JP2018515116A5 - - Google Patents
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- Publication number
- JP2018515116A5 JP2018515116A5 JP2017559661A JP2017559661A JP2018515116A5 JP 2018515116 A5 JP2018515116 A5 JP 2018515116A5 JP 2017559661 A JP2017559661 A JP 2017559661A JP 2017559661 A JP2017559661 A JP 2017559661A JP 2018515116 A5 JP2018515116 A5 JP 2018515116A5
- Authority
- JP
- Japan
- Prior art keywords
- guanidine
- agent
- fish
- salmon
- egg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 20
- 238000000034 method Methods 0.000 claims 19
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 10
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 10
- 241000251468 Actinopterygii Species 0.000 claims 9
- 235000019688 fish Nutrition 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 235000013601 eggs Nutrition 0.000 claims 7
- 230000000692 anti-sense effect Effects 0.000 claims 6
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 6
- 241000277331 Salmonidae Species 0.000 claims 4
- 241000277269 Oncorhynchus masou Species 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000007654 immersion Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 241000269799 Perca fluviatilis Species 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 101150100366 end gene Proteins 0.000 claims 2
- 230000026109 gonad development Effects 0.000 claims 2
- 210000004681 ovum Anatomy 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 231100000167 toxic agent Toxicity 0.000 claims 2
- 239000003440 toxic substance Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241001519451 Abramis brama Species 0.000 claims 1
- 241001584785 Anavitrinella pampinaria Species 0.000 claims 1
- 241000473391 Archosargus rhomboidalis Species 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 241000276616 Cichlidae Species 0.000 claims 1
- 241000252233 Cyprinus carpio Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 241000252212 Danio rerio Species 0.000 claims 1
- 101100263436 Drosophila melanogaster vas gene Proteins 0.000 claims 1
- 108010060374 FSH Receptors Proteins 0.000 claims 1
- 241001539176 Hime Species 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- 102000008238 LHRH Receptors Human genes 0.000 claims 1
- 108010021290 LHRH Receptors Proteins 0.000 claims 1
- 241000195947 Lycopodium Species 0.000 claims 1
- 241001125776 Melanochromis auratus Species 0.000 claims 1
- 241001481834 Morone Species 0.000 claims 1
- 241000202240 Morone americana Species 0.000 claims 1
- 241000202236 Morone chrysops Species 0.000 claims 1
- 241000202238 Morone mississippiensis Species 0.000 claims 1
- 241001481825 Morone saxatilis Species 0.000 claims 1
- 241000143387 Moronidae Species 0.000 claims 1
- 241000549556 Nanos Species 0.000 claims 1
- 241000277329 Oncorhynchus keta Species 0.000 claims 1
- 241000277338 Oncorhynchus kisutch Species 0.000 claims 1
- 241000277275 Oncorhynchus mykiss Species 0.000 claims 1
- 241000277277 Oncorhynchus nerka Species 0.000 claims 1
- 241001280377 Oncorhynchus tshawytscha Species 0.000 claims 1
- 241000276701 Oreochromis mossambicus Species 0.000 claims 1
- 241000276703 Oreochromis niloticus Species 0.000 claims 1
- 101100049051 Penaeus vannamei vasa gene Proteins 0.000 claims 1
- 241000269798 Perca flavescens Species 0.000 claims 1
- 241000277263 Salmo Species 0.000 claims 1
- 241000277288 Salmo trutta Species 0.000 claims 1
- 241000276707 Tilapia Species 0.000 claims 1
- 241001233037 catfish Species 0.000 claims 1
- 210000001136 chorion Anatomy 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 229940000406 drug candidate Drugs 0.000 claims 1
- -1 drug candidate Substances 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163511P | 2015-05-19 | 2015-05-19 | |
| US62/163,511 | 2015-05-19 | ||
| US201662274958P | 2016-01-05 | 2016-01-05 | |
| US62/274,958 | 2016-01-05 | ||
| PCT/US2016/032873 WO2016187198A2 (en) | 2015-05-19 | 2016-05-17 | Methods of agent delivery into eggs and embryos of egg-producing aquatic animals for drug screening, agent toxicity assay and production of infertile fish |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515116A JP2018515116A (ja) | 2018-06-14 |
| JP2018515116A5 true JP2018515116A5 (https=) | 2019-06-20 |
