JP2018534910A - 免疫細胞、特にｃｄ５６＋ ｎｋ細胞の同定のためのエピジェネティックマーカーとしてのｍｖｄ - Google Patents

免疫細胞、特にｃｄ５６＋ ｎｋ細胞の同定のためのエピジェネティックマーカーとしてのｍｖｄ Download PDF

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JP2018534910A
JP2018534910A JP2018512289A JP2018512289A JP2018534910A JP 2018534910 A JP2018534910 A JP 2018534910A JP 2018512289 A JP2018512289 A JP 2018512289A JP 2018512289 A JP2018512289 A JP 2018512289A JP 2018534910 A JP2018534910 A JP 2018534910A
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cells
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region
methylation
cpg
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JP2018534910A5 (enExample
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オレク，スフェン
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エピオンティス ゲーエムベーハー
エピオンティス ゲーエムベーハー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biotechnology (AREA)
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  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018512289A 2015-09-25 2016-09-22 免疫細胞、特にｃｄ５６＋ ｎｋ細胞の同定のためのエピジェネティックマーカーとしてのｍｖｄ Pending JP2018534910A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1516971.7A GB201516971D0 (en) 2015-09-25 2015-09-25 MVD as epigenetic marker for the identification of immune cells, in particular CD56+ NK cells
GB1516971.7 2015-09-25
PCT/EP2016/072522 WO2017050882A1 (en) 2015-09-25 2016-09-22 Mvd as epigenetic marker for the identification of immune cells, in particular cd56+ nk cells

Publications (2)

Publication Number Publication Date
JP2018534910A true JP2018534910A (ja) 2018-11-29
JP2018534910A5 JP2018534910A5 (enExample) 2019-10-31

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JP2018512289A Pending JP2018534910A (ja) 2015-09-25 2016-09-22 免疫細胞、特にｃｄ５６＋ ｎｋ細胞の同定のためのエピジェネティックマーカーとしてのｍｖｄ

Country Status (8)

Country Link
US (1) US11788141B2 (enExample)
EP (1) EP3353321B1 (enExample)
JP (1) JP2018534910A (enExample)
CN (1) CN108026577B (enExample)
CA (1) CA2995350A1 (enExample)
GB (1) GB201516971D0 (enExample)
HK (1) HK1257705A1 (enExample)
WO (1) WO2017050882A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017125013B4 (de) * 2017-10-25 2019-10-17 Epiontis Gmbh MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten
DE102018112644B4 (de) 2018-05-25 2020-06-10 Epiontis Gmbh CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen
DE102018116353B4 (de) 2018-07-05 2020-06-10 Epiontis Gmbh Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening
CN119372341B (zh) * 2024-12-30 2025-04-11 北京致谱医学检验实验室有限公司 基于基因甲基化检测实现人nk淋巴细胞计数的试剂盒

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060057564A1 (en) * 2001-08-10 2006-03-16 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2010125106A1 (en) * 2009-04-28 2010-11-04 Epiontis Gmbh Epigenetic marker for the identification of natural killer cells
WO2013014122A1 (en) * 2011-07-22 2013-01-31 Epiontis Gmbh Epigenetic marker for the identification of natural killer cells
US20130129668A1 (en) * 2011-09-01 2013-05-23 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1826279T3 (da) * 2006-02-28 2011-09-05 Charite Universitaetsmedizin Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet
US8216786B2 (en) * 2008-07-09 2012-07-10 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
CN102343086A (zh) * 2010-05-28 2012-02-08 四川大学 治疗或预防肿瘤的药物、肿瘤全细胞疫苗及其制备方法和用途
CA2814150A1 (en) * 2010-10-08 2012-04-12 Epiontis Gmbh Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060057564A1 (en) * 2001-08-10 2006-03-16 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2010125106A1 (en) * 2009-04-28 2010-11-04 Epiontis Gmbh Epigenetic marker for the identification of natural killer cells
WO2013014122A1 (en) * 2011-07-22 2013-01-31 Epiontis Gmbh Epigenetic marker for the identification of natural killer cells
US20130129668A1 (en) * 2011-09-01 2013-05-23 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics

Also Published As

Publication number Publication date
EP3353321A1 (en) 2018-08-01
CN108026577B (zh) 2022-09-23
EP3353321B1 (en) 2020-11-04
WO2017050882A1 (en) 2017-03-30
CA2995350A1 (en) 2017-03-30
HK1257705A1 (zh) 2019-10-25
GB201516971D0 (en) 2015-11-11
CN108026577A (zh) 2018-05-11
US20180237855A1 (en) 2018-08-23
US11788141B2 (en) 2023-10-17

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