JP2018523636A5 - - Google Patents
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- Publication number
- JP2018523636A5 JP2018523636A5 JP2017567791A JP2017567791A JP2018523636A5 JP 2018523636 A5 JP2018523636 A5 JP 2018523636A5 JP 2017567791 A JP2017567791 A JP 2017567791A JP 2017567791 A JP2017567791 A JP 2017567791A JP 2018523636 A5 JP2018523636 A5 JP 2018523636A5
- Authority
- JP
- Japan
- Prior art keywords
- bace1 inhibitor
- site
- group
- inhibitor according
- site bace1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940125759 BACE1 protease inhibitor Drugs 0.000 claims 11
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 6
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 6
- 230000009977 dual effect Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 208000037259 Amyloid Plaque Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 208000037765 diseases and disorders Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000006989 Alzheimer disease 9 Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical group [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178162 | 2015-07-24 | ||
| EP15178162.2 | 2015-07-24 | ||
| PCT/EP2016/067447 WO2017016982A1 (en) | 2015-07-24 | 2016-07-21 | Bace1 inhibitor peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523636A JP2018523636A (ja) | 2018-08-23 |
| JP2018523636A5 true JP2018523636A5 (https=) | 2019-08-29 |
| JP6814754B2 JP6814754B2 (ja) | 2021-01-20 |
Family
ID=53776361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567791A Expired - Fee Related JP6814754B2 (ja) | 2015-07-24 | 2016-07-21 | Ｂａｃｅ１阻害剤ペプチド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10947272B2 (https=) |
| EP (1) | EP3325500A1 (https=) |
| JP (1) | JP6814754B2 (https=) |
| CN (1) | CN107849092A (https=) |
| HK (1) | HK1251593A1 (https=) |
| WO (1) | WO2017016982A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019094608A1 (en) | 2017-11-08 | 2019-05-16 | Denali Therapeutics Inc. | Anti-bace1 antibodies and methods of use thereof |
| CN120591368B (zh) * | 2025-06-04 | 2026-04-21 | 武汉市米来生物科技有限公司 | 一种具有ace抑制活性的蛋黄多肽的制备方法及应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003285892A1 (en) | 2002-10-15 | 2004-05-04 | Bristol-Myers Squibb Company | Bace binding peptides and uses thereof |
| US20070149763A1 (en) | 2003-10-15 | 2007-06-28 | Bristol-Myers Squibb Company | Beta secretase exosite binding peptides and methods for identifying beta secretase modulators |
| EP2119455A1 (en) | 2004-04-08 | 2009-11-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tripartite raftophilic structures and their use |
| JP2008504329A (ja) | 2004-06-29 | 2008-02-14 | ヤド テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用 |
| CN103608344B (zh) * | 2011-06-07 | 2016-11-23 | 霍夫曼-拉罗奇有限公司 | [1,3]噁嗪类 |
| JP6134725B2 (ja) * | 2011-10-14 | 2017-05-24 | ジェネンテック， インコーポレイテッド | Ｂａｃｅ１のペプチド阻害剤 |
| CN104368009B (zh) * | 2014-06-25 | 2018-01-30 | 中国人民解放军第二军医大学 | 一种双功能肽修饰的阿尔茨海默病靶向基因递释复合物及其制备方法 |
| CN110051627A (zh) | 2014-09-15 | 2019-07-26 | 维罗纳制药公司 | 包含rpl554的液体吸入制剂 |
| WO2016044951A1 (en) | 2014-09-25 | 2016-03-31 | The Hospital For Sick Children | Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing |
| CN108064232B (zh) * | 2014-11-28 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 肽 |
| US10208087B2 (en) * | 2014-11-28 | 2019-02-19 | Hoffmann-La Roche Inc. | Peptides |
-
2016
- 2016-07-21 HK HK18111170.9A patent/HK1251593A1/zh unknown
- 2016-07-21 EP EP16744696.2A patent/EP3325500A1/en not_active Withdrawn
- 2016-07-21 CN CN201680040557.5A patent/CN107849092A/zh active Pending
- 2016-07-21 JP JP2017567791A patent/JP6814754B2/ja not_active Expired - Fee Related
- 2016-07-21 WO PCT/EP2016/067447 patent/WO2017016982A1/en not_active Ceased
- 2016-07-21 US US15/735,394 patent/US10947272B2/en not_active Expired - Fee Related
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