CN108472250A - 高分子量粘液穿透颗粒和致密涂层 - Google Patents

高分子量粘液穿透颗粒和致密涂层 Download PDF

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Publication number
CN108472250A
CN108472250A CN201680075874.0A CN201680075874A CN108472250A CN 108472250 A CN108472250 A CN 108472250A CN 201680075874 A CN201680075874 A CN 201680075874A CN 108472250 A CN108472250 A CN 108472250A
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CN
China
Prior art keywords
peg
poly
mucus
kda
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680075874.0A
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English (en)
Chinese (zh)
Inventor
J·哈尼斯
K·梅塞尔
L·M·恩塞恩
R·康
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CN108472250A publication Critical patent/CN108472250A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
CN201680075874.0A 2015-10-30 2016-10-31 高分子量粘液穿透颗粒和致密涂层 Pending CN108472250A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562248432P 2015-10-30 2015-10-30
US62/248,432 2015-10-30
PCT/US2016/059661 WO2017075565A1 (en) 2015-10-30 2016-10-31 Mucus penetrating particles with high molecular weight and dense coatings

Publications (1)

Publication Number Publication Date
CN108472250A true CN108472250A (zh) 2018-08-31

Family

ID=57288512

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680075874.0A Pending CN108472250A (zh) 2015-10-30 2016-10-31 高分子量粘液穿透颗粒和致密涂层

Country Status (8)

Country Link
US (1) US10668025B2 (enExample)
EP (1) EP3368008A1 (enExample)
JP (1) JP2018533579A (enExample)
KR (1) KR20180075650A (enExample)
CN (1) CN108472250A (enExample)
AU (1) AU2016343840A1 (enExample)
CA (1) CA3003733C (enExample)
WO (1) WO2017075565A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072710A2 (en) * 2004-01-28 2005-08-11 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
EP2538929A4 (en) 2010-02-25 2014-07-09 Univ Johns Hopkins DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE
US9346790B2 (en) 2010-12-06 2016-05-24 Autifony Therapeutics Limited Hydantoin derivatives useful as Kv3 inhibitors
CA2859046C (en) * 2011-12-14 2019-10-22 The Johns Hopkins University Nanoparticles with enhanced mucosal penetration or decreased inflammation
WO2019175290A1 (en) 2018-03-13 2019-09-19 Beckley Canopy Therapeutics Limited Cannabis or cannabis derived compositions for promoting cessation of chemical dependence
JP7164700B2 (ja) 2018-09-11 2022-11-01 リードバイオセラピューティクスリミテッド 粘膜付着性分散ナノ粒子系およびその製造方法
WO2020210805A1 (en) 2019-04-11 2020-10-15 The Johns Hopkins University Nanoparticles for drug delivery to brain
EP4164598A1 (en) * 2020-06-11 2023-04-19 Janssen Biotech, Inc. Controlled release of self-embedding particles for localized drug delivery
JP2022130270A (ja) * 2021-02-25 2022-09-06 シンバイオシス株式会社 腸管吸収用補助剤及びその利用方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013090804A2 (en) * 2011-12-14 2013-06-20 The Johns Hopkins University Nanoparticles with enhanced mucosal penetration or decreased inflammation
US20130183244A1 (en) * 2010-09-10 2013-07-18 The Johns Hopkins University Rapid Diffusion of Large Polymeric Nanoparticles in the Mammalian Brain
US20130236556A1 (en) * 2010-11-05 2013-09-12 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
CN103596558A (zh) * 2011-01-10 2014-02-19 圣地亚哥德孔波斯特拉大学 聚合物壳纳米微胶囊
CN104661647A (zh) * 2012-05-03 2015-05-27 卡拉制药公司 显示提高的粘膜转移的药物纳米粒子
CN104936620A (zh) * 2012-01-19 2015-09-23 约翰霍普金斯大学 增强粘膜渗透的纳米粒子调配物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
WO2005072710A2 (en) * 2004-01-28 2005-08-11 Johns Hopkins University Drugs and gene carrier particles that rapidly move through mucous barriers
CA2663003C (en) * 2006-09-08 2018-02-13 Justin Hanes Compositions and methods for enhancing transport through mucus
WO2013166408A1 (en) * 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
HK1208377A1 (en) * 2012-05-04 2016-03-04 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130183244A1 (en) * 2010-09-10 2013-07-18 The Johns Hopkins University Rapid Diffusion of Large Polymeric Nanoparticles in the Mammalian Brain
US20130236556A1 (en) * 2010-11-05 2013-09-12 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
CN103596558A (zh) * 2011-01-10 2014-02-19 圣地亚哥德孔波斯特拉大学 聚合物壳纳米微胶囊
WO2013090804A2 (en) * 2011-12-14 2013-06-20 The Johns Hopkins University Nanoparticles with enhanced mucosal penetration or decreased inflammation
CN104936620A (zh) * 2012-01-19 2015-09-23 约翰霍普金斯大学 增强粘膜渗透的纳米粒子调配物
CN104661647A (zh) * 2012-05-03 2015-05-27 卡拉制药公司 显示提高的粘膜转移的药物纳米粒子

Also Published As

Publication number Publication date
CA3003733A1 (en) 2017-05-04
AU2016343840A1 (en) 2018-06-07
CA3003733C (en) 2021-04-20
EP3368008A1 (en) 2018-09-05
WO2017075565A1 (en) 2017-05-04
KR20180075650A (ko) 2018-07-04
US10668025B2 (en) 2020-06-02
JP2018533579A (ja) 2018-11-15
US20180221293A1 (en) 2018-08-09

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Application publication date: 20180831

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