JP2018515116A5 - - Google Patents
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- Publication number
- JP2018515116A5 JP2018515116A5 JP2017559661A JP2017559661A JP2018515116A5 JP 2018515116 A5 JP2018515116 A5 JP 2018515116A5 JP 2017559661 A JP2017559661 A JP 2017559661A JP 2017559661 A JP2017559661 A JP 2017559661A JP 2018515116 A5 JP2018515116 A5 JP 2018515116A5
- Authority
- JP
- Japan
- Prior art keywords
- guanidine
- agent
- fish
- salmon
- egg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 20
- 238000000034 method Methods 0.000 claims 19
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 10
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 10
- 241000251468 Actinopterygii Species 0.000 claims 9
- 235000019688 fish Nutrition 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 235000013601 eggs Nutrition 0.000 claims 7
- 230000000692 anti-sense effect Effects 0.000 claims 6
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 6
- 241000277331 Salmonidae Species 0.000 claims 4
- 241000277269 Oncorhynchus masou Species 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000007654 immersion Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 241000269799 Perca fluviatilis Species 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 101150100366 end gene Proteins 0.000 claims 2
- 230000026109 gonad development Effects 0.000 claims 2
- 210000004681 ovum Anatomy 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 231100000167 toxic agent Toxicity 0.000 claims 2
- 239000003440 toxic substance Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241001519451 Abramis brama Species 0.000 claims 1
- 241001584785 Anavitrinella pampinaria Species 0.000 claims 1
- 241000473391 Archosargus rhomboidalis Species 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 241000276616 Cichlidae Species 0.000 claims 1
- 241000252233 Cyprinus carpio Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000252212 Danio rerio Species 0.000 claims 1
- 101100263436 Drosophila melanogaster vas gene Proteins 0.000 claims 1
- 108010060374 FSH Receptors Proteins 0.000 claims 1
- 241001539176 Hime Species 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- 102000008238 LHRH Receptors Human genes 0.000 claims 1
- 108010021290 LHRH Receptors Proteins 0.000 claims 1
- 241000195947 Lycopodium Species 0.000 claims 1
- 241001125776 Melanochromis auratus Species 0.000 claims 1
- 241001481834 Morone Species 0.000 claims 1
- 241000202240 Morone americana Species 0.000 claims 1
- 241000202236 Morone chrysops Species 0.000 claims 1
- 241000202238 Morone mississippiensis Species 0.000 claims 1
- 241001481825 Morone saxatilis Species 0.000 claims 1
- 241000143387 Moronidae Species 0.000 claims 1
- 241000549556 Nanos Species 0.000 claims 1
- 241000277329 Oncorhynchus keta Species 0.000 claims 1
- 241000277338 Oncorhynchus kisutch Species 0.000 claims 1
- 241000277275 Oncorhynchus mykiss Species 0.000 claims 1
- 241000277277 Oncorhynchus nerka Species 0.000 claims 1
- 241001280377 Oncorhynchus tshawytscha Species 0.000 claims 1
- 241000276701 Oreochromis mossambicus Species 0.000 claims 1
- 241000276703 Oreochromis niloticus Species 0.000 claims 1
- 101100049051 Penaeus vannamei vasa gene Proteins 0.000 claims 1
- 241000269798 Perca flavescens Species 0.000 claims 1
- 241000277263 Salmo Species 0.000 claims 1
- 241000277288 Salmo trutta Species 0.000 claims 1
- 241000276707 Tilapia Species 0.000 claims 1
- 241001233037 catfish Species 0.000 claims 1
- 210000001136 chorion Anatomy 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 229940000406 drug candidate Drugs 0.000 claims 1
- -1 drug candidate Substances 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163511P | 2015-05-19 | 2015-05-19 | |
| US62/163,511 | 2015-05-19 | ||
| US201662274958P | 2016-01-05 | 2016-01-05 | |
| US62/274,958 | 2016-01-05 | ||
| PCT/US2016/032873 WO2016187198A2 (en) | 2015-05-19 | 2016-05-17 | Methods of agent delivery into eggs and embryos of egg-producing aquatic animals for drug screening, agent toxicity assay and production of infertile fish |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515116A JP2018515116A (ja) | 2018-06-14 |
