JP2018513679A5 - - Google Patents
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- JP2018513679A5 JP2018513679A5 JP2017549623A JP2017549623A JP2018513679A5 JP 2018513679 A5 JP2018513679 A5 JP 2018513679A5 JP 2017549623 A JP2017549623 A JP 2017549623A JP 2017549623 A JP2017549623 A JP 2017549623A JP 2018513679 A5 JP2018513679 A5 JP 2018513679A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cdna
- ctcs
- droplet
- ctc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002299 complementary DNA Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 17
- 210000005266 circulating tumour cell Anatomy 0.000 claims 15
- 206010006187 Breast cancer Diseases 0.000 claims 11
- 208000026310 Breast neoplasm Diseases 0.000 claims 11
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 239000008280 blood Substances 0.000 claims 11
- 210000004369 blood Anatomy 0.000 claims 11
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 10
- 201000005202 lung cancer Diseases 0.000 claims 10
- 208000020816 lung neoplasm Diseases 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 9
- 229920002477 rna polymer Polymers 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 6
- 201000007270 liver cancer Diseases 0.000 claims 6
- 208000014018 liver neoplasm Diseases 0.000 claims 6
- 238000012360 testing method Methods 0.000 claims 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
- 201000001441 melanoma Diseases 0.000 claims 5
- 201000002528 pancreatic cancer Diseases 0.000 claims 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
- 125000006853 reporter group Chemical group 0.000 claims 5
- 108700020796 Oncogene Proteins 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000000356 contaminant Substances 0.000 claims 3
- 238000003752 polymerase chain reaction Methods 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 108020004635 Complementary DNA Proteins 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 102000043276 Oncogene Human genes 0.000 claims 1
- 239000012807 PCR reagent Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562137891P | 2015-03-25 | 2015-03-25 | |
| US62/137,891 | 2015-03-25 | ||
| US201562219339P | 2015-09-16 | 2015-09-16 | |
| US62/219,339 | 2015-09-16 | ||
| US201562253619P | 2015-11-10 | 2015-11-10 | |
| US62/253,619 | 2015-11-10 | ||
| PCT/US2016/024367 WO2016154600A1 (en) | 2015-03-25 | 2016-03-25 | Digital analysis of circulating tumor cells in blood samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012116A Division JP7203128B2 (ja) | 2015-03-25 | 2021-01-28 | 血液試料中の循環腫瘍細胞のデジタル分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513679A JP2018513679A (ja) | 2018-05-31 |
| JP2018513679A5 true JP2018513679A5 (cg-RX-API-DMAC7.html) | 2019-05-09 |
| JP7144934B2 JP7144934B2 (ja) | 2022-09-30 |
Family
ID=56977798
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549623A Active JP7144934B2 (ja) | 2015-03-25 | 2016-03-25 | 血液試料中の循環腫瘍細胞のデジタル分析 |
| JP2021012116A Active JP7203128B2 (ja) | 2015-03-25 | 2021-01-28 | 血液試料中の循環腫瘍細胞のデジタル分析 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012116A Active JP7203128B2 (ja) | 2015-03-25 | 2021-01-28 | 血液試料中の循環腫瘍細胞のデジタル分析 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20180057889A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3274476B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7144934B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102502087B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107614698A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016238253B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2980562A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2954456T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL254639B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016154600A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107326085B (zh) | 2012-02-03 | 2022-05-03 | 加州理工学院 | 多路生化测定中信号的编码和解码 |
