JP7050135B2 - Oral or external composition - Google Patents

Description

The present invention relates to an oral or external composition containing peppermint oil, a phosphocholine group-containing polymer, and water, but in which the formation of precipitates is suppressed.

Mentha oil is an essential oil obtained by steam-distilling a plant belonging to the genus Mentha, and is known to have effects such as imparting aroma with a refreshing sensation and sterilizing, and is used in oral or external compositions.

In addition, phosphocholine group-containing polymers such as 2-methacryloyloxyethylphosphorylcholine and butyl methacrylate copolymer have high affinity for living organisms, and have moisturizing properties, prevention of adhesion of microorganisms to the oral cavity, prevention of gingival inflammation, etc. Has also been reported, and has been used in oral or external compositions (see, for example, Patent Documents 1 to 3).

On the other hand, conventionally, the pharmaceutical stability in the oral or external composition in which mint oil and the phosphocholine group-containing polymer are used in combination has not been sufficiently investigated.

Japanese Unexamined Patent Publication No. 2006-219450 Japanese Unexamined Patent Publication No. 2011-153101 Japanese Unexamined Patent Publication No. 2015-853

The present inventor investigated the formulation stability of an oral or external composition containing mentha oil and a phosphocholine group-containing polymer in order to put it into practical use. As a result, precipitation was observed when mentha oil was contained alone. However, when mentha oil coexists with a phosphocholine group-containing polymer, precipitation occurs, and the new problem of reducing the pharmaceutical stability of the oral composition is faced. That is, it has been clarified that the oral or external composition containing mint oil and the phosphocholine group-containing polymer has a peculiar problem of forming a precipitate.

Therefore, an object of the present invention is to provide a formulation technique for suppressing the formation of a precipitate while containing mentha oil, a phosphocholine group-containing polymer, and water in an oral or external composition. ..

The present inventor has made diligent studies to solve the above problems, and found that the composition for oral use or external use contains a quaternary ammonium salt together with mentha oil, a phosphocholine group-containing polymer, and water. It has been found that the formation of precipitates generated in the coexistence of mentha oil and a phosphocholine group-containing polymer can be suppressed. The present invention has been completed by further studies based on such findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. An oral or external composition containing (A) mentha oil, (B) a phosphocholine group-containing polymer, (C) a quaternary ammonium salt, and (D) water.
Item 2. Item 2. The oral or external composition according to Item 1, wherein the component (B) is a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer.
Item 3. Item 2. The oral or external composition according to Item 1 or 2, wherein the component (C) is at least one selected from the group consisting of cetylpyridinium chloride, benzethonium chloride, and benzalkonium chloride.
Item 4. A precipitation inhibitor used to suppress the precipitation of the component (A) in an oral or external composition containing (A) mint oil, (B) a phosphocholine group-containing polymer, and (D) water. ,
A precipitation inhibitor containing a quaternary ammonium salt as an active ingredient.
Item 5. A method for suppressing the precipitation of the component (A) in an oral or external composition containing (A) peppermint oil, (B) a phosphocholine group-containing polymer, and (D) water.
A method for suppressing precipitation, wherein (C) a quaternary ammonium salt is added to the composition for oral use or external use together with the component (A), the component (B) and the component (D).

According to the oral or external composition of the present invention, although it contains mentha oil, a phosphocholine group-containing polymer, and water, it is possible to suppress the precipitation of mentha oil generated in the coexistence state of these components, and it is an excellent preparation. Since it has stability, it can maintain a good appearance shape during storage.

1. 1. Oral or external composition The oral or external composition of the present invention is mint oil (hereinafter, may be referred to as component (A)).
, Phosphocholine group-containing polymer (hereinafter, may be referred to as (B) component), quaternary ammonium salt (hereinafter, may be referred to as (C) component), and water (hereinafter, (D). ) It is characterized by containing (sometimes referred to as a component). Hereinafter, the oral or external composition of the present invention will be described in detail.

(A) Mentha oil The oral or external composition of the present invention contains mint oil as a component (A). Mentha oil is an essential oil obtained by steam-distilling the above-ground part of mentha and cooling the oil to remove solid content. A known ingredient also known as 8006-90-4.