| JP2018515116A5 true JP2018515116A5 (https=) | 2019-06-20 |
| JP6756960B2 JP6756960B2 (ja) | 2020-09-16 |
Family
ID=56084421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559661A Active JP6756960B2 (ja) | 2015-05-19 | 2016-05-17 | 卵生水生動物の卵内への薬剤送達方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10709119B2 (https=) |
| EP (1) | EP3297429A2 (https=) |
| JP (1) | JP6756960B2 (https=) |
| CN (1) | CN108040459B (https=) |
| AU (1) | AU2016265929B2 (https=) |
| BR (1) | BR112017024662A2 (https=) |
| CL (1) | CL2017002864A1 (https=) |
| DK (1) | DK180094B1 (https=) |
| IL (1) | IL255338B (https=) |
| MX (1) | MX386910B (https=) |
| RU (1) | RU2741645C2 (https=) |
| WO (1) | WO2016187198A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2929496C (en) | 2013-11-15 | 2022-08-23 | University Of Maryland Baltimore County | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
| EP3723479B1 (en) * | 2017-12-15 | 2024-05-22 | ACD Pharmaceuticals AS | Methods for the production of sterile fish |
| GEP20237545B (en) * | 2018-12-17 | 2023-10-10 | Alfred Wegener Inst Helmholtz Zentrum Fuer Polar Und Meeres Forschung | Method for producing caviar or caviar-like product from living, mature eggs of fish or crustaceans, and products of this kind |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005001028A2 (en) | 2003-05-19 | 2005-01-06 | University Of Hawaii | Method for direct nucleic acid uptake |
| US7194978B2 (en) | 2003-08-22 | 2007-03-27 | University Of Maryland Biotechnology Institute | Inducing sterility in fish by disrupting the development of the GnRH system |
| CN1294808C (zh) | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
| CN1274822C (zh) | 2004-02-19 | 2006-09-13 | 武汉康祥科技发展有限公司 | 活体化学诱导鱼类雌核发育方法 |
| CN101553210A (zh) * | 2006-09-20 | 2009-10-07 | 奈克斯特安全有限公司 | 经吸入输送药物的方法和系统 |
| JP2010516277A (ja) | 2007-01-26 | 2010-05-20 | シナジェバ・バイオファーマ・コーポレイション | トリにおける導入遺伝子発現 |
| US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
| US8383880B2 (en) | 2009-02-18 | 2013-02-26 | Academia Sinica | Infertility control of genetically modified fish |
| WO2011018798A2 (en) * | 2009-08-14 | 2011-02-17 | Indian Association For The Cultivation Of Science | Morpholino-based antisense agent |
| US8921643B2 (en) | 2010-02-09 | 2014-12-30 | National University Corporation Hokkaido University | Method for acquiring genetically identical gamete from lethal fish haploid-derived germ cell via germ line chimera |
| US9534235B2 (en) | 2011-02-01 | 2017-01-03 | Purdue Research Foundation | Efficient sterilization of fish by disruption of germ cell development |
| GB201117538D0 (en) * | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
| RU2504389C2 (ru) * | 2012-02-16 | 2014-01-20 | Федеральное государственное бюджетное учреждение науки Институт биохимии и физиологии микроорганизмов им. Г.К. Скрябина Российской академии наук (ИБФМ РАН) | СПОСОБ ПОРОФОРМИРОВАНИЯ В МЕМБРАНАХ КЛЕТОК ПЕЧЕНИ С ПОМОЩЬЮ ОБРАБОТКИ ИХ ГЕМОЛИЗИНОМ II Bacillus cereus |
| US9538734B2 (en) | 2013-03-12 | 2017-01-10 | The General Hospital Corporation | Germ cell ablation compounds and uses thereof |
| CA2929496C (en) * | 2013-11-15 | 2022-08-23 | University Of Maryland Baltimore County | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
-
2016
- 2016-05-17 CN CN201680028215.1A patent/CN108040459B/zh active Active
- 2016-05-17 US US15/568,729 patent/US10709119B2/en active Active
- 2016-05-17 AU AU2016265929A patent/AU2016265929B2/en active Active
- 2016-05-17 EP EP16725715.3A patent/EP3297429A2/en active Pending
- 2016-05-17 MX MX2017014856A patent/MX386910B/es unknown
- 2016-05-17 BR BR112017024662A patent/BR112017024662A2/pt not_active Application Discontinuation
- 2016-05-17 WO PCT/US2016/032873 patent/WO2016187198A2/en not_active Ceased
- 2016-05-17 DK DKPA201770877A patent/DK180094B1/en active IP Right Grant
- 2016-05-17 RU RU2017142635A patent/RU2741645C2/ru active
- 2016-05-17 JP JP2017559661A patent/JP6756960B2/ja active Active
-
2017
- 2017-10-30 IL IL255338A patent/IL255338B/en unknown
- 2017-11-10 CL CL2017002864A patent/CL2017002864A1/es unknown
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