| CN107614698A (zh) | 2015-03-25 | 2018-01-19 | 通用医疗公司 | 对血液样品中的循环肿瘤细胞的数字分析 |
| US11371101B2 (en) | 2016-10-27 | 2022-06-28 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
| US20180252722A1 (en) * | 2017-03-05 | 2018-09-06 | Yan Wang | PCR-based Method for Counting Circulating Tumor Cells |
| US11597963B2 (en) * | 2017-11-09 | 2023-03-07 | Biomillenia Sas | Microbial selection system |
| WO2019165242A1 (en) * | 2018-02-23 | 2019-08-29 | Paraskevi Giannakakou | Assay for detection of androgen receptor variants |
| CN108535145A (zh) * | 2018-03-09 | 2018-09-14 | 深圳市瑞图生物技术有限公司 | 快速检测外周血液中网织红细胞数量的方法及装置 |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| US20210172950A1 (en) | 2018-06-29 | 2021-06-10 | The General Hospital Corporation | Isolating and analyzing rare brain-derived cells and particles |
| US12203129B2 (en) * | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| WO2020055954A2 (en) * | 2018-09-11 | 2020-03-19 | The General Hospital Corporation | Methods for detecting liver diseases |
| KR102380529B1 (ko) * | 2020-04-29 | 2022-03-31 | 인제대학교 산학협력단 | 전이성 전립선 암의 진단 및 예후 예측을 위한 혈중종양세포 기반 바이오 마커 조성물 |
| CN112662774A (zh) * | 2021-01-12 | 2021-04-16 | 南方医科大学南方医院 | 一种肝癌循环肿瘤细胞标志物及其应用 |
| CN114395622A (zh) * | 2021-12-13 | 2022-04-26 | 深圳先进技术研究院 | 一种利用数字pcr检测循环肿瘤细胞egfr基因突变的方法及其应用 |
| DE102022211089A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Kombinierte Zellspezifische Markierung und Anreicherung von Biomarkern |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US889A (en) | 1838-08-20 | Mode of constructing metal bench-vises | ||
| US8535A (en) | 1851-11-18 | Stove-geate | ||
| DE29623597U1 (de) | 1996-11-08 | 1999-01-07 | Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg | Temperierblock mit Temperiereinrichtungen |
| US20080050393A1 (en) | 1998-12-03 | 2008-02-28 | Tang Y Tom | Novel nucleic acids and polypeptides |
| CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
| WO2002012328A2 (en) * | 2000-08-03 | 2002-02-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| US20030143539A1 (en) | 2000-12-08 | 2003-07-31 | Francois Bertucci | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| EP1399593A2 (en) | 2001-05-16 | 2004-03-24 | Novartis AG | Genes expressed in breast cancer as prognostic and therapeutic targets |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| WO2006121991A2 (en) | 2005-05-06 | 2006-11-16 | Diadexus, Inc. | Compositions and methods for detection, prognosis and treatment of breast cancer |
| CA2652052A1 (en) * | 2006-05-16 | 2007-11-29 | Nugen Technologies, Inc. | Nucleic acid separation and purification method based on reversible charge interactions |
| EP2589668A1 (en) * | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| WO2009051734A1 (en) * | 2007-10-17 | 2009-04-23 | The General Hospital Corporation | Microchip-based devices for capturing circulating tumor cells and methods of their use |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| US20120252015A1 (en) * | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| US9625454B2 (en) * | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| US20110166030A1 (en) * | 2009-09-30 | 2011-07-07 | Yixin Wang | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells |
| CA2789425C (en) | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Digital analyte analysis with polymerase error correction |
| WO2011112903A2 (en) * | 2010-03-11 | 2011-09-15 | Board Of Regents, The University Of Texas System | Quantitative rt-pcr detection for genes involved in epithelial mesenchymal transition in peripheral blood of breast cancer patients |
| AU2015268617A1 (en) | 2010-03-31 | 2016-01-07 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| CA2793133C (en) | 2010-03-31 | 2019-08-20 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| US9650629B2 (en) * | 2010-07-07 | 2017-05-16 | Roche Molecular Systems, Inc. | Clonal pre-amplification in emulsion |
