JP2018520647A5 - - Google Patents
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- JP2018520647A5 JP2018520647A5 JP2017558986A JP2017558986A JP2018520647A5 JP 2018520647 A5 JP2018520647 A5 JP 2018520647A5 JP 2017558986 A JP2017558986 A JP 2017558986A JP 2017558986 A JP2017558986 A JP 2017558986A JP 2018520647 A5 JP2018520647 A5 JP 2018520647A5
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- JP
- Japan
- Prior art keywords
- composition
- enzyme
- biological sample
- inactivating
- amount
- Prior art date
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- 102000004190 Enzymes Human genes 0.000 claims 40
- 108090000790 Enzymes Proteins 0.000 claims 40
- 230000000415 inactivating effect Effects 0.000 claims 16
- 230000002779 inactivation Effects 0.000 claims 16
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical group [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 150000002978 peroxides Chemical class 0.000 claims 5
- 239000003755 preservative agent Substances 0.000 claims 5
- 230000002335 preservative effect Effects 0.000 claims 5
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 102000003992 Peroxidases Human genes 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159297P | 2015-05-10 | 2015-05-10 | |
| US62/159,297 | 2015-05-10 | ||
| PCT/EP2016/060263 WO2016180747A1 (en) | 2015-05-10 | 2016-05-09 | Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205107A Division JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520647A JP2018520647A (ja) | 2018-08-02 |
| JP2018520647A5 true JP2018520647A5 (cg-RX-API-DMAC7.html) | 2019-05-30 |
| JP7044554B2 JP7044554B2 (ja) | 2022-03-30 |
Family
ID=55953158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558986A Active JP7044554B2 (ja) | 2015-05-10 | 2016-05-09 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
| JP2020205107A Pending JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205107A Pending JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11162877B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3295173B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7044554B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107980095A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016261279B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2984701C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016180747A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3853214A1 (en) | 2018-09-20 | 2021-07-28 | Ventana Medical Systems, Inc. | Coumarin-based crosslinking reagents |
| JP7346576B2 (ja) | 2018-12-25 | 2023-09-19 | ハンクス バイオファーマシューティクス，インコーポレイテッド | 抗ｏｘ４０モノクローナル抗体とその応用 |
| CN116783485A (zh) | 2021-01-15 | 2023-09-19 | 文塔纳医疗系统公司 | 储存稳定的笼状半抗原 |
| CN116868054A (zh) | 2021-01-25 | 2023-10-10 | 文塔纳医疗系统公司 | 包括用一个或多个可检测部分标记的一种或多种生物标志物的染色生物学样本 |
| WO2022210977A1 (ja) | 2021-03-30 | 2022-10-06 | サトーホールディングス株式会社 | ラベル構造体及びラベル |
| CN117177985A (zh) | 2021-04-18 | 2023-12-05 | 文塔纳医疗系统公司 | 形态学标志物染色 |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| CN120359417A (zh) | 2022-12-23 | 2025-07-22 | 文塔纳医疗系统公司 | 用于评估抗原呈递机制组分的材料和方法及其用途 |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3410400C2 (de) * | 1984-03-21 | 1987-04-02 | Titmus Eurocon Kontaktlinsen GmbH, 8750 Aschaffenburg | Kontaktlinsenpflegesatz und Verfahren zur Pflege von Kontaktlinsen |
| US5225325A (en) * | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| CO5080817A1 (es) * | 1997-10-21 | 2001-09-25 | Cancer Res Campaign Tech Ltd | Determinacion de anormalidades en el crecimiento celular |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| CA2320750C (en) | 1998-02-27 | 2004-08-24 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
| SE9804064D0 (sv) * | 1998-11-25 | 1998-11-25 | A & Science Invest Ab | Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells |
| US20050176072A1 (en) * | 2002-06-21 | 2005-08-11 | Martin Michelle D. | MTA1 is a predictive and prognostic factor in human breast cancer |
| US20040248223A1 (en) * | 2003-06-05 | 2004-12-09 | Idexx Laboratories, Inc. | Reduction of interfering peroxidase activity in peroxidase based detection methods |
| WO2005033333A2 (en) * | 2003-10-07 | 2005-04-14 | Dako Denmark A/S | Methods and compositions for the diagnosis of cancer |
| JP5733734B2 (ja) * | 2009-02-19 | 2015-06-10 | 国立大学法人 千葉大学 | 成長因子に誘発されるユークロマチン化（ｅｕｃｈｒｏｍａｔｉｎｉｚａｔｉｏｎ）に必要な、ＳＲＣ−ファミリーチロシンキナーゼの核局在 |
| CN102458464B (zh) | 2009-04-08 | 2016-08-03 | 利普厄姆公司 | 用于治疗炎性疾病的新方法 |
| KR101424414B1 (ko) | 2009-10-19 | 2014-08-01 | 벤타나 메디컬 시스템즈, 인코포레이티드 | 현미경 스테이지에 대한 디바이스 |
| DK2714912T3 (en) * | 2011-06-01 | 2018-08-13 | Intrexon Actobiotics Nv | POLYCISTRONIC EXPRESSION SYSTEM FOR BACTERIA |
| US20140178169A1 (en) | 2011-09-09 | 2014-06-26 | Ventana Medical Systems, Inc. | Imaging systems, cassettes, and methods of using the same |
| CA2867144C (en) | 2012-03-27 | 2019-07-02 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
-
2016
- 2016-05-09 EP EP16721425.3A patent/EP3295173B1/en active Active
- 2016-05-09 CN CN201680027053.XA patent/CN107980095A/zh active Pending
- 2016-05-09 WO PCT/EP2016/060263 patent/WO2016180747A1/en not_active Ceased
- 2016-05-09 AU AU2016261279A patent/AU2016261279B2/en active Active
- 2016-05-09 JP JP2017558986A patent/JP7044554B2/ja active Active
- 2016-05-09 CA CA2984701A patent/CA2984701C/en active Active
-
2017
- 2017-11-09 US US15/807,612 patent/US11162877B2/en active Active
-
2020
- 2020-12-10 JP JP2020205107A patent/JP2021058193A/ja active Pending
-
2021
- 2021-10-04 US US17/493,477 patent/US11971337B2/en active Active
-
2024
- 2024-03-30 US US18/622,914 patent/US20240328910A1/en active Pending
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