JP2019069929A - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP2019069929A JP2019069929A JP2017198057A JP2017198057A JP2019069929A JP 2019069929 A JP2019069929 A JP 2019069929A JP 2017198057 A JP2017198057 A JP 2017198057A JP 2017198057 A JP2017198057 A JP 2017198057A JP 2019069929 A JP2019069929 A JP 2019069929A
- Authority
- JP
- Japan
- Prior art keywords
- component
- silica
- composition
- weight
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 88
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 182
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 91
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 76
- 125000002525 phosphocholine group Chemical group OP(=O)(OCC[N+](C)(C)C)O* 0.000 claims abstract description 46
- 238000010521 absorption reaction Methods 0.000 claims abstract description 44
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims abstract description 39
- 229960000401 tranexamic acid Drugs 0.000 claims abstract description 37
- 229920000642 polymer Polymers 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 13
- 210000000214 mouth Anatomy 0.000 claims description 47
- 229920001577 copolymer Polymers 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 16
- 230000008719 thickening Effects 0.000 claims description 15
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical group CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 claims description 12
- SOGAXMICEFXMKE-UHFFFAOYSA-N alpha-Methyl-n-butyl acrylate Natural products CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 3
- 238000009472 formulation Methods 0.000 abstract description 12
- -1 tranexamic acid ester Chemical class 0.000 description 32
- 239000000178 monomer Substances 0.000 description 24
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 19
- 239000006185 dispersion Substances 0.000 description 14
- 230000009471 action Effects 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 12
- 239000007788 liquid Substances 0.000 description 11
- 239000002253 acid Substances 0.000 description 10
- 239000000606 toothpaste Substances 0.000 description 10
- 150000007513 acids Chemical class 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 235000010443 alginic acid Nutrition 0.000 description 7
- 229920000615 alginic acid Polymers 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 229940083542 sodium Drugs 0.000 description 7
- 229940034610 toothpaste Drugs 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000551 dentifrice Substances 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- 229940072056 alginate Drugs 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 230000003266 anti-allergic effect Effects 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 239000004386 Erythritol Substances 0.000 description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 3
- 102000000340 Glucosyltransferases Human genes 0.000 description 3
- 108010055629 Glucosyltransferases Proteins 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000000783 alginic acid Substances 0.000 description 3
- 229960001126 alginic acid Drugs 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 3
- 235000019414 erythritol Nutrition 0.000 description 3
- 229940009714 erythritol Drugs 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 235000010449 maltitol Nutrition 0.000 description 3
- 239000000845 maltitol Substances 0.000 description 3
- 229940035436 maltitol Drugs 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- YHHSONZFOIEMCP-UHFFFAOYSA-N 2-(trimethylazaniumyl)ethyl hydrogen phosphate Chemical compound C[N+](C)(C)CCOP(O)([O-])=O YHHSONZFOIEMCP-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004373 Pullulan Substances 0.000 description 2
- 229920001218 Pullulan Polymers 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000002272 anti-calculus Effects 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000000739 antihistaminic agent Substances 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 239000002781 deodorant agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229950004354 phosphorylcholine Drugs 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 235000019423 pullulan Nutrition 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 229960004029 silicic acid Drugs 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- CAKDFKUXFMLCAR-UIOGXPPZSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@]1(C)CC[C@](C[C@H]14)(C)C(=O)OC)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O CAKDFKUXFMLCAR-UIOGXPPZSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- TXASKRGBMHFMPT-UHFFFAOYSA-O 1-methoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium-2-ol Chemical compound C1=[N+](C)C2=C3C=C4OCOC4=CC3=CC=C2C2=C1C(OC)=C(O)C=C2 TXASKRGBMHFMPT-UHFFFAOYSA-O 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- SVIJYLPSHPPVQF-UHFFFAOYSA-N 2-[2,2-diaminoethyl(dodecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCN(CC(N)N)CC(O)=O SVIJYLPSHPPVQF-UHFFFAOYSA-N 0.000 description 1
- GMGBBMQOXFAWRS-UHFFFAOYSA-N 2-[2,2-diaminoethyl(tetradecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCN(CC(N)N)CC(O)=O GMGBBMQOXFAWRS-UHFFFAOYSA-N 0.000 description 1
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- XHPXSMWMAJGYBS-UHFFFAOYSA-N 4-[[(4-carboxycyclohexyl)methylamino]methyl]cyclohexane-1-carboxylic acid Chemical compound C1CC(C(=O)O)CCC1CNCC1CCC(C(O)=O)CC1 XHPXSMWMAJGYBS-UHFFFAOYSA-N 0.000 description 1
- JLLYLQLDYORLBB-UHFFFAOYSA-N 5-bromo-n-methylthiophene-2-sulfonamide Chemical compound CNS(=O)(=O)C1=CC=C(Br)S1 JLLYLQLDYORLBB-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- QSAZFJIPYFLRJS-UHFFFAOYSA-N C(C(=C)C)(=O)OCCP(=O)=C(O)CN Chemical compound C(C(=C)C)(=O)OCCP(=O)=C(O)CN QSAZFJIPYFLRJS-UHFFFAOYSA-N 0.000 description 1
- UYNKVBYVIGUBMK-UHFFFAOYSA-N CC.OOP(=O)OP(O)=O Chemical compound CC.OOP(=O)OP(O)=O UYNKVBYVIGUBMK-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- HQABUPZFAYXKJW-UHFFFAOYSA-N N-butylamine Natural products CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 229930182559 Natural dye Natural products 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- MHOXVFDPKKJOQH-UHFFFAOYSA-N OC(C[N+](C)(C)C)COC(C(=C)C)=O.C(=O)(C(=C)C)[Na] Chemical compound OC(C[N+](C)(C)C)COC(C(=C)C)=O.C(=O)(C(=C)C)[Na] MHOXVFDPKKJOQH-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000005205 Pinus Nutrition 0.000 description 1
- 241000218602 Pinus <genus> Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- KCLANYCVBBTKTO-UHFFFAOYSA-N Proparacaine Chemical compound CCCOC1=CC=C(C(=O)OCCN(CC)CC)C=C1N KCLANYCVBBTKTO-UHFFFAOYSA-N 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 241000533293 Sesbania emerus Species 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Natural products NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- RUYKUXOULSOEPZ-UHFFFAOYSA-N [2-hydroxy-3-(2-methylprop-2-enoyloxy)propyl]-trimethylazanium Chemical compound CC(=C)C(=O)OCC(O)C[N+](C)(C)C RUYKUXOULSOEPZ-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940024545 aluminum hydroxide Drugs 0.000 description 1
- 229940024548 aluminum oxide Drugs 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 235000010407 ammonium alginate Nutrition 0.000 description 1
- 239000000728 ammonium alginate Substances 0.000 description 1
- KPGABFJTMYCRHJ-YZOKENDUSA-N ammonium alginate Chemical compound [NH4+].[NH4+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O KPGABFJTMYCRHJ-YZOKENDUSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229940069765 bean extract Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 150000001559 benzoic acids Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 235000017663 capsaicin Nutrition 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229940045110 chitosan Drugs 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
- 229960002023 chloroprocaine Drugs 0.000 description 1
- 229940006423 chondroitin sulfate sodium Drugs 0.000 description 1
- 229960001747 cinchocaine Drugs 0.000 description 1
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- RMVRNAXXHCXCLR-UHFFFAOYSA-N ethenyl 2-methylprop-2-enoate;2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical compound CC(=C)C(=O)OC=C.OCC[N+](C)(C)C#P=O RMVRNAXXHCXCLR-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 239000010643 fennel seed oil Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000001055 magnesium Nutrition 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- JACMPVXHEARCBO-UHFFFAOYSA-N n-pentylpentan-1-amine Chemical compound CCCCCNCCCCC JACMPVXHEARCBO-UHFFFAOYSA-N 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- 229940042125 oral ointment Drugs 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 229940116257 pepper extract Drugs 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical group C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000010408 potassium alginate Nutrition 0.000 description 1
- 239000000737 potassium alginate Substances 0.000 description 1
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 229960003981 proparacaine Drugs 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000000395 remineralizing effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 150000003870 salicylic acids Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940079841 sodium copper chlorophyllin Drugs 0.000 description 1
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical compound [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229960003339 sodium phosphate Drugs 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 150000003398 sorbic acids Chemical class 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、トラネキサム酸、その誘導体及びそれらの塩(以下、「トラネキサム酸類」と表記することもある)と、ホスホコリン基含有重合体と、所定の総吸水値となるように配合されたシリカと、水とを含み、分散性が向上した口腔用組成物に関する。 In the present invention, tranexamic acid, derivatives thereof and salts thereof (hereinafter sometimes referred to as "tranexamic acids"), phosphocholine group-containing polymer, and silica compounded to have a predetermined total water absorption value And an aqueous composition containing water, and having improved dispersibility.
2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体等のホスホコリン基含有重合体は、生体への親和性が高く、更に保湿性、口腔内への微生物の付着防止、歯肉炎の予防等の作用も報告されており、口腔用組成物において利用されている(例えば、特許文献1〜3参照)。 Phosphocholine group-containing polymers such as 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer have high affinity to living bodies, and further have effects such as moisture retention, prevention of adhesion of microorganisms to the oral cavity, prevention of gingivitis, etc. Have also been reported and used in oral compositions (see, for example, Patent Documents 1 to 3).
トラネキサム酸は、抗プラスミン作用による抗出血作用、抗アレルギー作用、抗炎症作用等を有することが知られており、例えば歯周病予防剤等として口腔用組成物において利用されている(例えば、特許文献4参照)。 Tranexamic acid is known to have anti-bleeding action, anti-allergic action, anti-inflammatory action and the like by anti-plasmin action, and is used, for example, in oral compositions as an agent for preventing periodontal disease (eg, patent Reference 4).
