JP2018528236A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018528236A5 JP2018528236A5 JP2018515561A JP2018515561A JP2018528236A5 JP 2018528236 A5 JP2018528236 A5 JP 2018528236A5 JP 2018515561 A JP2018515561 A JP 2018515561A JP 2018515561 A JP2018515561 A JP 2018515561A JP 2018528236 A5 JP2018528236 A5 JP 2018528236A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- salt
- diastereomer
- enantiomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003839 salts Chemical class 0.000 claims description 28
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 claims description 27
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 claims description 27
- 239000003112 inhibitor Substances 0.000 claims description 27
- 239000012453 solvate Substances 0.000 claims description 27
- -1 Apitrisive Chemical compound 0.000 claims description 20
- 230000002500 effect on skin Effects 0.000 claims description 17
- 210000002950 fibroblast Anatomy 0.000 claims description 15
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 14
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 14
- 229960002930 sirolimus Drugs 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 11
- RFSMUFRPPYDYRD-CALCHBBNSA-N Ku-0063794 Chemical compound C1=C(CO)C(OC)=CC=C1C1=CC=C(C(=NC(=N2)N3C[C@@H](C)O[C@@H](C)C3)N3CCOCC3)C2=N1 RFSMUFRPPYDYRD-CALCHBBNSA-N 0.000 claims description 8
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 229960005167 everolimus Drugs 0.000 claims description 6
- 230000008719 thickening Effects 0.000 claims description 5
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims description 5
- 229950009819 zotarolimus Drugs 0.000 claims description 5
- QDITZBLZQQZVEE-YBEGLDIGSA-N (5z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)\C1=C\C1=CC=C(N=CC=C2C=3C=CN=CC=3)C2=C1 QDITZBLZQQZVEE-YBEGLDIGSA-N 0.000 claims description 4
- QLHHRYZMBGPBJG-UHFFFAOYSA-N 1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-pyrazolo[3,4-d]pyrimidinyl]phenyl]-3-methylurea Chemical compound C1=CC(NC(=O)NC)=CC=C1C1=NC(N2CC3CCC(O3)C2)=C(C=NN2C3CCC4(CC3)OCCO4)C2=N1 QLHHRYZMBGPBJG-UHFFFAOYSA-N 0.000 claims description 4
- RGJOJUGRHPQXGF-INIZCTEOSA-N 1-ethyl-3-[4-[4-[(3s)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5h-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea Chemical compound C1=CC(NC(=O)NCC)=CC=C1C(N=C1N2[C@H](COCC2)C)=NC2=C1CCN(C1COC1)C2 RGJOJUGRHPQXGF-INIZCTEOSA-N 0.000 claims description 4
- DPLMXAYKJZOTKO-UHFFFAOYSA-N 2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4h-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile Chemical compound C1=CC(C(C)(C#N)C)=CC=C1N1C2=C3C=C(C=4C=C5C=CC=CC5=NC=4)C=CC3=NC=C2COC1=O DPLMXAYKJZOTKO-UHFFFAOYSA-N 0.000 claims description 4
- IMXHGCRIEAKIBU-UHFFFAOYSA-N 4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester Chemical compound C1=CC(NC(=O)OC)=CC=C1C1=NC(N2CCOCC2)=C(C=NN2C3CCN(CC3)C(=O)OC)C2=N1 IMXHGCRIEAKIBU-UHFFFAOYSA-N 0.000 claims description 4
- GYLDXIAOMVERTK-UHFFFAOYSA-N 5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine Chemical compound C12=C(N)N=CN=C2N(C(C)C)N=C1C1=CC=C(OC(N)=N2)C2=C1 GYLDXIAOMVERTK-UHFFFAOYSA-N 0.000 claims description 4
- JEGHXKRHKHPBJD-UHFFFAOYSA-N 5-(7-methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine Chemical compound CS(=O)(=O)N1CCC2=C1N=C(N1CCOCC1)N=C2C1=CN=C(N)N=C1 JEGHXKRHKHPBJD-UHFFFAOYSA-N 0.000 claims description 4
