JP2018515623A - キナーゼ阻害剤としての複素環式化合物 - Google Patents
キナーゼ阻害剤としての複素環式化合物 Download PDFInfo
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
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| US201562163369P | 2015-05-18 | 2015-05-18 | |
| US62/163,369 | 2015-05-18 | ||
| US201562203070P | 2015-08-10 | 2015-08-10 | |
| US62/203,070 | 2015-08-10 | ||
| PCT/US2016/033111 WO2016187324A1 (en) | 2015-05-18 | 2016-05-18 | Heterocyclic compounds as kinase inhibitors |
Publications (2)
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| JP2018515623A true JP2018515623A (ja) | 2018-06-14 |
| JP2018515623A5 JP2018515623A5 (OSRAM) | 2019-06-27 |
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| US (3) | US10392402B2 (OSRAM) |
| EP (1) | EP3297437A4 (OSRAM) |
| JP (1) | JP2018515623A (OSRAM) |
| CN (1) | CN107835637A (OSRAM) |
| AU (1) | AU2016264220A1 (OSRAM) |
| CA (1) | CA3024113A1 (OSRAM) |
| HK (1) | HK1248070A1 (OSRAM) |
| IL (1) | IL255750A (OSRAM) |
| WO (1) | WO2016187324A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2023501799A (ja) * | 2019-11-15 | 2023-01-19 | 武漢朗来科技発展有限公司 | Ｒｏｃｋ阻害剤及びその製造方法と用途 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210069016A1 (en) * | 2008-11-13 | 2021-03-11 | Gholam A. Peyman | Neurodegenerative Disorder Treatment Method |
| JP6688735B2 (ja) | 2014-02-11 | 2020-04-28 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン |
| EA031655B1 (ru) | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
| US10392402B2 (en) * | 2015-05-18 | 2019-08-27 | Translational Drug Development, Llc | Heterocyclic compounds as kinase inhibitors |
| AU2020273376C1 (en) * | 2016-10-24 | 2024-02-29 | Translational Drug Development, Llc | Amide compounds as kinase inhibitors, compositions and methods of treatment |
| EP3541806A4 (en) | 2016-11-21 | 2020-07-01 | Translational Drug Development, LLC | HETEROCYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS |
| EP3784226B1 (en) | 2018-04-24 | 2024-08-14 | Translational Drug Development Llc | Pyrazole-phenylamide derivatives as inhibitors of the rho-associated protein kinase rock1 and rock2 for the treatment of cancer |
| WO2020142745A1 (en) * | 2019-01-04 | 2020-07-09 | Translational Drug Development, Llc | Methods of treating graft versus host disease and neoplastic disease with amide compounds |
| TWI777325B (zh) | 2019-12-31 | 2022-09-11 | 財團法人工業技術研究院 | β-胺基酸衍生物、含其之激酶抑制劑與醫藥組成物以及其用途 |
| KR20220164471A (ko) * | 2020-01-07 | 2022-12-13 | 디스암 테라퓨틱스, 인크. | Sarm1의 억제제 |
| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| US11945796B2 (en) | 2020-09-16 | 2024-04-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| AU2022320699A1 (en) | 2021-07-28 | 2024-02-29 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007026920A2 (en) * | 2005-09-02 | 2007-03-08 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| CA2709883A1 (en) | 2007-12-19 | 2009-06-25 | The Scripps Research Institute | Benzimidazoles and analogs as rho kinase inhibitors |
| US20090258907A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Laboratories | Compounds useful as inhibitors of rock kinases |
| US20130129677A1 (en) | 2009-02-27 | 2013-05-23 | Siga Technologies, Inc. | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections |
| AR078793A1 (es) * | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
| US9221808B2 (en) * | 2010-04-16 | 2015-12-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use |
| US8697911B2 (en) * | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| JP5976778B2 (ja) * | 2011-04-11 | 2016-08-24 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤としてのピラゾリル−ピリミジン誘導体 |
| US10392402B2 (en) * | 2015-05-18 | 2019-08-27 | Translational Drug Development, Llc | Heterocyclic compounds as kinase inhibitors |
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2016
- 2016-05-18 US US15/574,800 patent/US10392402B2/en active Active
- 2016-05-18 EP EP16797227.2A patent/EP3297437A4/en not_active Withdrawn
- 2016-05-18 CA CA3024113A patent/CA3024113A1/en not_active Abandoned
- 2016-05-18 CN CN201680041168.4A patent/CN107835637A/zh active Pending
- 2016-05-18 JP JP2018512823A patent/JP2018515623A/ja not_active Withdrawn
- 2016-05-18 WO PCT/US2016/033111 patent/WO2016187324A1/en not_active Ceased
- 2016-05-18 HK HK18107657.9A patent/HK1248070A1/zh unknown
- 2016-05-18 AU AU2016264220A patent/AU2016264220A1/en not_active Abandoned
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2017
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2019
- 2019-08-26 US US16/551,694 patent/US10633393B2/en active Active
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2020
- 2020-04-27 US US16/859,977 patent/US20200255448A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023501799A (ja) * | 2019-11-15 | 2023-01-19 | 武漢朗来科技発展有限公司 | Ｒｏｃｋ阻害剤及びその製造方法と用途 |
| JP7688633B2 (ja) | 2019-11-15 | 2025-06-04 | 武漢朗来科技発展有限公司 | Ｒｏｃｋ阻害剤及びその製造方法と用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016264220A1 (en) | 2018-01-04 |
| CN107835637A (zh) | 2018-03-23 |
| US20200017520A1 (en) | 2020-01-16 |
| US10633393B2 (en) | 2020-04-28 |
| EP3297437A4 (en) | 2019-02-27 |
| IL255750A (en) | 2018-01-31 |
| CA3024113A1 (en) | 2016-11-24 |
| HK1248070A1 (zh) | 2018-10-12 |
| US20200255448A1 (en) | 2020-08-13 |
| EP3297437A1 (en) | 2018-03-28 |
| US10392402B2 (en) | 2019-08-27 |
| US20180141959A1 (en) | 2018-05-24 |
| WO2016187324A1 (en) | 2016-11-24 |
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