JP2009007285A - Hinokitiol-containing hydrophilic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hinokitiol-containing hydrophilic composition which holds sufficient viscosity, exhibits an inconspicuous transparent appearance after coated on an oral cavity mucous membrane such as gum, and is excellent in the storage stability of hinokitiol. <P>SOLUTION: This hinokitiol-containing hydrophilic composition is characterized by containing a dihydric alcohol such as ethylene glycol, propylene glycol, or butylene glycol in an amount of ≥30 wt.% on the basis of the total amount of the composition and not containing glycerol. It is preferable that the hinokitiol-containing hydrophilic composition has viscosity of ≥10,000 cP as measured with a type B viscometer. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a hydrophilic composition containing hinokitiol, and more particularly to a hinokitiol-containing hydrophilic composition used as an oral ointment that exerts a bactericidal action of hinokitiol by directly applying it to oral mucosa such as gums. .

  Hinokitiol is known to have bactericidal and tissue astringent effects, and it has traditionally been known that gingivitis or alveoli, such as gum bleeding, redness, swelling, itchiness, pain, itching, mouth stickiness, bad breath, etc. It has been used in oral compositions such as ointments and dentifrices for the purpose of alleviating various symptoms of purulent discharge and treating stomatitis.

  The composition for oral cavity used as an ointment for oral mucosa such as gums is a hydrophobic composition using a hydrophobic base such as fats and oils because of its excellent bactericidal action and usability of hinokitiol. It is more preferable to configure as a hydrophilic composition based on a hydrophilic substance.

  However, under hydrophilic conditions, hinokitiol is extremely unstable and is known to decompose by exposure to light, heat, resin, metal, etc., and its content tends to decrease over time. ing. In order to solve this problem, Patent Document 1 uses an aluminum tube in which 1% by weight or more of ethyl alcohol is blended with a hinokitiol-containing hydrophilic paste-like composition, and a specific resin is coated and baked as a container. Patent Document 2 describes filling a hinokitiol-containing liquid oral composition in a multilayer plastic bottle having an inner layer of carbon black, and Patent Document 3 discloses edetate disodium as a hinokitiol compounding agent. It is described that butylhydroxyanisole and dibutylhydroxytoluene are blended, and Patent Document 4 describes that a water-soluble inorganic salt such as sodium chloride is blended with an oral composition containing hinokitiol. .

  However, the hydrophilic composition conventionally used as an ointment for oral mucosa such as gums was milky white, and when this was applied to gums etc., the application part could be easily identified by a third party, It was not preferable in appearance.

Furthermore, since the composition exhibits a therapeutic effect by adhering to the oral mucosa such as gums, it is desirable that the composition has a certain degree of viscosity from the viewpoint of stickiness and the feeling of use at the time of application. However, the viscosity of the conventional product was not a sufficient level.
JP 2002-3354 A JP 2002-3355 A JP 59-210404 JP-A-4-198121

  In view of the above situation, the present invention is a hinokitiol-containing hydrophilic composition suitable for direct application to the oral mucosa such as gums, from the viewpoint of adhesiveness to the gums and feeling during use. An object of the present invention is to provide a hinokitiol-containing hydrophilic composition that exhibits a transparent appearance so as to be inconspicuous after application to gums or the like while maintaining a sufficient viscosity, and that is also excellent in storage stability of hinokitiol.

  As a result of intensive investigations, the inventors have found that the composition becomes milky white when glycerin, which is the most common polyhydric alcohol blended in a hydrophilic composition, is blended with a hinokitiol-containing composition. It has been found that when a dihydric alcohol is added, the composition becomes transparent and the viscosity of the composition is remarkably increased. Furthermore, by increasing the blending amount of the dihydric alcohol, it was found that the storage stability of hinokitiol was remarkably improved (that is, the amount of hinokitiol decreased with time), and the present invention was completed. It came.

  That is, the present invention is a hydrophilic composition containing hinokitiol, containing 30% by weight or more of divalent alcohols based on the total amount of the composition, and containing no glycerin. The present invention relates to a hydrophilic composition.

  The divalent alcohol is preferably at least one selected from the group consisting of ethylene glycol, propylene glycol, and butylene glycol.

  The hinokitiol-containing hydrophilic composition preferably has a viscosity of 10,000 cp or more measured using a B-type viscometer.

