JP2018530349A5 - - Google Patents

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Publication number
JP2018530349A5
JP2018530349A5 JP2018538060A JP2018538060A JP2018530349A5 JP 2018530349 A5 JP2018530349 A5 JP 2018530349A5 JP 2018538060 A JP2018538060 A JP 2018538060A JP 2018538060 A JP2018538060 A JP 2018538060A JP 2018530349 A5 JP2018530349 A5 JP 2018530349A5
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JP
Japan
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human
oocyte
scnt
cell
embryo
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JP2018538060A
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English (en)
Japanese (ja)
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JP2018530349A (ja
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Priority claimed from PCT/US2016/055890 external-priority patent/WO2017062706A1/en
Publication of JP2018530349A publication Critical patent/JP2018530349A/ja
Publication of JP2018530349A5 publication Critical patent/JP2018530349A5/ja
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JP2018538060A 2015-10-09 2016-10-07 ヒストンｈ３−リシントリメチル化の排除によりヒト体細胞核移入（ｓｃｎｔ）の効率を増加する方法および組成物、ならびにヒトｎｔ−ｅｓｃの誘導方法 Pending JP2018530349A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562239318P 2015-10-09 2015-10-09
US62/239,318 2015-10-09
US201562242050P 2015-10-15 2015-10-15
US62/242,050 2015-10-15
PCT/US2016/055890 WO2017062706A1 (en) 2015-10-09 2016-10-07 Methods and compositions to increase human somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation, and derivation of human nt-esc

Publications (2)

Publication Number Publication Date
JP2018530349A JP2018530349A (ja) 2018-10-18
JP2018530349A5 true JP2018530349A5 (https=) 2019-11-14

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ID=58488507

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JP2018538060A Pending JP2018530349A (ja) 2015-10-09 2016-10-07 ヒストンｈ３−リシントリメチル化の排除によりヒト体細胞核移入（ｓｃｎｔ）の効率を増加する方法および組成物、ならびにヒトｎｔ−ｅｓｃの誘導方法

Country Status (6)

Country Link
US (3) US20180291400A1 (https=)
EP (1) EP3359167A4 (https=)
JP (1) JP2018530349A (https=)
KR (1) KR20210143952A (https=)
CN (1) CN109641015A (https=)
WO (1) WO2017062706A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044271A2 (en) 2014-09-15 2016-03-24 Children's Medical Center Corporation Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation
CN107299113A (zh) * 2017-06-12 2017-10-27 内蒙古大学 H3K27me3及其去甲基化酶KDM6A/B在小鼠核移植重构胚中的应用方法
CN108624621B (zh) * 2018-01-17 2019-04-12 中国科学院上海生命科学研究院 非人灵长类的体细胞克隆动物的制备方法
KR20190089782A (ko) * 2018-01-23 2019-07-31 차의과학대학교 산학협력단 멜라토닌을 포함하는, 배아 발달용 조성물 및 이를 이용하여 배아 발달의 효율을 향상시키는 방법
JP7650661B2 (ja) * 2018-01-23 2025-03-25 チャ ユニバーシティ インダストリー－アカデミック コオペレーション ファンデーション Ｒａｄ５１活性化剤を含む胚芽発達用組成物、及びそれを利用して胚芽発達率を向上させる方法
AU2019247490A1 (en) * 2018-04-06 2020-10-22 Children's Medical Center Corporation Compositions and methods for somatic cell reprogramming and modulating imprinting
WO2020018106A1 (en) * 2018-07-19 2020-01-23 Children's Medical Center Corporation Compositions and methods for generating physiological x chromosome inactivation
EP4386081A3 (en) * 2019-05-21 2024-10-16 President and Fellows of Harvard College Endocrine differentiation-inducing molecule
CN110607325B (zh) * 2019-09-19 2021-03-23 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 一种提高修正的人三原核受精卵体外培养囊胚发育率的方法
CN116113421A (zh) 2020-05-14 2023-05-12 阿莱兹精准医疗公司 使用siRNA调节PRDM2/RIZ蛋白表达的癌症治疗
US11857551B1 (en) * 2020-07-10 2024-01-02 Ting Therapeutics Llc Methods for the prevention and treatment of hearing loss
US20230372311A1 (en) * 2020-07-21 2023-11-23 The Regents Of The University Of California Compositions and methods of treating age-related retinal dysfunction
CN112382339B (zh) * 2020-11-17 2024-08-13 中国人民解放军军事科学院军事医学研究院 一种识别合子型基因激活zga基因的方法及装置
CN114805357B (zh) * 2021-01-21 2023-12-19 四川大学 一种靶向setdb1-ttd的小分子抑制剂及其制药用途
CN113186152B (zh) * 2021-05-19 2023-05-26 南方医科大学 Dna甲基转移酶抑制剂在提高动物圆形精子注射胚胎发育效率中的应用
CN115247175B (zh) * 2021-11-25 2025-10-17 南京启真基因工程有限公司 构建setdb1基因突变的表观遗传失调模型猪核移植供体细胞的基因编辑系统及其应用
WO2025042589A1 (en) * 2023-08-18 2025-02-27 University Of Washington Compositions and methods for improving cardiac regeneration
CN118001405B (zh) * 2024-02-07 2025-12-12 中国药科大学 Prmt1抑制剂在治疗急性肝损伤中的用途
CN118956808B (zh) * 2024-10-17 2025-01-07 天津赛萌生物技术有限公司 一种setdb1突变体及其在生物大分子制备中的应用
CN121202972B (zh) * 2025-09-23 2026-04-03 北京大学 一种靶向suv39h1的短肽及其在治疗肿瘤中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1483817A (zh) * 2002-09-18 2004-03-24 李建远 一种克隆无动物成分的人胚胎干细胞的方法
CN101535468A (zh) * 2005-10-21 2009-09-16 国际干细胞公司 单性生殖激活人类卵母细胞用于产生人类胚胎干细胞
WO2009134418A2 (en) * 2008-04-30 2009-11-05 Fox Chase Cancer Center Assay for identifying agents that modulate epigenetic silencing, and agents identified thereby
US20110136145A1 (en) * 2008-05-22 2011-06-09 The Johns Hopkins University Methods for promoting fusion and reprogramming of somatic cells
US20130189780A1 (en) * 2009-12-31 2013-07-25 Fate Therapeutics, Inc. Reprogramming compositions
JP6290931B2 (ja) * 2013-02-15 2018-03-07 ソン クヮン メデイカル ファウンデーション 体細胞核移植を利用する単為生殖幹細胞および患者特異的ヒト胚幹細胞の製造法
US9546383B2 (en) * 2013-05-13 2017-01-17 Oregon Health & Science University Human pluripotent embryonic stem cells produced by nuclear transfer using a somatic cell nucleus treated with HVJ-E extract and an oocyte from a donor cycle that produced 15 or fewer oocytes
WO2014197835A2 (en) * 2013-06-06 2014-12-11 The General Hospital Corporation Methods and compositions for the treatment of cancer

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