JP2018515511A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018515511A5 JP2018515511A5 JP2017558481A JP2017558481A JP2018515511A5 JP 2018515511 A5 JP2018515511 A5 JP 2018515511A5 JP 2017558481 A JP2017558481 A JP 2017558481A JP 2017558481 A JP2017558481 A JP 2017558481A JP 2018515511 A5 JP2018515511 A5 JP 2018515511A5
- Authority
- JP
- Japan
- Prior art keywords
- enema composition
- enema
- phospholipid
- composition according
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 29
- 241000792859 Enema Species 0.000 claims 21
- 239000007920 enema Substances 0.000 claims 21
- 229940095399 enema Drugs 0.000 claims 21
- 150000003904 phospholipids Chemical class 0.000 claims 10
- 229920001451 polypropylene glycol Polymers 0.000 claims 10
- 229920001400 block copolymer Polymers 0.000 claims 8
- -1 polyoxypropylene Polymers 0.000 claims 8
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000003246 corticosteroid Substances 0.000 claims 5
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 229960004436 budesonide Drugs 0.000 claims 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 4
- 229920002959 polymer blend Polymers 0.000 claims 4
- 150000003872 salicylic acid derivatives Chemical class 0.000 claims 4
- 229920000428 triblock copolymer Polymers 0.000 claims 4
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 3
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical group NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 3
- 229960004963 mesalazine Drugs 0.000 claims 3
- 229960000890 hydrocortisone Drugs 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 1
- 229960004168 balsalazide Drugs 0.000 claims 1
- IPOKCKJONYRRHP-FMQUCBEESA-N balsalazide Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1\N=N\C1=CC=C(O)C(C(O)=O)=C1 IPOKCKJONYRRHP-FMQUCBEESA-N 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- 229960004110 olsalazine Drugs 0.000 claims 1
- QQBDLJCYGRGAKP-FOCLMDBBSA-N olsalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=C(C(O)=CC=2)C(O)=O)=C1 QQBDLJCYGRGAKP-FOCLMDBBSA-N 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 claims 1
- 229960001940 sulfasalazine Drugs 0.000 claims 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562156682P | 2015-05-04 | 2015-05-04 | |
| US62/156,682 | 2015-05-04 | ||
| PCT/US2016/030682 WO2016179227A1 (en) | 2015-05-04 | 2016-05-04 | Compositions and methods for delivering therapeutic agents into the colon |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515511A JP2018515511A (ja) | 2018-06-14 |
| JP2018515511A5 true JP2018515511A5 (https=) | 2019-06-06 |
| JP6814162B2 JP6814162B2 (ja) | 2021-01-13 |
Family
ID=57218315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558481A Active JP6814162B2 (ja) | 2015-05-04 | 2016-05-04 | 結腸に治療剤を送達するための組成物及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20180140619A1 (https=) |
| EP (2) | EP3291818B1 (https=) |
| JP (1) | JP6814162B2 (https=) |
| KR (1) | KR20170142181A (https=) |
| AU (2) | AU2016257911B2 (https=) |
| CA (1) | CA2984111A1 (https=) |
| DK (1) | DK3291818T3 (https=) |
| ES (1) | ES2761636T3 (https=) |
| WO (1) | WO2016179227A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015191547A1 (en) * | 2014-06-09 | 2015-12-17 | Cornell University | Implantable therapeutic delivery system and methods thereof |
| WO2016179227A1 (en) * | 2015-05-04 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering therapeutic agents into the colon |
| CN113271979A (zh) | 2018-10-24 | 2021-08-17 | 费灵有限公司 | 皮质类固醇的粘膜粘附性药物组合物 |