In the oral or external composition of the present invention, the content of the component (A) is not particularly limited and may be appropriately set according to the degree of action of the peppermint oil to be applied, for example, 0. 01 to 2% by weight, preferably 0.03 to 1% by weight, more preferably 0.05 to 0.5% by weight.

(B) Phosphocholine Group-Containing Polymer The oral or external composition of the present invention contains a phosphocholine group-containing polymer as a component (B).

The phosphocholine group-containing polymer is a polymer obtained by polymerizing a monomer containing a phosphocholine group (hereinafter, may be referred to as “phosphocholine group-containing monomer”), and is a known component having a moisturizing effect and the like. ..

In the phosphocholine group-containing polymer, the type of the phosphocholine group-containing monomer is not particularly limited, and examples thereof include a monomer having a phosphocholine group and a vinyl group. More specific examples of the phosphocholine group-containing monomer include 2-methacryloyloxyethyl phosphorylcholine and 2-methacryloyloxyethylphosphorylethanolamine. In the phosphocholine group-containing polymer, the phosphocholine group-containing monomer may be contained alone or in combination of two or more. Among these phosphocholine group-containing monomers, 2-methacryloyloxyethylphosphorylcholine is preferably mentioned from the viewpoint of further improving the effect of suppressing the formation of precipitates of mint oil.

The phosphocholine group-containing polymer used in the present invention may be a homopolymer composed of one kind of phosphocholine group-containing monomer, or may be a copolymer composed of two or more kinds of monomers. good.

When the phosphocholine group-containing polymer is a copolymer, it may be a copolymer composed of two or more kinds of phosphocholine group-containing monomers, and at least one kind of phosphocholine group-containing monomer and at least one kind. It may be a copolymer composed of a monomer other than the phosphocholine group-containing monomer.

The types of monomers other than the phosphocholine group-containing monomer contained in the phosphocholine group-containing polymer are pharmaceutically acceptable and are particularly capable of radical polymerization with a phosphocholine group-containing single amount. Examples include, but are not limited to, monomers having a vinyl group. Specific examples of the monomer other than the phosphocholine group-containing monomer include methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) acrylate, and 2-. Alkyl (meth) acrylates such as ethylhexyl (meth) acrylates; benzyl (meth) acrylates, phenoxyethyl (meth) acrylates, cyclohexyl (meth) acrylates, polypropylene glycol mono (meth) acrylates, polytetramethylene glycol mono (meth) acrylates, Examples thereof include polypropylene glycol di (meth) acrylate, polytetramethylene glycol mono (meth) acrylate, polypropylene glycol polyethylene glycol mono (meth) acrylate, sodium methacrylate, 2-hydroxy-3-methacryloyloxypropyltrimethylammonium and the like. In the phosphocholine group-containing polymer, a monomer other than the phosphocholine group-containing monomer may be contained alone or in combination of two or more. Among the monomers other than these phosphocholine group-containing monomers, alkyl (meth) acrylates are preferable from the viewpoint of further improving the effect of suppressing the formation of precipitates of peppermint oil while effectively exerting a moisturizing effect. 2-Hydroxy-3-methacryloyloxypropyltrimethylammonium, more preferably an alkyl (meth) acrylate having an alkyl group having 1 to 18 carbon atoms, and more preferably an alkyl (meth) acrylate having an alkyl group having 3 to 5 carbon atoms. Particularly preferred are butyl (meth) acrylates. In addition, in this specification, "(meth) acrylate" means a methacrylate and / or an acrylate.

Specific examples of the phosphocholine group-containing polymer used in the present invention include polymethacryloxyethyl phosphorylcholine homopolymer, 2-methacryloyloxyethylphosphorylcholine-butyl methacrylate copolymer (polyquaternium-51), and 2-methacryloyloxy. Ethylenephosphorylcholine, butyl metaerylate, sodium metaerylate copolymer (polyquaternium-65), 2-methacryloyloxyethyl phosphorylcholine, 2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer (polyquaternium-64), 2-methacryloyloxy Examples thereof include an ethylphosphorylcholine / stearyl methacrylate copolymer (polyquaternium-61). In the above notation regarding the phosphocholine group-containing polymer, the names in parentheses indicate the cosmetic ingredient display names.

