JP2017508802A5 - - Google Patents
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- Publication number
- JP2017508802A5 JP2017508802A5 JP2016575611A JP2016575611A JP2017508802A5 JP 2017508802 A5 JP2017508802 A5 JP 2017508802A5 JP 2016575611 A JP2016575611 A JP 2016575611A JP 2016575611 A JP2016575611 A JP 2016575611A JP 2017508802 A5 JP2017508802 A5 JP 2017508802A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alcohol
- betamethasone
- optionally
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 47
- 229960002537 betamethasone Drugs 0.000 claims 9
- -1 betamethasone compound Chemical class 0.000 claims 6
- QRFGDGZPNFSNCE-UHFFFAOYSA-N 2-hydroxyprop-2-enal Chemical compound OC(=C)C=O QRFGDGZPNFSNCE-UHFFFAOYSA-N 0.000 claims 5
- 239000003246 corticosteroid Substances 0.000 claims 5
- 239000012535 impurity Substances 0.000 claims 5
- 239000007921 spray Substances 0.000 claims 5
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 4
- 229940055577 oleyl alcohol Drugs 0.000 claims 4
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 3
- 239000003995 emulsifying agent Substances 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- WNZVVHVYAKZZBU-UHFFFAOYSA-N 1,17-Heptadecanediol Chemical compound OCCCCCCCCCCCCCCCCCO WNZVVHVYAKZZBU-UHFFFAOYSA-N 0.000 claims 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 229960001102 betamethasone dipropionate Drugs 0.000 claims 2
- CIWBQSYVNNPZIQ-XYWKZLDCSA-N betamethasone dipropionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CIWBQSYVNNPZIQ-XYWKZLDCSA-N 0.000 claims 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- IKYKEVDKGZYRMQ-PDBXOOCHSA-N (9Z,12Z,15Z)-octadecatrien-1-ol Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCO IKYKEVDKGZYRMQ-PDBXOOCHSA-N 0.000 claims 1
- YEGNTQBFSQBGJT-UHFFFAOYSA-N 2-heptylundecan-1-ol Chemical compound CCCCCCCCCC(CO)CCCCCCC YEGNTQBFSQBGJT-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 239000002280 amphoteric surfactant Substances 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 claims 1
- 229940116224 behenate Drugs 0.000 claims 1
- 229960000870 betamethasone benzoate Drugs 0.000 claims 1
- SOQJPQZCPBDOMF-YCUXZELOSA-N betamethasone benzoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@@H]1C)C(=O)CO)C(=O)C1=CC=CC=C1 SOQJPQZCPBDOMF-YCUXZELOSA-N 0.000 claims 1
- 229960005354 betamethasone sodium phosphate Drugs 0.000 claims 1
- PLCQGRYPOISRTQ-LWCNAHDDSA-L betamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-LWCNAHDDSA-L 0.000 claims 1
- 229960004311 betamethasone valerate Drugs 0.000 claims 1
- SNHRLVCMMWUAJD-SUYDQAKGSA-N betamethasone valerate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O SNHRLVCMMWUAJD-SUYDQAKGSA-N 0.000 claims 1
- 239000003093 cationic surfactant Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 238000005187 foaming Methods 0.000 claims 1
- 229920000591 gum Polymers 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 231100000344 non-irritating Toxicity 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- ALSTYHKOOCGGFT-MDZDMXLPSA-N oleyl alcohol Chemical compound CCCCCCCC\C=C\CCCCCCCCO ALSTYHKOOCGGFT-MDZDMXLPSA-N 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229940041677 topical spray Drugs 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
- 239000002888 zwitterionic surfactant Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461951165P | 2014-03-11 | 2014-03-11 | |
| US61/951,165 | 2014-03-11 | ||
| PCT/US2015/020031 WO2015138650A1 (en) | 2014-03-11 | 2015-03-11 | Topical corticosteroid compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017508802A JP2017508802A (ja) | 2017-03-30 |
