JP2018502883A - 拡張型心筋症(dcm)の処置のための4−メチルスルホニル置換ピペリジンウレア化合物 - Google Patents
拡張型心筋症(dcm)の処置のための4−メチルスルホニル置換ピペリジンウレア化合物 Download PDFInfo
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- JP2018502883A JP2018502883A JP2017538593A JP2017538593A JP2018502883A JP 2018502883 A JP2018502883 A JP 2018502883A JP 2017538593 A JP2017538593 A JP 2017538593A JP 2017538593 A JP2017538593 A JP 2017538593A JP 2018502883 A JP2018502883 A JP 2018502883A
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- compound
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- piperidine
- sulfonyl
- methyl
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 37
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Abstract
Description
本出願は、その全体の内容が参照によって本明細書に組み入れられている、2015年1月22日に出願の米国仮特許出願第62/106,571号への優先権の利益を主張する。
適用不可
一連の4−メチルスルホニル置換ピペリジンウレアおよび薬学的に許容されるその塩が、ミオシンからのリン酸放出を増強することにより、収縮期の延長または拡張期の短縮を起こすことなく、収縮性を高めることが見出された。こうして、本化合物は、DCM患者における収縮機能を改善すること、すなわち労作性呼吸困難を弱くし、および多くの場合、疾患を併発する疲労を克服する一助となることを可能にする。本化合物はまた、心拍出量を低減させることを特徴とする、他の心臓障害を処置するために使用することもできる。
本明細書で使用する場合、用語「アルキル」とは、示されている炭素原子数を有する、直鎖または分岐の飽和脂肪族ラジカルを指す。アルキルは、C1〜2、C1〜3、C1〜4、C1〜5、C1〜6、C1〜7、C1〜8、C2〜3、C2〜4、C2〜5、C2〜6、C3〜4、C3〜5、C3〜6、C4〜5、C4〜6およびC5〜6のような任意の炭素数を含むことができる。例えば、C1〜6アルキルには、以下に限定されないが、メチル、エチル、プロピル、イソプロピル、ブチル、イソブチル、sec−ブチル、tert−ブチル、ペンチル、イソペンチル、ヘキシルなどが含まれる。アルキルとは、以下に限定されないが、ヘプチル、オクチル、ノニル、デシルなどのような最大20個の炭素原子を有するアルキル基を指すことができる。特に明記されない限り、アルキル基は無置換である。「置換アルキル」基は、ハロ、ヒドロキシ、アミノ、アルキルアミノ、ニトロ、シアノおよびアルコキシから選択される1つまたはそれ以上の部分により置換されている。
一態様では、式:
Ar2は、1〜5つのRbにより場合により置換されている、5〜10員のアリールまたはヘテロアリールであり;
R1およびR2は、それぞれ独立して、H、F、C1〜C4アルキル、C1〜C4ジュウテロアルキルおよびC1〜C4ハロアルキルからなる群から選択されるメンバーである;または場合により、R1およびR2は一緒になって、1つまたは2つのFにより場合によ
り置換されている、C3〜C5炭素環式環を形成することができ;
R3は、H、F、OHおよびC1〜C4アルキルからなる群から選択されるメンバーであり;