In the oral or external composition of the present invention, one kind of phosphocholine group-containing polymer may be used as the component (B), or two or more kinds of phosphocholine group-containing polymers may be used in combination. ..

Among these components (B), 2-methacryloyloxyethyl phosphorylcholine and butyl methacrylate are preferable from the viewpoint of further improving the effect of suppressing the formation of precipitates of peppermint oil while effectively exerting the moisturizing effect. Combined, polymethacryloxyethyl phosphorylcholine homopolymer, 2-methacryloxyethylphosphorylcholine, 2-hydroxy-3-methacryloxypropyltrimethylammonium copolymer; more preferably 2-methacryloxyethylphosphorylcholine, butyl methacrylate copolymer. , 2-Methylloyloxyethyl phosphorylcholine 2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer; particularly preferably, 2-methacryloyloxyethylphosphorylcholine / butylmethacrylate copolymer.

The content of the component (B) in the oral or external composition of the present invention is not particularly limited, and examples thereof include 0.05 to 1% by weight of the total amount of the component (B). From the viewpoint of further improving the effect of suppressing the formation of mint oil precipitates while effectively exerting the moisturizing effect, the total amount of the component (B) is preferably 0.05 to 0.5% by weight, more preferably 0. .05-0.3
By weight%, more preferably 0.05 to 0.25% by weight.

In the oral or external composition of the present invention, the ratio of the component (B) to the component (A) is determined according to the contents of the component (A) and the component (B). The total amount of the component (B) is 0.025 to 50 parts by weight per part by weight. As the ratio of the component (B) to the component (A), from the viewpoint of further improving the effect of suppressing the formation of mint oil precipitates while effectively exerting the moisturizing effect, the total amount of the component (A) per 1 part by weight. The total amount of the component (B) is preferably 0.05 to 20 parts by weight, more preferably 0.1 to 10 parts by weight.

(C) Quaternary Ammonium Salt The oral or external composition of the present invention contains a quaternary ammonium salt as a component (C). By containing the quaternary ammonium salt in this way, it becomes possible to suppress the formation of the precipitate of mentha oil generated when the mentha oil and the phosphocholine group-containing polymer coexist and are stored.

The type of the quaternary ammonium salt used in the present invention is not particularly limited as long as it is pharmaceutically acceptable, but for example, a quaternary ammonium salt having a bactericidal action can be preferably used. Specific examples of such a quaternary ammonium salt include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, decalinium chloride, alkyldimethylammonium chloride, alkyltrimethylammonium chloride, methylbenzethonium chloride, and lauroylcolaminoformyl chloride. Methylpyridinium and the like can be mentioned.

In the composition for oral use or external use of the present invention, one kind of quaternary ammonium salt may be used as the component (C), or two or more kinds of quaternary ammonium salts may be used in combination. ..

Among these components (C), cetylpyridinium chloride, benzethonium chloride, and benzalkonium chloride, more preferably cetylpyridinium chloride and, from the viewpoint of further improving the effect of suppressing the formation of precipitates of peppermint oil. Benzalkonium chloride, and particularly preferably cetylpyridinium chloride.

In the oral or external composition of the present invention, the content of the component (C) may be appropriately set according to the type of the component (C) used. For example, the total amount of the component (C) is 0. 005% by weight or more, preferably 0.005 to 2% by weight is mentioned.

More specifically, when cetylpyridinium chloride is used as the component (C), the content of cetylpyridinium chloride is usually 0 from the viewpoint of further improving the effect of suppressing the formation of precipitates of mentha oil. 0.01% by weight or more, preferably 0.01 to 2% by weight, more preferably 0.01 to 1% by weight, and particularly preferably 0.01 to 0.5% by weight.

When benzethonium chloride is used as the component (C), the content of benzethonium chloride is usually 0.005% by weight or more from the viewpoint of further improving the effect of suppressing the formation of precipitates of mentha oil. It is preferably 0.005 to 2% by weight, more preferably 0.008 to 1% by weight, and particularly preferably 0.01 to 0.5% by weight.

