such as chloride stearyl dimethyl benzyl ammonium.

  Examples of the solvent include monohydric alcohols such as ethanol, propanol, butanol, pentanol, hexanol and isopropanol.

  As a pH adjuster, for example, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, malic acid, lactic acid, phosphoric acid, benzoic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium acetate, sodium carbonate, sodium citrate, citric acid Examples include sodium hydrogen, sodium lactate, calcium lactate, sodium phosphate, sodium hydrogen phosphate, sodium benzoate and the like.

  In the composition for oral cavity of the present invention, when these components are contained, the content thereof may be appropriately set in the range generally used in the relevant technical field.

pH
In addition, the pH of the composition for oral cavity of the present invention may be appropriately set in the range in which application to the oral cavity is permitted, and for example, 4 to 8, preferably 5 to 7.5, and more preferably 6 -7 are mentioned. Here, pH is a value measured under a temperature condition of 25 ° C.

Dosage form The dosage form of the composition for oral cavity of the present invention is not particularly limited as far as it can be applied to the oral cavity, but includes, for example, liquid or semisolid (gel or paste). .

  The preparation form of the oral composition of the present invention is not particularly limited as long as it can be applied in the oral cavity and can be retained in the oral cavity for a certain period of time, for example, liquid dentifrice, liquid dentifrice, toothpaste, Oral hygiene agents such as mouthwash (liquid dentifrice, mouthrinse may be generally referred to as mouthrinse, mouthwash, dental rinse etc.), mouth freshener (mouse spray etc), oral ointment etc Can be mentioned. Among these, preferred are liquid dentifrices, liquid dentifrices, toothpastes and mouthrinses, and more preferably liquid dentifrices, toothpastes and mouthrinses.

Container The material of the container filled with the composition for oral cavity of the present invention is not particularly limited. Examples of the material of the container include glass and resin. Specific examples of the resin include polyolefin resins such as polypropylene and polyester resins such as polyethylene terephthalate. From the viewpoint of further exhibiting the color change suppressing effect, polyolefin resins are preferable, and polypropylene is more preferable. In addition, when a container contains resin and it is comprised by the laminated body which consists of multilayer structures, it is comprised so that the resin layer which consists of the above-mentioned resin may become the innermost layer of a container. In addition, although the insoluble component adheres to the inner wall of a glass container, the composition for oral cavity which does not mix | blend the above-mentioned (C) component is a glass-made container by mix | blending (C) component in the composition for oral cavity of this invention It is also possible to suppress the adsorption of insoluble components on the inner wall of
Further, the shape of the container is not particularly limited, and any shape such as a tube or a bottle may be used.

2. Discoloration inhibitors, and method for suppressing discoloration to above, phosphocholine group-containing polymer, hinokitiol, allantoin compounds, and in oral compositions comprising water, it is possible to suppress the discoloration. Therefore, the present invention is a discoloration inhibitor used to suppress discoloration in an oral composition containing hinokitiol, allantoins and water, which comprises a phosphocholine group-containing polymer as an active ingredient. I will provide a. Further, the present invention is a method for suppressing discoloration in an oral composition containing hinokitiol, allantoins, and water, wherein the oral composition includes a phosphocholine group-containing polymer together with hinokitiol, allantoins, and water. Provide a way to formulate

  The color change inhibitor is used as an additive for a phosphocholine group-containing polymer, and the method for suppressing the color change uses a phosphocholine group-containing polymer and is for oral cavity containing hinokitiol, allantoins, and water. It is a method of suppressing the discoloration in a composition.

  In the color change inhibitor and the method for suppressing color change, the types and amounts of the components used, the form of the composition for oral cavity and the like are as described in the section of “1. Composition for oral cavity”.

  EXAMPLES The present invention will be more specifically described below by way of Examples, but the present invention is not limited thereto.