  The content of the hinokitiol is preferably 0.05% by weight or more based on the total amount of the composition.

  The hinokitiol-containing hydrophilic composition is preferably an oral composition.

  The hinokitiol-containing hydrophilic composition of the present invention exhibits a transparent appearance so as to be inconspicuous after application to the oral mucosa such as gums while maintaining a sufficient viscosity, and is excellent in storage stability of hinokitiol. It is what.

  The present invention is described in detail below.

  The hinokitiol-containing composition of the present invention is a hydrophilic composition and contains 30% by weight or more of divalent alcohols with respect to the total amount of the composition, and does not contain glycerin and exhibits a transparent appearance. Is.

  Here, the term “hydrophilic” is intended to distinguish the composition of the present invention from a hydrophobic composition using a hydrophobic base such as oil or fat, and the base of the composition is a divalent alcohol. The thing which consists of a hydrophilic substance containing. In particular, the composition of the present invention is preferably configured as a gel by mixing water with a base other than a dihydric alcohol and further adding a thickener.

  The transparent appearance of the hinokitiol-containing composition of the present invention is intended to distinguish a general ointment or the like from white or milky white, and includes translucent. It is preferable that the appearance is transparent because it is difficult for a third party to recognize the applied portion at a glance after applying the composition of the present invention to the oral mucosa such as gums.

  Hinokitiol is an alcoholic compound having a seven-ring structure, and is the most abundant component of natural tree essential oil in Aomori hiba oil. One of the few natural fungicides with strong antibacterial activity and broad antibacterial spectrum. In the present invention, natural hinokitiol may be used, or chemically synthesized hinokitiol may be used. For convenience, hinokitiol is commercially available from Takasago Chemical Co., Ltd. under the trade name “hinokitiol”, for example.

  The content of hinokitiol in the composition of the present invention is not particularly limited and can be appropriately determined according to its use and desired therapeutic effect, but is usually 0.005 to 1 wt. %. Preferably it is 0.01 weight%-0.5 weight%. If the amount is too small, the sterilizing effect of hinokitiol will not be sufficiently exerted. Conversely, if the amount is too large, a problem may occur in terms of flavor and safety. In general, as the content of hinokitiol in the composition increases, the rate of decrease over time increases, so it is more difficult to prevent the degradation of hinokitiol over time in a composition with a high content of hinokitiol, the active ingredient. Become. However, in the composition of the present invention, even if the content of hinokitiol is high (specifically 0.05% by weight or more, further 0.1% by weight or more based on the total amount of the composition) Also) a sufficient level of storage stability can be achieved.

  The composition of the present invention contains substantially no glycerin and one or more divalent alcohols. This makes the composition transparent so that the appearance after application to the oral mucosa is good, and the viscosity of the composition is higher than when glycerin is used, so the viscosity is suitable for application to the oral mucosa. It is easy to make adjustments, and the therapeutic effect can be enhanced.

  Divalent alcohols are compounds having two alcoholic hydroxyl groups in one molecule, such as ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetra Examples include methylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, and the like. To 6 dihydric alcohols are preferred, and at least one selected from the group consisting of ethylene glycol, propylene glycol, and butylene glycol is particularly preferred.

  The composition of the present invention contains a divalent alcohol in an amount of 30% by weight or more based on the total amount of the composition. Glycerin is known to improve the stability of hinokitiol, and glycerin is frequently included in hinokitiol-containing compositions, but when glycerin is used as a wetting agent, the glycerin content in the composition Although the stability of hinokitiol does not change so much even when the value of the humic acid changes, when the wetting agent is a dihydric alcohol, the stability of the hinokitiol tends to be remarkably improved as the content increases. For this reason, from the viewpoint of the stability of hinokitiol, the content of dihydric alcohol is preferably 40% by weight or more, and more preferably 50% by weight or more.

  When the content in the composition is less than 30% by weight, the stability of hinokitiol is the same regardless of whether it is a dihydric alcohol or glycerin. The stability of hinokitiol is greatly improved, and a high level of stability that cannot be achieved when only glycerin is used can be achieved. However, not only is the effect of increasing the content of dihydric alcohols (for example, improving the residual ratio of hinokitiol in a synthetic resin baked metal container, etc.) difficult to formulate, and the feeling during use is deteriorated. The content of dihydric alcohols is preferably 80% by weight or less, more preferably 70% by weight or less. The content of the dihydric alcohol refers to the total content when two or more dihydric alcohols are blended.