Raはそれぞれ、ハロ、CN、ヒドロキシル、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4ヒドロキシアルキル、C1〜C4アルコキシ、C1〜C4ハロアルコキシ、−CORa1、−CO2Ra1、−SO2Ra1、−SO2NRa1Ra2および−CONRa1Ra2からなる群から独立して選択され、ここで、Ra1およびRa2はそれぞれ、HおよびC1〜C4アルキルからなる群から独立して選択されるか、または場合により、Ra1およびRa2は、窒素原子に結合している場合、一緒になって、4〜6員環を形成する;または場合により、隣接環員上の2つのRb置換基は、一緒になって、O、NおよびSから選択される、0、1または2環員を有する5員または6員の環を形成する;および
Rbはそれぞれ、ハロ、CN、ヒドロキシル、C1〜C4アルキル、C1〜C4ジュウテロアルキル、C1〜C4ハロアルキル、C1〜C4アルコキシ、C1〜C4ハロアルコキシ、C3〜C6シクロアルキル、−NRb1Rb2、−CORb1、−CO2Rb1、−SO2Rb1、−SO2NRb1Rb2、−CONRb1Rb2、および5員または6員のヘテロアリールであって、C1〜C4アルキルにより場合により置換されているヘテロアリールからなる群から独立して選択され、Rb1およびRb2はそれぞれ、HおよびC1〜C4アルキルからなる群から独立して選択されるか、または場合によりRb1およびRb2は、窒素原子に結合している場合、4〜6員環を形成する;または場合により、隣接環員上の2つのRb置換基は、一緒になって、O、NおよびSから選択される、0、1または2環員を有する5員または6員の環を形成する。
別の態様では、式Iの化合物または薬学的に許容されるその塩、および薬学的に許容される添加剤を含有する医薬組成物が、本明細書において提供される。本組成物は、ヒトおよび他の対象における拡張型心筋症の処置に有用である。
DCMをもたらす変異は、ミオシン機構に大きな逸脱を引き起こす。これらの変異は、ミオシン遺伝子におけるそれらの位置に応じて、異なる機構によりその作用を発揮する。いかなる特定の理論により拘泥されることを望むものではないが、本明細書において提供されている化合物またはそれらの薬学的に許容される塩は、シス(同一の特定機能を発揮することによる)またはトランス(相補的機能を改変することによる)のどちらかで、サルコメアタンパク質の変異体に直接結合して、その機能異常を修正することができると考えられる。こうして、本明細書において提供されている化合物またはそれらの薬学的に許容される塩は、DCMに関連する低収縮および/または弛緩の障害を打ち消すことにより、この疾患の患者に治療的利益を実現することができる。さらに、収縮機能を高めるこれらの化合物は、症状および/または臨床的転帰が収縮機能障害(左側または右側の心不全)または収縮予備量の低下(例えば、HFpEF)に起因する、幅広いスペクトルの障害を処置する見込みを保持する。
aq:水性;BBr3:三臭化ホウ素;BTC:ビス(トリクロロメチル)カーボネート;CH2Cl2:ジクロロメタン;CH3CN:アセトニトリル;CH3OH:メタノール;DAST:三フッ化ジエチルアミノ硫黄;DIAD:ジイソプロピルアゾジカルボキシレート;DIEA:ジイソプロピルエチルアミン;DMF:ジメチルホルムアミド;DMSO:ジメチルスルホキシド;dppf:[1,1’−ビス(ジフェニルホスフィノ)フェロセン]ジクロロパラジウム(II)、ジクロロメタンとの錯体;DPPA:ジフェニルホスホリルアジド;equiv.:当量;Et3N:トリメチルアミン;Et2O:ジエチルエーテル;EtOH:エタノール;h、hr:時間;HATU:(1−[ビス(ジメチルアミノ)メチレン]−1H−1,2,3−トリアゾロ[4,5−b]ピリジニウム3−オキシドヘキサフルオロホスフェート);HCl:塩化水素;H2O:水;K2
CO3:炭酸カリウム;KHSO4:重硫酸カリウム;KNCO:イソシアン酸カリウム;LDA:リチウムジイソプロピルアミド;mCPBA:メタ−クロロ過安息香酸;MgSO4:硫酸マグネシウム;mL:ミリリットル;MW:マイクロ波(マイクロ波用反応器中で行われる反応);NaCl:塩化ナトリウム;NaH:水素化ナトリウム;NaHCO3:炭酸水素ナトリウム;NaOEt:ナトリウムエトキシド;NaOH:水酸化ナトリウム;NaOMe:ナトリウムメトキシド;Na2SO4:硫酸ナトリウム;Na2SO3:亜硫酸ナトリウム;NBS:N−ブロモスクシンイミド;NFSI:N−フルオロベンゼンスルホンイミド;NH4Cl:塩化アンモニウム;NMP:n−メチルピロリジン;pH:−log[H+];POCl3:三塩化ホスホリル;PPTS:p−トルエンスルホン酸ピリジニウム;RP−HPLC:逆相高速液体クロマトグラフィー;RT:室温;RTx:保持時間;SFC:超臨界流体クロマトグラフィー;TEBAC:塩化トリエチルベンジルアンモニウム;TFA:トリフルオロ酢酸;およびTHF:テトラヒドロフラン。