When benzalkonium chloride is used as the component (C), the content of benzalkonium chloride is usually 0.005 from the viewpoint of further improving the effect of suppressing the formation of precipitates of mentha oil. By weight or more, preferably 0.005 to 2% by weight, more preferably 0.008 to 1% by weight, and particularly preferably 0.01 to 0.5% by weight.

In the oral or external composition of the present invention, the ratio of the component (C) to the component (A) is determined according to the contents of the component (A) and the component (C). The total amount of the component (C) is 0.001 part by weight or more per 1 part by weight.

More specifically, when cetylpyridinium chloride is used as the component (C), the ratio of cetylpyridinium chloride to the component (A) is from the viewpoint of further improving the effect of suppressing the formation of precipitates of peppermint oil. Therefore, cetylpyridinium chloride is 0.002 parts by weight or more, preferably 0.005 to 200 parts by weight, more preferably 0.01 to 34 parts by weight, and particularly preferably 0.02, per 1 part by weight of the component (A). Up to 10 parts by weight can be mentioned.

When benzethonium chloride is used as the component (C), the component (A) is used as the ratio of benzethonium chloride to the component (A) from the viewpoint of further improving the effect of suppressing the formation of deposits of peppermint oil. Cetylpyridinium chloride is 0.001 part by weight or more, preferably 0.0025 to 200 parts by weight, more preferably 0.008 to 34 parts by weight, and particularly preferably 0.02 to 10 parts by weight per 1 part by weight. Be done.

In addition, when benzalkonium chloride is used as the component (C), the ratio of benzalkonium chloride to the component (A) is from the viewpoint of further improving the effect of suppressing the formation of the precipitate of peppermint oil. (A) Benzalkonium chloride is 0.00 per 1 part by weight of the total amount of the component
1 part by weight or more, preferably 0.0025 to 200 parts by weight, more preferably 0.008 to 34 parts by weight, and particularly preferably 0.02 to 10 parts by weight.

(D) Water The oral or external composition of the present invention contains water as a base. The component (A) tends to cause precipitation when stored in a state of coexistence with the component (B) in the presence of water, but according to the oral or external composition of the present invention, such (A) Precipitation of components can be effectively suppressed.

In the oral or external composition of the present invention, the content of the component (D) is appropriately set according to the pharmaceutical form and the like, and is, for example, 1 to 95% by weight, preferably 3 to 95% by weight. More preferably, it is 5 to 95% by weight.

Other Ingredients In addition to the above-mentioned ingredients, the oral or external composition of the present invention is usually used in the art as long as the effect of the present invention is not impaired, depending on the form of the oral or external composition. May contain components. Such ingredients include, for example, preservatives, bactericides, antibacterial agents, anti-inflammatory agents, abrasives, glucosyltransferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, tartar preventives, dentin strengthening / re-strengthening agents. Examples thereof include calcifying agents, antihistamines, local anesthetics, blood circulation promoters, thickeners, wetting agents, excipients, fragrances, sweeteners, pigments, deodorants, surfactants, solvents, pH adjusters and the like.

Examples of preservatives, bactericides and antibacterial agents include hinokithiol, benzoic acids, salicylic acids, sorbic acids, parabens, chlorhexidine chloride, chlorhexidine gluconate, isopropylmethylphenol, triclosan, lysozyme chloride, chlorhexidine hydrochloride, potassium iodide and the like. Can be mentioned.

Examples of the anti-inflammatory agent include dipotassium glycyrrhizinate, glycyrrhetinic acid, methyl glycyrrhizinate, stearyl glycyrrhizinate, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glycyrrhetinate, monoglucuronide glycyrrhetinate, allantoin, tranexamic acid, and azulene aminocaproic acid. , Sodium chloride, vitamins and the like.

Examples of the polishing agent include anhydrous silicic acid, hydrous silicic acid, aluminum oxide, aluminum hydroxide, calcium hydrogen phosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, crystalline cellulose, polyethylene powder, charcoal granules and the like.