| AU2011291599B2 (en) | 2010-08-18 | 2015-09-10 | Caris Life Sciences Switzerland Holdings Gmbh | Circulating biomarkers for disease |
| WO2012115885A1 (en) | 2011-02-22 | 2012-08-30 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers |
| WO2012135397A2 (en) | 2011-03-29 | 2012-10-04 | Lisanti Michael P | Lactate-and ketones-induced gene signatures and use the same for diagnosing disease and predicting clinical outcome |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| EP2771685B1 (en) * | 2011-10-24 | 2018-06-13 | The General Hospital Corporation | Biomarkers of cancer |
| WO2014008155A1 (en) | 2012-07-02 | 2014-01-09 | The General Hospital Corporation | Diagnosis and monitoring treatment of prostate cancer |
| US10161007B2 (en) * | 2012-08-13 | 2018-12-25 | The Regents Of The University Of California | Methods and systems for detecting biological components |
| AU2013315128B2 (en) | 2012-09-14 | 2019-01-03 | Memorial Sloan-Kettering Cancer Center | Genes associated with dasatinib sensitivity |
| WO2014047285A1 (en) | 2012-09-19 | 2014-03-27 | Paraskevi Giannakakou | Identifying taxane sensitivity in prostate cancer patients |
| WO2014075067A1 (en) | 2012-11-12 | 2014-05-15 | Nanostring Technologies, Inc. | Methods to predict breast cancer outcome |
| WO2014165762A1 (en) | 2013-04-05 | 2014-10-09 | Raindance Technologies, Inc. | Rare cell analysis after negative selection |
| CA2920317A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| EP3560591B1 (en) | 2013-10-18 | 2021-02-17 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| AU2015228860A1 (en) | 2014-03-13 | 2016-09-08 | F. Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
| BR112016024332A2 (pt) | 2014-05-21 | 2017-08-15 | Hoffmann La Roche | métodos para o tratamento, para a determinação dos compostos a serem utilizados, para a seleção de pacientes, para a monitoração da eficácia terapêutica, para a optimização da eficácia terapêutica, para a identificação de um biomarcador, artigo de fabricação, utilização de gdc-0941, gdc-0941 e um agente de terapia endócrina e composto para a utilização |
| WO2016094904A1 (en) | 2014-12-12 | 2016-06-16 | Celcuity Llc | Methods of measuring erbb signaling pathway activity to diagnose and treat cancer patients |
| US20180057899A1 (en) | 2015-02-20 | 2018-03-01 | Comelz S.P.A. | Method for cutting natural hides and the like |
| LT3268493T (lt) | 2015-03-12 | 2022-03-10 | Janssen Pharmaceutica Nv | Viso kraujo mrnr žymenys, skirti prostatos vėžio prognozavimui, ir jo nustatymo būdai |
| CN107614698A (zh) | 2015-03-25 | 2018-01-19 | 通用医疗公司 | 对血液样品中的循环肿瘤细胞的数字分析 |
| US11371101B2 (en) | 2016-10-27 | 2022-06-28 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
-
2016
- 2016-03-25 CN CN201680029396.XA patent/CN107614698A/zh active Pending
- 2016-03-25 CA CA2980562A patent/CA2980562A1/en active Pending
- 2016-03-25 AU AU2016238253A patent/AU2016238253B2/en active Active
- 2016-03-25 JP JP2017549623A patent/JP7144934B2/ja active Active
- 2016-03-25 ES ES16769818T patent/ES2954456T3/es active Active
- 2016-03-25 EP EP16769818.2A patent/EP3274476B1/en active Active
- 2016-03-25 KR KR1020177030104A patent/KR102502087B1/ko active Active
- 2016-03-25 WO PCT/US2016/024367 patent/WO2016154600A1/en not_active Ceased
- 2016-03-25 US US15/560,324 patent/US20180057889A1/en not_active Abandoned
-
2017
- 2017-09-24 IL IL254639A patent/IL254639B/en unknown
-
2020
- 2020-10-08 US US17/065,889 patent/US11898209B2/en active Active
-
2021
- 2021-01-28 JP JP2021012116A patent/JP7203128B2/ja active Active
-
2022
- 2022-09-15 AU AU2022231734A patent/AU2022231734A1/en not_active Abandoned
-
2023
- 2023-12-26 US US18/396,156 patent/US20240132969A1/en active Pending
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