JP2018528211A5 - - Google Patents
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- JP2018528211A5 JP2018528211A5 JP2018511473A JP2018511473A JP2018528211A5 JP 2018528211 A5 JP2018528211 A5 JP 2018528211A5 JP 2018511473 A JP2018511473 A JP 2018511473A JP 2018511473 A JP2018511473 A JP 2018511473A JP 2018528211 A5 JP2018528211 A5 JP 2018528211A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021060982A JP7335288B2 (ja) | 2015-09-02 | 2021-03-31 | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562213143P | 2015-09-02 | 2015-09-02 | |
| US201562213187P | 2015-09-02 | 2015-09-02 | |
| US62/213,143 | 2015-09-02 | ||
| US62/213,187 | 2015-09-02 | ||
| US201662274915P | 2016-01-05 | 2016-01-05 | |
| US62/274,915 | 2016-01-05 | ||
| PCT/IL2016/050968 WO2017037719A1 (en) | 2015-09-02 | 2016-09-02 | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021060982A Division JP7335288B2 (ja) | 2015-09-02 | 2021-03-31 | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018528211A JP2018528211A (ja) | 2018-09-27 |
| JP2018528211A5 true JP2018528211A5 (https=) | 2019-10-31 |
| JP6862428B2 JP6862428B2 (ja) | 2021-04-28 |
| JP6862428B6 JP6862428B6 (ja) | 2021-06-02 |
Family
ID=58186771
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511473A Expired - Fee Related JP6862428B6 (ja) | 2015-09-02 | 2016-09-02 | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 |
| JP2021060982A Active JP7335288B2 (ja) | 2015-09-02 | 2021-03-31 | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021060982A Active JP7335288B2 (ja) | 2015-09-02 | 2021-03-31 | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10899785B2 (https=) |
| EP (1) | EP3344641A4 (https=) |
| JP (2) | JP6862428B6 (https=) |
| CN (2) | CN108350014B (https=) |
| AU (2) | AU2016314379B2 (https=) |
| BR (1) | BR112018004257A2 (https=) |
| CA (1) | CA2996763A1 (https=) |
| HK (1) | HK1257935A1 (https=) |
| IL (2) | IL295474A (https=) |
| WO (1) | WO2017037719A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3344641A4 (en) | 2015-09-02 | 2019-09-18 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| EP3350194A4 (en) | 2015-09-02 | 2019-04-24 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| EP3344640A4 (en) | 2015-09-02 | 2019-05-01 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| AU2018235441C1 (en) * | 2017-03-15 | 2024-10-24 | Eloxx Pharmaceuticals Ltd. | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof |
| CN110997689B (zh) * | 2017-06-05 | 2023-11-07 | Eloxx制药有限公司 | 氨基糖苷衍生物及其在治疗遗传紊乱中的用途 |
| US11673907B2 (en) * | 2018-04-03 | 2023-06-13 | Revagenix, Inc. | Modular synthesis of aminoglycosides |
| WO2020113124A1 (en) * | 2018-11-29 | 2020-06-04 | Eloxx Pharmaceuticals | Methods, compositions, and kits for treating ocular diseases |
| JP7653846B2 (ja) | 2021-06-24 | 2025-03-31 | 株式会社アシックス | 靴底および靴 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897412A (en) | 1972-05-04 | 1975-07-29 | Bristol Myers Co | Paromomycin antibiotic derivatives |
| US4024332A (en) | 1973-06-05 | 1977-05-17 | Pfizer Inc. | Aminoglycoside antibiotics and intermediates therefor |
| US4029882A (en) | 1974-03-19 | 1977-06-14 | Schering Corporation | Selective acylation of the C-1 amino group of aminoglycoside antibiotics |
| US4396609A (en) | 1975-02-18 | 1983-08-02 | Sterling Drug Inc. | Aminocyclitol antibiotics, pharmaceutical compositions and method of using same |
| US3978214A (en) * | 1975-05-02 | 1976-08-31 | Schering Corporation | Novel 4,6-di-o-(aminoglycosyl)-2-deoxystreptamine, method for its manufacture, method for its use as an antiprotozoal agent and compositions useful thereof |
| US3996205A (en) | 1975-09-08 | 1976-12-07 | The Upjohn Company | Aminoglycoside antibiotics and intermediates |
| US4169197A (en) | 1977-09-06 | 1979-09-25 | The Upjohn Company | 6-Deoxyneamines aminoglycoside compounds |
| FR2427341A1 (fr) | 1978-06-02 | 1979-12-28 | Delalande Sa | Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique |
| DE3100739A1 (de) | 1981-01-13 | 1982-08-26 | Bayer Ag, 5090 Leverkusen | Pseudotrisaccharide, verfahren zu deren herstellung, deren verwendung als arzneimittel und die pseudotrisaccharide enthaltende arzneimittel sowie deren herstellung |
| US5470836A (en) | 1988-04-29 | 1995-11-28 | Farmitalia Carlo Erba S.R.L. | Paromomycin or its derivatives or salts thereof in combination with sodium stirogluconate for parenteral treatment of human parasitic diseases |