Examples of the GTase inhibitor include an extract of the evening primrose genus plant of the evening primrose family, an extract of the genus Grapevine plant of the vine family family, dextranase, mutanase, tastain, tannins, ellagic acid, polyphenol, oolong tea extract, green tea extract, and the like. Examples include senburi, evening primrose, uikyo, sardine, gentiana, senso, dragon bile, and yellow primrose.

Examples of the plaque inhibitor include zinc citrate and gluconic acid.

Examples of the hypersensitivity inhibitor include potassium nitrate, strontium chloride and the like.

Examples of the tartar preventive agent include polyphosphates, zeolites, ethanehydroxydiphosphonates and the like.

Examples of the tooth substance strengthening / remineralizing agent include fluorine, sodium fluoride, sodium fluorophosphate, stannous fluoride and the like.

Examples of the antihistamine include diphenhydramine, diphenhydramine hydrochloride and the like.

Examples of the local anesthetic include procaine, tetracaine, bupipacaine, mepipacine, chloroprocaine, proparakine, meprilcaine or salts thereof, orthocaine, oxesazein, oxypolyentoxydecane, scopolia extract, percamin pase, tesitdecitin and the like.

Examples of the blood circulation promoting agent include nonyl acid vanillylamide, nicotinic acid benzyl ester, capsaicin, and capsicum extract.

Examples of the thickener include polysaccharides such as purulan, purulan derivatives, and starch; hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl methyl cellulose, carboxymethyl cellulose, and carboxymethyl cellulose salts (sodium carboxymethyl cellulose, potassium carboxymethyl cellulose, etc.). , Methyl cellulose, Ethyl cellulose, Polyacrylic acid, Polyacrylic acid salt (sodium alginate, acrylate / acrylate octyl ester copolymer, etc.), Polymers of methacrylic acids (methacrylic acid and n-butyl acrylate) Polymers, polymers of methacrylic acid and methyl methacrylic acid, polymers of methacrylic acid and ethyl acrylate, etc.) and other cellulose-based polymer substances; synthesis of carboxyvinyl polymers, polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, etc. Polymeric substances; lectin, alginate, alginate (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, triisopropanolamine alginate, ammonium alginate, butylamine alginate, diamylamine alginate, etc.), sodium chondroitin sulfate, Natural polymer substances such as agar, chitosan, and carrageenan; Amino acid polymer substances such as collagen and gelatin; Rubber polymer substances such as Arabic gum, Karaya gum, Tragacanth gum, Xanthan gum, Locust bean gum, Gua gum, Tamarind gum, Gellan gum, etc. And so on.

Examples of the wetting agent include glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactol, and erythritol.

Examples of the excipient include lactose, sucrose, mannitol, starch, dextrin, crystalline cellulose, silica (light anhydrous silicic acid and the like) and the like.

Examples of the fragrance include natural fragrances (fennel oil and the like), synthetic fragrances, and blended fragrances thereof.

Examples of the sweetener include sodium saccharin, stebioside, stevia extract, aspartame, xylitol, water candy, honey, sorbitol, maltitol, mannitol, erythritol, sugars (lactose, sucrose, fructose, glucose, etc.).

Examples of the dye include natural dyes, synthetic dyes, and mixtures thereof.

Examples of the deodorant include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, gobo powder, green tea, roasted rice bran extract and the like.

Examples of the surfactant include polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristolyl sulcocinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride. Anionic surfactants such as sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, sodium N-palmitoyl glutarumate, sodium N-methyl-N-acyltaurine; polyoxyethylene hydrogenated castor oil, sho Sugar fatty acid ester, maltose fatty acid ester, maltol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan monostearate, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene poly Nonionic surfactants such as oxypropylene fatty acid ester and polyglycerin fatty acid ester; coconut oil fatty acid amide propyl betaine, lauryl dimethylamino acetate betaine, lauryl dimethyl amine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole Amphoteric surfactants such as lumbetaine, N-lauryl diaminoethyl glycine, N-myristyl diaminoethyl glycine, N-alkyl-1-hydroxyethyl imidazoline betaine sodium; lauryl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride Such as cationic surfactants.

