JP2018537968A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018537968A5 JP2018537968A5 JP2018522020A JP2018522020A JP2018537968A5 JP 2018537968 A5 JP2018537968 A5 JP 2018537968A5 JP 2018522020 A JP2018522020 A JP 2018522020A JP 2018522020 A JP2018522020 A JP 2018522020A JP 2018537968 A5 JP2018537968 A5 JP 2018537968A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- light chain
- antibody
- rabbit
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 16
- 230000009261 transgenic effect Effects 0.000 claims description 16
- 108060003951 Immunoglobulin Proteins 0.000 claims description 15
- 102000018358 immunoglobulin Human genes 0.000 claims description 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 108091026890 Coding region Proteins 0.000 claims description 6
- 108700019146 Transgenes Proteins 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 2
- 101150117115 V gene Proteins 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000004777 loss-of-function mutation Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15192002.2A EP3184547A1 (en) | 2015-10-29 | 2015-10-29 | Anti-tpbg antibodies and methods of use |
| EP15192002.2 | 2015-10-29 | ||
| EP16162580 | 2016-03-29 | ||
| EP16162580.1 | 2016-03-29 | ||
| PCT/EP2016/075882 WO2017072208A1 (en) | 2015-10-29 | 2016-10-27 | Transgenic rabbit with common light chain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537968A JP2018537968A (ja) | 2018-12-27 |
| JP2018537968A5 true JP2018537968A5 (cg-RX-API-DMAC7.html) | 2019-11-21 |
| JP7085992B2 JP7085992B2 (ja) | 2022-06-17 |
Family
ID=57233408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522020A Active JP7085992B2 (ja) | 2015-10-29 | 2016-10-27 | 共通軽鎖を有するトランスジェニックウサギ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230332175A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3367786A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7085992B2 (cg-RX-API-DMAC7.html) |
| CN (3) | CN108347906A (cg-RX-API-DMAC7.html) |
| HK (1) | HK1258306A1 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202006332PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017072208A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20250348A (es) | 2018-03-12 | 2025-09-23 | Genmab As | ANTICUERPOS QUE SE UNEN A 5T4 (Divisional 2020-463) |
| US12467062B2 (en) | 2018-12-21 | 2025-11-11 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| IL298632A (en) * | 2020-06-02 | 2023-01-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Non-human animals genetically modified with a common light chain immunoglobulin locus |
| EP4242232A4 (en) * | 2020-11-06 | 2024-09-11 | Bio-Thera Solutions, Ltd. | BISPECIFIC ANTIBODY AND ITS USE |
| CN115702931A (zh) * | 2021-08-06 | 2023-02-17 | 百奥泰生物制药股份有限公司 | 抗pd-l1/cd47双特异抗体在治疗疾病中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4213224B2 (ja) * | 1997-05-02 | 2009-01-21 | ジェネンテック，インコーポレーテッド | ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法 |
| WO2000046251A2 (en) * | 1999-02-05 | 2000-08-10 | Buelow Jens Ulrich | Human polyclonal antibodies from transgenic nonhuman animals |
| US7129084B2 (en) * | 2000-08-03 | 2006-10-31 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
| CN103205436B (zh) * | 2003-07-15 | 2016-05-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| WO2006047367A2 (en) * | 2004-10-22 | 2006-05-04 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglubolin expression in non-human transgenic animals |
| CN101263158B (zh) * | 2005-08-03 | 2011-12-28 | 人类多克隆治疗股份有限公司 | 表达人源化免疫球蛋白的转基因动物中b细胞凋亡的抑制 |
| SG174053A1 (en) * | 2006-09-01 | 2011-09-29 | Therapeutic Human Polyclonals Inc | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| DK2280732T3 (en) | 2008-04-28 | 2019-01-28 | Humanigen Inc | ANTIBODIES AGAINST GRANULOCYT MACROPHAG COLONY STIMULATING FACTOR |
| EA201170028A1 (ru) | 2008-07-02 | 2011-12-30 | Эмерджент Продакт Дивелопмент Сиэтл, Ллс | СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ TNF-α |
| EP2315777B1 (en) | 2008-07-08 | 2017-04-26 | Geneuro SA | Therapeutic use of specific ligand in msrv associated diseases |
| WO2010032059A2 (en) * | 2008-09-19 | 2010-03-25 | Medimmune Llc | Targeted binding agents directed to cd105 and uses thereof |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| JP6016800B2 (ja) * | 2010-12-15 | 2016-10-26 | ワイス・エルエルシー | 抗ノッチ１抗体 |
| ES2740749T3 (es) * | 2012-04-20 | 2020-02-06 | Merus Nv | Métodos y medios para la producción de moléculas heterodiméricas similares a Ig |
| WO2014022540A1 (en) * | 2012-08-02 | 2014-02-06 | Regeneron Pharmaceuticals, Inc. | Multivalent antigen-binding proteins |
| DK2900694T3 (en) * | 2012-09-27 | 2018-11-19 | Merus Nv | BISPECIFIC IGG ANTIBODIES AS T-CELL ACTIVATORS |
| JP6267792B2 (ja) * | 2013-06-28 | 2018-01-24 | アムジエン・インコーポレーテツド | ホモ接合性家族性高コレステロール血症の治療方法 |
| HUE046249T2 (hu) | 2013-12-12 | 2020-02-28 | Shanghai hengrui pharmaceutical co ltd | PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása |
| US10844127B2 (en) | 2014-02-28 | 2020-11-24 | Merus N.V. | Antibodies that bind EGFR and ErbB3 |
| EP3825326A1 (en) * | 2014-04-01 | 2021-05-26 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
-
2016
- 2016-10-27 WO PCT/EP2016/075882 patent/WO2017072208A1/en not_active Ceased
- 2016-10-27 HK HK19100672.4A patent/HK1258306A1/zh unknown
- 2016-10-27 JP JP2018522020A patent/JP7085992B2/ja active Active
- 2016-10-27 SG SG10202006332PA patent/SG10202006332PA/en unknown
- 2016-10-27 CN CN201680063211.7A patent/CN108347906A/zh active Pending
- 2016-10-27 CN CN202111178978.3A patent/CN113897371A/zh active Pending
- 2016-10-27 SG SG11201802698XA patent/SG11201802698XA/en unknown
- 2016-10-27 CN CN202111174951.7A patent/CN113862300A/zh active Pending
- 2016-10-27 EP EP16790926.6A patent/EP3367786A1/en active Pending
-
2022
- 2022-11-02 US US18/052,113 patent/US20230332175A1/en active Pending