また、シリカは増粘作用や研磨作用があり、ホスホコリン基含有重合体及びトラネキサム酸類と同様に口腔用組成物に使用されている。しかしながら、従来、シリカと水とを含む口腔用組成物における製剤安定性についての検討は十分ではない。 In addition, silica has a thickening action and a polishing action, and is used in a composition for oral cavity like the phosphocholine group-containing polymer and tranexamic acid. However, studies on formulation stability in oral compositions containing silica and water are not sufficient.
本発明者は、トラネキサム酸類とシリカと水とを含む口腔用組成物の製剤安定性について検討を行ったところ、口腔用組成物に含まれるシリカの吸水量とその配合量の兼ね合いによっては分散性不良が生じ、口腔用組成物の製剤安定性が低下するという新たな課題に直面した。即ち、トラネキサム酸類とシリカと水とを含む口腔用組成物には、シリカの吸水量(mL/g)と含有量(重量%)との積(以下において、総吸水値と記載する場合がある)が所定範囲内で配合される場合に分散性不良の問題という特有の課題が存在することが明らかとなった。 The present inventor examined the formulation stability of an oral composition containing tranexamic acid, silica and water, and the dispersibility was determined depending on the balance between the water absorption of the silica contained in the oral composition and the amount thereof. Failures have occurred, and new challenges have been encountered: the formulation stability of the oral composition is reduced. That is, in the composition for oral cavity containing tranexamic acid, silica and water, the product of the water absorption (mL / g) and the content (% by weight) of silica (hereinafter referred to as total water absorption) may be described. It has become clear that there is a specific problem of the problem of poor dispersibility when the formulation is blended within the predetermined range.
そこで、本発明の目的は、トラネキサム酸類と、所定の総吸水値となるように配合されたシリカと、水とを含む口腔用組成物において、分散性を向上できる製剤化技術を提供することである。 Therefore, an object of the present invention is to provide a formulation technique capable of improving the dispersibility in an oral composition containing tranexamic acid, silica compounded to have a predetermined total water absorption value, and water. is there.
本発明者は、前記課題を解決すべく鋭意検討を行ったところ、口腔用組成物において、トラネキサム酸類、所定の総吸水値で配合されたシリカ及び水と共に、ホスホコリン基含有重合体を含有する口腔用組成物は、分散性が向上することを見出した。本発明は、かかる知見に基づいて更に検討を重ねることにより完成したものである。 The inventors of the present invention conducted intensive studies to solve the above problems. According to the oral composition, an oral cavity containing a phosphocholine group-containing polymer together with tranexamic acids, silica and water blended at a predetermined total water absorption value. The composition for compositions found that the dispersibility improved. The present invention has been completed by further studies based on such findings.
即ち、本発明は、下記に掲げる態様の発明を提供する。
項1. (A)トラネキサム酸、その誘導体及びそれらの塩よりなる群から選択される少なくとも1種と、(B)ホスホコリン基含有重合体と、(C)シリカと、(D)水と、を含有し、
前記(C)成分の吸水量(mL/g)と含有量(重量%)との積が7.4〜48である、口腔用組成物。
項2. 前記(B)成分が、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体である、項1に記載の口腔用組成物。
項3. 前記(C)成分の総量100重量部当たり、前記(B)成分が総量で0.1〜40重量部含まれる、項1又は2に記載の口腔用組成物。
項4. 前記(C)成分が増粘性シリカを含み、前記増粘性シリカの含有量が2.5重量%以上である、項1〜3のいずれかに記載の口腔用組成物。
項5. 前記(C)成分が研磨性シリカを含み、前記研磨性シリカの含有量が5.5重量%以上である、項1〜3のいずれかに記載の口腔用組成物。
項6. (A)トラネキサム酸、その誘導体及びそれらの塩よりなる群から選択される少なくとも1種と、(C)シリカと、(D)水とを含み、前記(C)成分の吸水量(mL/g)と含有量(重量%)との積が7.4〜48である口腔用組成物における前記(C)成分の分散性を向上させるために使用される分散性向上剤であって、
(B)ホスホコリン基含有重合体を有効成分とする、分散性向上剤。
項7. (A)トラネキサム酸、その誘導体及びそれらの塩よりなる群から選択される少なくとも1種と、(C)シリカと、(D)水とを含み、前記(C)成分の吸水量(mL/g)と含有量(重量%)との積が7.4〜48である口腔用組成物において前記(C)成分の分散性を向上する分散性向上方法であって、
口腔用組成物に、前記(A)成分と前記(C)成分と前記(D)成分と共に、(B)ホスホコリン基含有重合体を配合する、分散性向上方法。
That is, the present invention provides the invention of the aspects listed below.
Item 1. (A) at least one member selected from the group consisting of tranexamic acid, derivatives thereof and salts thereof, (B) a phosphocholine group-containing polymer, (C) silica, and (D) water,
The composition for oral cavity whose product of the water absorption amount (mL / g) of said (C) component and content (weight%) is 7.4-48.
Item 2. The composition for oral cavity of claim 1, wherein the component (B) is a 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer.
Item 3. The composition for oral cavity of claim 1 or 2, wherein the component (B) is contained in a total amount of 0.1 to 40 parts by weight per 100 parts by weight of the total of the component (C).
Item 4. The oral composition according to any one of Items 1 to 3, wherein the component (C) contains a thickening silica, and the content of the thickening silica is 2.5% by weight or more.
Item 5. The oral composition according to any one of Items 1 to 3, wherein the component (C) contains abrasive silica, and the content of the abrasive silica is 5.5% by weight or more.
Item 6. (A) at least one member selected from the group consisting of tranexamic acid, derivatives thereof and salts thereof, (C) silica, and (D) water, wherein the water absorption (mL / g) of the component (C) A dispersibility improver used to improve the dispersibility of the component (C) in an oral composition having a product of 7.4 to 48 as the product of the content (% by weight),
(B) A dispersibility improver comprising a phosphocholine group-containing polymer as an active ingredient.
Item 7. (A) at least one member selected from the group consisting of tranexamic acid, derivatives thereof and salts thereof, (C) silica, and (D) water, wherein the water absorption (mL / g) of the component (C) And a method for improving dispersibility of the component (C) in an oral composition having a product of 7.4 to 48 as the product of the content (% by weight),
The dispersibility improvement method which mix | blends the (B) phosphocholine group containing polymer with the said composition for oral cavity with the said (A) component, the said (C) component, and the said (D) component.
本発明の口腔用組成物によれば、トラネキサム酸類と所定の総吸水値となるように配合されたシリカと水とを含んでいながらも、シリカの分散性不良を抑制でき、優れた製剤安定性を有しているので、保存中に良好な外観を維持可能で、使用感に優れた製剤を提供することができる。 According to the composition for oral cavity of the present invention, poor dispersion of silica can be suppressed while containing tranexamic acid, silica and water formulated to have a predetermined total water absorption value, and excellent formulation stability Since it has a property, it is possible to maintain a good appearance during storage and provide a preparation with an excellent feeling in use.
1.口腔用組成物
本発明の口腔用組成物は、トラネキサム酸類、つまりトラネキサム酸、その誘導体及びそれらの塩よりなる群から選択される少なくとも1種(以下、(A)成分と表記することがある)と、ホスホコリン基含有重合体(以下、(B)成分と表記することがある)と、(C)シリカ(以下、(C)成分と表記することがある)と、水(以下、(D)成分と表記することがある)とを含有することを特徴とする。以下、本発明の口腔用組成物について詳述する。
1. Oral Composition The oral composition of the present invention is at least one selected from the group consisting of tranexamic acids, that is, tranexamic acid, derivatives thereof and salts thereof (hereinafter sometimes referred to as component (A)). A phosphocholine group-containing polymer (hereinafter sometimes referred to as component (B)), (C) silica (hereinafter sometimes referred to as component (C)), water (hereinafter referred to as (D) And the like, which are sometimes referred to as components). Hereinafter, the composition for oral cavity of this invention is explained in full detail.
(A)トラネキサム酸類
本発明の口腔用組成物は、(A)成分として、トラネキサム酸、その誘導体及び/又はそれらの塩を含有する。
(A) Tranexamic Acid The oral composition of the present invention contains tranexamic acid, a derivative thereof and / or a salt thereof as a component (A).
トラネキサム酸は、トランス−4−(アミノメチル)シクロヘキサンカルボン酸とも称される化合物であり、抗プラスミン作用による抗出血作用、抗アレルギー作用、抗炎症作用等を有することが知られている公知の薬剤である。 Tranexamic acid is a compound also referred to as trans-4- (aminomethyl) cyclohexanecarboxylic acid, and is a known drug known to have antibleeding action, antiallergic action, antiinflammatory action and the like by antiplasmin action. It is.
トラネキサム酸の誘導体としては、薬学的又は香粧学的に許容できることを限度として特に制限されないが、具体的には、トラネキサム酸二量体、トラネキサム酸エステル、トラネキサム酸ビタミンエステル、トラネキサム酸アルキルアミド、トラネキサム酸フェニルエステル、及びN,N−マレオイルミノトラネキサム酸などが挙げられる。トラネキサム酸エステルの具体例としては、炭素原子数1〜30のアルキルエステル;炭素原子数1〜30のアルキル基、ハロゲン原子、カルボキシル基などが置換していてもよいフェニルエステル等が挙げられる。トラネキサム酸アルキルアミドの具体例としては、トラネキサム酸メチルアミド、トラネキサム酸エチルアミドなどが挙げられる。これらのトラネキサム酸の誘導体は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 The derivative of tranexamic acid is not particularly limited as long as it is pharmaceutically or cosmetically acceptable. Specifically, tranexamic acid dimer, tranexamic acid ester, tranexamic acid vitamin ester, tranexamic acid alkylamide, Tranexamic acid phenyl ester, N, N-maleoyl minotranexamic acid and the like can be mentioned. Specific examples of tranexamic acid esters include alkyl esters having 1 to 30 carbon atoms; and phenyl esters that may be substituted with an alkyl group having 1 to 30 carbon atoms, a halogen atom, a carboxyl group, and the like. Specific examples of tranexamic acid alkylamides include tranexamic acid methylamide, tranexamic acid ethylamide and the like. These derivatives of tranexamic acid may be used alone or in combination of two or more.
