JP2018520682A - 幹細胞に基づいた器官および組織生成の方法 - Google Patents

幹細胞に基づいた器官および組織生成の方法 Download PDF

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JP2018520682A
JP2018520682A JP2018500321A JP2018500321A JP2018520682A JP 2018520682 A JP2018520682 A JP 2018520682A JP 2018500321 A JP2018500321 A JP 2018500321A JP 2018500321 A JP2018500321 A JP 2018500321A JP 2018520682 A JP2018520682 A JP 2018520682A
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human
nme7
cells
sequence
mammal
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JP2018520682A5 (enExample
Inventor
バンダッド，シンシア
スマッジ，ブノワ
カーター，マーク
スチュアート，アンドリュー
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ミネルバ バイオテクノロジーズ コーポレーション
ミネルバ バイオテクノロジーズ コーポレーション
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Publication of JP2018520682A publication Critical patent/JP2018520682A/ja
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2018500321A 2015-07-01 2016-07-01 幹細胞に基づいた器官および組織生成の方法 Pending JP2018520682A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562187638P 2015-07-01 2015-07-01
US62/187,638 2015-07-01
US201562234035P 2015-09-29 2015-09-29
US62/234,035 2015-09-29
PCT/US2016/040880 WO2017004601A1 (en) 2015-07-01 2016-07-01 Method of stem cell-based organ and tissue generation

Publications (2)

Publication Number Publication Date
JP2018520682A true JP2018520682A (ja) 2018-08-02
JP2018520682A5 JP2018520682A5 (enExample) 2019-08-15

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JP2018500321A Pending JP2018520682A (ja) 2015-07-01 2016-07-01 幹細胞に基づいた器官および組織生成の方法

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Country Link
US (1) US20180235193A1 (enExample)
EP (1) EP3316682A4 (enExample)
JP (1) JP2018520682A (enExample)
KR (2) KR20180032583A (enExample)
CN (1) CN107920501A (enExample)
AU (1) AU2016287603A1 (enExample)
CA (1) CA2991125A1 (enExample)
IL (1) IL256549A (enExample)
WO (1) WO2017004601A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021263227A2 (en) 2020-06-26 2021-12-30 Minerva Biotechnologies Corporation Anti-nme antibody and method of treating cancer or cancer metastasis
KR20250009592A (ko) 2022-04-12 2025-01-17 미네르바 바이오테크놀로지 코포레이션 항-가변 muc1* 항체 및 그의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102397115A (zh) * 2011-07-10 2012-04-04 黄必录 避免器官移植排斥的方案
JP2014530025A (ja) * 2011-10-17 2014-11-17 ミネルバ バイオテクノロジーズ コーポレーション 幹細胞の増殖及び誘導用の培地
US20150089677A1 (en) * 2013-02-20 2015-03-26 Minerva Biotechnologies Corporation Method for enhancing tumor growth

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2582399A4 (en) * 2010-06-16 2015-04-15 Minerva Biotechnologies Corp NEW PROGRAMMING OF CANCER CELLS
WO2014012115A2 (en) * 2012-07-13 2014-01-16 Minerva Biotechnologies Corporation Method for inducing cells to less mature state
US20160073616A1 (en) * 2013-01-29 2016-03-17 The University Of Tokyo Method for producing chimeric animal

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102397115A (zh) * 2011-07-10 2012-04-04 黄必录 避免器官移植排斥的方案
JP2014530025A (ja) * 2011-10-17 2014-11-17 ミネルバ バイオテクノロジーズ コーポレーション 幹細胞の増殖及び誘導用の培地
US20150089677A1 (en) * 2013-02-20 2015-03-26 Minerva Biotechnologies Corporation Method for enhancing tumor growth

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HIKITA, S. T. ET AL: "MUC1* mediates the growth of human pluripotent stem cells", PLOS ONE, vol. Vol. 3(10):e3312, JPN6020027746, 2008, pages 1 - 13, ISSN: 0004316417 *
SMAGGHE, B. J. ET AL.: "MUC1* ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more naive stat", PLOS ONE, vol. Vol. 8(3):e58601, JPN6020027750, 2013, pages 1 - 15, ISSN: 0004557287 *
SUGIMOTO, M. ET AL.: "A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by Wnt inhibi", STEM CELL REPORTS, vol. Vol. 4(4), JPN6020027752, 2015, pages 744 - 757, ISSN: 0004557289 *
TAKASHIMA, Y. ET AL.: "Resetting transcription factor control circuitry toward ground-state pluripotency in human", CELL, vol. Vol. 158(6), JPN6020027745, 2014, pages 1254 - 1269, ISSN: 0004557288 *
WANG, C. H. ET AL.: "A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal", STEM CELLS, vol. Vol. 30(10), JPN6020027748, 2012, pages 2199 - 2211, ISSN: 0004316416 *

Also Published As

Publication number Publication date
AU2016287603A1 (en) 2018-01-25
US20180235193A1 (en) 2018-08-23
WO2017004601A1 (en) 2017-01-05
KR20210045513A (ko) 2021-04-26
EP3316682A1 (en) 2018-05-09
CN107920501A (zh) 2018-04-17
IL256549A (en) 2018-02-28
EP3316682A4 (en) 2019-01-23
KR20180032583A (ko) 2018-03-30
CA2991125A1 (en) 2017-01-05

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