Examples of the solvent include monohydric alcohols such as ethanol, propanol, butanol, pentanol, hexanol and isopropanol.

Examples of the pH adjuster include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, malic acid, lactic acid, phosphoric acid, benzoic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, and citric acid. Examples thereof include sodium hydrogen hydrogen, sodium lactate, calcium lactate, sodium phosphate, sodium hydrogen phosphate, sodium benzoate and the like.

When these components are contained in the oral or external composition of the present invention, the content thereof may be appropriately set within the range normally used in the art.

pH
The pH of the oral or external composition of the present invention may be appropriately set within a range where intraoral application or transdermal application is permitted. For example, 4 to 8, preferably 5 to 7. 5, more preferably 6 to 7. Here, the pH is a value measured under a temperature condition of 25 ° C.

Formulation form

The oral or external composition of the present invention may be either an oral composition applied intraorally or an external composition applied transdermally, and an oral composition is preferable.

The dosage form of the oral or external composition of the present invention is not particularly limited as long as it can be applied intraorally or transdermally, and is, for example, liquid or semi-solid (gel-like or paste-like). ).

When the oral or external composition of the present invention is used as an oral composition, the formulation form thereof is not particularly limited as long as it is applied to the oral cavity and can stay in the oral cavity for a certain period of time, but is not particularly limited, for example, a liquid. Toothpaste, liquid dentifrice, kneaded dentifrice, mouthwash (liquid dentifrice, mouthwash may be generally referred to as mouth rinse, mouth wash, dental rinse, etc.), mouth refreshing agent (mouth spray, etc.) ), Oral hygiene agents such as oral ointments. Among these, liquid dentifrice, liquid dentifrice, dentifrice, mouthwash, and more preferably liquid dentifrice, dentifrice, mouthwash may be mentioned.

When the oral or external composition of the present invention is used as an external composition, the formulation form thereof is not particularly limited, but for example, a gel agent, a cream agent, a lotion agent, a milky lotion agent, a liquid agent, a patch, or an aerosol. Examples thereof include external skin medicines such as agents, ointments and packs; cosmetics such as gels, creams, milky lotions, lotions, lotions, packs and ointments; and skin cleaning agents such as body shampoos, hair shampoos and rinses. Among these formulation forms, preferably skin external medicines and cosmetics, more preferably skin external medicines such as gels, creams, lotions and emulsions; cosmetics such as gels, creams, emulsions and lotions can be mentioned. ..

The properties of the oral or external composition of the present invention are not particularly limited, but it is desirable that the composition is translucent, particularly transparent (including both colored transparent and colorless transparent). In the oral or external composition having translucency (particularly transparency), the produced precipitate is easily visible and the appearance is easily deteriorated, but in the oral or external composition of the present invention, the precipitate is easily recognized. Since the formation of light can be suppressed, a good appearance can be maintained even if the property has translucency (particularly transparency).

2. 2. Mentha Oil Precipitation Inhibitor and Method for Inhibiting Precipitation of Mentha Oil As described above, the quaternary ammonium salt is used for precipitation of mentha oil in an oral or external composition containing mentha oil, a phosphocholine group-containing polymer and water. Can be suppressed. Therefore, the present invention is a precipitation inhibitor used for suppressing the precipitation of mentha oil in an oral or external composition containing mentha oil, a phosphocholine group-containing polymer, and water, and is quaternary. Provided is a precipitation inhibitor containing an ammonium salt as an active ingredient. In addition, the present invention is a quaternary composition in an oral or external composition containing mentha oil, a phosphocholine group-containing polymer, and water, together with mentha oil, a phosphocholine group-containing polymer, and water in the oral or external composition. Provided is a method for suppressing precipitation, which comprises blending an ammonium salt.

The precipitation inhibitor is used as an additive for a quaternary ammonium salt, and the precipitate inhibitor method utilizes a quaternary ammonium salt and contains peppermint oil, a phosphocholine group-containing polymer, and water. This is a method for suppressing the precipitation of peppermint oil in an oral or external composition.