トラネキサム酸及び/又はその誘導体の塩としては、薬学的又は香粧学的に許容されるものである限り特に制限されないが、具体的には、塩酸塩、硝酸塩、硫酸塩などの無機酸塩;酢酸塩、乳酸塩、マレイン酸塩、フマル酸塩、酒石酸塩、クエン酸塩、メタンスルホン酸塩などの有機酸塩;モノエタノールアミン塩、ジエタノールアミン塩、トリエタノールアミン塩、などの有機アミン塩;アンモニウム塩;ナトリウム塩、カリウム塩などのアルカリ金属塩;マグネシウム塩などのアルカリ土類金属塩などが挙げられる。これらの塩は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。 The salt of tranexamic acid and / or its derivative is not particularly limited as long as it is pharmaceutically or cosmetically acceptable, and specifically, inorganic acid salts such as hydrochloride, nitrate, sulfate and the like; Organic acid salts such as acetates, lactates, maleates, fumarates, tartrates, citrates and methanesulfonates; organic amines such as monoethanolamine salts, diethanolamine salts and triethanolamine salts; Ammonium salts; alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as magnesium salts and the like. These salts may be used singly or in combination of two or more.
本発明の口腔用組成物において、(A)成分として、トラネキサム酸、トラネキサム酸の塩、トラネキサム酸の誘導体、トラネキサム酸の誘導体の塩の中から、1種を選択して使用してもよく、2種以上を組み合わせて使用してもよい。 In the composition for oral cavity of the present invention, one of tranexamic acid, a salt of tranexamic acid, a derivative of tranexamic acid and a salt of a derivative of tranexamic acid may be selected and used as the component (A), Two or more may be used in combination.
これらの(A)成分の中でも、抗出血作用、抗アレルギー作用、抗炎症作用等の点から、好ましくはトラネキサム酸またはその塩が挙げられ、より好ましくはトラネキサム酸が挙げられる。 Among these (A) components, tranexamic acid or a salt thereof is preferably mentioned from the viewpoint of antibleeding action, antiallergic action, antiinflammatory action and the like, and more preferably tranexamic acid.
本発明の口腔用組成物において、(A)成分の含有量については、当該口腔用組成物に備えさせるべき薬効、当該口腔用組成物の製剤形態等に応じて適宜設定すればよいが、例えば、0.001〜0.5重量%、好ましくは0.005〜0.1重量%、より好ましくは0.01〜0.1重量%、更に好ましくは0.05〜0.1重量%が挙げられる。 In the composition for oral cavity of the present invention, the content of the component (A) may be appropriately set according to the medicinal effect to be prepared for the composition for oral cavity, the formulation form of the composition for oral cavity, etc. 0.001 to 0.5% by weight, preferably 0.005 to 0.1% by weight, more preferably 0.01 to 0.1% by weight, still more preferably 0.05 to 0.1% by weight. Be
(B)ホスホコリン基含有重合体
本発明の口腔用組成物は、(B)成分として、ホスホコリン基含有重合体を含有する。ホスホコリン基含有重合体は、(A)成分及び後述する所定の総吸水値で含まれる(C)成分と共存させることによって、シリカの分散性を向上させることができる。
(B) Phosphocholine Group-Containing Polymer The composition for oral cavity of the present invention contains a phosphocholine group-containing polymer as the component (B). The phosphocholine group-containing polymer can improve the dispersibility of silica by making it coexist with the component (A) and the component (C) contained at a predetermined total water absorption value described later.
ホスホコリン基含有重合体とは、ホスホコリン基を含む単量体(以下、「ホスホコリン基含有単量体」と表記することがある)が重合したポリマーであり、保湿作用等を有する公知の成分である。 The phosphocholine group-containing polymer is a polymer obtained by polymerizing a monomer containing a phosphocholine group (hereinafter sometimes referred to as "phosphocholine group-containing monomer"), and is a known component having a moisturizing effect and the like. .
ホスホコリン基含有重合体において、ホスホコリン基含有単量体の種類については、特に制限されないが、例えば、ホスホコリン基とビニル基を有する単量体が挙げられる。ホスホコリン基含有単量体として、より具体的には、2−メタクリロイルオキシエチルホスホリルコリン、2−メタクリロイルオキシエチルホスホリルエタノールアミン等が挙げられる。ホスホコリン基含有重合体において、ホスホコリン基含有単量体は1種単独で含まれていてもよく、また2種以上組み合わされて含まれていてもよい。これらのホスホコリン基含有単量体の中でも、シリカの分散性の向上効果をより一層向上させるという観点から、好ましくは2−メタクリロイルオキシエチルホスホリルコリンが挙げられる。 In the phosphocholine group-containing polymer, the type of the phosphocholine group-containing monomer is not particularly limited, and examples thereof include monomers having a phosphocholine group and a vinyl group. More specifically, examples of the phosphocholine group-containing monomer include 2-methacryloyloxyethyl phosphoryl choline and 2-methacryloyloxyethyl phosphoryl ethanolamine. In the phosphocholine group-containing polymer, the phosphocholine group-containing monomer may be contained singly or in combination of two or more. Among these phosphocholine group-containing monomers, 2-methacryloyloxyethyl phosphorylcholine is preferably mentioned from the viewpoint of further improving the dispersibility improvement effect of silica.
本発明で使用されるホスホコリン基含有重合体は、1種のホスホコリン基含有単量体からなる単重合体であってもよく、また2種以上の単量体からなる共重合体であってもよい。 The phosphocholine group-containing polymer used in the present invention may be a homopolymer consisting of one kind of phosphocholine group-containing monomer, or a copolymer consisting of two or more kinds of monomers. Good.
ホスホコリン基含有重合体が共重合体である場合、2種以上のホスホコリン基含有単量体からなる共重合体であってもよく、また少なくとも1種のホスホコリン基含有単量体と少なくとも1種のホスホコリン基含有単量体以外の単量体からなる共重合体であってもよい。 When the phosphocholine group-containing polymer is a copolymer, it may be a copolymer composed of two or more types of phosphocholine group-containing monomers, and at least one type of a phosphocholine group-containing monomer and at least one type of monomer. The copolymer which consists of monomers other than a phosphocholine group containing monomer may be sufficient.
ホスホコリン基含有重合体に含まれるホスホコリン基含有単量体以外の単量体の種類については、薬学的に許容されるものであってホスホコリン基含有単量とラジカル重合可能であることを限度として特に制限されないが、例えば、ビニル基を有する単量体が挙げられる。ホスホコリン基含有単量体以外の単量体として、具体的には、メチル(メタ)アクリレート、エチル(メタ)アクリレート、ブチル(メタ)アクリレート、ラウリル(メタ)アクリレート、ステアリル(メタ)アクリレート、2−エチルヘキシル(メタ)アクリレート等のアルキル(メタ)アクリレート;ベンジル(メタ)アクリレート、フェノキシエチル(メタ)アクリレート、シクロヘキシル(メタ)アクリレート、ポリプロピレングリコールモノ(メタ)アクリレート、ポリテトラメチレングリコールモノ(メタ)アクリレート、ポリプロピレングリコールジ(メタ)アクリレート、ポリテトラメチレングリコールモノ(メタ)アクリレート、ポリプロピレングリコールポリエチレングリコールモノ(メタ)アクリレート、メタクリル酸ナトリウム、2−ヒドロキシ−3−メタクリロイルオキシプロピルトリメチルアンモニウム等が挙げられる。ホスホコリン基含有重合体において、ホスホコリン基含有単量体以外の単量体は1種単独で含まれていてもよく、また2種以上組み合わされて含まれていてもよい。これらのホスホコリン基含有単量体以外の単量体の中でも、保湿作用を有効に発揮させつつシリカの分散性の向上効果をより一層向上させるという観点から、好ましくはアルキル(メタ)アクリレート、2−ヒドロキシ−3−メタクリロイルオキシプロピルトリメチルアンモニウム、更に好ましくはアルキル基の炭素数が1〜18のアルキル(メタ)アクリレート、より好ましくはアルキル基の炭素数が3〜5のアルキル(メタ)アクリレート、特に好ましくはブチル(メタ)アクリレートが挙げられる。なお、本明細書において、「(メタ)アクリレート」とは、メタクリレート及び/又はアクリレートを示す。 The types of monomers other than the phosphocholine group-containing monomer contained in the phosphocholine group-containing polymer are pharmaceutically acceptable and particularly limited as far as they are radically polymerizable with a single amount of phosphocholine group-containing monomer. Although it does not restrict | limit, the monomer which has a vinyl group is mentioned, for example. As monomers other than the phosphocholine group-containing monomer, specifically, methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) acrylate, 2- Alkyl (meth) acrylates such as ethyl hexyl (meth) acrylate; benzyl (meth) acrylate, phenoxyethyl (meth) acrylate, cyclohexyl (meth) acrylate, polypropylene glycol mono (meth) acrylate, polytetramethylene glycol mono (meth) acrylate, Polypropylene glycol di (meth) acrylate, polytetramethylene glycol mono (meth) acrylate, polypropylene glycol polyethylene glycol mono (meth) acrylate, methacryl Sodium 2-hydroxy-3-methacryloyloxy propyl trimethyl ammonium, and the like. In the phosphocholine group-containing polymer, monomers other than the phosphocholine group-containing monomer may be contained singly or in combination of two or more. Among the monomers other than these phosphocholine group-containing monomers, from the viewpoint of further improving the dispersibility improvement effect of silica while exhibiting the moisturizing action effectively, alkyl (meth) acrylates, 2- Hydroxy-3-methacryloyloxypropyltrimethylammonium, more preferably alkyl (meth) acrylate having 1 to 18 carbon atoms, more preferably alkyl (meth) acrylate having 3 to 5 carbon atoms, particularly preferably And butyl (meth) acrylate. In the present specification, "(meth) acrylate" indicates methacrylate and / or acrylate.