7.32〜7.37(m,1H)、6.44〜6.45(t,1H)、6.80(m,1H)、3.90(s,3H)ppm。
7.11(s,1H)、6.68(t,J=54.7Hz,1H)、5.03(d,J=6.4Hz,0.5H)、4.87(d,J=6.4Hz,0.5H)、4.16(s,5H)、2.86〜2.69(m,2H)、2.45(s,1H)、2.04〜1.91(m,2H)、1.59〜1.50(m,2H)、1.46(s,9H)ppm。
7.15(s,1H)、4.97(dd,J=48.0,6.5Hz,1H)、4.21(m,5H)、2.71〜2.82(m,2H)、2.48(m,1H)、1.97(t,J=12.8Hz,2H)、1.48(m,2H)、1.46(s,9H)ppm。
69.75mmol)のH2O(7.5mL)溶液に、50℃で塩化3−クロロ−1−メチル−1H−ピラゾール−4−スルホニル(19.2、5.0g、23.25mmol)のジオキサン(2.5mL)溶液を加えた。この反応混合物を50℃で1.5時間、撹拌し、次に濃縮した。次に、得られた残留物を4−(ブロモメチル)ピリジン臭化水素酸塩(4.94g、19.53mmol)のDMF(100mL)溶液に加えた。得られた溶液を室温で15分間、撹拌し、次に、さらに2時間50℃まで加熱した。次に、H2O(200mL)を添加することによりこの反応物をクエンチし、EtOAc(3×100mL)により抽出してブライン(100mL)により洗浄し、Na2SO4により脱水し、ろ過して濃縮すると、所望の生成物が白色固体として得られ(3.7g、粗製物)、これを精製することなく、次の反応にそのまま使用した。LC−MS(ES、m/z):271.9[M+H]+、312.9[M+CH3CN]+;1H NMR(400MHz,DMSO−d6):δ 8.56(m,2H)、8.31(s,1H)、7.24(m,2H)、4.72(s,2H)、3.84(s,3H)ppm。
Hz,3H)、2.71〜2.56(m,4H)、1.91〜1.75(m,2H)、1.45(m,10H)、1.19〜1.04(m,2H)ppm。
化合物22は、化合物9と同様の方法で製造し、所望の生成物を黄色固体として得た(0.33g、47%)。LC−MS(ES、m/z):437[M+H]+;1H NMR(300MHz,DMSO−d6):δ 9.25〜9.26(m,1H)、9.23(s,1H)、9.04〜9.06(dd,J=6.9,1.2Hz,1H)、8.84〜8.86(dd,J=6.0,0.6Hz,1H)、8.22〜8.23(d,J=1.5Hz,1H)、8.03〜8.05(dd,J=7.2,0.9Hz,1H)、7.77〜7.78(d,J=1.5Hz,1H)、7.73〜7.76(dd,J=6.0,2.8Hz,1H)、7.18〜7.20(t,J=7.0Hz,1H)、4.22〜4.27(d,J=14.1Hz,2H)、2.89〜2.97(t,J=12.8Hz,3H)、2.08〜2.10(d,J=5.4Hz,2H)、1.48〜1.54(m,2H)ppm。
NMR(300MHz,DMSO−d6):δ 10.57(s,1H)、9.33〜9.15(m,2H)、8.87(m,1H)、8.17〜7.88(m,4H)、7.81〜7.69(m,1H)、4.24(d,J=13.2Hz,2H)、3.01(m,3H)、2.00(d,J=19.3Hz,2H)、1.54(m,2H)ppm。
エンチした。得られた溶液をEtOAc(3×50mL)により抽出し、有機層を合わせて、無水硫酸ナトリウムで脱水して濃縮した。得られた残留物を分取HPLC(カラム:X Bridge C18、19*250mm、10um;移動相A:水/10mM NH4HCO3、移動相B:ACN;流速:30mL/分;勾配:6分間で15〜60%B;254nm)により精製すると、所望の生成物が白色固体として得られた(0.0356g、24%)。LC−MS(ES、m/z):427[M+H]+;1H NMR(300MHz,CD3OD):δ 9.22〜9.26(m,2H)、8.87〜8.89(m,1H)、7.89〜7.99(m,3H)、7.73〜7.75(m,1H)、6.60〜6.64(m,1H)、5.56〜5.58(t,J=5.6Hz,1H)、4.90〜4.92(d,J=5.6Hz,2H),4.22〜4.25(m,2H)、2.88〜2.97(m,3H)、2.00〜2.07(m,2H)、1.46〜1.57(m,2H)ppm。
