JP2018515514A5 - - Google Patents

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Publication number
JP2018515514A5
JP2018515514A5 JP2017558660A JP2017558660A JP2018515514A5 JP 2018515514 A5 JP2018515514 A5 JP 2018515514A5 JP 2017558660 A JP2017558660 A JP 2017558660A JP 2017558660 A JP2017558660 A JP 2017558660A JP 2018515514 A5 JP2018515514 A5 JP 2018515514A5
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JP
Japan
Prior art keywords
amino
alkyl
substituted
compound according
cancer
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JP2017558660A
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English (en)
Japanese (ja)
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JP6863901B2 (ja
JP2018515514A (ja
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Priority claimed from PCT/US2016/031996 external-priority patent/WO2016183278A1/en
Publication of JP2018515514A publication Critical patent/JP2018515514A/ja
Publication of JP2018515514A5 publication Critical patent/JP2018515514A5/ja
Application granted granted Critical
Publication of JP6863901B2 publication Critical patent/JP6863901B2/ja
Expired - Fee Related legal-status Critical Current
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JP2017558660A 2015-05-13 2016-05-12 キナーゼ阻害のためのヘテロアリール化合物 Expired - Fee Related JP6863901B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562160989P 2015-05-13 2015-05-13
US62/160,989 2015-05-13
PCT/US2016/031996 WO2016183278A1 (en) 2015-05-13 2016-05-12 Heteroaryl compounds for kinase inhibition

Publications (3)

Publication Number Publication Date
JP2018515514A JP2018515514A (ja) 2018-06-14
JP2018515514A5 true JP2018515514A5 (enExample) 2019-06-13
JP6863901B2 JP6863901B2 (ja) 2021-04-28

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ID=57249337

Family Applications (1)

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JP2017558660A Expired - Fee Related JP6863901B2 (ja) 2015-05-13 2016-05-12 キナーゼ阻害のためのヘテロアリール化合物

Country Status (5)

Country Link
US (1) US20210323976A1 (enExample)
EP (1) EP3294712A4 (enExample)
JP (1) JP6863901B2 (enExample)
HK (1) HK1251567A1 (enExample)
WO (1) WO2016183278A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2704572B1 (en) 2011-05-04 2015-12-30 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
KR20180105161A (ko) 2016-01-07 2018-09-27 씨에스 파마테크 리미티드 Egfr 티로신 키나제의 임상적으로 중요한 돌연변이체의 선택적 억제제
CN108299419B (zh) * 2017-01-11 2022-04-26 南京圣和药业股份有限公司 一种新型egfr激酶抑制剂的几种新晶型及其制备方法
CN109705117A (zh) * 2017-10-25 2019-05-03 南京圣和药业股份有限公司 三环类化合物、其制备方法及用途
CN109705118B (zh) * 2017-10-25 2021-12-28 南京圣和药业股份有限公司 三环类egfr激酶抑制剂的制备方法
CN108191861B (zh) * 2018-03-01 2020-10-02 天津大学 N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-反式-2,4-戊二烯酰胺
BR112021025764A2 (pt) * 2019-06-20 2022-02-01 Oncobix Co Ltd Derivado de pirimidina que inibe o crescimento de células cancerígenas e uso medicinal do mesmo
CN115052881B (zh) * 2020-02-03 2024-07-09 勃林格殷格翰国际有限公司 作为HER2抑制剂的[1,3]二嗪并[5,4-d]嘧啶
US20230126204A1 (en) 2020-02-03 2023-04-27 Boehringer Ingelheim International Gmbh [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS
US11608343B2 (en) 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
CN112409192A (zh) * 2020-11-26 2021-02-26 启东东岳药业有限公司 一种4-氟-2-甲氧基苯胺的纯化方法
EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000251A1 (en) * 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel idolinones and uses thereof
JP5600063B2 (ja) * 2007-10-19 2014-10-01 セルジーン アビロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびその使用
US9273077B2 (en) * 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
PT2300013T (pt) * 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
EP2361248B1 (en) * 2008-06-27 2018-09-19 Celgene CAR LLC Heteroaryl compounds and uses thereof
PT3009431T (pt) * 2011-07-27 2017-12-26 Astrazeneca Ab Compostos de 2-(2,4,5-anilino-substituídos)pirimidina como moduladores úteis do egfr para o tratamento do cancro
WO2015058163A2 (en) * 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
JP6468611B2 (ja) * 2014-05-13 2019-02-13 アリアド ファーマシューティカルズ， インコーポレイテッド キナーゼ阻害のためのヘテロアリール化合物
EP3157916B1 (en) * 2014-06-19 2018-12-12 ARIAD Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
WO2016173438A1 (zh) * 2015-04-29 2016-11-03 南京明德新药研发股份有限公司 稠环或三环芳基嘧啶化合物用作激酶抑制剂

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