JP2018505697A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018505697A5 JP2018505697A5 JP2017557501A JP2017557501A JP2018505697A5 JP 2018505697 A5 JP2018505697 A5 JP 2018505697A5 JP 2017557501 A JP2017557501 A JP 2017557501A JP 2017557501 A JP2017557501 A JP 2017557501A JP 2018505697 A5 JP2018505697 A5 JP 2018505697A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- epitope
- construct
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 230000000890 antigenic effect Effects 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 239000013598 vector Substances 0.000 claims description 13
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 claims description 10
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 claims description 10
- 201000001320 Atherosclerosis Diseases 0.000 claims description 10
- 239000012634 fragment Substances 0.000 claims description 10
- 241000894007 species Species 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 8
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 8
- 229920001184 polypeptide Polymers 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 7
- 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 claims description 6
- 108010058432 Chaperonin 60 Proteins 0.000 claims description 6
- 210000001589 microsome Anatomy 0.000 claims description 6
- 230000037361 pathway Effects 0.000 claims description 6
- 206010003210 Arteriosclerosis Diseases 0.000 claims description 5
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims description 5
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims description 5
- 101710176384 Peptide 1 Proteins 0.000 claims description 5
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims description 5
- 101710204410 Scaffold protein Proteins 0.000 claims description 5
- 208000011775 arteriosclerosis disease Diseases 0.000 claims description 5
- 230000004044 response Effects 0.000 claims description 5
- 201000005019 Chlamydia pneumonia Diseases 0.000 claims description 4
- 101710164702 Major outer membrane protein Proteins 0.000 claims description 4
- 101710121440 Proteinase-activated receptor 1 Proteins 0.000 claims description 4
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 208000030773 pneumonia caused by chlamydia Diseases 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 241000186366 Mycobacterium bovis Species 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 102000007592 Apolipoproteins Human genes 0.000 claims description 2
- 108010071619 Apolipoproteins Proteins 0.000 claims description 2
- 101150066414 CPN1 gene Proteins 0.000 claims description 2
- 101000883686 Homo sapiens 60 kDa heat shock protein, mitochondrial Proteins 0.000 claims description 2
- 241000186359 Mycobacterium Species 0.000 claims description 2
- 101000944608 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Chaperonin GroEL 2 Proteins 0.000 claims description 2
- 101710116435 Outer membrane protein Proteins 0.000 claims description 2
- 102000001406 Perilipin Human genes 0.000 claims description 2
- 108060006002 Perilipin Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 239000000693 micelle Substances 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 102000002262 Thromboplastin Human genes 0.000 claims 2
- 108010000499 Thromboplastin Proteins 0.000 claims 2
- 101000658547 Escherichia coli (strain K12) Type I restriction enzyme EcoKI endonuclease subunit Proteins 0.000 claims 1
- 101000658543 Escherichia coli Type I restriction enzyme EcoAI endonuclease subunit Proteins 0.000 claims 1
- 101000658546 Escherichia coli Type I restriction enzyme EcoEI endonuclease subunit Proteins 0.000 claims 1
- 101000658530 Escherichia coli Type I restriction enzyme EcoR124II endonuclease subunit Proteins 0.000 claims 1