本発明で使用されるホスホコリン基含有重合体として、具体的には、ポリメタクリロイルオキシエチルホスホリルコリン単重合体、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体(ポリクオタニウム−51)、2−メタクリロイルオキシエチレンホスホリルコリン・メタクリル酸ブチル・メタクリル酸ナトリウム共重合体(ポリクオタニウム−65)、2−メタクリロイルオキシエチルホスホリルコリン・2−ヒドロキシ−3−メタクリロイルオキシプロピルトリメチルアンモニウム共重合体(ポリクオタニウム−64)、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ステアリル共重合体(ポリクオタニウム−61)等が挙げられる。なお、ホスホコリン基含有重合体に関する前記表記において、括弧内の名称は化粧品成分表示名称を示す。 Specific examples of the phosphocholine group-containing polymer used in the present invention include polymethacryloyloxyethyl phosphorylcholine homopolymer, 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer (polyquaternium-51), 2-methacryloyloxy Ethylene phosphorylcholine / butyl methacrylate / sodium methacrylate copolymer (polyquaternium-65), 2-methacryloyloxyethyl phosphorylcholine, 2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer (polyquaternium-64), 2-methacryloyloxy Ethyl phosphoryl choline / stearyl methacrylate copolymer (polyquaternium-61) etc. are mentioned. In addition, in the said description regarding a phosphocholine group containing polymer, the name in parenthesis shows a cosmetic component display name.
本発明の口腔用組成物において、(B)成分として、1種のホスホコリン基含有重合体を使用してもよく、また2種以上のホスホコリン基含有重合体を組み合わせて使用してもよい。 In the composition for oral cavity of the present invention, as the component (B), one kind of phosphocholine group-containing polymer may be used, or two or more kinds of phosphocholine group-containing polymers may be used in combination.
これらの(B)成分の中でも、保湿作用を有効に発揮させつつシリカの分散性の向上効果をより一層向上させるという観点から、好ましくは、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体、ポリメタクリロイルオキシエチルホスホリルコリン単重合体、2−メタクリロイルオキシエチルホスホリルコリン・2−ヒドロキシ−3−メタクリロイルオキシプロピルトリメチルアンモニウム共重合体;更に好ましくは、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体、2−メタクリロイルオキシエチルホスホリルコリン・2−ヒドロキシ−3−メタクリロイルオキシプロピルトリメチルアンモニウム共重合体;特に好ましくは、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体が挙げられる。 Among these (B) components, 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer is preferable, from the viewpoint of further improving the dispersibility improvement effect of silica while exhibiting the moisturizing action effectively. Polymethacryloyloxyethyl phosphorylcholine homopolymer, 2-methacryloyloxyethyl phosphorylcholine · 2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer; more preferably 2-methacryloyloxyethyl phosphorylcholine · butyl methacrylate copolymer, 2 -Methacryloyloxyethyl phosphoryl choline 2-hydroxy-3-methacryloyloxypropyl trimethyl ammonium copolymer; particularly preferably 2-methacryloyloxyethyl phosphoryl choline Butyl methacrylate copolymer.
本発明の口腔用組成物において、(B)成分の含有量については、特に制限されないが、例えば、(B)成分の総量で0.05〜1重量%が挙げられる。保湿作用を有効に発揮させつつシリカの分散性の向上効果をより一層向上させるという観点から、(B)成分の総量で、好ましくは0.05〜0.5重量%、更に好ましくは0.05〜0.3重量%、更に好ましくは0.05〜0.25重量%が挙げられる。 Although it does not restrict | limit in particular about content of the component (B) in the composition for oral cavity of this invention, For example, 0.05-1 weight% is mentioned in the total amount of the component (B). The total amount of the component (B) is preferably 0.05 to 0.5% by weight, more preferably 0.05 from the viewpoint of further improving the dispersibility improvement effect of silica while exhibiting the moisturizing action effectively. -0.3 weight%, More preferably, 0.05-0.25 weight% is mentioned.
本発明の口腔用組成物において、(C)成分に対する(B)成分の比率については、(B)成分の含有量及び(C)成分の総吸水値に応じて定まるが、例えば、(C)成分の総量100重量部当たり、(B)成分の総量が0.1〜40重量部が挙げられる。(C)成分に対する(B)成分の比率として、保湿作用を有効に発揮させつつシリカの分散性向上効果をより一層向上させるという観点から、(C)成分の総量100重量部当たり、(B)成分の総量が、好ましくは0.1〜20重量部、より好ましくは0.15〜7.5重量部、更に好ましくは0.16〜6.25重量部が挙げられる。 In the composition for oral cavity of the present invention, the ratio of the component (B) to the component (C) is determined according to the content of the component (B) and the total water absorption value of the component (C). The total amount of the component (B) is 0.1 to 40 parts by weight per 100 parts by weight of the total amount of the components. (B) per 100 parts by weight of the total amount of the component (C) from the viewpoint of further improving the dispersibility improvement effect of the silica while exerting the moisturizing action more effectively as the ratio of the component (B) to the component (C) The total amount of the components is preferably 0.1 to 20 parts by weight, more preferably 0.15 to 7.5 parts by weight, and still more preferably 0.16 to 6.25 parts by weight.
(C)シリカ
シリカは、無水ケイ酸または二酸化ケイ素と同義である。シリカは、増粘作用や汚れ除去作用を有する公知の成分である。
(C) Silica Silica is synonymous with silicic acid or silicon dioxide anhydrous. Silica is a known component having a thickening action and a soil removing action.
本発明の口腔用組成物において、(C)成分は、シリカの吸水量(mL/g)と口腔用組組成物中の含有量(重量%)との積(総吸水値)が7.4〜48となるように含まれ、好ましくは8〜40、より好ましくは9〜35、最も好ましくは10〜30が挙げられる。 (C)成分としては、総吸水値が上述の範囲内となる限り、任意の吸水量のシリカが任意の量で配合される。 In the composition for oral cavity of the present invention, the component (C) has a product (total water absorption value) of the water absorption amount (mL / g) of silica and the content (% by weight) in the composition for oral cavity as a total of 7.4. It is contained to be -48, preferably 8 to 40, more preferably 9 to 35, and most preferably 10 to 30. As the component (C), silica having any water absorption amount is blended in any amount as long as the total water absorption value falls within the range described above.
本発明において吸水量とは、後述の実施例の「シリカの吸水量」で記載するとおり、JIS K5101−13−1(吸油量の測定法)に準じ、油の代わりに水で吸液することによって定義される。 In the present invention, as described in the "water absorption of silica" in the examples described later, water absorption is carried out with water instead of oil according to JIS K5101-13-1 (measurement method of oil absorption). Defined by
(C)成分としては、増粘性シリカ及び研磨性シリカが挙げられる。増粘性シリカは、増粘作用を有する公知の成分であり、研磨性シリカは、汚れ除去作用を有する公知の成分である。増粘性シリカ及び研磨性シリカは、いずれか一方が単独で用いられてもよいし、双方が組み合わせられて用いられてもよい。増粘性シリカの吸水量としては、保形性等の観点から1.6mL/g以上であり、例えば1.6〜5mL/g、好ましくは2〜4mL/gが挙げられる。研磨性シリカは、増粘性シリカよりも吸水量が少ないシリカをいい、吸水量としては、汚れ除去性等の観点から、好ましくは1.5mL/g以下、例えば0.2〜1.5mL/g、より好ましくは0.5〜1.4mL/gが挙げられる。 As component (C), thickening silica and abrasive silica can be mentioned. Thickening silica is a known component having a thickening action, and abrasive silica is a known component having a soil removing action. Either of the thickening silica and the abrasive silica may be used alone, or both may be used in combination. The water absorption amount of the thickening silica is 1.6 mL / g or more from the viewpoint of shape retention and the like, and for example, 1.6 to 5 mL / g, preferably 2 to 4 mL / g can be mentioned. The abrasive silica is silica having a smaller amount of water absorption than the thickening silica, and the amount of water absorption is preferably 1.5 mL / g or less, for example 0.2 to 1.5 mL / g, from the viewpoint of soil removability and the like. More preferably, 0.5-1.4 mL / g is mentioned.
本発明の口腔用組成物において、(C)成分の含有量の下限としては、総吸水値が所定の範囲内となる限り特に限定されず、保形性及び/又は汚れ除去性等の観点から、(C)成分の総量で例えば2.5重量%以上、好ましくは3重量%以上、より好ましくは4重量%以上が挙げられる。また、(C)成分の含有量の上限としては、総吸水値が所定の範囲内となる限り特に限定されず、分散性等の観点から、(C)成分の総量で例えば45重量%以下、好ましくは35重量%以下、より好ましくは30重量%以下、更に好ましくは25重量%以下が挙げられる。 In the composition for oral cavity of the present invention, the lower limit of the content of the component (C) is not particularly limited as long as the total water absorption value falls within a predetermined range, and from the viewpoint of shape retention and / or dirt removal The total amount of the components (C) is, for example, 2.5% by weight or more, preferably 3% by weight or more, and more preferably 4% by weight or more. The upper limit of the content of the component (C) is not particularly limited as long as the total water absorption value falls within the predetermined range, and for example, 45% by weight or less in total of the component (C) from the viewpoint of dispersibility. Preferably it is 35 weight% or less, More preferably, it is 30 weight% or less, More preferably, it is 25 weight% or less.
