JP2018532403A5 - - Google Patents
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- Publication number
- JP2018532403A5 JP2018532403A5 JP2018516030A JP2018516030A JP2018532403A5 JP 2018532403 A5 JP2018532403 A5 JP 2018532403A5 JP 2018516030 A JP2018516030 A JP 2018516030A JP 2018516030 A JP2018516030 A JP 2018516030A JP 2018532403 A5 JP2018532403 A5 JP 2018532403A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- item
- tissue
- guide rna
- genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234340P | 2015-09-29 | 2015-09-29 | |
| US62/234,340 | 2015-09-29 | ||
| PCT/US2016/053960 WO2017058793A1 (en) | 2015-09-29 | 2016-09-27 | Delivery methods and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532403A JP2018532403A (ja) | 2018-11-08 |
| JP2018532403A5 true JP2018532403A5 (cg-RX-API-DMAC7.html) | 2019-10-31 |
Family
ID=58408949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516030A Pending JP2018532403A (ja) | 2015-09-29 | 2016-09-27 | 送達方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20170087224A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3355954A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018532403A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108601883A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016332704A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2999922A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1258900A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017058793A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| CN114098949B (zh) | 2016-06-27 | 2023-12-19 | 盖能适治疗股份有限公司 | 发生器和具有电极的导管 |
| KR102827276B1 (ko) | 2016-08-03 | 2025-07-01 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN110214180A (zh) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | 核碱基编辑器的aav递送 |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| CN111683613B (zh) | 2017-12-26 | 2024-05-28 | 盖能适治疗股份有限公司 | 用于各种应用的能量输送的优化 |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020015279A1 (zh) * | 2018-07-17 | 2020-01-23 | 杭州观梓健康科技有限公司 | 一种在干细胞中进行基因定向敲入的方法 |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| WO2020102532A1 (en) * | 2018-11-15 | 2020-05-22 | President And Fellows Of Harvard College | Genetically engineered skin cells for the systemic in vivo treatment of deficient enzymes, factors or proteins |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| CN114072527B (zh) * | 2019-03-25 | 2025-03-04 | 香港中文大学 | 确定循环核酸的线性和环状形式 |
| IL285920B2 (en) * | 2019-04-08 | 2025-03-01 | Velanidi Tech Llc | System, apparatus and method for sensing, detecting and effecting in a micro-to-nano environment |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| AU2021267940A1 (en) | 2020-05-08 | 2022-12-08 | President And Fellows Of Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| AU2021281307A1 (en) * | 2020-05-29 | 2022-12-15 | Georgia Tech Research Corporation | Devices, systems, and methods for facilitating tissue delivery of drug |
| CN116829691A (zh) * | 2020-08-04 | 2023-09-29 | 盖能适治疗股份有限公司 | 分子到体内细胞的脉冲电场转移 |
| CN112807273B (zh) * | 2021-02-23 | 2022-06-17 | 浙江大学 | 一种治疗炎症性皮肤病的基因编辑微针及其应用 |
| JP2023094496A (ja) * | 2021-12-23 | 2023-07-05 | 委子 陌間 | 抗菌・ウイルス治療薬の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
| JP2004535813A (ja) * | 2001-07-17 | 2004-12-02 | ミルナー，アン，ジョセフィーヌ | 遺伝子発現のサイレンシング |
| AU2011213242B2 (en) * | 2010-02-08 | 2015-01-29 | Sangamo Therapeutics, Inc. | Engineered cleavage half-domains |
| US10537725B2 (en) * | 2010-03-05 | 2020-01-21 | Cornell University | Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly |
| WO2015089465A1 (en) * | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders |
| JP2017506893A (ja) * | 2014-02-18 | 2017-03-16 | デューク ユニバーシティ | ウイルス複製不活化組成物並びにその製造方法及び使用 |
| US20160060655A1 (en) * | 2014-05-30 | 2016-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods to treat latent viral infections |
| JP2018516984A (ja) * | 2015-05-29 | 2018-06-28 | アジェノビア コーポレーション | 細胞を標的にしたｈｐｖ処置のための組成物および方法 |
| EP3420077A4 (en) * | 2016-02-25 | 2019-12-25 | Agenovir Corporation | VIRAL AND ONCOVIRAL NUCLEASE TREATMENT |
-
2016
- 2016-09-27 EP EP16852411.4A patent/EP3355954A4/en not_active Withdrawn
- 2016-09-27 US US15/277,595 patent/US20170087224A1/en not_active Abandoned
- 2016-09-27 CA CA2999922A patent/CA2999922A1/en not_active Abandoned
- 2016-09-27 AU AU2016332704A patent/AU2016332704A1/en not_active Abandoned
- 2016-09-27 HK HK19101376.1A patent/HK1258900A1/zh unknown
- 2016-09-27 CN CN201680068693.5A patent/CN108601883A/zh active Pending
- 2016-09-27 JP JP2018516030A patent/JP2018532403A/ja active Pending
- 2016-09-27 WO PCT/US2016/053960 patent/WO2017058793A1/en not_active Ceased
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