- 101000658540 Escherichia coli Type I restriction enzyme EcoprrI endonuclease subunit Proteins 0.000 claims 1
- 101000658545 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Type I restriction enyme HindI endonuclease subunit Proteins 0.000 claims 1
- 101000658548 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaIXP endonuclease subunit Proteins 0.000 claims 1
- 101000658542 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIIP endonuclease subunit Proteins 0.000 claims 1
- 101000658529 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIP endonuclease subunit Proteins 0.000 claims 1
- 101001042773 Staphylococcus aureus (strain COL) Type I restriction enzyme SauCOLORF180P endonuclease subunit Proteins 0.000 claims 1
- 101000838760 Staphylococcus aureus (strain MRSA252) Type I restriction enzyme SauMRSORF196P endonuclease subunit Proteins 0.000 claims 1
- 101000838761 Staphylococcus aureus (strain MSSA476) Type I restriction enzyme SauMSSORF170P endonuclease subunit Proteins 0.000 claims 1
- 101000838758 Staphylococcus aureus (strain MW2) Type I restriction enzyme SauMW2ORF169P endonuclease subunit Proteins 0.000 claims 1
- 101001042566 Staphylococcus aureus (strain Mu50 / ATCC 700699) Type I restriction enzyme SauMu50ORF195P endonuclease subunit Proteins 0.000 claims 1
- 101000838763 Staphylococcus aureus (strain N315) Type I restriction enzyme SauN315I endonuclease subunit Proteins 0.000 claims 1
- 101000838759 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) Type I restriction enzyme SepRPIP endonuclease subunit Proteins 0.000 claims 1
- 101000838756 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) Type I restriction enzyme SsaAORF53P endonuclease subunit Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 108010016851 thrombin receptor peptide (42-55) Proteins 0.000 claims 1
- OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000002163 immunogen Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 102000018616 Apolipoproteins B Human genes 0.000 description 1
- 108010027006 Apolipoproteins B Proteins 0.000 description 1
- 102100026789 Aryl hydrocarbon receptor repressor Human genes 0.000 description 1
- 101000690533 Homo sapiens Aryl hydrocarbon receptor repressor Proteins 0.000 description 1
- 102000032626 PAR-1 Receptor Human genes 0.000 description 1
- 108010070519 PAR-1 Receptor Proteins 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1501354.3 | 2015-01-27 | ||
| GBGB1501354.3A GB201501354D0 (en) | 2015-01-27 | 2015-01-27 | Multi-epitopic construct |
| GBGB1510195.9A GB201510195D0 (en) | 2015-06-11 | 2015-06-11 | Multi-epitopic construct |
| GB1510195.9 | 2015-06-11 | ||
| PCT/GB2016/050150 WO2016120596A1 (en) | 2015-01-27 | 2016-01-25 | Multi-epitopic construct |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020170199A Division JP7204226B2 (ja) | 2015-01-27 | 2020-10-08 | 複数エピトープ構築物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505697A JP2018505697A (ja) | 2018-03-01 |
| JP2018505697A5 true JP2018505697A5 (https=) | 2019-03-07 |
| JP6831334B2 JP6831334B2 (ja) | 2021-02-17 |
Family
ID=55237682
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557501A Active JP6831334B2 (ja) | 2015-01-27 | 2016-01-25 | 複数エピトープ構築物 |
| JP2020170199A Active JP7204226B2 (ja) | 2015-01-27 | 2020-10-08 | 複数エピトープ構築物 |
| JP2022204742A Active JP7662203B2 (ja) | 2015-01-27 | 2022-12-21 | 複数エピトープ構築物 |
| JP2025053425A Pending JP2025094254A (ja) | 2015-01-27 | 2025-03-27 | 複数エピトープ構築物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020170199A Active JP7204226B2 (ja) | 2015-01-27 | 2020-10-08 | 複数エピトープ構築物 |
| JP2022204742A Active JP7662203B2 (ja) | 2015-01-27 | 2022-12-21 | 複数エピトープ構築物 |