| JP2017508802A5 true JP2017508802A5 (https=) | 2017-06-29 |
| JP6487949B2 JP6487949B2 (ja) | 2019-03-20 |
Family
ID=52727460
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575611A Expired - Fee Related JP6487949B2 (ja) | 2014-03-11 | 2015-03-11 | 局所用コルチコステロイド組成物 |
| JP2017516360A Expired - Fee Related JP6535735B2 (ja) | 2014-03-11 | 2015-09-09 | 局所用コルチコステロイド組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516360A Expired - Fee Related JP6535735B2 (ja) | 2014-03-11 | 2015-09-09 | 局所用コルチコステロイド組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20150258119A1 (https=) |
| EP (2) | EP3116473B1 (https=) |
| JP (2) | JP6487949B2 (https=) |
| KR (2) | KR101930244B1 (https=) |
| CN (1) | CN106659682B (https=) |
| AU (2) | AU2015229403B2 (https=) |
| BR (1) | BR112016021023A2 (https=) |
| CA (2) | CA2945943C (https=) |
| EA (2) | EA201691808A8 (https=) |
| ES (1) | ES2857602T3 (https=) |
| MX (2) | MX381164B (https=) |
| WO (2) | WO2015138650A1 (https=) |
| ZA (1) | ZA201606704B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5833007B2 (ja) | 2009-08-31 | 2015-12-16 | ドクター・レディーズ・ラボラトリーズ・リミテッド | ステロイドを含む局所製剤 |
| US20160184431A1 (en) | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
| WO2017091168A1 (en) * | 2015-11-28 | 2017-06-01 | Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. | A topical spray comprising isoconazole nitrate and difluocortolone valerate |
| JP6905994B2 (ja) | 2016-01-12 | 2021-07-21 | ノーティック ホールディングス インコーポレイテッド | ベタメタゾン経口スプレー製剤及び運動失調の治療への使用方法 |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| US20180028766A1 (en) * | 2016-07-27 | 2018-02-01 | Sun Pharmaceutical Industries Limited | Touch-free topical spray of halobetasol |
| CN109789111B (zh) | 2016-09-21 | 2021-11-16 | 埃维克辛公司 | 药物组合物 |
| US10543177B2 (en) * | 2017-04-11 | 2020-01-28 | Kevin Mrohs | Composition and method for treating skin conditions |
| US11620886B2 (en) | 2018-02-19 | 2023-04-04 | Invue Security Products Inc. | Merchandise security system with inductive charging |
| CN113453670A (zh) * | 2018-09-28 | 2021-09-28 | 乔·斯图丁 | 类固醇和大分子的透孔递送 |
| JP7412292B2 (ja) * | 2019-07-10 | 2024-01-12 | 積水化学工業株式会社 | 製剤 |
| WO2021080527A1 (en) * | 2019-10-24 | 2021-04-29 | Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Topical pharmaceutical compositions containing difluocortolone and isoconazole |
| EP4103151A1 (en) * | 2020-02-11 | 2022-12-21 | Taro Pharmaceutical Industries Ltd. | Compositions comprising desoximetasone and tazarotene |
| US11382863B2 (en) * | 2020-03-04 | 2022-07-12 | Somerset Therapeutics Llc | Injectable suspension comprising an insoluble corticosteroid and a soluble corticosteroid |
| CN113092601B (zh) * | 2021-03-02 | 2022-12-20 | 苏州市药品检验检测研究中心 | 一种化妆品中倍他米松17-丙酸酯及倍他米松21-丙酸酯的检测方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892856A (en) | 1974-04-10 | 1975-07-01 | Squibb & Sons Inc | Topical steroid formulation |
| US3934013A (en) | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
| US4343798A (en) | 1981-06-23 | 1982-08-10 | The Procter & Gamble Company | Topical antimicrobial anti-inflammatory compositions |
| US4552872A (en) * | 1983-06-21 | 1985-11-12 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing corticosteroids |
| US5422361A (en) * | 1989-12-20 | 1995-06-06 | Schering Corporation | Stable cream and lotion bases for lipophilic drug compositions |
| IT1247529B (it) | 1991-04-24 | 1994-12-17 | Poli Ind Chimica Spa | Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale |
| ATE223202T1 (de) | 1994-09-30 | 2002-09-15 | Mika Pharma Ges Fuer Die Entwi | Pharmazeutische zusammensetzung |
| GB9504265D0 (en) | 1995-03-03 | 1995-04-19 | Medeva Plc | Corticosteroid-containing pharmaceutical composition |
