JP2018521011A5 - - Google Patents
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- JP2018521011A5 JP2018521011A5 JP2017561677A JP2017561677A JP2018521011A5 JP 2018521011 A5 JP2018521011 A5 JP 2018521011A5 JP 2017561677 A JP2017561677 A JP 2017561677A JP 2017561677 A JP2017561677 A JP 2017561677A JP 2018521011 A5 JP2018521011 A5 JP 2018521011A5
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- Prior art keywords
- cancer
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- Prior art date
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| US8158768B2 (en) * | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP6991857B2 (ja) * | 2014-10-10 | 2022-01-13 | イデラ ファーマシューティカルズ インコーポレイテッド | Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療 |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| KR102779525B1 (ko) * | 2015-05-29 | 2025-03-12 | 다이나박스 테크놀로지 코퍼레이션 | 폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
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| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| WO2020081398A1 (en) * | 2018-10-14 | 2020-04-23 | Dynavax Technologies Corporation | Combination including a cpg-c type oligonucleotide and a pd-1 antagonist for treating breast cancer |
| KR20210079319A (ko) * | 2018-10-18 | 2021-06-29 | 도이체스 크렙스포르슝스첸트룸 | 흡입용 건조 약학적 조성물 |
| CN111321159B (zh) * | 2018-12-14 | 2023-12-12 | 中天(上海)生物科技有限公司 | 用于免疫调节的嵌合核酸分子及其应用 |
| US20220370606A1 (en) * | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| WO2021007160A1 (en) | 2019-07-05 | 2021-01-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| TWI833056B (zh) * | 2019-12-31 | 2024-02-21 | 財團法人工業技術研究院 | 核酸藥物複合體以及其用途 |
| CN116056765A (zh) | 2020-08-07 | 2023-05-02 | 坦伯公司 | 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途 |
| CN114099535B (zh) * | 2020-12-10 | 2023-01-03 | 南京吉迈生物技术有限公司 | Toll样受体9(TLR9)激动剂水凝胶免疫调节组合物 |
| WO2022140661A1 (en) * | 2020-12-23 | 2022-06-30 | Cascade Prodrug Inc. | Combination therapy with a vinca alkaloid n-oxide and an immune checkpoint inhibitor |
| US20250009731A1 (en) | 2021-11-08 | 2025-01-09 | Nurix Therapeutics, Inc. | Toll-like receptor therapy combinations with cbl-b inhibitor compounds |
| WO2023141599A2 (en) * | 2022-01-21 | 2023-07-27 | Trisalus Life Sciences, Inc. | Methods of treating immune dysfunction in liver cancer with toll-like receptor agonists |
| WO2024186193A1 (ko) * | 2023-03-08 | 2024-09-12 | 인제대학교 산학협력단 | 국소적 방사선 치료에서 전신성 항암 치료를 위한 조성물 |
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| AU760549B2 (en) * | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| WO1999060166A1 (en) * | 1998-05-21 | 1999-11-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for the pulmonary delivery of nucleic acids |
| KR100881923B1 (ko) | 2000-12-27 | 2009-02-04 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극 폴리뉴클레오티드 및 그것의 사용 방법 |
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| US8158768B2 (en) * | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP5102959B2 (ja) * | 2002-12-23 | 2012-12-19 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激配列オリゴヌクレオチド及びその使用方法 |
| JP2007526253A (ja) * | 2004-02-19 | 2007-09-13 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫刺激性ウイルスｒｎａオリゴヌクレオチド |
| CN101134046B (zh) * | 2006-09-01 | 2011-10-05 | 中国医学科学院药物研究所 | Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用 |
| EP2391718A2 (en) * | 2009-01-30 | 2011-12-07 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of tlr9 |
| WO2012156817A2 (en) * | 2011-05-19 | 2012-11-22 | Teva Pharmaceutical Industries Ltd. | Method for treating non-small cell lung cancer |
| IL292510A (en) * | 2013-11-05 | 2022-06-01 | Cognate Bioservices Inc | Combinations of checkpoint inhibitors and therapeutics to treat cancer |
| MX2017015311A (es) * | 2015-05-29 | 2018-06-19 | Merck Sharp & Dohme | Combinacion de un anticuerpo anti-il-10 y un oligonucleotido tipo cpg-c para tratar cancer. |
| KR102779525B1 (ko) | 2015-05-29 | 2025-03-12 | 다이나박스 테크놀로지 코퍼레이션 | 폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여 |
| SG11201808913WA (en) * | 2016-04-15 | 2018-11-29 | Dynavax Tech Corp | Intratumoral administration of particles containing a toll-like receptor 9 agonist and a tumor antigen for treating cancer |
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