JP2018538290A5 - - Google Patents
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- Publication number
- JP2018538290A5 JP2018538290A5 JP2018529574A JP2018529574A JP2018538290A5 JP 2018538290 A5 JP2018538290 A5 JP 2018538290A5 JP 2018529574 A JP2018529574 A JP 2018529574A JP 2018529574 A JP2018529574 A JP 2018529574A JP 2018538290 A5 JP2018538290 A5 JP 2018538290A5
- Authority
- JP
- Japan
- Prior art keywords
- estradiol
- vaginal
- vaginal suppository
- administration
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006216 vaginal suppository Substances 0.000 claims 73
- 229940120293 vaginal suppository Drugs 0.000 claims 59
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 56
- 229960005309 estradiol Drugs 0.000 claims 56
- 229930182833 estradiol Natural products 0.000 claims 56
- 230000036470 plasma concentration Effects 0.000 claims 17
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 11
- 239000007788 liquid Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 208000004483 Dyspareunia Diseases 0.000 claims 4
- 206010047791 Vulvovaginal dryness Diseases 0.000 claims 4
- 239000000227 bioadhesive Substances 0.000 claims 4
- 230000002354 daily effect Effects 0.000 claims 4
- 238000011156 evaluation Methods 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 4
- 239000005556 hormone Substances 0.000 claims 4
- 238000011179 visual inspection Methods 0.000 claims 4
- 239000007903 gelatin capsule Substances 0.000 claims 3
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 3
- 239000002736 nonionic surfactant Substances 0.000 claims 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- -1 C12 fatty acids Chemical class 0.000 claims 2
- 206010057671 Female sexual dysfunction Diseases 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 2
- 210000003905 vulva Anatomy 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 241001313288 Labia Species 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010046788 Uterine haemorrhage Diseases 0.000 claims 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 claims 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 claims 1
- 230000037007 arousal Effects 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 210000003756 cervix mucus Anatomy 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 206010013990 dysuria Diseases 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 230000003203 everyday effect Effects 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 230000007794 irritation Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 238000005461 lubrication Methods 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 230000036299 sexual function Effects 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021070619A JP2021119155A (ja) | 2015-12-07 | 2021-04-19 | 膣挿入エストラジオール医薬組成物および方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264309P | 2015-12-07 | 2015-12-07 | |
| US62/264,309 | 2015-12-07 | ||
| US201662296552P | 2016-02-17 | 2016-02-17 | |
| US62/296,552 | 2016-02-17 | ||
| US201662324838P | 2016-04-19 | 2016-04-19 | |
| US62/324,838 | 2016-04-19 | ||
| US201662329940P | 2016-04-29 | 2016-04-29 | |
| US62/329,940 | 2016-04-29 | ||
| US201662348820P | 2016-06-10 | 2016-06-10 | |
| US62/348,820 | 2016-06-10 | ||
| PCT/US2016/065466 WO2017100378A2 (en) | 2015-12-07 | 2016-12-07 | Vaginal inserted estradiol pharmaceutical compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021070619A Division JP2021119155A (ja) | 2015-12-07 | 2021-04-19 | 膣挿入エストラジオール医薬組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018538290A JP2018538290A (ja) | 2018-12-27 |
| JP2018538290A5 true JP2018538290A5 (cg-RX-API-DMAC7.html) | 2020-01-30 |
Family
ID=59014200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018529574A Pending JP2018538290A (ja) | 2015-12-07 | 2016-12-07 | 膣挿入エストラジオール医薬組成物および方法 |
| JP2021070619A Pending JP2021119155A (ja) | 2015-12-07 | 2021-04-19 | 膣挿入エストラジオール医薬組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021070619A Pending JP2021119155A (ja) | 2015-12-07 | 2021-04-19 | 膣挿入エストラジオール医薬組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3386514A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2018538290A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180100567A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016366200B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018011483A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3007636A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL259884A (cg-RX-API-DMAC7.html) |
| MX (1) | MX384850B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017100378A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR120360A1 (es) * | 2019-10-31 | 2022-02-09 | Scherer Technologies Llc R P | Cápsula de supositorio |
| KR102696460B1 (ko) | 2021-01-20 | 2024-08-22 | 주식회사 바이올렛드림 | 질 내 수용성 겔 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2739558B1 (fr) * | 1995-10-05 | 1997-11-28 | Innothera Lab Sa | Forme galenique unitaire pour hormonotherapie locale de la secheresse vaginale |
| US6117446A (en) * | 1999-01-26 | 2000-09-12 | Place; Virgil A. | Drug dosage unit for buccal administration of steroidal active agents |
| SG155258A1 (en) * | 2004-10-20 | 2009-09-30 | Endorech Inc | Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cgmp phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausa |
| US10806697B2 (en) * | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| MX393195B (es) * | 2012-06-18 | 2025-03-24 | Therapeuticsmd Inc | Capsula de estradiol soluble para insercion por via vaginal |
| US9180091B2 (en) * | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
-
2016
- 2016-12-07 JP JP2018529574A patent/JP2018538290A/ja active Pending
- 2016-12-07 WO PCT/US2016/065466 patent/WO2017100378A2/en not_active Ceased
- 2016-12-07 KR KR1020187019331A patent/KR20180100567A/ko not_active Ceased
- 2016-12-07 CA CA3007636A patent/CA3007636A1/en active Pending
- 2016-12-07 BR BR112018011483A patent/BR112018011483A2/pt not_active Application Discontinuation
- 2016-12-07 MX MX2018006882A patent/MX384850B/es unknown
- 2016-12-07 EP EP16873806.0A patent/EP3386514A4/en not_active Withdrawn
- 2016-12-07 AU AU2016366200A patent/AU2016366200B2/en not_active Ceased
-
2018
- 2018-06-07 IL IL259884A patent/IL259884A/en unknown
-
2021
- 2021-04-19 JP JP2021070619A patent/JP2021119155A/ja active Pending
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