本発明の口腔用組成物が(C)成分として増粘性シリカを含む場合、増粘性シリカの含有量としては保形性等の観点から例えば2.5重量%以上、好ましくは3重量%以上、より好ましくは4重量%以上が挙げられ、分散性等の観点から、例えば20重量%以下、好ましくは15重量%以下、より好ましくは10重量%以下が挙げられる。 When the composition for oral cavity of the present invention contains a thickening silica as the component (C), the content of the thickening silica is, for example, 2.5% by weight or more, preferably 3% by weight or more, from the viewpoint of shape retention. More preferably, it is 4% by weight or more, and from the viewpoint of dispersibility etc., for example, 20% by weight or less, preferably 15% by weight or less, more preferably 10% by weight or less.
本発明の口腔用組成物が(C)成分として研磨性シリカを含む場合、研磨性シリカの含有量としては汚れ除去性等の観点から例えば5.5重量%以上、好ましくは6重量%以上が挙げられ、分散性等の観点から、例えば30重量%以下、好ましくは20重量%以下、より好ましくは15重量%以下が挙げられる。また、研磨性シリカの平均粒子径としては、例えば1〜50μm、好ましくは2〜20μmが挙げられる。なお、平均粒子径は、レーザ回折散乱法粒子径分布測定の体積基準の積算分率における50%径(D50)である。 When the composition for oral cavity of the present invention contains abrasive silica as the component (C), the content of the abrasive silica is, for example, 5.5% by weight or more, preferably 6% by weight or more from the viewpoint of stain removability etc. From the viewpoint of dispersibility etc., for example, it is 30% by weight or less, preferably 20% by weight or less, more preferably 15% by weight or less. The average particle diameter of the abrasive silica is, for example, 1 to 50 μm, preferably 2 to 20 μm. The average particle diameter is a 50% diameter (D 50 ) in a volume-based integrated fraction in the laser diffraction scattering particle diameter distribution measurement.
本発明の口腔用組成物において、(A)成分に対する(C)成分の比率については、(A)成分及び(C)成分の各含有量に応じて定まるが、例えば、(A)成分の総量1重量部当たり、(C)成分の総量が5〜50000重量部が挙げられる。(A)成分に対する(C)成分の比率として、シリカの分散性の向上効果を有効に発揮させつつ、トラネキサム酸類の抗出血作用、抗アレルギー作用、抗炎症作用等を有効に発揮させるという観点から、(A)成分の総量1重量部当たり、(C)成分の総量が、好ましくは10〜14500重量部、より好ましくは30〜7000重量部、更に好ましくは40〜3000重量部が挙げられる。 In the composition for oral cavity of the present invention, the ratio of the component (C) to the component (A) is determined according to the contents of the components (A) and (C), but for example, the total amount of the component (A) The total amount of the component (C) is 5 to 50000 parts by weight per 1 part by weight. From the viewpoint of effectively exerting the antibleeding action, antiallergic action, antiinflammatory action, etc. of tranexamic acids while effectively exerting the effect of improving the dispersibility of silica as the ratio of the (C) ingredient to the (A) ingredient The total amount of the component (C) is preferably 10 to 14500 parts by weight, more preferably 30 to 7000 parts by weight, and still more preferably 40 to 3000 parts by weight per part by weight of the total amount of the component (A).
(D)水
本発明の口腔用組成物は、基剤として水を含有する。前記の(C)成分は、所定の総吸水値となる含有量でトラネキサム酸類と水との共存下で保存すると、分散性不良でケーキング(振とうによる再分散が困難な沈積物の形成)や離水を生じる傾向を示すが、本発明の口腔用組成物によれば、このようなシリカの分散性をケーキングも離水も生じさせないほどに効果的に向上させることができる。
(D) The oral composition of the water present invention contains water as a base. When the component (C) is stored in the coexistence of tranexamic acid and water at a content that provides a predetermined total water absorption value, caking (formation of deposits that are difficult to redisperse by shaking) or dispersiveness may occur due to poor dispersibility. Although it shows a tendency to cause water separation, according to the composition for oral cavity of the present invention, the dispersibility of such silica can be effectively improved to neither caking nor separation.
本発明の口腔用組成物において、(D)成分の含有量については、その製剤形態等に応じて適宜設定されるが、例えば、1〜95重量%、好ましくは3〜90重量%、更に好ましくは5〜85重量%が挙げられる。 In the composition for oral cavity of the present invention, the content of the component (D) is appropriately set according to the form of the formulation etc., but it is, for example, 1 to 95% by weight, preferably 3 to 90% by weight, more preferably Is 5 to 85% by weight.
その他の成分
本発明の口腔用組成物は、前述する成分以外に、本発明の効果を損なわない範囲で、口腔用組成物の製剤形態に応じて、当該技術分野で通常使用される成分を含有していてもよい。このような成分としては、例えば、防腐剤、殺菌剤、抗菌剤、消炎剤、研磨剤、グルコシルトランスフェラーゼ(GTase)阻害剤、プラーク抑制剤、知覚過敏抑制剤、歯石予防剤、歯質強化/再石灰化剤、抗ヒスタミン剤、局所麻酔剤、血行促進剤、増粘剤、湿潤剤、賦形剤、香料、甘味剤、清涼化剤、色素、消臭剤、界面活性剤、溶剤、pH調整剤等が挙げられる。
Other Components The composition for oral cavity of the present invention contains, in addition to the components described above, components generally used in the technical field according to the formulation form of the composition for oral cavity as long as the effects of the present invention are not impaired. It may be done. Such components include, for example, preservatives, bactericides, antibacterial agents, anti-inflammatory agents, abrasives, glucosyl transferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, anti-calculus agents, dentinaceous agent Mineralizer, antihistamine, local anesthetic, circulation enhancer, thickener, wetting agent, excipient, flavor, sweetener, refreshing agent, pigment, deodorant, surfactant, solvent, pH adjuster, etc. Can be mentioned.
防腐剤、殺菌剤、抗菌剤としては、例えば、ヒノキチオール、安息香酸類、サリチル酸類、ソルビン酸類、パラベン類、塩化デカリニウム、塩化クロルヘキシジン、グルコン酸クロルヘキシジン、イソプロピルメチルフェノール、トリクロサン、塩化リゾチーム、塩酸クロルヘキシジン、ヨウ化カリウム等が挙げられる。 Examples of preservatives, bactericidal agents and antibacterial agents include hinokitiol, benzoic acids, salicylic acids, sorbic acids, parabens, decarinium chloride, chlorhexidine chloride, chlorhexidine gluconate, isopropylmethylphenol, triclosan, lysozyme chloride, chlorhexidine hydrochloride, iodine Potassium iodide and the like.
消炎剤としては、上述の(A)成分を除く成分であればよく、例えば、グリチルリチン酸ジカリウム、グリチルレチン酸、グリチルリチン酸メチル、グリチルリチン酸ステアリル、グリチルレチン酸ピリドキシン、グリチルレチン酸ステアリル、グリチルレチン酸グリセリル、グリチルレチン酸モノグルクロニド、アラントイン、イプシロンアミノカプロン酸、アズレン、塩化ナトリウム、ビタミン類等が挙げられる。 The anti-inflammatory agent may be any component other than the above-mentioned component (A), for example, dipotassium glycyrrhizinate, glycyrrhetinic acid, methyl glycyrrhizinate, stearyl glycyrrhizinate, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinate Monoglucuronide, allantoin, epsilon aminocaproic acid, azulene, sodium chloride, vitamins and the like can be mentioned.
研磨剤としては、例えば、含水ケイ酸、酸化アルミニウム、水酸化アルミニウム、リン酸水素カルシウム、リン酸カルシウム、ピロリン酸カルシウム、炭酸カルシウム、結晶セルロース、ポリエチレン末、炭粒等が挙げられる。 Examples of the abrasive include hydrated silica, aluminum oxide, aluminum hydroxide, calcium hydrogen phosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, crystalline cellulose, polyethylene powder, carbon particles and the like.
GTase阻害剤としては、例えば、アカバナ科マツヨイグサ属植物の抽出物、ブドウ科ブドウ属植物の抽出物、デキストラナーゼ、ムタナーゼ、タステイン、タンニン類、エラグ酸、ポリフェノール、ウーロン茶抽出物、緑茶抽出物、センブリ、タイソウ、ウイキョウ、芍薬、ゲンチアナ、センソ、龍胆、黄連等が挙げられる。 As a GTase inhibitor, for example, an extract of a plant belonging to the genus Pinus vulgare L., an extract of Vitis vines, a dextranase, mutanase, tastein, tannins, ellagic acid, polyphenol, oolong tea extract, green tea extract, There are Semburi, Taisou, fennel, glaze, gentiana, senso, long-bowl, Huangren, etc.
プラーク抑制剤としては、例えばクエン酸亜鉛やグルコン酸等が挙げられる。 Examples of the plaque inhibitor include zinc citrate and gluconic acid.
知覚過敏抑制剤としては、例えば、硝酸カリウム、塩化ストロンチウム等が挙げられる。 Examples of the hypersensitivity suppressor include potassium nitrate, strontium chloride and the like.
歯石予防剤としては、例えば、ポリリン酸塩類、ゼオライト、エタンヒドロキシジホスフォネート等が挙げられる。 As an anti-calculus agent, for example, polyphosphates, zeolite, ethane hydroxy diphosphonate and the like can be mentioned.
歯質強化/再石灰化剤としては、例えば、フッ素、フッ化ナトリウム、フルオロリン酸ナトリウム、フッ化第一スズ等が挙げられる。 Examples of the tooth strengthening / remineralizing agent include fluorine, sodium fluoride, sodium fluorophosphate and stannous fluoride.