| US20210361602A1 (en) * | 2020-05-22 | 2021-11-25 | Intact Therapeutics, Inc. | Dosing methods for treating inflammatory bowel conditions |
| JP2025504173A (ja) * | 2022-02-04 | 2025-02-06 | インタクト セラピューティクス， インコーポレイテッド | メサラミン薬学的製剤およびその使用法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4350690A (en) * | 1980-10-27 | 1982-09-21 | Cressington Investments Ltd. | Steroid composition |
| FR2586587B1 (fr) * | 1985-08-30 | 1987-10-23 | Adir | Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| US20040191276A1 (en) * | 1999-11-30 | 2004-09-30 | Cutispharma, Inc. | Compositions and kits for compounding pharmaceuticals |
| AU2007275660B2 (en) * | 2006-07-19 | 2012-08-02 | The Board Of Regents Of The University Of Texas System | Preparations of phospholipids and pharmaceuticals containing 5-amino salicylic acid for the treatment of inflammatory bowel disease |
| WO2010077911A1 (en) * | 2008-12-17 | 2010-07-08 | Altheus Therapeutics, Inc. | Enema formulations |
| IT1402047B1 (it) * | 2010-10-19 | 2013-08-28 | Cross Pharma Sa | Uso del mexiprostil nel trattamento delle malattie infiammatorie intestinali |
| WO2016179227A1 (en) * | 2015-05-04 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering therapeutic agents into the colon |
-
2016
- 2016-05-04 WO PCT/US2016/030682 patent/WO2016179227A1/en not_active Ceased
- 2016-05-04 AU AU2016257911A patent/AU2016257911B2/en active Active
- 2016-05-04 US US15/571,644 patent/US20180140619A1/en not_active Abandoned
- 2016-05-04 EP EP16789978.0A patent/EP3291818B1/en active Active
- 2016-05-04 DK DK16789978T patent/DK3291818T3/da active
- 2016-05-04 CA CA2984111A patent/CA2984111A1/en not_active Abandoned
- 2016-05-04 JP JP2017558481A patent/JP6814162B2/ja active Active
- 2016-05-04 EP EP19206063.0A patent/EP3659607A1/en active Pending
- 2016-05-04 KR KR1020177033487A patent/KR20170142181A/ko not_active Ceased
- 2016-05-04 ES ES16789978T patent/ES2761636T3/es active Active
-
2021
- 2021-05-14 AU AU2021203094A patent/AU2021203094A1/en not_active Abandoned
- 2021-05-27 US US17/332,431 patent/US20210283148A1/en active Pending
- 2021-05-27 US US17/332,506 patent/US20210330682A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018515511A5 (https=) | ||
| JP2012532889A5 (https=) | ||
| JP2020536888A5 (https=) | ||
| KR102378847B1 (ko) | 고적재량의 활성 제제를 갖는 구강용 박막 | |
| JP2017019845A5 (https=) | ||
| JP2010515761A5 (https=) | ||
| JP2016530239A5 (https=) | ||
| JP2010525059A5 (https=) | ||
| US12576131B2 (en) | Altering inflammatory states of immune cells in vivo by modulating cellular activation states | |
| JP2016523833A5 (https=) | ||
| JP2017514850A5 (https=) | ||
| JP2016504449A5 (https=) | ||
| JP2006507285A5 (https=) | ||
| JP2017526738A5 (https=) | ||
| HRP20240974T1 (hr) | Pripravci za uporabu u liječenju mijelofibroze | |
| CN101232869B (zh) | 局部给药的凝胶组合物 | |
| JP2014513089A5 (https=) | ||
| JP2017508802A5 (https=) | ||
| JP2019500340A5 (https=) | ||
| RU2748487C1 (ru) | Водорастворимые полимерные клеевые слои | |
| JP2016011293A (ja) | 口腔内付着フィルム製剤 | |
| JP2017513938A5 (https=) | ||
| AR089839A1 (es) | Composicion farmaceutica que combina cloruro de dietil-[6-(4-hidroxicarbamoil-fenil-carbamoiloxi-metil)-naftalen-2-il-metil]-amonio y al menos un agente activo antiinflamatorio para su uso en tratamiento de distrofia muscular | |
| JP2016506948A5 (https=) | ||
| Sobral et al. | Protective effects of 17β-oestradiol on coagulation and systemic inflammation after total occlusion of the descending aorta in male rats |