HK1251593A1 - Bace1抑制剂肽 - Google Patents

Bace1抑制剂肽 Download PDF

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Publication number
HK1251593A1
HK1251593A1 HK18111170.9A HK18111170A HK1251593A1 HK 1251593 A1 HK1251593 A1 HK 1251593A1 HK 18111170 A HK18111170 A HK 18111170A HK 1251593 A1 HK1251593 A1 HK 1251593A1
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HK
Hong Kong
Prior art keywords
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tyr
glu
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gly
Prior art date
Application number
HK18111170.9A
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English (en)
Chinese (zh)
Inventor
杰里米‧比彻姆
杰里米‧比徹姆
佩尔-奥拉‧弗雷斯克加德
埃里克‧A‧基塔斯
佩爾-奧拉‧弗雷斯克加德
维克托‧利亚米切夫
吉加尔‧帕特尔
維克托‧利亞米切夫
吉加爾‧帕特爾
Original Assignee
豪夫迈‧罗氏有限公司
豪夫邁‧羅氏有限公司
罗氏宁博根公司
羅氏寧博根公司
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Application filed by 豪夫迈‧罗氏有限公司, 豪夫邁‧羅氏有限公司, 罗氏宁博根公司, 羅氏寧博根公司 filed Critical 豪夫迈‧罗氏有限公司
Publication of HK1251593A1 publication Critical patent/HK1251593A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK18111170.9A 2015-07-24 2016-07-21 Bace1抑制剂肽 HK1251593A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15178162 2015-07-24
EP15178162.2 2015-07-24

Publications (1)

Publication Number Publication Date
HK1251593A1 true HK1251593A1 (zh) 2019-02-01

Family

ID=53776361

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18111170.9A HK1251593A1 (zh) 2015-07-24 2016-07-21 Bace1抑制剂肽

Country Status (6)

Country Link
US (1) US10947272B2 (https=)
EP (1) EP3325500A1 (https=)
JP (1) JP6814754B2 (https=)
CN (1) CN107849092A (https=)
HK (1) HK1251593A1 (https=)
WO (1) WO2017016982A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof
CN120591368B (zh) * 2025-06-04 2026-04-21 武汉市米来生物科技有限公司 一种具有ace抑制活性的蛋黄多肽的制备方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314726B2 (en) 2002-10-15 2008-01-01 Bristol-Myers Squibb Company Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
US20070149763A1 (en) 2003-10-15 2007-06-28 Bristol-Myers Squibb Company Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
EP2119455A1 (en) * 2004-04-08 2009-11-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tripartite raftophilic structures and their use
JP2008504329A (ja) 2004-06-29 2008-02-14 ヤド テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 脂質ラフト内の病理プロセスに関係する障害を治療するためのステロイド由来の医薬組成物の使用
CA2837797A1 (en) * 2011-06-07 2012-12-13 F. Hoffmann-La Roche Ag [1,3]oxazines
JP6134725B2 (ja) * 2011-10-14 2017-05-24 ジェネンテック， インコーポレイテッド Ｂａｃｅ１のペプチド阻害剤
CN104368009B (zh) 2014-06-25 2018-01-30 中国人民解放军第二军医大学 一种双功能肽修饰的阿尔茨海默病靶向基因递释复合物及其制备方法
MY196072A (en) 2014-09-15 2023-03-13 Verona Pharma Plc Liquid Inhalation Formulation Comprising RPL554
JP2017528505A (ja) 2014-09-25 2017-09-28 ザ・ホスピタル・フォー・シック・チルドレンＴｈｅ Ｈｏｓｐｉｔａｌ Ｆｏｒ Ｓｉｃｋ Ｃｈｉｌｄｒｅｎ 発毛増進、皮膚再生促進及び創傷治癒のための組成物及び方法
EP3224271B1 (en) * 2014-11-28 2019-09-25 F.Hoffmann-La Roche Ag Peptides
US10208087B2 (en) * 2014-11-28 2019-02-19 Hoffmann-La Roche Inc. Peptides

Also Published As

Publication number Publication date
US10947272B2 (en) 2021-03-16
JP6814754B2 (ja) 2021-01-20
WO2017016982A1 (en) 2017-02-02
EP3325500A1 (en) 2018-05-30
CN107849092A (zh) 2018-03-27
JP2018523636A (ja) 2018-08-23
US20180179252A1 (en) 2018-06-28

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