抗ヒスタミン剤としては、例えば、ジフェンヒドラミン、塩酸ジフェンヒドラミン等が挙げられる。 Examples of antihistamines include diphenhydramine, diphenhydramine hydrochloride and the like.
局所麻酔剤としては、例えば、プロカイン、テトラカイン、ブピパカイン、メピパカイン、クロロプロカイン、プロパラカイン、メプリルカイン又はこれらの塩、オルソカイン、オキセサゼイン、オキシポリエントキシデカン、ロートエキス、ペルカミンパーゼ、テシットデシチン等が挙げられる。 The local anesthetic includes, for example, procaine, tetracaine, bupipakine, mepipacain, chlorprocaine, proparacaine, meprilcain or salts thereof, orthokine, oxesazein, oxypolyentoxydecane, roto extract, percamine pase, tesitdectin and the like.
血行促進剤としては、例えば、ノニル酸ワニリルアミド、ニコチン酸ベンジルエステル、カプサイシン、トウガラシエキス等が挙げられる。 Examples of the blood circulation promoting agent include nonylic acid allirylamide, nicotinic acid benzyl ester, capsaicin, pepper extract and the like.
増粘剤としては、例えば、プルラン、プルラン誘導体、デンプン等の多糖類;ヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、ヒドロキシエチルメチルセルロース、カルボキシメチルセルロース、カルボキシメチルセルロース塩類(カルボキシメチルセルロースナトリウム、カルボキシメチルセルロースカリウム等)、メチルセルロース、エチルセルロース、ポリアクリル酸、ポリアクリル酸塩(ポリアクリル酸ナトリウム、アクリル酸・アクリル酸オクチルエステル共重合体等)、メタアクリル酸類の共重合体(メタアクリル酸とアクリル酸 n−ブチルの重合体、メタアクリル酸とメタアクリル酸メチルの重合体及びメタアクリル酸とアクリル酸エチルの重合体等)等のセルロース系高分子物質;カルボキシビニルポリマー、ポリエチレングリコール、ポリビニルアルコール、ポリビニルピロリドン等の合成高分子物質;レクチン、アルギン酸、アルギン酸塩(アルギン酸ナトリウム、アルギン酸カリウム、アルギン酸マグネシウム、アルギン酸プロピレングリコールエステル、アルギン酸トリエタノールアミン、アルギン酸トリイソプロパノールアミン、アルギン酸アンモニウム、アルギン酸ブチルアミン、アルギン酸ジアミルアミン等)、コンドロイチン硫酸ナトリウム、寒天、キトサン、カラギーナン等の天然系高分子物質;コラーゲン、ゼラチン等のアミノ酸系高分子物質;アラビアガム、カラヤガム、トラガカントガム、キサンタンガム、ローカストビーンガム、グアガム、タマリンドガム、ジェランガム等のゴム系高分子物質等が挙げられる。 As the thickener, for example, polysaccharides such as pullulan, pullulan derivatives, starch and the like; hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, carboxymethyl cellulose, carboxymethyl cellulose salts (sodium carboxymethylcellulose, potassium carboxymethylcellulose etc.) , Methylcellulose, ethylcellulose, polyacrylic acid, polyacrylate (sodium polyacrylate, acrylic acid / acrylic acid octyl ester copolymer, etc.), methacrylic acid copolymers (methacrylic acid and n-butyl acrylate) Polymers, polymers of methacrylic acid and methyl methacrylate, polymers of methacrylic acid and ethyl acrylate, etc.) Polymeric substances; Synthetic polymeric substances such as carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, etc .; Lectin, alginic acid, alginate (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, alginate Natural polymeric substances such as triisopropanolamine, ammonium alginate, butylamine alginic acid, diamylamine alginic acid sodium, chondroitin sulfate sodium, agar, chitosan, carrageenan, etc .; amino acid type polymeric substances such as collagen, gelatin; gum arabic, karaya gum, tragacanth gum, Xanthan gum, locust bean gum, guar gum, tamarind gum, gellan gum, etc. System polymer material, and the like.
湿潤剤としては、例えば、グリセリン、ソルビトール、エチレングリコール、プロピレングリコール、ポリエチレングリコール、ポリプロピレングリコール、キシリトール、マルチトール、ラクトール、エリスリトール等が挙げられる。 As the humectant, for example, glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactol, erythritol and the like can be mentioned.
賦形剤としては、例えば、乳糖、白糖、マンニトール、デンプン、デキストリン、結晶セルロース等が挙げられる。 As the excipient, for example, lactose, sucrose, mannitol, starch, dextrin, crystalline cellulose and the like can be mentioned.
香料としては、例えば、天然香料(ウイキョウ油等)、合成香料、これらの調合香料等が挙げられる。 Examples of the fragrant include natural fragrant (such as fennel oil), synthetic fragrant, and blended fragrants thereof.
甘味剤としては、サッカリンナトリウム、ステビオサイド、ステビアエキス、アスパルテーム、キシリトール、水飴、蜂蜜、ソルビトール、マルチトール、マンニトール、エリスリトール、糖類(乳糖、白糖、果糖、ブドウ糖等)等が挙げられる。 As the sweetening agent, saccharin sodium, stevioside, stevia extract, aspartame, xylitol, starch syrup, honey, sorbitol, maltitol, mannitol, erythritol, saccharides (lactose, sucrose, fructose, glucose, etc.) and the like can be mentioned.
清涼化剤としては、例えば、メントール、エリスリトール、カンフル、ボルネオール、ゲラニオール、これらを含む精油等が挙げられる。 Examples of the refreshing agent include menthol, erythritol, camphor, borneol, geraniol, essential oils containing these, and the like.
色素としては、例えば、天然色素、合成色素、これらの混合物が挙げられる。 The dyes include, for example, natural dyes, synthetic dyes, and mixtures thereof.
消臭剤としては、例えば、塩化亜鉛、銅クロロフィリンナトリウム、コーヒー生豆抽出物、ゴボウパウダー、緑茶、焙煎米糠エキス等が挙げられる。 Examples of the deodorant include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, burdock powder, green tea, roasted rice bran extract and the like.
界面活性剤としては、例えば、ポリオキシエチレンラウリルエーテル硫酸ナトリウム、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、N−ラウロイルサルコシン酸ナトリウム、N−ミリストリルサルコシン酸ナトリウム、ドデシルベンゼンスルホン酸ナトリウム、水素添加ココナッツ脂肪酸モノグリセリドモノ硫酸ナトリウム、ラウリルスルホ酢酸ナトリウム、α−オレフィンスルホン酸ナトリウム、N−パルミトイルグルタルミン酸ナトリウム、N−メチル−N−アシルタウリンナトリウム等の陰イオン性界面活性剤;ポリオキシエチレン硬化ヒマシ油、ショ糖脂肪酸エステル、マルトース脂肪酸エステル、マルチトール脂肪酸エステル、ラクトール脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレン高級アルコールエーテル、ポリオキシエチレンポリオキシプロピレン共重合体、ポリオキシエチレンポリオキシプロピレン脂肪酸エステル、ポリグリセリン脂肪酸エステル等の非イオン性界面活性剤;ヤシ油脂肪酸アミドプロピルベタイン、ラウリルジメチルアミノ酢酸ベタイン、ラウリルジメチルアミンオキシド、2-アルキル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリウムベタイン、N−ラウリルジアミノエチルグリシン、N−ミリスチルジアミノエチルグリシン、N−アルキル−1−ヒドロキシエチルイミダゾリンベタインナトリウム等の両性界面活性剤;塩化ラウリルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、塩化ベンゼトニウム、塩化ベンザルコニウム、塩化ステアリルジメチルベンジルアンモニウム等の陽イオン性界面活性剤が挙げられる。 As the surfactant, for example, sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristryl sarcosinate, sodium dodecyl benzene sulfonate, hydrogenated coconut fatty acid monoglyceride Anionic surfactants such as sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoylglutarate, sodium N-methyl-N-acyl taurine, etc .; polyoxyethylene hydrogenated castor oil, Sugar fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan mo Nonionic surfactants such as stearate, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, polyglycerin fatty acid ester; coconut oil fatty acid amidopropyl betaine, lauryl Dimethylaminoacetic acid betaine, lauryldimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, N-alkyl-1-hydroxyethylimidazoline Amphoteric surfactants such as betaine sodium; lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, benzethonium chloride, benzalkonium chloride , Cationic surfactants such as chloride stearyl dimethyl benzyl ammonium.
溶剤としては、例えば、エタノール、プロパノール、ブタノール、ペンタノール、ヘキサノール、イソプロパノール等の1価アルコール等が挙げられる。 Examples of the solvent include monohydric alcohols such as ethanol, propanol, butanol, pentanol, hexanol and isopropanol.
pH調整剤としては、例えば、酢酸、塩酸、硫酸、硝酸、クエン酸、リンゴ酸、乳酸、リン酸、安息香酸、水酸化ナトリウム、水酸化カリウム、酢酸ナトリウム、炭酸ナトリウム、クエン酸ナトリウム、クエン酸水素ナトリウム、乳酸ナトリウム、乳酸カルシウム、リン酸ナトリウム、リン酸水素ナトリウム、安息香酸ナトリウム等が挙げられる。 As a pH adjuster, for example, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, malic acid, lactic acid, phosphoric acid, benzoic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium acetate, sodium carbonate, sodium citrate, citric acid Examples include sodium hydrogen, sodium lactate, calcium lactate, sodium phosphate, sodium hydrogen phosphate, sodium benzoate and the like.