| IL152486A0 (en) * | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US20080206161A1 (en) * | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| US7820145B2 (en) * | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| ZA200507018B (en) * | 2003-12-16 | 2008-02-27 | Foamix Ltd | Oleaginous pharmaceutical and cosmetic foam |
| AU2005279704B2 (en) * | 2004-08-31 | 2010-05-13 | Stiefel Research Australia Pty Ltd | Microemulsion and sub-micron emulsion process and compositions |
| CN101048136B (zh) * | 2004-08-31 | 2011-06-22 | 施蒂福研究澳大利亚股份有限公司 | 微乳化和亚微米乳化方法和组合物 |
| US20060246098A1 (en) * | 2005-03-16 | 2006-11-02 | Srinivasa Rao | Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
| KR20080047312A (ko) | 2005-04-25 | 2008-05-28 | 다우 파마슈티컬 사이언시즈 | 건선 치료를 위한 클로베타솔 분무 제형의 용도 |
| GB2443162B (en) | 2006-10-28 | 2011-02-09 | Nupharm Lab Ltd | Betamethasone spray |
| JP5833007B2 (ja) * | 2009-08-31 | 2015-12-16 | ドクター・レディーズ・ラボラトリーズ・リミテッド | ステロイドを含む局所製剤 |
| WO2011064631A1 (en) * | 2009-10-02 | 2011-06-03 | Foamix Ltd. | Surfactant-free, water-free, foamable compositions and breakable foams and their uses |
| NL2004437C2 (en) * | 2010-03-19 | 2011-09-20 | Forte Iq B V | Spray-pumpable comprising composition suitable for topical skin application. |
| WO2011156030A2 (en) * | 2010-06-11 | 2011-12-15 | Precision Dermatology, Inc. | High oil-content emollient aerosol foam compositions |
| IN2015DN01009A (https=) * | 2012-08-10 | 2015-06-12 | Asahi Glass Co Ltd | |
| WO2014145067A1 (en) * | 2013-03-15 | 2014-09-18 | Medicis Pharmaceutical Corporation | Topical compositions of flunisolide and methods of treatment |
| US10111956B2 (en) * | 2013-06-03 | 2018-10-30 | Tolmar, Inc. | Corticosteroid compositions |
-
2015
- 2015-03-11 ES ES15712008T patent/ES2857602T3/es active Active
- 2015-03-11 WO PCT/US2015/020031 patent/WO2015138650A1/en not_active Ceased
- 2015-03-11 BR BR112016021023-9A patent/BR112016021023A2/pt not_active Application Discontinuation
- 2015-03-11 KR KR1020167028054A patent/KR101930244B1/ko not_active Expired - Fee Related
- 2015-03-11 JP JP2016575611A patent/JP6487949B2/ja not_active Expired - Fee Related
- 2015-03-11 US US14/645,338 patent/US20150258119A1/en not_active Abandoned
- 2015-03-11 AU AU2015229403A patent/AU2015229403B2/en not_active Ceased
- 2015-03-11 CA CA2945943A patent/CA2945943C/en active Active
- 2015-03-11 EA EA201691808A patent/EA201691808A8/ru unknown
- 2015-03-11 MX MX2016011842A patent/MX381164B/es unknown
- 2015-03-11 EP EP15712008.0A patent/EP3116473B1/en active Active
- 2015-09-09 EA EA201692334A patent/EA201692334A1/ru unknown
- 2015-09-09 AU AU2015385750A patent/AU2015385750B2/en not_active Ceased
- 2015-09-09 WO PCT/US2015/049244 patent/WO2016144381A1/en not_active Ceased
- 2015-09-09 CN CN201580035342.XA patent/CN106659682B/zh not_active Expired - Fee Related
- 2015-09-09 KR KR1020167030914A patent/KR101930246B1/ko not_active Expired - Fee Related
- 2015-09-09 JP JP2017516360A patent/JP6535735B2/ja not_active Expired - Fee Related
- 2015-09-09 MX MX2016011841A patent/MX2016011841A/es unknown
- 2015-09-09 EP EP15884898.6A patent/EP3197432A4/en not_active Withdrawn
- 2015-09-09 CA CA2946201A patent/CA2946201C/en active Active
- 2015-09-09 US US14/849,465 patent/US20160030450A1/en not_active Abandoned
-
2016
- 2016-09-28 ZA ZA2016/06704A patent/ZA201606704B/en unknown
-
2018
- 2018-04-20 US US15/958,368 patent/US20180250312A1/en not_active Abandoned
-
2019
- 2019-08-27 US US16/551,872 patent/US20200230155A1/en not_active Abandoned
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