JP2018518181A - 血液細胞系列の細胞に機能的ポリペプチドを導入するためのCRISPR/Cas9複合体 - Google Patents
血液細胞系列の細胞に機能的ポリペプチドを導入するためのCRISPR/Cas9複合体 Download PDFInfo
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- JP2018518181A JP2018518181A JP2017565262A JP2017565262A JP2018518181A JP 2018518181 A JP2018518181 A JP 2018518181A JP 2017565262 A JP2017565262 A JP 2017565262A JP 2017565262 A JP2017565262 A JP 2017565262A JP 2018518181 A JP2018518181 A JP 2018518181A
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- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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- C12N2800/00—Nucleic acids vectors
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562181145P | 2015-06-17 | 2015-06-17 | |
| US62/181,145 | 2015-06-17 | ||
| PCT/US2016/038125 WO2016205680A1 (en) | 2015-06-17 | 2016-06-17 | Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518181A true JP2018518181A (ja) | 2018-07-12 |
| JP2018518181A5 JP2018518181A5 (cg-RX-API-DMAC7.html) | 2019-07-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565262A Pending JP2018518181A (ja) | 2015-06-17 | 2016-06-17 | 血液細胞系列の細胞に機能的ポリペプチドを導入するためのCRISPR/Cas9複合体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11555207B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3310931B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018518181A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108026545A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016278959A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2989858A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016205680A1 (cg-RX-API-DMAC7.html) |
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| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| JP7030522B2 (ja) | 2015-05-11 | 2022-03-07 | エディタス・メディシン、インコーポレイテッド | 幹細胞における遺伝子編集のための最適化crispr/cas9システムおよび方法 |
| US11911415B2 (en) | 2015-06-09 | 2024-02-27 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for improving transplantation |
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| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| KR102827276B1 (ko) | 2016-08-03 | 2025-07-01 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
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| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| KR20240027153A (ko) | 2017-06-15 | 2024-02-29 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 표적화된 비-바이러스 dna 삽입 |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| WO2019018410A1 (en) * | 2017-07-17 | 2019-01-24 | The General Hospital Corporation | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASES |
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Also Published As
| Publication number | Publication date |
|---|---|
| US11555207B2 (en) | 2023-01-17 |
| CA2989858A1 (en) | 2016-12-22 |
| CN108026545A (zh) | 2018-05-11 |
| US20190032089A1 (en) | 2019-01-31 |
| WO2016205680A1 (en) | 2016-12-22 |
| EP3310931B1 (en) | 2021-11-17 |
| AU2016278959A1 (en) | 2018-01-18 |
| EP3310931A1 (en) | 2018-04-25 |
| EP3310931A4 (en) | 2019-01-09 |
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