本発明の口腔用組成物において、これらの成分を含有させる場合、その含有量については、当該技術分野で通常使用される範囲で適宜設定すればよい。 In the composition for oral cavity of the present invention, when these components are contained, the content thereof may be appropriately set in the range generally used in the relevant technical field.
pH
また、本発明の口腔用組成物のpHについては、口腔内への適用が許容される範囲で適宜設定すればよいが、例えば、4〜8、好ましくは5〜7.5、更に好ましくは6〜7が挙げられる。ここで、pHとは、25℃の温度条件下で測定される値である。
pH
In addition, the pH of the composition for oral cavity of the present invention may be appropriately set in the range in which application to the oral cavity is permitted, and for example, 4 to 8, preferably 5 to 7.5, and more preferably 6 -7 are mentioned. Here, pH is a value measured under a temperature condition of 25 ° C.
製剤形態
本発明の口腔用組成物の剤型については、口腔内への適用が可能であることを限度として特に制限されないが、例えば、液状又は半固形状(ゲル状、ペースト状)が挙げられる。
Dosage form The dosage form of the composition for oral cavity of the present invention is not particularly limited as far as it can be applied to the oral cavity, but includes, for example, liquid or semisolid (gel or paste). .
本発明の口腔用組成物の製剤形態については、口腔内に適用されて口腔内で一定時間滞留し得るものである限り特に制限されないが、例えば、液体歯磨剤、液状歯磨剤、練歯磨剤、洗口液(液体歯磨剤、洗口液は、一般にマウスリンス、マウスウォッシュ、デンタルリンス等と呼称されることがある)、口中清涼剤(マウススプレー等)、口腔用軟膏剤等の口腔衛生剤が挙げられる。これらの中でも、好ましくは液体歯磨剤、液状歯磨剤、練歯磨剤、洗口液、更に好ましくは液体歯磨剤、練歯磨剤、洗口液が挙げられ、特に好ましくは、練歯磨剤が挙げられる。 The preparation form of the oral composition of the present invention is not particularly limited as long as it can be applied in the oral cavity and can be retained in the oral cavity for a certain period of time, for example, liquid dentifrice, liquid dentifrice, toothpaste, Oral hygiene agents such as mouthwash (liquid dentifrice, mouthrinse may be generally referred to as mouthrinse, mouthwash, dental rinse etc.), mouth freshener (mouse spray etc), oral ointment etc Can be mentioned. Among these, preferred are liquid dentifrices, liquid dentifrices, toothpastes, mouthrinses, more preferably liquid dentifrices, toothpastes and mouthrinses, and particularly preferably toothpastes. .
2.シリカの分散性向上剤、及びシリカの分散性向上方法
前述するように、ホスホコリン基含有重合体は、トラネキサム酸類、所定の総吸水値で配合されるシリカ及び水を含む口腔用組成物において、シリカの分散性を向上させることができる。従って、本発明は、更に、トラネキサム酸類、所定の総吸水値で配合されるシリカ及び水を含む口腔用組成物におけるシリカの分散性を向上させるために使用される分散性向上剤であって、ホスホコリン基含有重合体を有効成分とする分散性向上剤を提供する。また、本発明は、トラネキサム酸類、所定の総吸水値で配合されるシリカ及び水を含む口腔用組成物において、シリカの分散性を向上させる分散性向上方法であって、口腔用組成物に、トラネキサム酸類、所定の総吸水値で配合されるシリカ及び水と共に、ホスホコリン基含有重合体を配合する、分散性向上方法を提供する。
2. Method of improving dispersibility of silica and method of improving dispersibility of silica As described above, the phosphocholine group-containing polymer is a composition for oral cavity containing tranexamic acids, silica blended with a predetermined total water absorption value, and water. It is possible to improve the dispersion of Therefore, the present invention is also a dispersion improver used to improve the dispersibility of silica in oral compositions comprising tranexamic acids, silica formulated with a predetermined total water absorption value, and water, Disclosed is a dispersibility improver comprising a phosphocholine group-containing polymer as an active ingredient. Further, the present invention is a method for improving dispersibility of silica in a composition for oral cavity containing tranexamic acids, silica blended with a predetermined total water absorption value, and water, which comprises the composition for oral cavity, Disclosed is a method for improving dispersibility, in which a phosphocholine group-containing polymer is blended with tranexamic acids, silica blended with a predetermined total water absorption value, and water.
前記分散性向上剤はホスホコリン基含有重合体の添加剤としての用途であり、また、前記分散性向上方法は、ホスホコリン基含有重合体を利用して、トラネキサム酸類、所定の総吸水値で配合されるシリカ及び水を含む口腔用組成物におけるシリカの分散性を向上させる方法である。 The dispersion improver is used as an additive for a phosphocholine group-containing polymer, and the dispersion improvement method is formulated with tranexamic acids at a predetermined total water absorption value using a phosphocholine group-containing polymer. Method of improving the dispersibility of silica in an oral composition containing water and silica.
前記分散性向上剤及び分散性向上方法において、使用する成分の種類や使用量、口腔用組成物の形態等については、前記「1.口腔用組成物」の欄に示す通りである。 In the dispersion improver and the dispersion improvement method, the types and amounts of the components to be used, the form of the composition for oral cavity and the like are as described in the section of “1. Composition for oral cavity”.
以下に実施例を示して本発明をより具体的に説明するが、本発明はこれらに限定されるものではない。 EXAMPLES The present invention will be more specifically described below by way of Examples, but the present invention is not limited thereto.
試験例1
表1〜表8に示す組成の液剤を調製した。具体的には、実施例においては、トラネキサム酸を精製水に加えて撹拌して溶解させた後、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体を溶解させた。その後、シリカを加えて混合して液剤を得た。比較例及び参考例においては、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体を用いなかったことを除いて同様に液剤を得た。得られた液剤5mLをガラス製スクリュー管瓶(容量6mL)に充填し、遮光条件下で室温(25℃)で1日間静置した。1日間静置後の各液剤の外観を観察し、以下に示す判定基準に従ってシリカの分散の程度を評価した。
Test Example 1
The solutions of the compositions shown in Tables 1 to 8 were prepared. Specifically, in the examples, tranexamic acid was added to purified water and stirred to be dissolved, and then a 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer was dissolved. Thereafter, silica was added and mixed to obtain a solution. In Comparative Examples and Reference Examples, solutions were similarly obtained except that 2-methacryloyloxyethyl phosphorylcholine-butyl methacrylate copolymer was not used. 5 mL of the obtained solution was filled in a glass screw tube bottle (volume 6 mL) and allowed to stand at room temperature (25 ° C.) for 1 day under light-shielded conditions. The appearance of each solution after standing for 1 day was observed, and the degree of dispersion of silica was evaluated according to the judgment criteria shown below.
<シリカの分散の程度の判定基準>
○:1日静置後に、上下に激しく20回振って撹拌させた際、全てのシリカが溶液中に分散される。
×:1日静置後に、上下に激しく20回振って撹拌させた際、容器底部に一部のシリカが分散せずに凝集した状態で付着している(ケーキング)。
<Criteria for Determining the Degree of Dispersion of Silica>
Good: All silicas are dispersed in the solution when left to stand vigorously and shaken vigorously 20 times after being allowed to stand.
X: When left to stand for a day and shaken vigorously 20 times up and down and stirring, a part of the silica adheres to the bottom of the container in a coagulated state without being dispersed (caking).
<シリカの吸水量>
シリカの総吸水値を求めるための吸水量(mL/g)は、JIS K5101−13−1(吸油量の測定法)を参考にして以下のように定義した。即ち、測定試料(シリカ)1gをガラス版の上に置き、精製水を4,5滴ずつ徐々に加え、その都度パレットナイフで精製水を試料に練り込み;これを繰り返し、試料が塊になるまで精製水の滴下を続け;さらに、精製水を1滴ずつ塊に滴下して、均一になるまで練りこむ作業を、試料が滑らかなペースト状になるまで繰り返し(この場合においてペースト状とは、水分過不足のない状態をいい、具体的には、パレットナイフでガラス板に塗り広げたときに塗り広げられた試料に割れ目が生じず、さらにパレットナイフで1つの塊としてまとめ直すこともできる性状をいう);当該ペースト状になるまでに要した水量(ml)を吸水量とした。
<Water absorption of silica>
The water absorption amount (mL / g) for determining the total water absorption value of silica was defined as follows with reference to JIS K 5101-13 1 (measurement method of oil absorption). That is, 1 g of a measurement sample (silica) is placed on a glass plate, and 4 or 5 drops of purified water are gradually added, and in each case, the purified water is kneaded into the sample with a pallet knife; Continue adding dropwise the purified water until the sample is in the form of a smooth paste (in this case, paste-like). It means that there is no excess and deficiency of water, and specifically, there is no crack in the sample that is spread when it is spread on a glass plate with a pallet knife, and furthermore, it is a property that can be regrouped as one lump with a pallet knife. The amount of water (ml) required to form the paste was taken as the amount of water absorption.
得られた結果を表1〜表4に示す。表に示されるように、トラネキサム酸を含むとともにシリカの総吸水値が7.4未満である液剤(参考例1及び参考例2)の場合にはケーキングが起らないが、トラネキサム酸を含むとともに総吸水値が7.4〜48の範囲内である液剤(比較例1〜10)の場合にはケーキングが起こる。これに対して、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体を含む液剤(実施例1〜20)では、ケーキングが抑制できていた。つまり、シリカの良好な分散状態を維持できていた。 The obtained results are shown in Tables 1 to 4. As shown in the table, caking does not occur in the case of solutions containing tranexamic acid and having a total water absorption value of silica of less than 7.4 (Reference Example 1 and Reference Example 2), while containing tranexamic acid In the case of the liquid agent (comparative example 1-10) whose total water absorption value is in the range of 7.4-48, caking occurs. On the other hand, in the liquid agent (Examples 1 to 20) containing 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, caking could be suppressed. That is, the good dispersion state of the silica could be maintained.