| JP2025053425A Pending JP2025094254A (ja) | 2015-01-27 | 2025-03-27 | 複数エピトープ構築物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11332515B2 (https=) |
| EP (1) | EP3250584B1 (https=) |
| JP (4) | JP6831334B2 (https=) |
| GB (1) | GB2539743A (https=) |
| WO (1) | WO2016120596A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6831334B2 (ja) | 2015-01-27 | 2021-02-17 | スロムボーシス リサーチ インスティチュート | 複数エピトープ構築物 |
| USD807376S1 (en) | 2015-06-14 | 2018-01-09 | Google Inc. | Display screen with animated graphical user interface for smart home automation system having a multifunction status |
| WO2022043686A1 (en) * | 2020-08-25 | 2022-03-03 | Thrombosis Research Institute | Vaccine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0002625D0 (en) | 2000-02-05 | 2000-03-29 | Trigen Ltd | Dendroaspin molecules |
| WO2001094411A1 (en) * | 2000-06-05 | 2001-12-13 | The Regents Of The University Of California | Peptides modulating protease activated receptors and methods of using same |
| EP2281007B1 (en) | 2008-04-10 | 2014-07-09 | Thrombosis Research Institute | Anti-atheroma vaccine |
| GB201206761D0 (en) * | 2012-04-17 | 2012-05-30 | Thrombosis Res Inst | Anti-atherogenic peptides |
| JP6831334B2 (ja) | 2015-01-27 | 2021-02-17 | スロムボーシス リサーチ インスティチュート | 複数エピトープ構築物 |
-
2016
- 2016-01-25 JP JP2017557501A patent/JP6831334B2/ja active Active
- 2016-01-25 US US15/546,858 patent/US11332515B2/en active Active
- 2016-01-25 WO PCT/GB2016/050150 patent/WO2016120596A1/en not_active Ceased
- 2016-01-25 GB GB1601286.6A patent/GB2539743A/en not_active Withdrawn
- 2016-01-25 EP EP16701871.2A patent/EP3250584B1/en active Active
-
2020
- 2020-10-08 JP JP2020170199A patent/JP7204226B2/ja active Active
-
2022
- 2022-03-14 US US17/693,785 patent/US20220195013A1/en not_active Abandoned
- 2022-12-21 JP JP2022204742A patent/JP7662203B2/ja active Active
-
2025
- 2025-03-27 JP JP2025053425A patent/JP2025094254A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023524054A (ja) | ベータコロナウイルスの予防と治療 | |
| JP2021042247A (ja) | Ａ群レンサ球菌ワクチン | |
| Wang et al. | Protective immune responses against systemic candidiasis mediated by phage-displayed specific epitope of Candida albicans heat shock protein 90 in C57BL/6J mice | |
| JP2023052092A (ja) | 免疫原性組成物 | |
| US20250230197A1 (en) | Malaria vaccine | |
| JP2018505697A5 (https=) | ||
| US20260014250A1 (en) | Immunoconjugate | |
| KR20240163165A (ko) | 에피토프의 조합과 그의 용도, 백신 구조물, 면역 반응의 유도 방법 에피토프의 식별 방법 | |
| US20040109871A1 (en) | M cell directed vaccines | |
| AU2016201589B2 (en) | Peptide adjuvants | |
| EP3713600B1 (en) | Synthetic hemagglutinin as universal vaccine against infection by type b influenza viruses (ibv) | |
| Ge et al. | Fusion expression of major antigenic segment of JEV E protein-hsp70 and the identification of domain acting as adjuvant in hsp70 | |
| Basirnejad et al. | Development of HCV therapeutic vaccines using Hp91 peptide and small heat shock protein 20 as an adjuvant | |
| WO2002072015A2 (en) | M cell directed vaccines | |
| TW200920748A (en) | Immunopeptides of HPV E6 and E7 proteins | |
| CN102127147B (zh) | 表皮生长因子受体模拟表位肽及其应用 | |
| US20260007734A1 (en) | Immunogenic compositions for the prevention of influenza a | |
| US7192590B2 (en) | Compounds for treatment of infectious and immune system disorders and methods for their use | |
| WO2017163083A1 (en) | Hcv vaccines | |
| JP2023520990A5 (https=) | ||
| JP2023543801A5 (https=) | ||
| CN103539840A (zh) | 表皮生长因子受体模拟表位肽及其应用 | |
| OA20058A (en) | Malaria vaccine. | |
| Shihab et al. | Recombinant listeriolysin-O as a platform for next-generation vaccines: Mechanisms, immunological evidence, and translational applications in human and veterinary medicine | |
| Nakagami et al. | Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats |