JP2018531218A5 - - Google Patents
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- Publication number
- JP2018531218A5 JP2018531218A5 JP2018507641A JP2018507641A JP2018531218A5 JP 2018531218 A5 JP2018531218 A5 JP 2018531218A5 JP 2018507641 A JP2018507641 A JP 2018507641A JP 2018507641 A JP2018507641 A JP 2018507641A JP 2018531218 A5 JP2018531218 A5 JP 2018531218A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- tautomer
- pharmaceutically acceptable
- acceptable salt
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 229910052794 bromium Inorganic materials 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- -1 hydroxyethyl group Chemical group 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005257 alkyl acyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510484124.6 | 2015-08-07 | ||
| CN201510484124 | 2015-08-07 | ||
| CN201510908082 | 2015-12-09 | ||
| CN201510908082.4 | 2015-12-09 | ||
| PCT/CN2016/092989 WO2017024968A1 (zh) | 2015-08-07 | 2016-08-03 | 作为fgfr和vegfr抑制剂的乙烯基化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531218A JP2018531218A (ja) | 2018-10-25 |
| JP2018531218A6 JP2018531218A6 (ja) | 2018-12-13 |
| JP2018531218A5 true JP2018531218A5 (OSRAM) | 2019-09-19 |
| JP6898306B2 JP6898306B2 (ja) | 2021-07-07 |
Family
ID=57983012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507641A Active JP6898306B2 (ja) | 2015-08-07 | 2016-08-03 | Ｆｇｆｒ及びｖｅｇｆｒ阻害剤であるビニル化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10519133B2 (OSRAM) |
| EP (1) | EP3333157B1 (OSRAM) |
| JP (1) | JP6898306B2 (OSRAM) |
| CN (1) | CN107922349B (OSRAM) |
| WO (1) | WO2017024968A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6803410B2 (ja) * | 2017-02-14 | 2020-12-23 | 富士フイルム株式会社 | インダゾール化合物の製造方法およびインダゾール化合物 |
| JP6974618B2 (ja) * | 2017-12-07 | 2021-12-01 | ハルビン チェンバオ ファーマシューティカル カンパニー リミテッド | Ｆｇｆｒ及びｖｅｇｆｒ阻害剤としての化合物の塩形態、結晶形およびその製造方法 |
| CN113490667B (zh) * | 2018-12-29 | 2023-10-27 | 盛世泰科生物医药技术(苏州)股份有限公司 | 作为fgfr和vegfr双重抑制剂的咪唑并吡啶衍生物 |
| KR102754529B1 (ko) * | 2019-02-02 | 2025-01-14 | 노바온코 제이에스 테라퓨틱스 컴퍼니 리미티드 | Pd-l1 면역조절제인 플루오로 비닐 벤즈아미드 화합물 |
| WO2020156564A1 (zh) | 2019-02-02 | 2020-08-06 | 南京明德新药研发有限公司 | 作为pd-l1免疫调节剂的乙烯基吡啶甲酰胺基化合物 |
| CA3141424C (en) * | 2019-06-14 | 2023-11-07 | Zhengxia CHEN | Fused ring compound as fgfr and vegfr dual inhibitor |
| EP4056558A4 (en) * | 2019-11-06 | 2023-12-27 | Jinan University | INDAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USES THEREOF |
| WO2021138391A1 (en) * | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| EP4186894B1 (en) * | 2020-08-11 | 2024-12-04 | Henan Medinno Pharmaceutical Technology Co., Ltd. | Fgfr inhibitor compound and use thereof |
| AU2021401741A1 (en) * | 2020-12-17 | 2023-06-29 | Blossomhill Therapeutics, Inc. | Macrocycles and their use |
| PE20240687A1 (es) * | 2020-12-30 | 2024-04-10 | Tyra Biosciences Inc | Compuestos de indazol como inhibidores de cinasas |
| CN116761798A (zh) * | 2020-12-30 | 2023-09-15 | 泰拉生物科学公司 | 作为激酶抑制剂的吲唑类化合物 |
| WO2023279041A1 (en) * | 2021-06-30 | 2023-01-05 | Tyra Biosciences, Inc. | Indazole compounds |
| CA3259217A1 (en) * | 2022-06-29 | 2024-01-04 | Tyra Biosciences Inc | INDAZOLE COMPOUNDS |
| CN116239623B (zh) * | 2022-11-18 | 2025-11-18 | 江西亚太科技发展有限公司 | 一种硼酸酯的制备方法及其应用 |
| WO2024137742A1 (en) | 2022-12-20 | 2024-06-27 | Blueprint Medicines Corporation | Compounds and compositions as fgfr3 degraders and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020010137A1 (en) * | 1997-09-18 | 2002-01-24 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| ES2302106T3 (es) | 2000-09-11 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina. |
| JP2004536113A (ja) * | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン／スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
| TW200406385A (en) | 2002-05-31 | 2004-05-01 | Eisai Co Ltd | Pyrazole compound and pharmaceutical composition containing the same |
| AU2003289287A1 (en) | 2002-12-03 | 2004-06-23 | Kyowa Hakko Kogyo Co., Ltd. | Jnk inhibitor |
| BR0317548A (pt) * | 2002-12-19 | 2005-11-22 | Pfizer | Compostos de indazole e composições farmacêuticas para a inibição de proteìnas-cinases e métodos para o seu uso |
| WO2007058626A1 (en) * | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Indazole compounds |
| EP2001480A4 (en) * | 2006-03-31 | 2011-06-15 | Abbott Lab | Indazole CONNECTIONS |
| AR078411A1 (es) * | 2009-05-07 | 2011-11-09 | Lilly Co Eli | Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende |
-
2016
- 2016-08-03 US US15/750,704 patent/US10519133B2/en active Active
- 2016-08-03 EP EP16834592.4A patent/EP3333157B1/en active Active
- 2016-08-03 JP JP2018507641A patent/JP6898306B2/ja active Active
- 2016-08-03 CN CN201680046188.0A patent/CN107922349B/zh active Active
- 2016-08-03 WO PCT/CN2016/092989 patent/WO2017024968A1/zh not_active Ceased
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