JP2018514564A5 - - Google Patents
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- Publication number
- JP2018514564A5 JP2018514564A5 JP2017556853A JP2017556853A JP2018514564A5 JP 2018514564 A5 JP2018514564 A5 JP 2018514564A5 JP 2017556853 A JP2017556853 A JP 2017556853A JP 2017556853 A JP2017556853 A JP 2017556853A JP 2018514564 A5 JP2018514564 A5 JP 2018514564A5
- Authority
- JP
- Japan
- Prior art keywords
- powder
- zolmitriptan
- particles
- powder formulation
- phosphatidyl choline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 claims 47
- 239000000203 mixture Substances 0.000 claims 35
- 238000009472 formulation Methods 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 19
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N Zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 claims 16
- 229960001360 zolmitriptan Drugs 0.000 claims 16
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 13
- 239000011780 sodium chloride Substances 0.000 claims 11
- 235000002639 sodium chloride Nutrition 0.000 claims 11
- KILNVBDSWZSGLL-KXQOOQHDSA-N Dipalmitoylphosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 9
- 229960003136 leucine Drugs 0.000 claims 7
- 239000004395 L-leucine Substances 0.000 claims 6
- 235000019454 L-leucine Nutrition 0.000 claims 6
- 150000003904 phospholipids Chemical class 0.000 claims 6
- 229960002668 sodium chloride Drugs 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 230000002685 pulmonary Effects 0.000 claims 3
- 239000005913 Maltodextrin Substances 0.000 claims 2
- 229920002774 Maltodextrin Polymers 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 229940035034 maltodextrin Drugs 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- -1 sugar alcohols Chemical class 0.000 claims 2
- IJFVSSZAOYLHEE-SSEXGKCCSA-O 1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) Chemical compound CCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCC IJFVSSZAOYLHEE-SSEXGKCCSA-O 0.000 claims 1
- 230000037275 AUC 0-24 Effects 0.000 claims 1
- 229960003767 Alanine Drugs 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 230000037242 Cmax Effects 0.000 claims 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 229960002449 Glycine Drugs 0.000 claims 1
- 229960000310 ISOLEUCINE Drugs 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 206010027599 Migraine Diseases 0.000 claims 1
- 208000008085 Migraine Disorders Diseases 0.000 claims 1
- 206010027603 Migraine headache Diseases 0.000 claims 1
- 229960005190 Phenylalanine Drugs 0.000 claims 1
- 229940067631 Phospholipids Drugs 0.000 claims 1
- 229940005581 Sodium Lactate Drugs 0.000 claims 1
- NGSFWBMYFKHRBD-UHFFFAOYSA-M Sodium lactate Chemical compound [Na+].CC(O)C([O-])=O NGSFWBMYFKHRBD-UHFFFAOYSA-M 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K Trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims 1
- 230000001058 adult Effects 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 150000002337 glycosamines Chemical class 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 150000008105 phosphatidylcholines Chemical class 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- 239000001540 sodium lactate Substances 0.000 claims 1
- 235000011088 sodium lactate Nutrition 0.000 claims 1
- 239000011778 trisodium citrate Substances 0.000 claims 1
- 235000019263 trisodium citrate Nutrition 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 229960004295 valine Drugs 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562155910P | 2015-05-01 | 2015-05-01 | |
US62/155,910 | 2015-05-01 | ||
PCT/US2016/030219 WO2016179026A1 (en) | 2015-05-01 | 2016-04-29 | Zolmitriptan powders for pulmonary delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018514564A JP2018514564A (ja) | 2018-06-07 |
JP2018514564A5 true JP2018514564A5 (US07981874-20110719-C00313.png) | 2019-06-06 |
Family
ID=56027187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017556853A Pending JP2018514564A (ja) | 2015-05-01 | 2016-04-29 | 肺送達用のゾルミトリプタン粉末 |
Country Status (9)
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3316865A4 (en) * | 2015-07-02 | 2019-01-23 | Civitas Therapeutics, Inc. | POWDERS CONTAINING TRIPTAN, FOR PULMONARY DELIVERY |
MX2020006633A (es) * | 2017-12-21 | 2021-01-15 | Civitas Therapeutics Inc | Formulaciones de surfactantes para inhalacion. |
EP3880172A1 (en) * | 2018-11-13 | 2021-09-22 | Civitas Therapeutics, Inc. | Respirable polynucleotide powder formulations for inhalation |
SI3962455T1 (sl) | 2020-05-18 | 2022-11-30 | Orexo Ab | Nov farmacevtski sestavek za dostavo zdravil |
EP4236921A1 (en) | 2021-11-25 | 2023-09-06 | Orexo AB | Pharmaceutical composition comprising adrenaline |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
US6766799B2 (en) | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
US6848197B2 (en) | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
JP2005520843A (ja) * | 2002-03-20 | 2005-07-14 | アドバンスト インハレーション リサーチ,インコーポレイテッド | 呼吸用持続性治療製剤 |
US7763280B2 (en) | 2002-11-28 | 2010-07-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing powder formulation for inhalation |
WO2008156586A2 (en) | 2007-06-12 | 2008-12-24 | Alkermes, Inc. | Inhalation device for powdered substances |
CA2728808A1 (en) * | 2008-02-01 | 2009-08-06 | Vectura Limited | Pulmonary formulations of triptans |
AU2011326529B2 (en) * | 2010-11-09 | 2015-07-30 | Mannkind Corporation | Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines |
ITMI20130572A1 (it) * | 2013-04-10 | 2014-10-11 | Eratech Srl | Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione |
-
2016
- 2016-04-29 MX MX2017013950A patent/MX2017013950A/es unknown
- 2016-04-29 CA CA2984339A patent/CA2984339A1/en not_active Abandoned
- 2016-04-29 WO PCT/US2016/030219 patent/WO2016179026A1/en active Application Filing
- 2016-04-29 KR KR1020177034671A patent/KR20180002750A/ko unknown
- 2016-04-29 US US15/143,131 patent/US20160317503A1/en not_active Abandoned
- 2016-04-29 EP EP16724183.5A patent/EP3288591A1/en not_active Withdrawn
- 2016-04-29 AU AU2016257729A patent/AU2016257729A1/en not_active Abandoned
- 2016-04-29 JP JP2017556853A patent/JP2018514564A/ja active Pending
-
2018
- 2018-09-04 HK HK18111327.1A patent/HK1251998A1/zh unknown
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