- YEAHTLOYHVWAKW-UHFFFAOYSA-N 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one Chemical compound C1=CC(OC)=CC=C1COC(C(=C1)OC)=CC2=C1C1=CC=C(C(C)O)C=C1C(=O)O2 YEAHTLOYHVWAKW-UHFFFAOYSA-N 0.000 claims description 4
- BUROJSBIWGDYCN-GAUTUEMISA-N AP 23573 Chemical compound C1C[C@@H](OP(C)(C)=O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 BUROJSBIWGDYCN-GAUTUEMISA-N 0.000 claims description 4
- KVLFRAWTRWDEDF-IRXDYDNUSA-N AZD-8055 Chemical compound C1=C(CO)C(OC)=CC=C1C1=CC=C(C(=NC(=N2)N3[C@H](COCC3)C)N3[C@H](COCC3)C)C2=N1 KVLFRAWTRWDEDF-IRXDYDNUSA-N 0.000 claims description 4
- 206010003694 Atrophy Diseases 0.000 claims description 4
- YUXMAKUNSXIEKN-BTJKTKAUSA-N BGT226 Chemical compound OC(=O)\C=C/C(O)=O.C1=NC(OC)=CC=C1C1=CC=C(N=CC2=C3N(C=4C=C(C(N5CCNCC5)=CC=4)C(F)(F)F)C(=O)N2C)C3=C1 YUXMAKUNSXIEKN-BTJKTKAUSA-N 0.000 claims description 4
- TUVCWJQQGGETHL-UHFFFAOYSA-N PI-103 Chemical compound OC1=CC=CC(C=2N=C3C4=CC=CN=C4OC3=C(N3CCOCC3)N=2)=C1 TUVCWJQQGGETHL-UHFFFAOYSA-N 0.000 claims description 4
- NVRXTLZYXZNATH-UHFFFAOYSA-N PP121 Chemical compound N1=C(C=2C=C3C=CNC3=NC=2)C=2C(N)=NC=NC=2N1C1CCCC1 NVRXTLZYXZNATH-UHFFFAOYSA-N 0.000 claims description 4
- 206010039796 Seborrhoeic keratosis Diseases 0.000 claims description 4
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 4
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims description 4
- LNFBAYSBVQBKFR-UHFFFAOYSA-N [7-(6-aminopyridin-3-yl)-3,5-dihydro-2h-1,4-benzoxazepin-4-yl]-(3-fluoro-2-methyl-4-methylsulfonylphenyl)methanone Chemical compound CC1=C(F)C(S(C)(=O)=O)=CC=C1C(=O)N1CC2=CC(C=3C=NC(N)=CC=3)=CC=C2OCC1 LNFBAYSBVQBKFR-UHFFFAOYSA-N 0.000 claims description 4
- 208000009621 actinic keratosis Diseases 0.000 claims description 4
- 230000037444 atrophy Effects 0.000 claims description 4
- XDLYKKIQACFMJG-WKILWMFISA-N chembl1234354 Chemical compound C1=NC(OC)=CC=C1C(C1=O)=CC2=C(C)N=C(N)N=C2N1[C@@H]1CC[C@@H](OCCO)CC1 XDLYKKIQACFMJG-WKILWMFISA-N 0.000 claims description 4
- JROFGZPOBKIAEW-HAQNSBGRSA-N chembl3120215 Chemical compound N1C=2C(OC)=CC=CC=2C=C1C(=C1C(N)=NC=NN11)N=C1[C@H]1CC[C@H](C(O)=O)CC1 JROFGZPOBKIAEW-HAQNSBGRSA-N 0.000 claims description 4
- 229950006418 dactolisib Drugs 0.000 claims description 4
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical group O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 claims description 4
- VDOCQQKGPJENHJ-UHFFFAOYSA-N methyl n-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1C1=NC(N2CCOCC2)=C(C=NN2C3CCN(CC=4C=NC=CC=4)CC3)C2=N1 VDOCQQKGPJENHJ-UHFFFAOYSA-N 0.000 claims description 4
- 229960001302 ridaforolimus Drugs 0.000 claims description 4
- 229950009216 sapanisertib Drugs 0.000 claims description 4
- 201000003385 seborrheic keratosis Diseases 0.000 claims description 4
- 229960001967 tacrolimus Drugs 0.000 claims description 4
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 4
- 229960000235 temsirolimus Drugs 0.000 claims description 4
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims description 4
- AKCRNFFTGXBONI-UHFFFAOYSA-N torin 1 Chemical compound C1CN(C(=O)CC)CCN1C1=CC=C(N2C(C=CC3=C2C2=CC(=CC=C2N=C3)C=2C=C3C=CC=CC3=NC=2)=O)C=C1C(F)(F)F AKCRNFFTGXBONI-UHFFFAOYSA-N 0.000 claims description 4
- GUXXEUUYCAYESJ-UHFFFAOYSA-N torin 2 Chemical compound C1=NC(N)=CC=C1C1=CC=C(N=CC2=C3N(C=4C=C(C=CC=4)C(F)(F)F)C(=O)C=C2)C3=C1 GUXXEUUYCAYESJ-UHFFFAOYSA-N 0.000 claims description 4
- MFAQYJIYDMLAIM-UHFFFAOYSA-N torkinib Chemical compound C12=C(N)N=CN=C2N(C(C)C)N=C1C1=CC2=CC(O)=CC=C2N1 MFAQYJIYDMLAIM-UHFFFAOYSA-N 0.000 claims description 4
- 230000037303 wrinkles Effects 0.000 claims description 4
