JP2018515514A5 - - Google Patents
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- Publication number
- JP2018515514A5 JP2018515514A5 JP2017558660A JP2017558660A JP2018515514A5 JP 2018515514 A5 JP2018515514 A5 JP 2018515514A5 JP 2017558660 A JP2017558660 A JP 2017558660A JP 2017558660 A JP2017558660 A JP 2017558660A JP 2018515514 A5 JP2018515514 A5 JP 2018515514A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- substituted
- compound according
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160989P | 2015-05-13 | 2015-05-13 | |
| US62/160,989 | 2015-05-13 | ||
| PCT/US2016/031996 WO2016183278A1 (en) | 2015-05-13 | 2016-05-12 | Heteroaryl compounds for kinase inhibition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515514A JP2018515514A (ja) | 2018-06-14 |
| JP2018515514A5 true JP2018515514A5 (enExample) | 2019-06-13 |
| JP6863901B2 JP6863901B2 (ja) | 2021-04-28 |
Family
ID=57249337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558660A Expired - Fee Related JP6863901B2 (ja) | 2015-05-13 | 2016-05-12 | キナーゼ阻害のためのヘテロアリール化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210323976A1 (enExample) |
| EP (1) | EP3294712A4 (enExample) |
| JP (1) | JP6863901B2 (enExample) |
| HK (1) | HK1251567A1 (enExample) |
| WO (1) | WO2016183278A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| WO2017120429A1 (en) | 2016-01-07 | 2017-07-13 | CS Pharmasciences, Inc. | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
| CN108299419B (zh) * | 2017-01-11 | 2022-04-26 | 南京圣和药业股份有限公司 | 一种新型egfr激酶抑制剂的几种新晶型及其制备方法 |
| CN109705117A (zh) * | 2017-10-25 | 2019-05-03 | 南京圣和药业股份有限公司 | 三环类化合物、其制备方法及用途 |
| CN109705118B (zh) * | 2017-10-25 | 2021-12-28 | 南京圣和药业股份有限公司 | 三环类egfr激酶抑制剂的制备方法 |
| CN108191861B (zh) * | 2018-03-01 | 2020-10-02 | 天津大学 | N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-反式-2,4-戊二烯酰胺 |
| CN114008028B (zh) * | 2019-06-20 | 2024-07-09 | 昂科比克斯有限公司 | 抑制癌细胞生长的嘧啶衍生物及其医药用途 |
| US20230126204A1 (en) | 2020-02-03 | 2023-04-27 | Boehringer Ingelheim International Gmbh | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS |
| CN115052881B (zh) * | 2020-02-03 | 2024-07-09 | 勃林格殷格翰国际有限公司 | 作为HER2抑制剂的[1,3]二嗪并[5,4-d]嘧啶 |
| US11608343B2 (en) | 2020-04-24 | 2023-03-21 | Boehringer Ingelheim International Gmbh | Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors |
| CN112409192A (zh) * | 2020-11-26 | 2021-02-26 | 启东东岳药业有限公司 | 一种4-氟-2-甲氧基苯胺的纯化方法 |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| CN119630652A (zh) * | 2022-07-29 | 2025-03-14 | 安锐生物医药公司 | 氨基杂芳基激酶抑制剂 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960572B2 (en) * | 2001-06-21 | 2005-11-01 | Ariad Pharmaceuticals, Inc. | Indolinones and uses thereof |
| JP5600063B2 (ja) * | 2007-10-19 | 2014-10-01 | セルジーン アビロミクス リサーチ， インコーポレイテッド | ヘテロアリール化合物およびその使用 |
| US9273077B2 (en) * | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| JP2011523646A (ja) * | 2008-05-21 | 2011-08-18 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのリン誘導体 |
| AU2009262068C1 (en) * | 2008-06-27 | 2015-07-02 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| DK3686193T3 (da) * | 2011-07-27 | 2022-05-30 | Astrazeneca Ab | 2-(2,4,5-substitueret anilino)pyrimidinforbindelser |
| WO2015058163A2 (en) * | 2013-10-18 | 2015-04-23 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| US20170166598A1 (en) * | 2014-05-13 | 2017-06-15 | Ariad Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
| CA2949793C (en) * | 2014-06-19 | 2024-02-27 | Ariad Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
| CN107614503B (zh) * | 2015-04-29 | 2020-03-10 | 广东众生药业股份有限公司 | 稠环或三环芳基嘧啶化合物用作激酶抑制剂 |
-
2016
- 2016-05-12 US US15/573,211 patent/US20210323976A1/en not_active Abandoned
- 2016-05-12 HK HK18111064.8A patent/HK1251567A1/zh unknown
- 2016-05-12 EP EP16793497.5A patent/EP3294712A4/en not_active Withdrawn
- 2016-05-12 JP JP2017558660A patent/JP6863901B2/ja not_active Expired - Fee Related
- 2016-05-12 WO PCT/US2016/031996 patent/WO2016183278A1/en not_active Ceased
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