JP2018521031A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018521031A5 JP2018521031A5 JP2017564367A JP2017564367A JP2018521031A5 JP 2018521031 A5 JP2018521031 A5 JP 2018521031A5 JP 2017564367 A JP2017564367 A JP 2017564367A JP 2017564367 A JP2017564367 A JP 2017564367A JP 2018521031 A5 JP2018521031 A5 JP 2018521031A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- parts
- configuration
- composition
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 32
- 229930003270 Vitamin B Natural products 0.000 description 20
- 235000019156 vitamin B Nutrition 0.000 description 20
- 239000011720 vitamin B Substances 0.000 description 20
- 239000000203 mixture Substances 0.000 description 16
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 14
- 229930003268 Vitamin C Natural products 0.000 description 14
- 239000011718 vitamin C Substances 0.000 description 14
- 235000019154 vitamin C Nutrition 0.000 description 14
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 5
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical group CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 4
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 3
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 239000002211 L-ascorbic acid Substances 0.000 description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 229960004874 choline bitartrate Drugs 0.000 description 2
- QWJSAWXRUVVRLH-UHFFFAOYSA-M choline bitartrate Chemical compound C[N+](C)(C)CCO.OC(=O)C(O)C(O)C([O-])=O QWJSAWXRUVVRLH-UHFFFAOYSA-M 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 239000011755 sodium-L-ascorbate Substances 0.000 description 1
- 235000019187 sodium-L-ascorbate Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510321294.2 | 2015-06-12 | ||
| CN201510321294.2A CN106265696A (zh) | 2015-06-12 | 2015-06-12 | 使用复合维生素b、c组合物促进胃肠系统动力的方法 |
| PCT/CN2016/084938 WO2016197889A1 (zh) | 2015-06-12 | 2016-06-06 | 复合维生素组合物在制备促进胃肠系统动力的药物中的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018521031A JP2018521031A (ja) | 2018-08-02 |
| JP2018521031A5 true JP2018521031A5 (https=) | 2019-07-04 |
Family
ID=57502901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564367A Pending JP2018521031A (ja) | 2015-06-12 | 2016-06-06 | 胃腸系運動を刺激するための薬物の製造におけるマルチビタミン組成物の使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10881639B2 (https=) |
| EP (1) | EP3308787A4 (https=) |
| JP (1) | JP2018521031A (https=) |
| CN (2) | CN111803514A (https=) |
| AU (1) | AU2016276482A1 (https=) |
| BR (1) | BR112017026834A2 (https=) |
| CA (1) | CA2989214A1 (https=) |
| WO (1) | WO2016197889A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079008A (zh) * | 2016-11-23 | 2018-05-29 | 上海泽生科技开发股份有限公司 | 促进胃肠系统动力的复合维生素组合物 |
| CN108567792A (zh) * | 2017-03-07 | 2018-09-25 | 上海泽生科技开发股份有限公司 | 一种治疗阿尔茨海默病的复合维生素组合物 |
| CN115581699A (zh) * | 2018-04-28 | 2023-01-10 | 上海泽生科技开发股份有限公司 | 促进胃肠系统动力的复合维生素组合物及其制备方法 |
| EP3801498A1 (en) * | 2018-06-08 | 2021-04-14 | DSM IP Assets B.V. | Methods and compositions to support the growth or maintenance of oxygen-sensitive bacteria in the gastrointestinal tract |