- 230000003902 lesion Effects 0.000 claims description 3
- 238000011200 topical administration Methods 0.000 claims description 3
- RGHYDLZMTYDBDT-UHFFFAOYSA-N 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone Chemical compound O=C1N(CC)C2=NC(N)=NC(C)=C2C=C1C=1C=CNN=1 RGHYDLZMTYDBDT-UHFFFAOYSA-N 0.000 claims description 2
- 208000032544 Cicatrix Diseases 0.000 claims description 2
- 206010014982 Epidermal and dermal conditions Diseases 0.000 claims description 2
- 239000004264 Petrolatum Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 239000003906 humectant Substances 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 230000008520 organization Effects 0.000 claims description 2
- 229940066842 petrolatum Drugs 0.000 claims description 2
- 235000019271 petrolatum Nutrition 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 231100000241 scar Toxicity 0.000 claims description 2
- 230000037387 scars Effects 0.000 claims description 2
- 230000009758 senescence Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 229950001576 voxtalisib Drugs 0.000 claims description 2
- 239000001993 wax Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 238000000034 method Methods 0.000 description 19
- 210000003491 skin Anatomy 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021169263A JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2023130574A JP7573078B2 (ja) | 2015-09-24 | 2023-08-10 | 真皮障害を治療または予防するための新規組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232228P | 2015-09-24 | 2015-09-24 | |
| US62/232,228 | 2015-09-24 | ||
| PCT/US2016/052442 WO2017053222A1 (en) | 2015-09-24 | 2016-09-19 | Novel compositions and methods for treating or preventing dermal disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169263A Division JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018528236A JP2018528236A (ja) | 2018-09-27 |
| JP2018528236A5 true JP2018528236A5 (https=) | 2019-10-31 |
Family
ID=58387119
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515561A Withdrawn JP2018528236A (ja) | 2015-09-24 | 2016-09-19 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2021169263A Active JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2023130574A Active JP7573078B2 (ja) | 2015-09-24 | 2023-08-10 | 真皮障害を治療または予防するための新規組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169263A Active JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2023130574A Active JP7573078B2 (ja) | 2015-09-24 | 2023-08-10 | 真皮障害を治療または予防するための新規組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10695326B2 (https=) |
| EP (2) | EP4729121A2 (https=) |
| JP (3) | JP2018528236A (https=) |
| KR (1) | KR20180081501A (https=) |
| CN (2) | CN115645534A (https=) |
| AU (1) | AU2016325446B2 (https=) |
| CA (1) | CA3037469C (https=) |
| ES (1) | ES3060762T3 (https=) |
| WO (1) | WO2017053222A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014117035A1 (en) | 2013-01-24 | 2014-07-31 | Transderm, Inc. | COMPOSITIONS FOR TRANSDERMAL DELIVERY OF mTOR INHIBITORS |
| KR20180081501A (ko) * | 2015-09-24 | 2018-07-16 | 드렉셀유니버시티 | 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법 |
| WO2018031789A1 (en) * | 2016-08-10 | 2018-02-15 | The Board Of Regents Of The University Of Texas System | Topical rapamycin therapy |
| JP7108631B2 (ja) | 2017-01-06 | 2022-07-28 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物およびその使用方法 |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| CA3115691A1 (en) * | 2018-10-11 | 2020-04-16 | Drexel University | Methods for treating or preventing skin conditions |