| JP6756960B2 JP6756960B2 (ja) | 2020-09-16 |
Family
ID=56084421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559661A Active JP6756960B2 (ja) | 2015-05-19 | 2016-05-17 | 卵生水生動物の卵内への薬剤送達方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10709119B2 (https=) |
| EP (1) | EP3297429A2 (https=) |
| JP (1) | JP6756960B2 (https=) |
| CN (1) | CN108040459B (https=) |
| AU (1) | AU2016265929B2 (https=) |
| BR (1) | BR112017024662A2 (https=) |
| CL (1) | CL2017002864A1 (https=) |
| DK (1) | DK180094B1 (https=) |
| IL (1) | IL255338B (https=) |
| MX (1) | MX386910B (https=) |
| RU (1) | RU2741645C2 (https=) |
| WO (1) | WO2016187198A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3068216T3 (pl) | 2013-11-15 | 2024-10-14 | University Of Maryland At Baltimore County | Sposób wytwarzania bezpłodnych ryb i zwierząt wodnych wytwarzających jajeczka i dostarczania związków do jajeczek i zarodków |
| AU2018385901B2 (en) | 2017-12-15 | 2024-12-05 | Acd Pharmaceuticals As | Methods for the production of sterile fish and other egg-producing aquatic animals and compounds for use in the methods |
| GEAP202315696A (en) * | 2018-12-17 | 2023-06-12 | Alfred Wegener Inst Helmholtz Zentrum Fuer Polar Und Meeres Forschung | Method for producing caviar or caviar-like product from living, mature eggs of fish or crustaceans, and products of this kind |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115794B2 (en) * | 2003-05-19 | 2006-10-03 | University Of Hawaii | Method for direct nucleic acid uptake |
| US7194978B2 (en) | 2003-08-22 | 2007-03-27 | University Of Maryland Biotechnology Institute | Inducing sterility in fish by disrupting the development of the GnRH system |
| CN1294808C (zh) | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
| CN1274822C (zh) | 2004-02-19 | 2006-09-13 | 武汉康祥科技发展有限公司 | 活体化学诱导鱼类雌核发育方法 |
| CN101553210A (zh) * | 2006-09-20 | 2009-10-07 | 奈克斯特安全有限公司 | 经吸入输送药物的方法和系统 |
| NZ578390A (en) | 2007-01-26 | 2012-01-12 | Synageva Biopharma Corp | Transgene expression in avians using oviduct specific promoters and SIN vectors |
| US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
| US8383880B2 (en) | 2009-02-18 | 2013-02-26 | Academia Sinica | Infertility control of genetically modified fish |
| US9914745B2 (en) * | 2009-08-14 | 2018-03-13 | Indian Association For The Cultivation Of Science | Morpholino-based antisense agent |
| JP5843153B2 (ja) | 2010-02-09 | 2016-01-13 | 国立大学法人北海道大学 | 生殖系列キメラを介して致死的魚類半数体に由来する生殖細胞から遺伝的に同一な配偶子を得る方法 |
| WO2012106026A2 (en) | 2011-02-01 | 2012-08-09 | Purdue Research Foundation | Efficient sterilization of fish by disruption of germ cell development |
| GB201117538D0 (en) * | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
| RU2504389C2 (ru) * | 2012-02-16 | 2014-01-20 | Федеральное государственное бюджетное учреждение науки Институт биохимии и физиологии микроорганизмов им. Г.К. Скрябина Российской академии наук (ИБФМ РАН) | СПОСОБ ПОРОФОРМИРОВАНИЯ В МЕМБРАНАХ КЛЕТОК ПЕЧЕНИ С ПОМОЩЬЮ ОБРАБОТКИ ИХ ГЕМОЛИЗИНОМ II Bacillus cereus |
| US9538734B2 (en) | 2013-03-12 | 2017-01-10 | The General Hospital Corporation | Germ cell ablation compounds and uses thereof |
| PL3068216T3 (pl) | 2013-11-15 | 2024-10-14 | University Of Maryland At Baltimore County | Sposób wytwarzania bezpłodnych ryb i zwierząt wodnych wytwarzających jajeczka i dostarczania związków do jajeczek i zarodków |
-
2016
- 2016-05-17 BR BR112017024662A patent/BR112017024662A2/pt not_active Application Discontinuation
- 2016-05-17 JP JP2017559661A patent/JP6756960B2/ja active Active
- 2016-05-17 RU RU2017142635A patent/RU2741645C2/ru active
- 2016-05-17 CN CN201680028215.1A patent/CN108040459B/zh active Active
- 2016-05-17 US US15/568,729 patent/US10709119B2/en active Active
- 2016-05-17 EP EP16725715.3A patent/EP3297429A2/en active Pending
- 2016-05-17 WO PCT/US2016/032873 patent/WO2016187198A2/en not_active Ceased
- 2016-05-17 AU AU2016265929A patent/AU2016265929B2/en active Active
- 2016-05-17 MX MX2017014856A patent/MX386910B/es unknown
- 2016-05-17 DK DKPA201770877A patent/DK180094B1/en active IP Right Grant
-
2017
- 2017-10-30 IL IL255338A patent/IL255338B/en unknown
- 2017-11-10 CL CL2017002864A patent/CL2017002864A1/es unknown
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