| EP3893674A1 (en) * | 2018-12-11 | 2021-10-20 | DSM IP Assets B.V. | Use of riboflavin to benefit bowel health |
| CN115003172A (zh) * | 2020-02-12 | 2022-09-02 | 帝斯曼知识产权资产管理有限公司 | 抗氧化剂至肠道的直接递送 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE322275T1 (de) * | 1998-06-10 | 2006-04-15 | Albert B Crum | Vorbeugender und therapeutischer nahrungsmittelzusatz zur schaffung/erhaltung einer die gesundheit schützenden darmmikroflora und zur stärkung des immunsystems |
| WO2006108208A1 (en) | 2004-10-14 | 2006-10-19 | Adventures Plus Pty Ltd | A method for the treatment of gastrointestinal and other disorders with an admixture of vitamins and minerals |
| JP2012019691A (ja) * | 2010-06-17 | 2012-02-02 | Morinaga Milk Ind Co Ltd | 腎疾患患者用経口栄養組成物 |
| JP2013532661A (ja) * | 2010-07-22 | 2013-08-19 | リベン ファーマシューティカルズ インコーポレイテッド | 磁気双極子安定化溶液の使用を含む疾患を処置または改善する方法および行動を向上させる方法 |
| CN104337813A (zh) * | 2013-07-23 | 2015-02-11 | 上海泽生科技开发有限公司 | 使用维生素b组合物促进胃肠系统动力的方法 |
| CN104256652A (zh) | 2014-10-08 | 2015-01-07 | 李明刚 | 一种口服复合维生素纳米脂质体 |
-
2015
- 2015-06-12 CN CN202010700288.9A patent/CN111803514A/zh active Pending
- 2015-06-12 CN CN201510321294.2A patent/CN106265696A/zh active Pending
-
2016
- 2016-06-06 WO PCT/CN2016/084938 patent/WO2016197889A1/zh not_active Ceased
- 2016-06-06 JP JP2017564367A patent/JP2018521031A/ja active Pending
- 2016-06-06 CA CA2989214A patent/CA2989214A1/en not_active Abandoned
- 2016-06-06 BR BR112017026834-5A patent/BR112017026834A2/pt not_active Application Discontinuation
- 2016-06-06 US US15/735,568 patent/US10881639B2/en active Active
- 2016-06-06 EP EP16806787.4A patent/EP3308787A4/en not_active Withdrawn
- 2016-06-06 AU AU2016276482A patent/AU2016276482A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018521031A5 (https=) | ||
| US8349376B1 (en) | Anti-dementia regimen | |
| JP2018534348A5 (https=) | ||
| FI3641819T3 (fi) | Kannabidiolin käyttö tuberoosisklerooosikompleksin hoitoon | |
| AR088195A1 (es) | Composiciones farmaceuticas de n-metil-2-[3-(e)-2-piridin-2-il-vinil)-1h-indazol-6-ilsulfanil]-benzamida | |
| JP2018530592A5 (https=) | ||
| CN108026053A8 (zh) | 作为mIDH1抑制剂的稠合的咪唑类化合物 | |
| JP2015131825A5 (https=) | ||
| JP2015509909A5 (https=) | ||
| JP2020528888A5 (https=) | ||
| JP2007528876A5 (https=) | ||
| JP2023011769A5 (https=) | ||
| JP2016530291A5 (https=) | ||
| BR112017010953A2 (pt) | composição farmacêutica | |
| BR112017010933A2 (pt) | composição farmacêutica | |
| ECSP15033787A (es) | Nueva formulación granular de disolución rápida que tiene solubilidad mejorada | |
| HRP20210010T1 (hr) | Injekcijske farmaceutske formulacije lefamulina | |
| SA519410841B1 (ar) | تركيبة مستحلب نانو زيت في ماء من كلوبيتاسول | |
| MY168531A (en) | Medicament form for release of active ingredients | |
| CN110520135A (zh) | 维生素组合物在制备用于预防、治疗或延迟阿尔茨海默病的药物中的用途 | |
| HRP20231448T1 (hr) | Primjena delgocitiniba za liječenje kroničnog ekcema ruku | |
| JP2019532098A5 (https=) | ||
| MY191149A (en) | Oral composition | |
| JP2014504628A5 (https=) | ||
| EA202092864A1 (ru) | Фармацевтическая композиция для парентерального капельного введения |