| US20210353701A1 (en) * | 2018-11-02 | 2021-11-18 | Shiseido Company, Ltd. | Ultraviolet light-induced inflammation suppressing agent comprising alternative autophagy inducing agent |
| KR102132921B1 (ko) * | 2018-12-13 | 2020-07-13 | 영남대학교 산학협력단 | 조타로리무스를 유효성분으로 함유하는 세포노화 관련 질환 예방 또는 치료용 조성물 |
| AU2020277132B1 (en) * | 2020-11-24 | 2021-11-04 | Aft Pharmaceuticals Limited | A Rapamycin Composition |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5286730A (en) | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
| GB9723669D0 (en) | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
| US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
| US20040180430A1 (en) * | 1999-09-07 | 2004-09-16 | West Michael D. | Methods of restoring telomere length and extending cell lifespan using nuclear transfer |
| US7026374B2 (en) | 2002-06-25 | 2006-04-11 | Aruna Nathan | Injectable microdispersions for medical applications |
| WO2005010010A1 (en) | 2003-07-16 | 2005-02-03 | Wyeth | Cci-779 isomer c |
| US20050250805A1 (en) * | 2004-05-06 | 2005-11-10 | Glenmark Pharmaceuticals Limited | Pharmaceutical ointment formulations |
| CA2601694A1 (en) | 2005-03-14 | 2006-09-21 | Macrochem Corporation | Enhancement of macrolide penetration through human skin |
| PL2001466T3 (pl) | 2006-03-23 | 2016-06-30 | Santen Pharmaceutical Co Ltd | Rapamycyna w małej dawce do leczenia chorób związanych z przepuszczalnością naczyń |
| MXPA06008797A (es) * | 2006-08-03 | 2008-02-04 | Fernando Ahumada Ayala | Preparacion topica para el tratamiento de enfermedades inflamatorias de la piel que contiene sirolimus. |
| WO2008022256A2 (en) * | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
| WO2008143928A1 (en) | 2007-05-15 | 2008-11-27 | Puretech Ventures | Methods and compositions for treating skin conditions |
| WO2009046436A1 (en) * | 2007-10-04 | 2009-04-09 | Memorial Sloan-Kettering Cancer Center | Methods for inhibiting senescence of epithelial cells |
| EP2362866B1 (en) | 2008-11-11 | 2015-07-08 | Signum Biosciences, Inc. | Isoprenyl compounds and methods thereof |
| AU2013204219B2 (en) | 2009-04-10 | 2015-05-07 | Haiyan Qi | Novel anti-aging agents and methods to identify them |
| AU2010233073B2 (en) | 2009-04-10 | 2014-07-31 | Haiyan Qi | Novel anti-aging agents and methods to identify them |
| CA2822746A1 (en) | 2009-12-21 | 2011-06-30 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
| US20110150856A1 (en) | 2009-12-21 | 2011-06-23 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
| CA2825786A1 (en) | 2011-01-31 | 2012-08-09 | Osaka University | Externally-used drug for treating skin disorder and method for producing same |
| US20130102572A1 (en) | 2011-04-12 | 2013-04-25 | Dow Pharmaceutical Sciences | Methods of treating skin conditions exhibiting telangiectasia |
| CA2854926A1 (en) * | 2011-11-08 | 2013-05-16 | Intellikine, Llc | Treatment regimens using multiple pharmaceutical agents |
| US20150202187A1 (en) | 2012-06-26 | 2015-07-23 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| CN105899232A (zh) * | 2013-11-13 | 2016-08-24 | 诺华股份有限公司 | 用于增强免疫应答的mTOR抑制剂 |
| US9980976B2 (en) * | 2015-02-17 | 2018-05-29 | Northwestern University | Use of REDD1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor agonists |
| KR20180081501A (ko) | 2015-09-24 | 2018-07-16 | 드렉셀유니버시티 | 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법 |
-
2016
- 2016-09-19 KR KR1020187011292A patent/KR20180081501A/ko not_active Ceased
