JP2018515514A5 - - Google Patents
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- Publication number
- JP2018515514A5 JP2018515514A5 JP2017558660A JP2017558660A JP2018515514A5 JP 2018515514 A5 JP2018515514 A5 JP 2018515514A5 JP 2017558660 A JP2017558660 A JP 2017558660A JP 2017558660 A JP2017558660 A JP 2017558660A JP 2018515514 A5 JP2018515514 A5 JP 2018515514A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- substituted
- compound according
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562160989P | 2015-05-13 | 2015-05-13 | |
| US62/160,989 | 2015-05-13 | ||
| PCT/US2016/031996 WO2016183278A1 (en) | 2015-05-13 | 2016-05-12 | Heteroaryl compounds for kinase inhibition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515514A JP2018515514A (ja) | 2018-06-14 |
| JP2018515514A5 true JP2018515514A5 (enExample) | 2019-06-13 |
| JP6863901B2 JP6863901B2 (ja) | 2021-04-28 |
Family
ID=57249337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558660A Expired - Fee Related JP6863901B2 (ja) | 2015-05-13 | 2016-05-12 | キナーゼ阻害のためのヘテロアリール化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210323976A1 (enExample) |
| EP (1) | EP3294712A4 (enExample) |
| JP (1) | JP6863901B2 (enExample) |
| HK (1) | HK1251567A1 (enExample) |
| WO (1) | WO2016183278A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| TWI726968B (zh) | 2016-01-07 | 2021-05-11 | 開曼群島商Ｃｓ醫藥技術公司 | Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑 |
| CN108299419B (zh) * | 2017-01-11 | 2022-04-26 | 南京圣和药业股份有限公司 | 一种新型egfr激酶抑制剂的几种新晶型及其制备方法 |
| CN109705117A (zh) * | 2017-10-25 | 2019-05-03 | 南京圣和药业股份有限公司 | 三环类化合物、其制备方法及用途 |
| CN109705118B (zh) * | 2017-10-25 | 2021-12-28 | 南京圣和药业股份有限公司 | 三环类egfr激酶抑制剂的制备方法 |
| CN108191861B (zh) * | 2018-03-01 | 2020-10-02 | 天津大学 | N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-反式-2,4-戊二烯酰胺 |
| US20220227781A1 (en) * | 2019-06-20 | 2022-07-21 | Oncobix Co., Ltd. | Pyrimidine derivative inhibiting growth of cancer cell and medicinal use thereof |
| WO2021156180A1 (en) | 2020-02-03 | 2021-08-12 | Boehringer Ingelheim International Gmbh | [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors |
| US20230126204A1 (en) | 2020-02-03 | 2023-04-27 | Boehringer Ingelheim International Gmbh | [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS |
| US11608343B2 (en) | 2020-04-24 | 2023-03-21 | Boehringer Ingelheim International Gmbh | Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors |
| CN112409192A (zh) * | 2020-11-26 | 2021-02-26 | 启东东岳药业有限公司 | 一种4-氟-2-甲氧基苯胺的纯化方法 |
| CA3213079A1 (en) | 2021-04-13 | 2022-10-20 | Kristin Lynne ANDREWS | Amino-substituted heterocycles for treating cancers with egfr mutations |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960572B2 (en) * | 2001-06-21 | 2005-11-01 | Ariad Pharmaceuticals, Inc. | Indolinones and uses thereof |
| US7982036B2 (en) * | 2007-10-19 | 2011-07-19 | Avila Therapeutics, Inc. | 4,6-disubstitued pyrimidines useful as kinase inhibitors |
| US9273077B2 (en) * | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| EP2300013B2 (en) * | 2008-05-21 | 2024-11-13 | Takeda Pharmaceutical Company Limited | Phosphorous derivatives as kinase inhibitors |
| NZ603525A (en) * | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| MY161925A (en) * | 2011-07-27 | 2017-05-15 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer |
| EP3057954A2 (en) * | 2013-10-18 | 2016-08-24 | Syros Pharmaceuticals, Inc. | Heteromaromatic compounds useful for the treatment of proliferative diseases |
| JP6468611B2 (ja) * | 2014-05-13 | 2019-02-13 | アリアド ファーマシューティカルズ， インコーポレイテッド | キナーゼ阻害のためのヘテロアリール化合物 |
| MY186839A (en) * | 2014-06-19 | 2021-08-25 | Takeda Pharmaceuticals Co | Heteroaryl compounds for kinase inhibition |
| US10494373B2 (en) * | 2015-04-29 | 2019-12-03 | Guangdong Zhongsheng Pharmaceutical Co., Ltd | Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor |
-
2016
- 2016-05-12 JP JP2017558660A patent/JP6863901B2/ja not_active Expired - Fee Related
- 2016-05-12 WO PCT/US2016/031996 patent/WO2016183278A1/en not_active Ceased
- 2016-05-12 HK HK18111064.8A patent/HK1251567A1/zh unknown
- 2016-05-12 US US15/573,211 patent/US20210323976A1/en not_active Abandoned
- 2016-05-12 EP EP16793497.5A patent/EP3294712A4/en not_active Withdrawn
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