  In order to make the composition transparent, glycerin is not substantially blended in the composition of the present invention. However, if the transparency is maintained, a trace amount (for example, 1% by weight based on the total amount of the composition). Hereinafter, it is possible to mix | blend 0.5 weight% or less or 0.1 weight% or less glycerin. Although it is known that hinokitiol is stabilized when a certain amount of glycerin is blended in the hinokitiol-containing composition, the composition of the present invention uses a dihydric alcohol as a wetting agent, so that hinokitiol is blended without blending glycerin. Sufficient stability can be achieved. In addition, when glycerin is mix | blended, it is considered that the composition becomes milky white because hinokitiol is a compound having a relatively high lipophilicity, and thus has low solubility in glycerin having high hydrophilicity.

  It is also known that hinokitiol is stabilized when a certain amount of lower alcohol (ethyl alcohol, propyl alcohol, butyl alcohol (preferably ethyl alcohol)) is blended with the hinokitiol-containing composition. Although a lower alcohol may be blended with the composition of the present invention, the composition of the present invention can achieve sufficient stability of hinokitiol even when it does not contain ethyl alcohol, for example. it can. For example, since ethyl alcohol induces irritation when applied to gums, when the composition of the present invention is for application to gums or the like, it is preferable not to add lower alcohol, but the stability of hinokitiol is improved. In consideration, the lower alcohol may be blended in an amount of 1% by weight or more, preferably 1 to 50% by weight, more preferably 1 to 30% by weight, and still more preferably 1 to 10% by weight based on the total amount of the composition. . If the irritation due to the lower alcohol is taken into consideration, the blending amount is very small (for example, less than 1% by weight, less than 0.5% by weight, or less than 0.1% by weight based on the total amount of the composition). preferable.

  The composition of the present invention usually contains water as a base together with a dihydric alcohol. The blending amount of water may be appropriately determined according to the blending amount of the dihydric alcohol, but the total amount of the dihydric alcohol and water accounts for about 80 to 95% by weight with respect to the total amount of the composition. It is preferable.

  The viscosity of the composition of the present invention is not particularly limited, but using a B-type viscometer (for example, a B-type viscometer with a helipath stand (DV-II + manufactured by BrookField), a helipath spindle set (type C = 93)). The measured viscosity is preferably 5000 cp or more, more preferably 8000 cp or more, further preferably 10,000 cp or more, particularly preferably 12000 cp or more, and most preferably 15000 cp or more. In this range, the usability when applied to the oral mucosa is improved, and the therapeutic effect derived from hinokitiol can be enhanced by improving the adhesiveness of the composition to the oral mucosa. Moreover, when the kind and compounding quantity of a bihydric alcohol are the same, since there exists a tendency for the stability of hinokitiol to improve, so that the viscosity of a composition becomes high, it is preferable also from this viewpoint. However, not only the effects of increasing the viscosity (for example, the improvement of the remaining ratio of hinokitiol in a synthetic resin-baked metal container) are difficult to appear, but the formulation tends to be difficult and the feeling of use during application tends to deteriorate. Therefore, it is preferable to adjust the viscosity to about 50,000 cp or less. The viscosity of the composition of the present invention can be easily adjusted mainly by appropriately changing the type and blending amount of the thickener to be blended in the composition.

  The thickener is not particularly limited, and examples thereof include carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol ester alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate, ammonium alginate, and the like. Derivatives, xanthan gum, guar gum, gelatin, agar, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, sodium polyacrylate, carboxyvinyl polymer and the like. Of these, only one type may be used, or two or more types may be used. Of these, sodium carboxymethylcellulose and hydroxypropylmethylcellulose are preferred. When sodium carboxymethyl cellulose and hydroxypropyl methyl cellulose are used in combination as a thickener, the 2% viscosity (25 ° C.) of sodium carboxymethyl cellulose is preferably 500 cp or less, more preferably 5 to 300 cp, and more preferably 5 to 200 cp. Is more preferable, 5 to 100 cp is particularly preferable, and 5 to 50 cp is most preferable. The 2% viscosity (25 ° C.) of hydroxypropylmethylcellulose is preferably 1000 to 6000 cp, more preferably 2000 to 5000 cp, and still more preferably 3000 to 5000 cp. If it exists in this range, it can be set as the composition which was excellent especially not only in the viscosity but also in the adhesive strength as a composition with much moisture, for example, oral cavity.