Test Example A solution of the composition shown in Table 1 was prepared. Specifically, in the examples, hinokitiol was added to purified water, stirred and dissolved, and then 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer was added and stirred and mixed. Then, allantoin was added and stirred to dissolve. All steps were performed at 80 ° C. heating conditions. In Comparative Examples and Reference Examples, solutions were similarly obtained except that 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, or further allantoin or hinokitiol was not used. The resulting solution was filled 50 mL each in a glass screw tube bottle (volume 110 mL), a polypropylene (PP) bottle container (volume 100 mL), or a polyethylene terephthalate (PET) bottle container (volume 100 mL). In addition, all containers used the transparent type thing. The discoloration inhibition was evaluated for each solution as follows.

<Color change inhibition property>
The filled solution was stored at 60 ° C. for 7 days under light-shielded conditions. Thereafter, the temperature was returned to normal temperature, and the degree of discoloration inhibition was evaluated according to the judgment criteria shown below.
××: extremely remarkable discoloration is observed in the preparation.
×: Remarkable discoloration is observed in the preparation.
○: no significant discoloration was observed in the preparation.
◎: Almost no discoloration is observed in the preparation.

  The obtained results are shown in Table 1. As shown in Table 1, no discoloration was observed in the solutions containing hinokitiol or allantoin alone (Reference Examples 1 and 2), but in the solutions containing both Hinokitiol and Allantoin (Comparative Examples 1 and 2), Significant discoloration was observed. In particular, with the liquid agent ("PP" of Comparative Examples 1 and 2) filled in a container made of polypropylene (PP), extremely remarkable discoloration was observed. On the other hand, in the liquid preparation (Examples 1 to 4) in which 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer was blended, the color change was dramatically suppressed.

  In addition, although not shown in the table, in the solution for which the discoloration inhibition evaluation was performed, the solution containing both hinokitiol and allantoin and filled in a glass screw tube (“glass in Comparative Example 1 and 2” In the case of ")", fogging due to the adsorption of the precipitate on the inner wall of the screw tube bottle in contact with the solution was observed. On the other hand, in the liquid agent ("glass" of Examples 1-4) which mix | blended 2-methacryloyl oxyethyl phosphoryl choline and the butyl methacrylate copolymer, the cloudiness by adsorption of a precipitate was not recognized, either.

Formulation example 1
An oral composition having the composition shown in Table 2 and Table 3 was prepared. In addition, the unit of content of each component in a table | surface is weight%. The obtained composition for oral cavity of Table 2 was used as a glass screw tube bottle (volume 110 mL), a polypropylene (PP) bottle container (volume 100 mL), or a polyethylene terephthalate (PET) bottle container (volume 100 mL) The oral cavity composition of Table 3 obtained in each of the above was filled in 50 mL, the glass screw tube bottle (9 mL capacity), a laminated tube made of polypropylene (PP), or a bottle container made of polyethylene terephthalate (PET) (volume Each 10 mL) was filled with 5 mL. The color change inhibition was evaluated in the same manner as in Test Example 1 for each preparation. Discoloration was suppressed in any of the obtained oral compositions.

Formulation example 2
The composition for oral cavity of the composition shown to Tables 4-11 was manufactured. In addition, the unit of content of each component in a table | surface is weight%. The color change was suppressed about the obtained composition for oral cavity.

Claims (4)

  An oral composition comprising (A) hinokitiol, (B) at least one member selected from the group consisting of allantoin, and (C) a phosphocholine group-containing polymer, and (D) water.   The composition for oral cavity of Claim 1 whose said (C) component is 2-methacryloyl oxyethyl phosphoryl choline * butyl methacrylate copolymer. A discoloration inhibitor used to inhibit discoloration in an oral composition comprising (A) hinokitiol, (B) allantoin and at least one member selected from the group consisting of (D) water, ,
(C) A discoloration inhibitor comprising a phosphocholine group-containing polymer as an active ingredient. A method for suppressing discoloration in an oral composition comprising at least one member selected from the group consisting of (A) hinokitiol, (B) allantoin and derivatives thereof and (D) water,
A method for suppressing discoloration by incorporating a (C) phosphocholine group-containing polymer into the composition for oral cavity together with the (A) component, the (B) component and the (D) component.