試験例2
本試験例では、増粘性シリカを研磨性シリカに変更し表5〜表8に示す組成の液剤を調製したことを除き、試験例1と同様にシリカの分散の程度を評価した。
Test example 2
In this test example, the degree of dispersion of silica was evaluated in the same manner as in Test Example 1 except that the thickening silica was changed to abrasive silica to prepare a solution having a composition shown in Tables 5 to 8.
得られた結果を表5〜表8に示す。表に示されるように、トラネキサム酸を含むとともにシリカの総吸水値が7.4未満の範囲である液剤(参考例3〜4)の場合にはケーキングが起らないが、トラネキサム酸を含むとともに総吸水値が7.4〜48の範囲である液剤(比較例11〜22)の場合にはケーキングが起こる。これに対して、2−メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体を含む液剤(実施例21〜44)では、ケーキングが抑制できていた。つまり、シリカの良好な分散状態を維持できていた。 Tables 5 to 8 show the obtained results. As shown in the table, caking does not occur in the case of a solution containing tranexamic acid and having a total water absorption value of silica in the range of less than 7.4 (Reference Examples 3 to 4), but it also contains tranexamic acid. Caking occurs in the case of a liquid preparation (comparative examples 11 to 22) whose total water absorption value is in the range of 7.4 to 48. On the other hand, caking could be suppressed in the liquid agent (Examples 21 to 44) containing the 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. That is, the good dispersion state of the silica could be maintained.
製剤例1
表9に示す組成の練歯磨剤を製造した。得られた練歯磨剤をチューブ容器に入れて保存した。以下に示す判定基準に従って、シリカの分散の程度を評価した。なお、表9において、各成分の含有量の単位は、重量%である。
Formulation example 1
A toothpaste having the composition shown in Table 9 was produced. The obtained toothpaste was placed in a tube container and stored. The degree of dispersion of silica was evaluated according to the criteria shown below. In Table 9, the unit of the content of each component is% by weight.
<シリカの分散の程度の判定基準>
チューブ容器に入れた練歯磨剤を、遮光条件下、50℃で1か月静置した後、容器を切り開き、製剤表面の離水を目視にて確認した。
◎:離水が認められない、または、やや表面が濡れている程度である。
×:離水が認められた。
<Criteria for Determining the Degree of Dispersion of Silica>
The toothpaste placed in a tube container was allowed to stand at 50 ° C. for 1 month at light-shielded conditions, and then the container was cut open to visually confirm the syneresis of the preparation surface.
◎: no separation of water, or slight surface wetting.
X: Water separation was observed.
表9に示す通り、得られた練歯磨剤については、離水が抑制されていたためシリカが良好に分散していた。 As shown in Table 9, in the obtained toothpaste, silica was well dispersed since syneresis was suppressed.
製剤例2
表10に示す組成の練歯磨剤を製造した。なお、表中の各成分の含有量の単位は、重量%である。また、表中の増粘性シリカ及び研磨性シリカは、それぞれ、上述の実施例等における増粘性シリカ及び研磨性シリカと同じものを用いた。得られた練歯磨剤については、いずれも保存後に離水が抑制されていたためシリカが良好に分散していた。
Formulation example 2
A toothpaste having the composition shown in Table 10 was produced. In addition, the unit of content of each component in a table | surface is weight%. Further, as the viscosifying silica and the abrasive silica in the table, the same as the viscosifying silica and the abrasive silica in the above-mentioned Examples and the like were used, respectively. With respect to the obtained toothpaste, silica was well dispersed since syneresis was suppressed after storage.
Claims (7)
前記(C)成分の吸水量(mL/g)と含有量(重量%)との積が7.4〜48である、口腔用組成物。 (A) at least one member selected from the group consisting of tranexamic acid, derivatives thereof and salts thereof, (B) a phosphocholine group-containing polymer, (C) silica, and (D) water,
The composition for oral cavity whose product of the water absorption amount (mL / g) of said (C) component and content (weight%) is 7.4-48.
(B)ホスホコリン基含有重合体を有効成分とする、分散性向上剤。 (A) at least one member selected from the group consisting of tranexamic acid, derivatives thereof and salts thereof, (C) silica, and (D) water, wherein the water absorption (mL / g) of the component (C) A dispersibility improver used to improve the dispersibility of the component (C) in an oral composition having a product of 7.4 to 48 as the product of the content (% by weight),
(B) A dispersibility improver comprising a phosphocholine group-containing polymer as an active ingredient.
口腔用組成物に、前記(A)成分と前記(C)成分と前記(D)成分と共に、(B)ホスホコリン基含有重合体を配合する、分散性向上方法。 (A) at least one member selected from the group consisting of tranexamic acid, derivatives thereof and salts thereof, (C) silica, and (D) water, wherein the water absorption (mL / g) of the component (C) And a method for improving dispersibility of the component (C) in an oral composition having a product of 7.4 to 48 as the product of the content (% by weight),
The dispersibility improvement method which mix | blends the (B) phosphocholine group containing polymer with the said composition for oral cavity with the said (A) component, the said (C) component, and the said (D) component.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017198057A JP2019069929A (en) | 2017-10-11 | 2017-10-11 | Oral composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017198057A JP2019069929A (en) | 2017-10-11 | 2017-10-11 | Oral composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2019069929A true JP2019069929A (en) | 2019-05-09 |
Family
ID=66441752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017198057A Pending JP2019069929A (en) | 2017-10-11 | 2017-10-11 | Oral composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2019069929A (en) |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04139120A (en) * | 1990-09-27 | 1992-05-13 | Lion Corp | Composition for use in oral cavity |
JPH07149514A (en) * | 1993-08-07 | 1995-06-13 | Degussa Ag | Preparation of precipitated silica |
JP2002249684A (en) * | 2001-02-23 | 2002-09-06 | Nof Corp | Ink and its usage |
JP2003081799A (en) * | 2001-06-27 | 2003-03-19 | Lion Corp | Toothpaste composition |
JP2009510062A (en) * | 2005-09-27 | 2009-03-12 | コルゲート・パーモリブ・カンパニー | Single-phase whitening dentifrice |
JP2011252819A (en) * | 2010-06-03 | 2011-12-15 | Furukawa Electric Co Ltd:The | Labeling reagent silica nano-particle |
JP2016124787A (en) * | 2014-12-26 | 2016-07-11 | ライオン株式会社 | Dentifrice composition |
JP2017081967A (en) * | 2016-12-28 | 2017-05-18 | 東ソー・シリカ株式会社 | Silica, and tooth polishing agent using the silica |
JP2017119791A (en) * | 2015-12-28 | 2017-07-06 | ライオン株式会社 | Washing agent for dishwasher and method for producing thereof, and washing agent product packed in squeezable container |
JP2017128533A (en) * | 2016-01-20 | 2017-07-27 | 日油株式会社 | Silica dispersion stabilizer for oral cavity, and dentifrice composition containing the same |
-
2017
- 2017-10-11 JP JP2017198057A patent/JP2019069929A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04139120A (en) * | 1990-09-27 | 1992-05-13 | Lion Corp | Composition for use in oral cavity |
JPH07149514A (en) * | 1993-08-07 | 1995-06-13 | Degussa Ag | Preparation of precipitated silica |
JP2002249684A (en) * | 2001-02-23 | 2002-09-06 | Nof Corp | Ink and its usage |
JP2003081799A (en) * | 2001-06-27 | 2003-03-19 | Lion Corp | Toothpaste composition |
JP2009510062A (en) * | 2005-09-27 | 2009-03-12 | コルゲート・パーモリブ・カンパニー | Single-phase whitening dentifrice |
JP2011252819A (en) * | 2010-06-03 | 2011-12-15 | Furukawa Electric Co Ltd:The | Labeling reagent silica nano-particle |
JP2016124787A (en) * | 2014-12-26 | 2016-07-11 | ライオン株式会社 | Dentifrice composition |
JP2017119791A (en) * | 2015-12-28 | 2017-07-06 | ライオン株式会社 | Washing agent for dishwasher and method for producing thereof, and washing agent product packed in squeezable container |
JP2017128533A (en) * | 2016-01-20 | 2017-07-27 | 日油株式会社 | Silica dispersion stabilizer for oral cavity, and dentifrice composition containing the same |
JP2017081967A (en) * | 2016-12-28 | 2017-05-18 | 東ソー・シリカ株式会社 | Silica, and tooth polishing agent using the silica |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2019052110A (en) | Oral composition | |
WO2016031461A1 (en) | Oral composition for alleviation of dentin hypersensitivity | |
JPWO2014038195A1 (en) | Oral composition | |
JP6381912B2 (en) | Oral composition | |
JP7011407B2 (en) | Oral composition | |
JP7455317B2 (en) | Oral composition | |
JP6946075B2 (en) | Oral composition | |
JP6968523B2 (en) | Oral or external composition | |
JP7108383B2 (en) | oral composition | |
JP7000048B2 (en) | Oral composition | |
JP2019112375A (en) | Oral composition | |
JP2019069929A (en) | Oral composition | |
JP2019069928A (en) | Oral composition | |
JP6734090B2 (en) | Oral composition | |
JP7048272B2 (en) | Oral composition | |
JP2019069930A (en) | Oral composition | |
JP6925929B2 (en) | Oral composition | |
JP6574150B2 (en) | Oral composition | |
JP7050135B2 (en) | Oral or external composition | |
JP2019116424A (en) | Gum activating agents | |
JP2019112376A (en) | Toothpaste | |
JPH07267840A (en) | Composition for oral cavity | |
JP6349709B2 (en) | Oral composition | |
JP2014073989A (en) | Dentifrice composition | |
JP2019116426A (en) | Inhibitors of gingival tissue destruction |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200903 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20210726 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210817 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20211018 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211214 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220510 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20221025 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230125 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20230125 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20230202 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20230207 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20230421 |
|
C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20230425 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240826 |