  Further, the amount of the thickener is not particularly limited, and may be appropriately adjusted so that the composition of the present invention has a desired viscosity, but is usually about 0.1 to 10% by weight.

  In addition to the above-described components, the following components can be blended in the composition of the present invention within the range of the usual amount of use, if necessary, depending on the purpose and type.

  <Surfactant> Sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acyl glutamate, N-acyl amino acid salts, 2-alkyl- N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, poly Oxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, etc.

  <Sweeting agent> Saccharin sodium, acesulfame potassium, sorbitol, xylitol, erythritol, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine and the like.

  <Preservative> Parabens such as methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like.

  <Perfume ingredients> l-menthol, anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamic aldehyde, trans-2-hexenal and the like. These components may be blended alone, but may be blended as an essential oil containing these components. In addition to the above fragrance components, fragrance components such as aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes, ketones, and lactones, and essential oils may be blended.

  <Active ingredients other than hinokitiol> Allantoin, panthenol, lysozyme chloride, monofluorophosphate, sodium fluoride, potassium fluoride, sodium monofluorophosphate, polyethylene glycol, polyvinylpyrrolidone, zeolite, ascorbic acid, chlorhexidine salts, cetylpyridinium chloride Benzalkonium chloride, benzethonium chloride, bisabolol, triclosan, isopropylmethylphenol, tocopherol acetate, ε-aminocaproic acid, tranexamic acid, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinate, copper chlorophyllin salt, sodium chloride, guaiazulene sulfonic acid Salt, dextranase, pyridoxine hydrochloride, etc.

<Abrasive>
Precipitated silica, silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, silicic acid Zirconium, synthetic resin abrasive, etc.

  <Others> Pigments such as Blue No. 1, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, tea dry distillation liquid, and flavoring agents such as sodium glutamate.

  The hinokitiol-containing hydrophilic composition of the present invention is preferably used as an oral composition. The composition for oral cavity used herein includes alleviation of various symptoms in gingivitis or alveolar abscess, such as gum bleeding, redness, swelling, itch, pain, itching, mouth stickiness, bad breath, etc. A composition intended for the prevention and treatment of oral diseases such as inflammation, alveolar pyorrhea, dental caries and stomatitis. The dosage form includes toothpaste, liquid dentifrice, liquid dentifrice and other dentifrices and ointments. , Liquids, pasta agents, etc., but can be most suitably used especially as an ointment intended to be applied directly to the oral mucosa such as gums, especially a gel-type ointment with excellent transparency. .

  Although the composition of this invention can be manufactured by mixing and stirring various components, the manufacturing method is not specifically limited.

  The container for filling the composition is not particularly limited, and may be in any form such as a tube or a bottle. The material of the container is not particularly limited, and examples thereof include metals such as aluminum, plastics such as glass, polyethylene terephthalate, polyethylene, and polypropylene. Since degradation of hinokitiol is accelerated by exposure to light, when using translucent glass or plastic, it is preferable to shield the outer surface by covering it with a non-translucent film or the like. Moreover, when using a metal, in order to avoid contact with a hinokitiol and a metal, it is preferable to use what baked the inner surface of the metal coated with various synthetic resins. The synthetic resin is not particularly limited, and examples thereof include polyamideimide resin, polyamide resin, polyimide resin, epoxy / phenol resin, epoxy resin, phenol resin, polyurethane resin, etc., but lower alcohol such as ethyl alcohol in the composition. Is preferably a polyamide resin, a polyimide resin or a polyamideimide resin from the viewpoint of the stability of hinokitiol.

