JP2018503489A - 温度受容体の化学的活性化により睡眠を調整する方法及び装置 - Google Patents
温度受容体の化学的活性化により睡眠を調整する方法及び装置 Download PDFInfo
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Abstract
Description
本願は、METHOD AND APPARATUSES FOR MODULATING SLEEP BY CHEMICAL ACTIVATION OF TEMPERATURE RECEPTORSと題された2015年1月27日に出願の米国仮特許出願第62/108461の優先権を主張するものである。
本明細書で挙げる全ての出版物及び特許出願は、あたかも各出版物又は特許出願が具体的且つ個別に示されて参照により援用されるのと同程度まで、参照により全て本明細書に援用される。
本発明の新規な特徴は、後出の請求項において具体的に記載する。本発明の特徴及び利点は、本発明の原理を利用した例示的な実施形態についての以下の詳細な説明及び添付のその図面を参照することでより深く理解できる。
本明細書に記載の装置及び方法はいずれも、温度(加温/冷却)刺激と化学的刺激とを組み合わせ得る。加えて又は代替的に、本明細書に記載されるような装置は代わりに又は加えて機械的な(例えば、振動)エネルギーを特には額を含めた本明細書に記載の身体領域のいずれか、一部又は全てに印加し得る。機械的エネルギーは、印加される低周波数(例えば、1000Hz未満、900Hz未満、800Hz未満、700Hz未満、600Hz未満、500Hz未満、400Hz未満、300Hz未満、200Hz未満、100Hz未満、80Hz未満、50Hz未満、40Hz未満、30Hz未満、20Hz未満、10Hz未満、5Hz未満等)になり得る。
Claims (29)
- 被験者において睡眠を増強する方法であって、以下の工程、
冷感受性受容体、温感受性受容体、又は温感受性受容体及び冷感受性受容体を化学的に活性化する生理活性物質を有するアプリケータを被験者の皮膚上に位置決めする工程、
前記被験者の皮膚上に前記生理活性物質を送達する工程、
前記被験者の皮膚上に加温又は冷却の感覚を化学的に引き起こすことで前記被験者において入眠を短縮する、睡眠維持を改善する、睡眠時間を増加させる、覚醒を減少させる又は浅い睡眠に対する深い睡眠の比を高める工程、
を含むことを特徴とする方法。 - 被験者において睡眠を増強する方法であって、以下の工程、
冷感受性受容体、温感受性受容体、又は温感受性受容体及び冷感受性受容体を活性化する生理活性物質を有するアプリケータを被験者の額、手又は足の皮膚上に位置決めする工程、
前記被験者の皮膚上に前記生理活性物質を送達する工程、
皮膚温を実質的に変化させることなく前記被験者の皮膚上に加温又は冷却の感覚を化学的に引き起こすことで前記被験者において入眠を短縮する、睡眠維持を改善する、睡眠時間を増加させる、覚醒を減少させる又は浅い睡眠に対する深い睡眠の比を高める工程、
を含むことを特徴とする方法。 - 被験者において睡眠を増強する方法であって、以下の工程、
冷感受性受容体、温感受性受容体、又は温感受性受容体及び冷感受性受容体を活性化する生理活性物質を有するアプリケータを被験者の額の皮膚上に位置決めする工程、
前記被験者の皮膚上に前記生理活性物質を送達する工程、
前記被験者の皮膚を加温又は冷却することなく前記被験者の皮膚上に加温又は冷却の感覚を化学的に引き起こすことで前記被験者において入眠を短縮する、睡眠維持を改善する、睡眠時間を増加させる、覚醒を減少させる又は浅い睡眠に対する深い睡眠の比を高める工程、
を含むことを特徴とする方法。 - 前記位置決めが、前記アプリケータを前記被験者の足、額又は手の上に置くことを含む、請求項1に記載の方法。
