JP2018507880A5 - - Google Patents

Info

Publication number

JP2018507880A5

JP2018507880A5 JP2017547148A JP2017547148A JP2018507880A5 JP 2018507880 A5 JP2018507880 A5 JP 2018507880A5 JP 2017547148 A JP2017547148 A JP 2017547148A JP 2017547148 A JP2017547148 A JP 2017547148A JP 2018507880 A5 JP2018507880 A5 JP 2018507880A5

Authority

JP

Japan

Prior art keywords

composition

hydrogen

hydroxyl

dose

amino acid

Prior art date

2016-03-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229910052739 hydrogen Inorganic materials 0.000 claims description 30
• 239000001257 hydrogen Substances 0.000 claims description 30
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 28
• 150000001875 compounds Chemical class 0.000 claims description 16
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
• 150000001413 amino acids Chemical class 0.000 claims description 15
• 150000003839 salts Chemical class 0.000 claims description 15
• 201000010099 disease Diseases 0.000 claims description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
• 208000019423 liver disease Diseases 0.000 claims description 7
• 208000024891 symptom Diseases 0.000 claims description 7
• 206010008635 Cholestasis Diseases 0.000 claims description 6
• 230000037182 bone density Effects 0.000 claims description 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
• 230000001404 mediated effect Effects 0.000 claims description 4
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 3
• 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 3
• 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 3
• 206010008609 Cholangitis sclerosing Diseases 0.000 claims description 2
• 208000029725 Metabolic bone disease Diseases 0.000 claims description 2
• 206010049088 Osteopenia Diseases 0.000 claims description 2
• 208000001132 Osteoporosis Diseases 0.000 claims description 2
• 230000008468 bone growth Effects 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
• 230000011164 ossification Effects 0.000 claims description 2
• 201000000742 primary sclerosing cholangitis Diseases 0.000 claims description 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 208000010157 sclerosing cholangitis Diseases 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 30
• 238000000034 method Methods 0.000 description 32
• 125000000217 alkyl group Chemical group 0.000 description 4
• 150000002431 hydrogen Chemical class 0.000 description 2
• 238000011282 treatment Methods 0.000 description 2