EXAMPLES The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples. Each evaluation and measurement was performed as follows.
(1) Transparency Observe each prepared ointment by visual observation, evaluate that it was judged to be transparent as "○", and evaluate that it was milky white or white that could not be judged as transparent as "X" did.
(2) Viscosity As an instrument for measuring the viscosity, a B-type viscometer with a helipath stand (DV-II + manufactured by BrookField) and a helicopter spindle set (type C = 93) were used. The procedure for measuring the viscosity was as follows.
1) Each prepared ointment 65g is filled so that air may not enter M-70 bottles (manufactured by Koyo Glass Co., Ltd.) and covered. Leave at 25 ° C for 1 hour or longer to deflate naturally.
2) Sink the DV-II + with the helipath spindle type C set so that the spindle comes to the center of the sample (spindle speed is 100 rpm).
3) Rotate the spindle and move the helicopt stand up and down. At this time, the uppermost point of the helipath stand is a range where the spindle does not come out from the sample, and the lowermost point is a height at which the spindle does not contact the lower surface of the M-70 bin (manufactured by Koyo Glass Co., Ltd.). After adjusting the torque% to the maximum, switch to the viscosity display and measure the viscosity.
(3) Remaining amount of hinokitiol Each ointment prepared was filled in each container shown in Tables 2 to 4 so as not to enter air, and then stored for 1 month under conditions of 50 ° C. and 60% RH. . The hinokitiol in each ointment was quantitatively tested by liquid chromatography before and after storage. The residual ratio of hinokitiol was calculated from the following formula for each ointment.
Residual rate (%) = [(hinokitiol content after storage) / (hinokitiol content during preparation of ointment)] / 100
The remaining amounts of hinokitiol shown in Tables 2 to 4 are the relative ratios (%) of the residual ratios of the examples and comparative examples, with the residual ratio obtained in the case of Comparative Example 13 in Table 4 being 100.0%. ). The “average value” in each table is a numerical value calculated by arithmetically averaging the residual amount obtained for each container.
Comparative Examples 1-12
According to the composition (unit: wt%) shown in Table 1, the hinokitiol solution, thickener dispersion and dipotassium glycyrrhizinate solution prepared by the following method were mixed in a vacuum stirrer (model PVQ-5 (3) UN (Mizuho Industry Co., Ltd.). Made by the company))) for a certain period of time to produce a paste-like ointment for the treatment of alveolar pyorrhea intended to be applied directly to the gums with a finger and used for transparency Evaluated. The results are shown in Table 1.
(Hinokitiol solution)
Hinokitiol solution was prepared by dissolving hinokitiol in light-weight oil, fragrance, part of dihydric alcohol and polyoxyethylene sorbitan monooleate.
(Thickener dispersion)
A thickener dispersion in which thickeners (sodium carboxymethylcellulose and hydroxypropylmethylcellulose) were dispersed in the remaining dihydric alcohol was prepared.
(Dipotassium glycyrrhizinate solution)
A dipotassium glycyrrhizinate solution in which dipotassium glycyrrhizinate and glycerin were dissolved in purified water was prepared.

湿潤剤が２価アルコールとグリセリンの混合物である比較例１〜９、及び湿潤剤がグリセリンのみである比較例１０〜１２のいずれにおいても、軟膏剤は乳白色又は白色を呈しており、透明な軟膏剤を得ることはできなかった。
実施例１〜２１及び比較例１３〜２４
同様に、歯茎への直接塗布による使用を目的としたペースト状の歯槽膿漏治療用軟膏剤を、表２〜４に示す組成（単位：重量％）に従い、比較例１と同様に調製し、その透明性、粘度、及びヒノキチオール残存量を評価、測定した。結果を表２〜４に示す。

In any of Comparative Examples 1 to 9 in which the wetting agent is a mixture of dihydric alcohol and glycerin and Comparative Examples 10 to 12 in which the wetting agent is only glycerin, the ointment is milky white or white and is transparent ointment The agent could not be obtained.
Examples 1-21 and Comparative Examples 13-24
Similarly, a paste-like alveolus treatment ointment intended for use by direct application to the gums was prepared in the same manner as in Comparative Example 1 according to the composition shown in Tables 2 to 4 (unit:% by weight). The transparency, viscosity, and residual amount of hinokitiol were evaluated and measured. The results are shown in Tables 2-4.

湿潤剤として２価アルコールを使用しグリセリンを含有しない場合には、透明な軟膏剤を得ることができた。

When dihydric alcohol was used as the wetting agent and no glycerin was contained, a transparent ointment could be obtained.

  Examples 1-21 containing 30% by weight or more of dihydric alcohol and not containing glycerin are Comparative Examples 14-22, in which the content of dihydric alcohol is 20% by weight or less, and Comparative Examples 13, 23 using glycerin. It can be seen that the remaining amount of hinokitiol is much larger than those of No. 24 and No. 24, and that the storage stability of hinokitiol is much superior.

