JP2019043914A - Skin external preparation - Google Patents
Skin external preparation Download PDFInfo
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- JP2019043914A JP2019043914A JP2017170902A JP2017170902A JP2019043914A JP 2019043914 A JP2019043914 A JP 2019043914A JP 2017170902 A JP2017170902 A JP 2017170902A JP 2017170902 A JP2017170902 A JP 2017170902A JP 2019043914 A JP2019043914 A JP 2019043914A
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- external preparation
- skin
- skin external
- feeling
- ascorbic acid
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- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 12
- 239000000194 fatty acid Substances 0.000 claims abstract description 12
- 229930195729 fatty acid Natural products 0.000 claims abstract description 12
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 12
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001651 pyrus cydonia seed extract Substances 0.000 claims abstract description 8
- 125000003289 ascorbyl group Chemical class [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims abstract description 4
- 229940105990 diglycerin Drugs 0.000 claims description 7
- 230000003020 moisturizing effect Effects 0.000 abstract description 12
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 10
- 238000002156 mixing Methods 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 235000010323 ascorbic acid Nutrition 0.000 description 4
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000010561 standard procedure Methods 0.000 description 4
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 description 3
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 3
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 3
- 240000000912 Macadamia tetraphylla Species 0.000 description 3
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- -1 ascorbic acid palmitate ester Chemical class 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940071097 ascorbyl phosphate Drugs 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical group CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- 235000017788 Cydonia oblonga Nutrition 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- IWWCATWBROCMCW-UHFFFAOYSA-N batyl alcohol Natural products CCCCCCCCCCCCCCCCCCOC(O)CO IWWCATWBROCMCW-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000002942 palmitic acid derivatives Chemical class 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、アスコルビン酸誘導体及びその塩から選択される１種又は２種以上を含有する、皮膚外用剤に関する。 The present invention relates to a skin external preparation containing one or more kinds selected from ascorbic acid derivatives and salts thereof.
小じわ改善、美白などを目的とした有効成分を含有する様々な化粧料が開発され、有効成分の効果に加え、使い心地の良さを考えた様々な感触の製品が発売されている。
例えば、特許文献１には、アルキル変性カルボキシビニルポリマー、アスコルビン酸硫酸エステル二ナトリウム、ヒドロキシプロピルセルロースを含有する乳化物が記載され、特許文献２には、アルキル変性カルボキシビニルポリマー、アスコルビン酸パルミチン酸エステルを含有する乳化物が記載されている。
Various cosmetic compositions containing active ingredients for the purpose of improving fine lines, whitening and the like have been developed, and products with various feels in consideration of comfort are added to the effects of the active ingredients.
For example, Patent Document 1 describes an emulsion containing an alkyl-modified carboxyvinyl polymer, ascorbic acid sulfuric acid ester disodium, hydroxypropyl cellulose, and Patent Document 2 discloses an alkyl-modified carboxyvinyl polymer, ascorbic acid palmitate ester. An emulsion containing is described.
しかしながら、これらの化粧料では、塗布しやすいようにとろみをだすため、水溶性ポリマーを配合しており、塗布時に化粧料のべたつきが生じ、いつまでも肌の上に残ったような膜感を感じ、保湿感にも改善の余地があることが分かった。
そこで本発明は、使用時のべたつきや膜感がなく、保湿感に優れた皮膚外用剤を提供することを課題とする。
However, these cosmetics contain a water-soluble polymer to make them easy to apply, so that the cosmetic becomes sticky at the time of application and feels like a film that remains on the skin for a long time, It turned out that there is room for improvement in the feeling of moisture.
Therefore, it is an object of the present invention to provide a skin external preparation which is free from stickiness and film feeling during use and is excellent in moisturizing feeling.
（１）
下記の（Ａ）〜（Ｃ）を含有する皮膚外用剤。
（Ａ）アスコルビン酸誘導体及びその塩から選択される１種又は２種以上
（Ｂ）クインスシードエキス
（Ｃ）ジグリセリン
(1)
The skin external preparation containing the following (A)-(C).
