JP2018533579A - 高分子量かつ密な被覆を有する粘液浸透粒子 - Google Patents

高分子量かつ密な被覆を有する粘液浸透粒子 Download PDF

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Publication number
JP2018533579A
JP2018533579A JP2018522081A JP2018522081A JP2018533579A JP 2018533579 A JP2018533579 A JP 2018533579A JP 2018522081 A JP2018522081 A JP 2018522081A JP 2018522081 A JP2018522081 A JP 2018522081A JP 2018533579 A JP2018533579 A JP 2018533579A
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JP
Japan
Prior art keywords
peg
poly
mucus
particles
kda
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JP2018522081A
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English (en)
Japanese (ja)
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JP2018533579A5 (enExample
Inventor
ジャスティン ヘインズ，
ジャスティン ヘインズ，
カサリーナ マイセル，
カサリーナ マイセル，
ローラ エム． エンサイン，
ローラ エム． エンサイン，
リチャード コーン，
リチャード コーン，
Original Assignee
ザ・ジョンズ・ホプキンス・ユニバーシティー
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Publication of JP2018533579A publication Critical patent/JP2018533579A/ja
Publication of JP2018533579A5 publication Critical patent/JP2018533579A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
JP2018522081A 2015-10-30 2016-10-31 高分子量かつ密な被覆を有する粘液浸透粒子 Pending JP2018533579A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562248432P 2015-10-30 2015-10-30
US62/248,432 2015-10-30
PCT/US2016/059661 WO2017075565A1 (en) 2015-10-30 2016-10-31 Mucus penetrating particles with high molecular weight and dense coatings

Publications (2)

Publication Number Publication Date
JP2018533579A true JP2018533579A (ja) 2018-11-15
JP2018533579A5 JP2018533579A5 (enExample) 2019-12-12

Family

ID=57288512

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018522081A Pending JP2018533579A (ja) 2015-10-30 2016-10-31 高分子量かつ密な被覆を有する粘液浸透粒子

Country Status (8)

Country Link
US (1) US10668025B2 (enExample)
EP (1) EP3368008A1 (enExample)
JP (1) JP2018533579A (enExample)
KR (1) KR20180075650A (enExample)
CN (1) CN108472250A (enExample)
AU (1) AU2016343840A1 (enExample)
CA (1) CA3003733C (enExample)
WO (1) WO2017075565A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022130270A (ja) * 2021-02-25 2022-09-06 シンバイオシス株式会社 腸管吸収用補助剤及びその利用方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957034B2 (en) * 2004-01-28 2015-02-17 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
WO2011106702A2 (en) 2010-02-25 2011-09-01 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
WO2012076877A1 (en) 2010-12-06 2012-06-14 Autifony Therapeutics Limited Hydantoin derivatives useful as kv3 inhibitors
AU2012351994B2 (en) * 2011-12-14 2015-11-05 The Johns Hopkins University Nanoparticles with enhanced mucosal penetration or decreased inflammation
WO2019175290A1 (en) 2018-03-13 2019-09-19 Beckley Canopy Therapeutics Limited Cannabis or cannabis derived compositions for promoting cessation of chemical dependence
CA3110773C (en) 2018-09-11 2023-02-28 Lead Biotherapeutics Ltd. Mucoadhesive dispersion nanoparticle system and method for production the same
EP4164598A1 (en) * 2020-06-11 2023-04-19 Janssen Biotech, Inc. Controlled release of self-embedding particles for localized drug delivery

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015505855A (ja) * 2011-12-14 2015-02-26 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘膜浸透が増強されたかまたは炎症が低減されたナノ粒子

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US8957034B2 (en) * 2004-01-28 2015-02-17 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
ES2360538T3 (es) * 2006-09-08 2011-06-06 Johns Hopkins University Composiciones para aumentar el transporte a través de moco.
WO2012039979A2 (en) * 2010-09-10 2012-03-29 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
CA2816977C (en) * 2010-11-05 2019-10-29 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
ES2385995B2 (es) * 2011-01-10 2013-05-21 Universidade De Santiago De Compostela Nanocápsulas con cubierta polimérica
KR101811917B1 (ko) * 2012-01-19 2017-12-22 더 존스 홉킨스 유니버시티 점액 침투 강화를 나타내는 나노 입자 제형
NZ741873A (en) * 2012-05-03 2019-04-26 Kala Pharmaceuticals Inc Pharmaceutical nanoparticles showing improved mucosal transport
KR102154880B1 (ko) 2012-05-03 2020-09-10 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
HK1208377A1 (en) * 2012-05-04 2016-03-04 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015505855A (ja) * 2011-12-14 2015-02-26 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘膜浸透が増強されたかまたは炎症が低減されたナノ粒子

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022130270A (ja) * 2021-02-25 2022-09-06 シンバイオシス株式会社 腸管吸収用補助剤及びその利用方法

Also Published As

Publication number Publication date
CA3003733C (en) 2021-04-20
CA3003733A1 (en) 2017-05-04
WO2017075565A1 (en) 2017-05-04
AU2016343840A1 (en) 2018-06-07
KR20180075650A (ko) 2018-07-04
CN108472250A (zh) 2018-08-31
US20180221293A1 (en) 2018-08-09
US10668025B2 (en) 2020-06-02
EP3368008A1 (en) 2018-09-05

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