JP2018537968A5 - - Google Patents
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- Publication number
- JP2018537968A5 JP2018537968A5 JP2018522020A JP2018522020A JP2018537968A5 JP 2018537968 A5 JP2018537968 A5 JP 2018537968A5 JP 2018522020 A JP2018522020 A JP 2018522020A JP 2018522020 A JP2018522020 A JP 2018522020A JP 2018537968 A5 JP2018537968 A5 JP 2018537968A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- light chain
- antibody
- rabbit
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 16
- 230000009261 transgenic effect Effects 0.000 claims description 16
- 108060003951 Immunoglobulin Proteins 0.000 claims description 15
- 102000018358 immunoglobulin Human genes 0.000 claims description 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 108091026890 Coding region Proteins 0.000 claims description 6
- 108700019146 Transgenes Proteins 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 2
- 101150117115 V gene Proteins 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000004777 loss-of-function mutation Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15192002.2A EP3184547A1 (en) | 2015-10-29 | 2015-10-29 | Anti-tpbg antibodies and methods of use |
| EP15192002.2 | 2015-10-29 | ||
| EP16162580 | 2016-03-29 | ||
| EP16162580.1 | 2016-03-29 | ||
| PCT/EP2016/075882 WO2017072208A1 (en) | 2015-10-29 | 2016-10-27 | Transgenic rabbit with common light chain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537968A JP2018537968A (ja) | 2018-12-27 |
| JP2018537968A5 true JP2018537968A5 (cg-RX-API-DMAC10.html) | 2019-11-21 |
| JP7085992B2 JP7085992B2 (ja) | 2022-06-17 |
Family
ID=57233408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522020A Active JP7085992B2 (ja) | 2015-10-29 | 2016-10-27 | 共通軽鎖を有するトランスジェニックウサギ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230332175A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3367786A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP7085992B2 (cg-RX-API-DMAC10.html) |
| CN (3) | CN108347906A (cg-RX-API-DMAC10.html) |
| HK (1) | HK1258306A1 (cg-RX-API-DMAC10.html) |
| SG (2) | SG10202006332PA (cg-RX-API-DMAC10.html) |
| WO (1) | WO2017072208A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA52152A (fr) | 2018-03-12 | 2021-01-20 | Genmab As | Anticorps |
| EP3897117A1 (en) * | 2018-12-21 | 2021-10-27 | Compass Therapeutics LLC | Transgenic mouse expressing common human light chain |
| US12674001B2 (en) | 2019-09-12 | 2026-07-07 | Genmab A/S | Method of treating cancer by administering an antibody which binds to 5T4 |
| CN115667532A (zh) * | 2020-06-02 | 2023-01-31 | 百奥赛图(北京)医药科技股份有限公司 | 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物 |
| WO2022095970A1 (zh) * | 2020-11-06 | 2022-05-12 | 百奥泰生物制药股份有限公司 | 双特异抗体及其应用 |
| CN115702931A (zh) * | 2021-08-06 | 2023-02-17 | 百奥泰生物制药股份有限公司 | 抗pd-l1/cd47双特异抗体在治疗疾病中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0979281B1 (en) * | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| DE60023451T2 (de) * | 1999-02-05 | 2006-07-20 | Therapeutic Human Polyclonals, Inc., Mountain View | Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper |
| IL154751A0 (en) * | 2000-08-03 | 2003-10-31 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals | |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| US20080184380A1 (en) * | 2004-10-22 | 2008-07-31 | Therapeutic Human Polyclonals Inc. | Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals |
| ES2347979T3 (es) * | 2005-08-03 | 2010-11-26 | Therapeutic Human Polyclonals, Inc. | Supresion de la apoptosis en linfocitos b en animales transgenicos que expresan inmunoglobulina humanizada. |
| EP2064325B1 (en) * | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| WO2009082624A2 (en) * | 2007-12-10 | 2009-07-02 | Zymogenetics, Inc. | Antagonists of il-17a, il-17f, and il-23 and methods of using the same |
| KR101824512B1 (ko) * | 2008-04-28 | 2018-02-02 | 휴머니건, 아이엔씨. | 과립구-대식세포 콜로니 자극 인자에 대한 항체 |
| KR20110044991A (ko) * | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | ＴＮＦ-α 길항제 다-표적 결합 단백질 |
| DK3211005T3 (da) * | 2008-07-08 | 2021-06-07 | Geneuro Sa | Terapeutisk anvendelse af specifik ligand i msrv-associerede sygdomme |
| CA2737667A1 (en) * | 2008-09-19 | 2010-03-25 | Medimmune, Llc | Targeted binding agents directed to cd105 and uses thereof |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| WO2012080926A2 (en) * | 2010-12-15 | 2012-06-21 | Wyeth Llc | Anti-notch1 antibodies |
| WO2013157953A1 (en) * | 2012-04-20 | 2013-10-24 | Merus B.V. | Methods and means for the production of ig-like molecules |
| US20150203591A1 (en) * | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| BR112015006824A2 (pt) * | 2012-09-27 | 2017-07-04 | Merus B V | anticorpo igg biespecífico, método para produzir um anticorpo igg biespecífico, anticorpo, composição farmacêutica e uso de um anticorpo igg biespecífico |
| JP6267792B2 (ja) * | 2013-06-28 | 2018-01-24 | アムジエン・インコーポレーテツド | ホモ接合性家族性高コレステロール血症の治療方法 |
| CR20160319A (es) * | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
| CA2941030C (en) * | 2014-02-28 | 2025-05-13 | Merus N.V. | ANTIBODIES THAT BIND TO EGFR AND ERBB3 |
| EP4050026A1 (en) * | 2014-04-01 | 2022-08-31 | Adimab, LLC | Method of obtaining or identifying one or more common light chains for use in preparing a multispecific antibody |
-
2016
- 2016-10-27 HK HK19100672.4A patent/HK1258306A1/zh unknown
- 2016-10-27 SG SG10202006332PA patent/SG10202006332PA/en unknown
- 2016-10-27 SG SG11201802698XA patent/SG11201802698XA/en unknown
- 2016-10-27 JP JP2018522020A patent/JP7085992B2/ja active Active
- 2016-10-27 CN CN201680063211.7A patent/CN108347906A/zh active Pending
- 2016-10-27 WO PCT/EP2016/075882 patent/WO2017072208A1/en not_active Ceased
- 2016-10-27 EP EP16790926.6A patent/EP3367786A1/en active Pending
- 2016-10-27 CN CN202111178978.3A patent/CN113897371A/zh active Pending
- 2016-10-27 CN CN202111174951.7A patent/CN113862300A/zh active Pending
-
2022
- 2022-11-02 US US18/052,113 patent/US20230332175A1/en active Pending