- 前記アプリケータの前記位置決めが、接着性パッチを前記被験者の皮膚上に置くことを含み、前記パッチが、前記生理活性物質を含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、前記生理活性物質を前記被験者の皮膚上に受動的に送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、前記生理活性物質を前記被験者の皮膚にエレクトロトランスポートにより送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、前記生理活性物質を経皮送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、前記生理活性物質及び浸透促進剤を前記被験者の皮膚上に送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記生理活性物質の前記被験者の皮膚上への送達が、2−アラキドノイルグリセロール、5(S)−HETE、12(s)−HpETE、15(S)−HpETE、アラキドノイルエタノールアミド(AEA又はアナンダミド)、カプサイシン、カプサイシノイド、冷受容体アゴニスト、イシリン(1−(2−ヒドロキシフェニル)−4−(3−ニトロフェニル)−3,6−ジヒドロピリミジン−2−オン)、ジヒドロカプサイシン、ユーカリプトール、ホモエディヒドロカプサイシン、ロイコトリエンB4、メントール(dメントール、dlメントール、lメントール)、メントール類似体、ノルジヒドロカプサイシン、N−アラキドノイルドーパミン(NADA)、N−オレオイルドーパミン(OLDA)、オレオイルエタノールアミド(OEA)、レシニフェラトキシン(RTX)、TRPA(一過性受容体電位A)アゴニスト、TRPA1アゴニスト、TRPA(一過性受容体電位A)アンタゴニスト、TRPA1アンタゴニスト、TRPM 2、4又は5アゴニスト、TRPM 2、4又は5(メラスタチン一過性受容体電位2、4又は5)アンタゴニスト、TRPV1−4(一過性受容体電位バニロイド−1−4)アゴニスト、TRPV1−4(一過性受容体電位バニロイド−1−4)アンタゴニスト、TRPM 2、4、5又は8(メラスタチン一過性受容体電位2、4、5又は8)アゴニスト又はメントール、バニロイド、n−ノナン酸のバニリアミド(NVA又はPAVA)及び温受容体アゴニストの少なくとも1種を送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、複数の生理活性物質を連続的に送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、1種以上の生理活性物質の前記被験者の皮膚への徐放を含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記送達が、複数の生理活性物質を前記被験者の皮膚に送達することを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記皮膚温を実質的に変化させることなく加温又は冷却の感覚を前記被験者の皮膚上で引き起こすことが、前記被験者の体温を0.11℃(0.2°F)未満変化させることを含む、請求項1又は2に記載の方法。
- 前記皮膚温を実質的に変化させることなく加温又は冷却の感覚を被験者の皮膚上で引き起こすことが、前記被験者の体温を0.28℃(0.5°F)未満変化させることを含む、請求項1又は2に記載の方法。
- 前記位置決めが、前記被験者に熱がない時に前記被験者上に位置決めすることを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記位置決めが、前記被験者の皮膚温が37℃(98.6°F)の0.28℃(0.5°F)以内である時に前記被験者上に位置決めすることを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記位置決めが、前記アプリケータを、睡眠障害を患っている被験者上に位置決めすることを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記位置決めが、前記アプリケータを、急性不眠症を患っている被験者上に位置決めすることを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記位置決めが、前記アプリケータを、慢性不眠症を患っている被験者上に位置決めすることを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 前記位置決めが、前記アプリケータを、前記被験者の顔の眼窩周囲又は頬領域に接触させることなく、前記被験者の額上に位置決めすることを含む、請求項1〜3のうちのいずれか1項に記載の方法。
- 被験者において睡眠を経皮的に増強するデバイスであって、以下、
