AU2016257911B2 - Compositions and methods for delivering therapeutic agents into the colon - Google Patents

Compositions and methods for delivering therapeutic agents into the colon Download PDF

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Publication number
AU2016257911B2
AU2016257911B2 AU2016257911A AU2016257911A AU2016257911B2 AU 2016257911 B2 AU2016257911 B2 AU 2016257911B2 AU 2016257911 A AU2016257911 A AU 2016257911A AU 2016257911 A AU2016257911 A AU 2016257911A AU 2016257911 B2 AU2016257911 B2 AU 2016257911B2
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Australia
Prior art keywords
composition according
mixture
enema composition
enema
block copolymer
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AU2016257911A
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AU2016257911A1 (en
Inventor
Aida Habtezion
Ravinder D. Pamnani
Jayakumar Rajadas
Sidhartha Ranjit SINHA
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016257911A 2015-05-04 2016-05-04 Compositions and methods for delivering therapeutic agents into the colon Active AU2016257911B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021203094A AU2021203094A1 (en) 2015-05-04 2021-05-14 Compositions and methods for delivering therapeutic agents into the colon

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562156682P 2015-05-04 2015-05-04
US62/156,682 2015-05-04
PCT/US2016/030682 WO2016179227A1 (en) 2015-05-04 2016-05-04 Compositions and methods for delivering therapeutic agents into the colon

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021203094A Division AU2021203094A1 (en) 2015-05-04 2021-05-14 Compositions and methods for delivering therapeutic agents into the colon

Publications (2)

Publication Number Publication Date
AU2016257911A1 AU2016257911A1 (en) 2017-11-09
AU2016257911B2 true AU2016257911B2 (en) 2021-02-18

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AU2016257911A Active AU2016257911B2 (en) 2015-05-04 2016-05-04 Compositions and methods for delivering therapeutic agents into the colon
AU2021203094A Abandoned AU2021203094A1 (en) 2015-05-04 2021-05-14 Compositions and methods for delivering therapeutic agents into the colon

Family Applications After (1)

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AU2021203094A Abandoned AU2021203094A1 (en) 2015-05-04 2021-05-14 Compositions and methods for delivering therapeutic agents into the colon

Country Status (9)

Country Link
US (3) US20180140619A1 (https=)
EP (2) EP3291818B1 (https=)
JP (1) JP6814162B2 (https=)
KR (1) KR20170142181A (https=)
AU (2) AU2016257911B2 (https=)
CA (1) CA2984111A1 (https=)
DK (1) DK3291818T3 (https=)
ES (1) ES2761636T3 (https=)
WO (1) WO2016179227A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015191547A1 (en) * 2014-06-09 2015-12-17 Cornell University Implantable therapeutic delivery system and methods thereof
WO2016179227A1 (en) * 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for delivering therapeutic agents into the colon
CN113271979A (zh) 2018-10-24 2021-08-17 费灵有限公司 皮质类固醇的粘膜粘附性药物组合物
US20210361602A1 (en) * 2020-05-22 2021-11-25 Intact Therapeutics, Inc. Dosing methods for treating inflammatory bowel conditions
JP2025504173A (ja) * 2022-02-04 2025-02-06 インタクト セラピューティクス， インコーポレイテッド メサラミン薬学的製剤およびその使用法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350690A (en) * 1980-10-27 1982-09-21 Cressington Investments Ltd. Steroid composition
US4765987A (en) * 1985-08-30 1988-08-23 Adir & Cie Artificial surfactants, pharmaceutical compositions containing them and use thereof
US20080020056A1 (en) * 2006-07-19 2008-01-24 The Board Of Regents Of The University Of Texas System Preparations of phospholipids and pharmaceuticals containing 5-amino salicylic acid for the treatment of inflammatory bowel disease
US20120111756A1 (en) * 2008-12-17 2012-05-10 Altheus Therapeutics, Inc. Enema formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040191276A1 (en) * 1999-11-30 2004-09-30 Cutispharma, Inc. Compositions and kits for compounding pharmaceuticals
IT1402047B1 (it) * 2010-10-19 2013-08-28 Cross Pharma Sa Uso del mexiprostil nel trattamento delle malattie infiammatorie intestinali
WO2016179227A1 (en) * 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for delivering therapeutic agents into the colon

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350690A (en) * 1980-10-27 1982-09-21 Cressington Investments Ltd. Steroid composition
US4765987A (en) * 1985-08-30 1988-08-23 Adir & Cie Artificial surfactants, pharmaceutical compositions containing them and use thereof
US20080020056A1 (en) * 2006-07-19 2008-01-24 The Board Of Regents Of The University Of Texas System Preparations of phospholipids and pharmaceuticals containing 5-amino salicylic acid for the treatment of inflammatory bowel disease
US20120111756A1 (en) * 2008-12-17 2012-05-10 Altheus Therapeutics, Inc. Enema formulations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLINICALTRIALS.GOV, Clinical Trials, (2012-11), pages 1 - 6, URL: https://clinicaltrials.gov/ct2/show/NCT01008410?term=NCT01008410&rank=1, (2016-06-28) *
KIM, DW et al., "The Influence of Bile Salt on the Chemotherapeutic Response of Docetaxel-Loaded Thermosensitive Nanomicelles.", International Journal of Nanomedicine., (2014-08-08), vol. 9, no. 1, pages 3816 - 3824 *
MOLOUGHNEY, JG et al., "Poloxamer 188 (P188) as a Membrane Resealing Reagent in Biomedical Applications.", Recent Patents on Biotechnology., (2012-12), vol. 6, no. 3, pages 1 - 21 *

Also Published As

Publication number Publication date
EP3659607A1 (en) 2020-06-03
EP3291818B1 (en) 2019-10-30
EP3291818A4 (en) 2018-12-12
EP3291818A1 (en) 2018-03-14
DK3291818T3 (da) 2019-12-09
US20180140619A1 (en) 2018-05-24
JP2018515511A (ja) 2018-06-14
AU2016257911A1 (en) 2017-11-09
ES2761636T3 (es) 2020-05-20
JP6814162B2 (ja) 2021-01-13
KR20170142181A (ko) 2017-12-27
WO2016179227A1 (en) 2016-11-10
AU2021203094A1 (en) 2021-06-10
US20210283148A1 (en) 2021-09-16
US20210330682A1 (en) 2021-10-28
CA2984111A1 (en) 2016-11-10

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