(A) At least one ascorbic acid derivative and salts thereof (B) quince seed extract (C) diglycerin
（２） さらに
（Ｄ）高級脂肪酸フィトステリル
を含有する請求項１に記載の皮膚外用剤。
(2) The external preparation for skin according to claim 1, further comprising (D) higher fatty acid phytosteryl.
本発明の皮膚外用剤は、使用時のべたつきや膜感がなく、かつ高い保湿効果を発揮する。 The external preparation for skin of the present invention does not have stickiness or feel during use, and exhibits high moisturizing effect.
以下本発明を実施するための形態を説明する。 Hereinafter, modes for carrying out the present invention will be described.
本発明の皮膚外用剤は、下記の（Ａ）〜（Ｃ）を必須成分として含有する。
（Ａ）アスコルビン酸誘導体及びその塩から選択される１種又は２種以上
（Ｂ）クインスシードエキス
（Ｃ）ジグリセリン
The skin external preparation of the present invention contains the following (A) to (C) as essential components.
(A) At least one ascorbic acid derivative and salts thereof (B) quince seed extract (C) diglycerin
本発明の皮膚外用剤に配合する（Ａ）アスコルビン酸誘導体及びその塩から選択される１種又は２種以上は、通常化粧料、医薬部外品に配合し得るものであれば特に限定されない。アスコルビン酸誘導体として具体的には、ビタミンＣ誘導体としてパルミチン酸アスコルビルリン酸３Ｎａ、テトラヘキシルデカン酸アスコルビル、（アスコルビル／トコヘリル）リン酸Ｋ、アスコルビン酸−２リン酸−６パルミチン酸、Ｌ‐アスコルビン酸２‐グルコシド、アスコルビルリン酸Ｎａ、アスコルビルリン酸Ｍｇ等が例示される。
本発明においては、その効果の点からパルミチン酸アスコルビルリン酸３Ｎａを用いることが最も好ましい。
The (A) ascorbic acid derivative to be blended in the external preparation for skin of the present invention and one or more species selected from the salts thereof are not particularly limited as long as they can be generally blended in cosmetics and quasi-drugs. As an ascorbic acid derivative, specifically, ascorbic acid palmitate 3 Na as palmitic acid derivative, ascorbyl tetrahexyl decanoic acid, ascorbic acid (ascorbyl / tocopheryl) phosphate K, ascorbic acid-2 phosphate 6 palmitic acid, L-ascorbic acid 2 And glucoside, ascorbyl phosphate Na, ascorbyl phosphate Mg and the like.
In the present invention, it is most preferable to use ascorbic acid palmitate 3Na from the viewpoint of the effect.
これらのアスコルビン酸誘導体及びその塩から選択される１種又は２種以上は、１種を単独で使用してもよく、また２種以上を組み合わせて使用してもよい。これらのアスコルビン酸及びその誘導体の中でも、安定性や美白効果等の観点から、好ましくはアスコルビン酸の誘導体、更に好ましくはアスコルビン酸２−グルコシドが挙げられる。アスコルビン酸誘導体及びその塩から選択される１種又は２種以上の配合量は、皮膚外用剤全量に対し０．０５〜５質量％が好ましい。０．０５質量％未満の配合ではアスコルビン酸及びその塩の皮膚への有効性が発揮されない場合がある。５質量％を超えて配合すると、使用感がべたつく原因となり得る。 One or more selected from these ascorbic acid derivatives and salts thereof may be used alone or in combination of two or more. Among these ascorbic acids and their derivatives, preferred are ascorbic acid derivatives, more preferably ascorbic acid 2-glucoside, from the viewpoint of stability and whitening effect. The blending amount of one or more selected from the ascorbic acid derivative and a salt thereof is preferably 0.05 to 5% by mass with respect to the total amount of the external skin preparation. If the amount is less than 0.05% by mass, the effectiveness of ascorbic acid and its salts on the skin may not be exhibited. Blending in excess of 5% by mass may cause the feeling of use to be sticky.
本発明の皮膚外用剤に配合する（Ｂ）クインスシードエキスは、マルメロの木の種子より得られる抽出物であり、市販されているものを用いることができる。クインスシードエキスを得る際の抽出溶媒としては、水を用いることが好ましい。 The quince seed extract (B) to be added to the external preparation for skin of the present invention is an extract obtained from seeds of a quince tree, and commercially available ones can be used. It is preferable to use water as an extraction solvent at the time of obtaining a quince seed extract.
本発明の皮膚外用剤におけるクインスシードエキスの配合量は、エキス純分として皮膚外用剤全量に対して０．００５〜０．１質量％が好ましく、特に同０．００５〜０．０５質量％が好ましい。皮膚外用剤全量に対して０．００５質量％未満の配合量であるとアスコルビン酸誘導体による膜感を十分に抑制することができず、また同０．１質量％を超えて配合すると肌に高分子特有の皮膜が形成され、使用感触が損なわれることになり好ましくなく、かつ保管中などにゲル状に変化するなど安定性に問題がある。 The blending amount of quince seed extract in the external preparation for skin of the present invention is preferably 0.005 to 0.1% by mass, and particularly preferably 0.005 to 0.05% by mass based on the total amount of external preparation for the extract as a pure component. preferable. If the blending amount is less than 0.005% by mass with respect to the total amount of the external skin preparation, the film feeling by the ascorbic acid derivative can not be sufficiently suppressed, and if it is incorporated in more than 0.1% by mass A film specific to the molecule is formed, which is not preferable because the feeling in use is impaired, and there is a problem with stability such as a gel-like change during storage or the like.
本発明の皮膚外用剤に配合する（Ｃ）ジグリセリンは、通常化粧料、医薬部外品に用いられ得るものであれば特に限定されず、市販されているものを用いることができる。 The (C) diglycerin to be added to the external preparation for skin of the present invention is not particularly limited as long as it can be used for ordinary cosmetics and quasi-drugs, and commercially available ones can be used.
本発明におけるジグリセリンの配合量は、皮膚外用剤全量に対して１〜２０質量％が好ましく、特に同１〜１０質量％が好ましい。 The blending amount of diglycerin in the present invention is preferably 1 to 20% by mass, particularly preferably 1 to 10% by mass, with respect to the total amount of the skin external preparation.
本発明においては、ジグリセリンと合わせて、他の多価アルコールを併用して用いることが好ましい。かかる多価アルコールとしては、グリセリン、１，３−ブチレングリコール、ジプロピレングリコール等が挙げられる。本発明の皮膚外用剤においては、これらの保湿剤の配合量を調整することにより、使用感を調整することが可能となる。 In the present invention, it is preferable to use other polyhydric alcohol in combination with diglycerin. Examples of such polyhydric alcohols include glycerin, 1,3-butylene glycol, dipropylene glycol and the like. In the external preparation for skin of the present invention, it is possible to adjust the feeling of use by adjusting the blending amount of these moisturizers.
本発明の皮膚外用剤は、さらに高級脂肪酸フィトステリルを配合することにより、より高い保湿効果を発揮する。高級脂肪酸フィトステリルとしては、イソステアリン酸フィトステリル、コメヌカ油脂肪酸フィトステリル、ヒマワリ種子油脂肪酸フィトステリル、マカデミアナッツ脂肪酸フィトステリル等が例示される。本発明においては、その効果の点からマカデミアナッツ脂肪酸フィトステリルを用いることが好ましい。 The external preparation for skin of the present invention exerts a higher moisturizing effect by further blending higher fatty acid phytosteryl. Examples of higher fatty acid phytosteryl include phytosteryl isostearate, rice bran oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, macadamia nut fatty acid phytosteryl and the like. In the present invention, it is preferable to use macadamia nut fatty acid phytosteryl from the viewpoint of its effect.
高級脂肪酸フィトステリルの配合量は、皮膚外用剤の剤型、求められる使用感によって変化するが０．３〜１０質量％の配合が好ましい。 The blending amount of higher fatty acid phytosteryl varies depending on the form of the external preparation for skin and the feeling of use required, but a blending of 0.3 to 10% by mass is preferable.
本発明の皮膚外用剤は、上述の成分の他に、通常の化粧料、医薬部外品に用いられる任意成分を、本発明の効果を阻害しない程度に配合することができる。具体的には、油剤、界面活性剤、増粘剤、防腐剤、香料、保湿剤、抗酸化剤、抗炎症剤、抗菌剤等を挙げることができる。 The external preparation for skin of the present invention can contain, in addition to the above-mentioned components, optional components used for ordinary cosmetics and quasi-drugs as long as the effects of the present invention are not inhibited. Specifically, oil agents, surfactants, thickeners, preservatives, perfumes, moisturizers, antioxidants, anti-inflammatory agents, antibacterial agents and the like can be mentioned.
本発明の皮膚外用剤の剤型は、乳化型であることが好ましく、さらに水中油乳化型化粧料であることが好ましい。 The formulation of the external preparation for skin of the present invention is preferably an emulsion type, and more preferably an oil-in-water emulsion cosmetic.
本発明の皮膚外用剤は定法により調製することができる。 The skin external preparation of the present invention can be prepared by a conventional method.
本発明の皮膚外用剤は、例えば、ローション剤、乳剤、軟膏の剤型で用いることができる。 The external preparation for skin of the present invention can be used, for example, in the form of lotion, emulsion and ointment.
以下、実施例により本発明を具体的に説明するが、これにより本発明の範囲が限定されるものではない。なお、配合量は特に断りのない限り質量％である。 EXAMPLES Hereinafter, the present invention will be specifically described by way of examples, but the scope of the present invention is not limited thereby. In addition, a compounding quantity is mass% unless there is particular notice.
まず、本発明の実施例及び比較例の評価方法を示す。 First, the evaluation method of the Example of this invention and a comparative example is shown.
＜べたつき評価＞
本発明の皮膚外用剤を定法により塗布した後、３名の専門パネルを用いて官能的に評価した。実施例及び比較例の各試料を塗布後のべたつきについて合議により下記の３段階で評価した。なお、官能評価は実施例、比較例を区別がつかない状態で使用し、絶対評価で評価を行った。以下の官能試験も同様である。
○：あまりべたつかない
△：少しべたつく
×：非常にべたつく
<Evaluation of stickiness>
After the skin external preparation of the present invention was applied by a standard method, it was evaluated sensoryally using three expert panels. Each sample of the example and the comparative example was evaluated by the following three stages by consultation about the stickiness after application. In addition, sensory evaluation used an Example and a comparative example in the state which can not be distinguished, and evaluated by absolute evaluation. The following sensory test is also the same.
○: not very sticky :: slightly sticky ×: very sticky
＜膜感評価＞
本発明の皮膚外用剤を定法により塗布した後、３名の専門パネルを用いて官能的に評価した。実施例及び比較例の各試料を塗布後の膜感について合議により下記の３段階で評価した。
○：ちょうどいい膜感がある
△：少し膜感が気になる
×：かなり膜感が気になる
<Evaluation of film feeling>
After the skin external preparation of the present invention was applied by a standard method, it was evaluated sensoryally using three expert panels. Each sample of the example and the comparative example was evaluated by the following three steps about the film feeling after application.
○: There is a good feeling of film 少 し: A little feeling of film feeling ×: A considerable feeling of film feeling
＜保湿効果感評価＞
本発明の皮膚外用剤を定法により塗布した後、３名の専門パネルを用いて官能的に評価した。実施例及び比較例の各試料を塗布後の保湿効果感について合議により下記の４段階で評価した。
◎：保湿効果感が非常に良い
○：保湿効果感がよい
△：保湿効果感があまり良くない
×：保湿効果感が悪い
<Moisturizing effect feeling evaluation>
After the skin external preparation of the present invention was applied by a standard method, it was evaluated sensoryally using three expert panels. Each sample of the example and the comparative example was evaluated by the following four steps by consultation about the moisturizing effect feeling after application.
:: very good moisturizing effect ○: good moisturizing effect △: poorly moisturizing effect ×: poor moisturizing effect
表１に示す処方を用い、実施例１、２及び比較例１〜３を定法により調製した。 Using the formulations shown in Table 1, Examples 1 and 2 and Comparative Examples 1 to 3 were prepared by a standard method.
表１に示した通り、本発明の皮膚外用剤である実施例１は、アスコルビン酸誘導体塩を配合しているにもかかわらず、使用時のべたつきや膜感がなく、保湿効果を発揮する使用感であった。またさらにバチルアルコールの一部を高級脂肪酸フィトステリルであるマカデミアナッツ脂肪酸フィトステリルに代替した実施例２は実施例１の使用感に加え、高い保湿効果を発揮する使用感であった。これに対し、ジグリセリンをＢＧに代替した比較例１は、非常にべたつきが、少し膜感が気になる使用感であった。また、クインスシードエキスをグリセリンに代替した比較例２は、少しべたつきが、かなり膜感が気になる使用感であった。 As shown in Table 1, Example 1 which is an external preparation for skin of the present invention is a use that exerts a moisturizing effect without stickiness or film feeling at the time of use, even though it contains an ascorbic acid derivative salt. It was a feeling. Furthermore, in addition to the feeling of use of Example 1, Example 2 in which a part of batyl alcohol was replaced with macadamia nut fatty acid phytosteryl, which is higher fatty acid phytosteryl, had a feeling of use that exhibited a high moisturizing effect. On the other hand, Comparative Example 1 in which diglycerin was substituted for BG was very sticky, but had a feeling of use in which the film feeling was a little anxious. Moreover, Comparative Example 2 in which the quince seed extract was replaced with glycerin had a slight stickiness and a feeling of use that the film feeling was considerably anxious.
Claims (2)
（Ａ）アスコルビン酸誘導体及びその塩から選択される１種又は２種以上
（Ｂ）クインスシードエキス
（Ｃ）ジグリセリン The skin external preparation containing the following (A)-(C).
(A) At least one ascorbic acid derivative and salts thereof (B) quince seed extract (C) diglycerin
（Ｄ）高級脂肪酸フィトステリル
を含有する請求項１に記載の皮膚外用剤。 The skin external preparation according to claim 1, further comprising (D) higher fatty acid phytosteryl.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004002281A (en) * | 2002-03-27 | 2004-01-08 | Kose Corp | Liquid cosmetic |
| JP2007204399A (en) * | 2006-01-31 | 2007-08-16 | Haba Laboratories Inc | Water-in-oil type emulsion composition |
| JP2010189363A (en) * | 2009-02-20 | 2010-09-02 | Seiwa Kasei Co Ltd | Cosmetic |
| JP2013136544A (en) * | 2011-12-28 | 2013-07-11 | Kao Corp | Gelled skin care preparation |
| JP2013209320A (en) * | 2012-03-30 | 2013-10-10 | Kose Corp | Liposome composition incorporated with ascorbic acid derivative |
| JP2017114845A (en) * | 2015-09-29 | 2017-06-29 | 富士フイルム株式会社 | Transparent cosmetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004002281A (en) * | 2002-03-27 | 2004-01-08 | Kose Corp | Liquid cosmetic |
| JP2007204399A (en) * | 2006-01-31 | 2007-08-16 | Haba Laboratories Inc | Water-in-oil type emulsion composition |
| JP2010189363A (en) * | 2009-02-20 | 2010-09-02 | Seiwa Kasei Co Ltd | Cosmetic |
| JP2013136544A (en) * | 2011-12-28 | 2013-07-11 | Kao Corp | Gelled skin care preparation |
| JP2013209320A (en) * | 2012-03-30 | 2013-10-10 | Kose Corp | Liposome composition incorporated with ascorbic acid derivative |
| JP2017114845A (en) * | 2015-09-29 | 2017-06-29 | 富士フイルム株式会社 | Transparent cosmetic |
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