アプリケータ本体と、
前記アプリケータ本体上の皮膚接触面であって、前記アプリケータ表面の下の皮膚温を0.28℃(0.5°F)を越えて変化させることなく生理活性物質を被験者の皮膚に伝達するように構成された、前記アプリケータ本体上の皮膚接触面と、
前記皮膚接触面上の生理活性物質であって、該生理活性物質が、冷感受性皮膚受容体、温感受性皮膚受容体、又は温感受性皮膚受容体及び冷感受性皮膚受容体を活性化する、前記皮膚接触面上の生理活性物質と、
を含み、
前記生理活性物質が、前記皮膚接触面により徐放されるように構成されることを特徴とするデバイス。 - 被験者において睡眠を経皮的に増強するデバイスであって、以下、
アプリケータ本体と、
前記アプリケータ本体上の皮膚接触面であって、前記アプリケータ表面の下の皮膚温を0.28℃(0.5°F)を越えて変化させることなく複数の生理活性物質を被験者の皮膚に伝達するように構成された、アプリケータ本体上の皮膚接触面と、
前記皮膚接触面上の複数の生理活性物質であって、該生理活性物質が、冷感受性皮膚受容体、温感受性皮膚受容体、又は温感受性皮膚受容体及び冷感受性皮膚受容体を活性化する、皮膚接触面上の複数の生理活性物質と、
を含み、
前記生理活性物質が、前記皮膚接触面から徐放されるように構成されることを特徴とするデバイス。 - 前記アプリケータが、接着性パッチとして構成される、請求項22又は23に記載のデバイス。
- 前記アプリケータが、異なる生理活性物質の複数のマイクロドメインを含み、マイクロドメイン群が、前記皮膚接触面から異なるタイミングで放出されるように構成される、請求項22又は23に記載のデバイス。
- 浸透促進剤を前記皮膚接触面上に更に含む、請求項22又は23に記載のデバイス。
- コントローラ、前記コントローラに接続された電源及び前記皮膚接触面と係合し且つ前記電源と接触している生理活性物質の貯蔵部を更に含み、前記コントローラが、電力を印加して前記生理活性物質をエレクトロトランスポートにより送達するように構成される、請求項22又は23に記載のデバイス。
- 前記生理活性物質が、2−アラキドノイルグリセロール、5(S)−HETE、12(s)−HpETE、15(S)−HpETE、アラキドノイルエタノールアミド(AEA又はアナンダミド)、カプサイシン、カプサイシノイド、冷受容体アゴニスト、イシリン(1−(2−ヒドロキシフェニル)−4−(3−ニトロフェニル)−3,6−ジヒドロピリミジン−2−オン)、ジヒドロカプサイシン、ユーカリプトール、ホモエディヒドロカプサイシン、ロイコトリエンB4、メントール(dメントール、dlメントール、lメントール)、メントール類似体、ノルジヒドロカプサイシン、N−アラキドノイルドーパミン(NADA)、N−オレオイルドーパミン(OLDA)、オレオイルエタノールアミド(OEA)、レシニフェラトキシン(RTX)、TRPA(一過性受容体電位A)アゴニスト、TRPA1アゴニスト、TRPA(一過性受容体電位A)アンタゴニスト、TRPA1アンタゴニスト、TRPM 2、4又は5アゴニスト、TRPM 2、4又は5(メラスタチン一過性受容体電位2、4又は5)アンタゴニスト、TRPV1−4(一過性受容体電位バニロイド−1−4)アゴニスト、TRPV1−4(一過性受容体電位バニロイド−1−4)アンタゴニスト、TRPM 2、4、5又は8(メラスタチン一過性受容体電位2、4、5又は8)アゴニスト又はメントール、バニロイド、n−ノナン酸のバニリアミド(NVA又はPAVA)及び温受容体アゴニストの少なくとも1種を含む、請求項22又は23に記載のデバイス。
- 前記皮膚接触面が、被験者の顔の眼窩周囲又は頬領域に接触することなく前記被験者の額を覆うように構成される、請求項22又は23に記載のデバイス。
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CA2975092A1 (en) | 2016-08-04 |
EP3250276A4 (en) | 2018-10-03 |
US20170319815A1 (en) | 2017-11-09 |
AU2016211528A1 (en) | 2017-05-18 |
WO2016123241A1 (en) | 2016-08-04 |
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