- 2016-09-19 AU AU2016325446A patent/AU2016325446B2/en active Active
- 2016-09-19 CN CN202211246255.7A patent/CN115645534A/zh active Pending
- 2016-09-19 ES ES16849389T patent/ES3060762T3/es active Active
- 2016-09-19 EP EP25225780.3A patent/EP4729121A2/en active Pending
- 2016-09-19 EP EP16849389.8A patent/EP3352755B1/en active Active
- 2016-09-19 WO PCT/US2016/052442 patent/WO2017053222A1/en not_active Ceased
- 2016-09-19 JP JP2018515561A patent/JP2018528236A/ja not_active Withdrawn
- 2016-09-19 CN CN201680065172.4A patent/CN108348508A/zh active Pending
- 2016-09-19 US US15/762,317 patent/US10695326B2/en active Active
- 2016-09-19 CA CA3037469A patent/CA3037469C/en active Active
-
2020
- 2020-05-21 US US16/880,186 patent/US11179374B2/en active Active
-
2021
- 2021-08-11 US US17/399,763 patent/US20220031673A1/en active Pending
- 2021-10-15 JP JP2021169263A patent/JP7332666B2/ja active Active
-
2023
- 2023-08-10 JP JP2023130574A patent/JP7573078B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018528236A5 (https=) | ||
| US5993790A (en) | Nail evulsion compositions and method for evulsing nails and treating nail and nail bed infections | |
| CL2023001738A1 (es) | Inhibidores de prmt5 | |
| BRPI0914404A2 (pt) | "compostos, composição farmacêutica e método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak quinase em um paciente" | |
| Li et al. | Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones | |
| FR2887886B1 (fr) | Polymere cationique neutralise, composition le comprenant et procede de traitement cosmetique | |
| AR088730A1 (es) | Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas | |
| WO2017127430A8 (en) | Irak4 inhibiting agents | |
| NO20074697L (no) | Ikke-aromatisk, nitrogenholdig heterosyklisk-1-karboksylatester-pyridylderivat | |
| WO2011113802A3 (en) | Imidazopyridine and purine compounds, compositions and methods of use | |
| TR201802944T4 (tr) | İlaç olarak azai̇ndazol veya di̇azai̇ndazol türünün türevleri̇ | |
| MX2009010407A (es) | Derivados fluorados de deferiprona. | |
| KR20180081501A (ko) | 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법 | |
| FR3029776B1 (fr) | Composition anhydre sous forme d'aerosol comprenant un actif anti-transpirant, un polymere ethylenique filmogene non hydrosoluble et sequence et une silicone phenylee | |
| WO2010017609A8 (en) | Antiperspirant compositions and methods for reducing perspiration in humans | |
| PE20200793A1 (es) | Compuestos de cetonas biciclicas sustituidas, como inhibidores de la rip1 cinasa y composiciones farmaceuticas que los comprenden | |
| AR080871A1 (es) | Tieno[3,2-b]piridinas sustituidas como inhibidores de la actividad de la proteina tirosina quinasa | |
| NZ608375A (en) | Pharmaceutical combination of an mtor catalytic inhibitor and an allosteric mtor inhibitor | |
| KR20240137128A (ko) | 조합 항박테리아 조성물 및 단기 항박테리아 요법 | |
| MX2022014290A (es) | Inhibidor de vcp/p97 para tratamiento de cancer. | |
| WO2023141432A3 (en) | Apol1 inhibitors and methods of use | |
| EP4183264A4 (en) | COMPOSITION FOR THE TREATMENT OF BRAIN DISEASES WITH PEDIOCOCCUS INOPINATUS OR EXTRACELLULAR VESICLES THEREOF AS ACTIVE INGREDIENT | |
| CY1123386T1 (el) | Συνεργιστικες συνθεσεις που περιλαμβανουν (r)-διμιρακεταμη (1) και (s)-διμιρακεταμη (2) σε μη ρακεμικη αναλογια | |
| BR112021025618A2 (pt) | Composto, método para prevenir, tratar ou diminuir a gravidade de uma doença, composição farmacêutica e uso de um composto | |
| JP2021504466A5 (https=) |