  In Comparative Examples 13, 23 and 24 in which glycerin was blended, the remaining amount of hinokitiol did not change much even when the glycerin content was increased, and the stability of hinokitiol was significantly improved by increasing the blending amount (for example, Example 1). 4 and 7 and Comparative Examples 14 and 17) are characteristic of dihydric alcohols.

  From comparison between Comparative Examples 20 to 22 and Comparative Example 23, when the blending amount is about 20% by weight, the stability of hinokitiol in the case of dihydric alcohol is almost the same as that in the case of glycerin (rather than glycerin). Is better). However, when the blending amount is 30% by weight or more, the dihydric alcohol significantly improves the stability of hinokitiol, and can achieve a high level of hinokitiol stability that cannot be achieved when glycerin is used.

  In addition, for example, when the types and blending amounts of the dihydric alcohol are the same from the comparison between Examples 7 to 9 and Examples 17 to 19 or the comparison between Examples 8 and 13 to 16, the viscosity of the ointment It turns out that there exists a tendency for the stability of hinokitiol to increase, so that becomes high.

  However, for example, when Examples 17 to 19 and Comparative Examples 14 to 16 are compared, the viscosity of Examples 17 to 19 is half that of Comparative Examples 14 to 16 because the amount of the thickener is small. In spite of the following, the hinokitiol stability is better in Examples 17-19. This is considered to be because the dihydric alcohol content is higher in Examples 17-19. From this, it is understood that not only the viscosity of the ointment is high but also that 30% by weight or more of dihydric alcohol is contained in the stability of hinokitiol. Comparative Examples 13, 23 and 24 show that the viscosity of the ointment is very low when the wetting agent is glycerin.

  Further, for example, in the case of the formulation prepared in the same manner as in Example 8 except that 10.0% by weight of ethyl alcohol was further added, the relative ratio (average) of the remaining ratio of hinokitiol was 123.9%, and the dihydric alcohol The results are almost the same as the case of containing only dihydric alcohol, and it was found that if dihydric alcohol was added, good hinokitiol stability could be achieved even in combination with lower alcohols such as ethyl alcohol. . Further, in the case of the formulation prepared in the same manner as in Example 8 except that the content of propylene glycol was 25% by weight and further 25% by weight of butylene glycol (in combination with dihydric alcohol), the relative ratio of hinokitiol residual ratio ( The average) was 122.5%, which was the same result as when dihydric alcohol was used alone.

Formulation Examples 1 to 65
Various compositions were prepared by conventional methods according to the formulations described in Tables 5-12.

表１０中の粘着強さは以下に従って測定した。
＊１） ＪＩＳ Ｔ ６５２５−１「義歯床安定用こ（糊）材−第１部：粘着型義歯床安定用こ（糊）材」に記載の「６．５粘着強さ試験Ｉ」の測定方法に従って測定した。
＊２） ＪＩＳ Ｔ ６５２５−１「義歯床安定用こ（糊）材−第１部：粘着型義歯床安定用こ（糊）材」に記載の「６．５粘着強さ試験ＩＩ」の測定方法に従って測定した。

The adhesive strength in Table 10 was measured according to the following.
* 1) Measurement of “6.5 Adhesive Strength Test I” described in JIS T 6525-1, “Dentition Base Stabilizer (Glue) Material—Part 1: Adhesive Denture Base Stabilizer Material (Glue)” Measured according to the method.
* 2) Measurement of “6.5 Adhesive Strength Test II” described in JIS T 6525-1, “Dentition Base Stabilizer (Glue)-Part 1: Adhesive Denture Base Stabilizer (Glue)” Measured according to the method.

Claims (5)

A hydrophilic composition containing hinokitiol,
A hinokitiol-containing hydrophilic composition comprising 30% by weight or more of a divalent alcohol based on the total amount of the composition and containing no glycerin.   The hinokitiol-containing hydrophilic composition according to claim 1, wherein the divalent alcohol is at least one selected from the group consisting of ethylene glycol, propylene glycol, and butylene glycol.   The hinokitiol-containing hydrophilic composition according to claim 1 or 2, wherein the viscosity measured using a B-type viscometer is 10,000 cp or more.   The hinokitiol-containing hydrophilic composition according to claim 1, wherein the hinokitiol content is 0.05% by weight or more based on the total amount of the composition.   It is a composition for oral cavity, The hinokitiol containing hydrophilic composition in any one of Claims 1-4 characterized by the above-mentioned.