| JPH0446189A (ja) | 1990-06-08 | 1992-02-17 | Meiji Seika Kaisha Ltd | 新規なリボスタマイシン誘導体 |
| US5096596B1 (en) | 1990-06-27 | 1995-10-03 | Hellenbrand Water Conditioners | Process and apparatus fof removal of mineral contaminants from water |
| US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| WO2004093821A2 (en) | 2003-04-22 | 2004-11-04 | Hawaii Biotech, Inc. | Treatment of anthrax infection using inhibitors of lethal factor protease activity |
| US20050004052A1 (en) | 2003-07-03 | 2005-01-06 | Technion Research & Development Foundation Ltd. | Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes |
| US7635685B2 (en) | 2003-07-03 | 2009-12-22 | Technion Research & Development Foundation Ltd. | Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes and for inhibition of anthrax lethal factor |
| US20070161581A1 (en) | 2004-01-21 | 2007-07-12 | Nobuto Minowa | Novel aminoglycoside antibiotics effective against methicillin resistant staphylococcus auerus (mrsas) |
| US7879240B2 (en) | 2005-02-22 | 2011-02-01 | Jeremy Weissman | Method and system for aerating wastewater for re-use |
| EP2390255B1 (en) * | 2006-04-03 | 2016-07-13 | Technion Research & Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| KR101072899B1 (ko) | 2008-01-21 | 2011-10-17 | 주식회사 파나진 | 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용 |
| US8865664B2 (en) | 2008-07-09 | 2014-10-21 | University Of Manitoba | Hydrophobically enhanced aminoglycosides |
| WO2011044538A1 (en) | 2009-10-09 | 2011-04-14 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| CA2791253A1 (en) | 2010-04-06 | 2011-10-13 | Frank Schweizer | Polyol modified aminoglycoside-lipid conjugates |
| HRP20180056T1 (hr) * | 2010-11-18 | 2018-02-09 | Technion Research & Development Foundation Ltd. | Aminoglikozidi i upotreba istih u svrhu liječenja genetskih poremećaja |
| AU2013271336B2 (en) * | 2012-06-04 | 2017-11-30 | Centre For Digestive Diseases | Compositions and methods for treating Crohn's Disease and related conditions and infections |
| KR101703137B1 (ko) | 2014-05-30 | 2017-02-07 | 선문대학교 산학협력단 | 당 부가 아미노글리코사이드 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
| CA2949754A1 (en) * | 2014-06-05 | 2015-12-10 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
| EP3344640A4 (en) | 2015-09-02 | 2019-05-01 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| EP3350194A4 (en) | 2015-09-02 | 2019-04-24 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| EP3344641A4 (en) | 2015-09-02 | 2019-09-18 | Eloxx Pharmaceuticals Ltd. | AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES |
| US20190016746A1 (en) | 2016-01-05 | 2019-01-17 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US20190016745A1 (en) | 2016-01-05 | 2019-01-17 | Technion Research & Development Foundation Limited | Aminoglycoside derivatives and uses thereof in treating microbial infections |
-
2016
- 2016-09-02 EP EP16840988.6A patent/EP3344641A4/en not_active Withdrawn
- 2016-09-02 CA CA2996763A patent/CA2996763A1/en active Pending
- 2016-09-02 JP JP2018511473A patent/JP6862428B6/ja not_active Expired - Fee Related
- 2016-09-02 BR BR112018004257A patent/BR112018004257A2/pt not_active Application Discontinuation
- 2016-09-02 CN CN201680062161.0A patent/CN108350014B/zh not_active Expired - Fee Related
- 2016-09-02 CN CN202210562830.8A patent/CN114957357A/zh active Pending
- 2016-09-02 US US15/756,691 patent/US10899785B2/en active Active
- 2016-09-02 HK HK19100297.9A patent/HK1257935A1/zh unknown
- 2016-09-02 WO PCT/IL2016/050968 patent/WO2017037719A1/en not_active Ceased
- 2016-09-02 AU AU2016314379A patent/AU2016314379B2/en not_active Ceased
- 2016-09-02 IL IL295474A patent/IL295474A/en unknown
- 2016-09-02 IL IL257820A patent/IL257820B/en unknown
-
2020
- 2020-12-17 US US17/126,007 patent/US11613551B2/en active Active
-
2021
- 2021-03-31 JP JP2021060982A patent/JP7335288B2/ja active Active
- 2021-06-04 AU AU2021203691A patent/AU2021203691B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7335288B2 (ja) | アミノグリコシド誘導体および遺伝性疾患の治療におけるその使用 | |
| US10973839B2 (en) | Aminoglycosides and uses thereof in treating genetic disorders | |
| JP2018528211A5 (https=) | ||
| US20190016746A1 (en) | Aminoglycoside derivatives and uses thereof in treating genetic disorders |