The types and amounts of the components used in the precipitation inhibitor and the precipitation inhibitor method, the form of the oral composition, and the like are as shown in the column of "1. Oral or external composition".

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Test Example 1
The liquid preparations having the compositions shown in Table 1 were prepared under a temperature condition of 50 ° C., 5 mL of the obtained liquid preparation was filled in a glass screw tube bottle (capacity 6 mL), and allowed to stand at 4 ° C. for 3 days under light-shielding conditions. .. The appearance of each liquid after standing for 3 days was observed, and the degree of precipitation formation was evaluated according to the criteria shown below. In addition, no precipitate was observed in any of the liquids immediately after preparation, and the appearance was clear. <Criteria for determining the degree of precipitate formation>
⊚: No precipitates were observed, and a clear state could be maintained.
◯: Precipitates were generated only slightly, but the overall clear state could be maintained.
X: A large amount of precipitates are generated, and the clear state is lost.
XX: Remarkably large amounts of precipitates are formed, and the clear state is lost.

The results obtained are shown in Table 1. In the liquid preparation containing mint oil alone (Reference Example 1), no precipitation was observed after storage. On the other hand, in the liquid preparation containing peppermint oil and a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer (Comparative Examples 1 and 2), the formation of precipitates was observed after storage. On the other hand, a liquid preparation containing a quaternary ammonium salt (cetylpyridinium chloride, benzalkonium chloride, and / or benzethonium chloride) together with peppermint oil and a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer (Example). In 1 to 12), the formation of precipitates could be suppressed after storage, and a clear appearance property could be maintained. When a liquid preparation having the composition shown in Table 1 was prepared by the same method as in Test Example 1 and allowed to stand at 25 ° C. for 3 days under light-shielding conditions for evaluation, the same tendency was observed regarding the degree of precipitation formation. It was seen.

Examples of formulations : Kneaded toothpaste having the composition shown in Table 2, mouthwash or liquid dentifrice having the composition shown in Table 3, mouth spray having the composition shown in Table 4, oral ointment having the composition shown in Table 5, and showing in Table 6. An oral solution having the composition shown in Table 7, an external lotion having the composition shown in Table 7, an external gel agent having the composition shown in Table 8, an external cream agent having the composition shown in Table 9, and an external emulsion agent having the composition shown in Table 10 were produced. In Tables 2 to 10, the unit of the content of each component is% by weight. For each of the obtained oral compositions and external compositions, the formation of precipitates could be suppressed after storage.

Claims (5)

It contains (A) mentha oil, (B) a phosphocholine group-containing polymer, (C) a quaternary ammonium salt, and (D) water.
The total amount of the component (B) per 1 part by weight of the component (A) is 0.5 to 10 parts by weight.
An oral composition in which the total amount of the component (C) per part by weight of the component (A) is 0.01 parts by weight or more. The oral composition according to claim 1, wherein the component (B) is a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. The oral composition according to claim 1 or 2, wherein the component (C) is at least one selected from the group consisting of cetylpyridinium chloride, benzethonium chloride, and benzalkonium chloride. For oral use, which contains (A) mentha oil, (B) phosphocholine group-containing polymer, and (D) water, and the total amount of (B) component per 1 part by weight of (A) component is 0.5 to 10 parts by weight. A precipitation inhibitor used to suppress the precipitation of the component (A) in the composition.
Using quaternary ammonium salt as an active ingredient
A precipitation inhibitor having a usage amount of 0.01 parts by weight or more per 1 part by weight of the component (A) of the quaternary ammonium salt. For oral cavity containing (A) mentha oil, (B) phosphocholine group-containing polymer, and (D) water, and the total amount of (B) component per 1 part by weight of (A) component is 0.5 to 10 parts by weight. A method for suppressing precipitation, which suppresses precipitation of the component (A) in the composition.
In the oral composition, the component (A), the component (B) and the component (D), as well as the (C) quaternary ammonium salt, and the total amount of the component (C) per part by weight of the component (A) A method for suppressing precipitation, which comprises blending so that the amount is 0.01 parts by weight or more.