心臓ミオシンからのADP(アデノシン二リン酸)の放出を、ピルビン酸キナーゼおよび乳酸デヒドロゲナーゼからなる酵素カップリング系(PK/LDH)に結びつける生化学アッセイを使用して、NADH(340nmにおける)の吸光度低下を時間の関数としてモニタリングし、ウシ心臓ミオシンの酵素活性を活性化させる低分子剤の能力に関して、該低分子を評価した。PKは、PEP(ホスホエノールピルビン酸)をピルビン酸に変換することにより、ADPをATP(アデノシン三リン酸)に変換する。ピルビン酸は、次に、NADH(ニコチンアミドアデニンジヌクレオチド)をNAD(酸化型ニコチンアミドアデニンジヌクレオチド)に変換することにより、LDHによって乳酸に変換される。心臓ミオシン源は、表面を剥がした筋原繊維の形態のウシ心臓に由来した。低分子剤を試験する前に、カルシウム応答性についてウシ筋原繊維を評価し、低分子剤の活性化活性を評価するための最終条件として、筋原繊維系の50%(pCa50またはpCa=約6)または<5%(pCa=10)活性化のどちらかで達成するカルシウム濃度を選択した。酵素活性はすべて、12mM PIPES(ピペラジン−N,N’−ビス(2−エタンスルホン酸))、2mM塩化マグネシウムを含有する、pH6.8の緩衝溶液(PM12緩衝液)で測定した。最終アッセイ条件は、ウシ心臓筋原繊維の50%または<5%活性化のどちらかを達成するのに必要な所望の遊離カルシウム濃度において、上記筋原繊維1mg/mL、PK/LDH 0.4mM、ATP 50uM、BSA(ウシ血清アルブミン)0.1mg/mL、消泡剤10ppm、2mM BME、0.5mM NADH、1.5mM PEPとした。
成体ラットの心室筋細胞の収縮性を、IonOptix収縮性システムによるエッジ検出によって決定する。Tyrode緩衝液(137mM NaCl、3.7mM KCl、0.5mM MgCl2、1.5mM CaCl2、4mM HEPES、11mMグルコース)中の筋細胞の一定分量を潅流チャンバ(Series 20RC−27NE;Warner Instruments)に入れ、カバーガラスに付着させて、次に、37℃のTyrode緩衝液により潅流させた。筋細胞は、1Hzおよび10Vにおいて電界刺激した。120〜180ミクロンの細胞長、該細胞長の3〜8%に等しい基底左室内径短縮率および1秒あたり100ミクロン超の収縮速度による、ペーシング前の休眠状態の、明確な縦じわを有する筋細胞のみを収縮性実験のために使用した。化合物に対する応答を決定するため、筋細胞を、最初にTyrodes緩衝液で60秒間、次いで化合物で5分間、潅流し、Tyrodes緩衝液により140秒間、ウォッシュアウトした。データは、IonOptixソフトウェアを使用して、連続的に記録した。収縮データは、Ionwizardソフトウェア(IonOptix)を使用して分析した。各細胞について、10〜20の収縮性一過性(contractility transient)を平均し、基底条件(化合物なし)および化合物処理条件下で比較した。化合物活性は、左室内径短縮率(FS)に及ぼす作用により測定され、ここで、左室内径短縮率は、収縮期における細胞のピーク長を基底細胞長により除算した比を、未処理細胞に対して100%に標準化したものである。
Claims (35)
- 式(I)を有する化合物:
Ar1は、少なくとも1個の窒素原子の環員を有する5〜6員のヘテロアリールであり、1〜3つのRaにより場合により置換されており;
Ar2は、1〜5つのRbにより場合により置換されている、5〜10員のアリールまたはヘテロアリールであり;
R1およびR2は、それぞれ独立して、H、F、C1〜C4アルキル、C1〜C4ジュウテロアルキルおよびC1〜C4ハロアルキルからなる群から選択されるメンバーである;または場合により、R1およびR2は一緒になって、1つまたは2つのFにより場合により置換されている、C3〜C5炭素環式環を形成することができ;
R3は、H、F、OHおよびC1〜C4アルキルからなる群から選択されるメンバーであり;
Raはそれぞれ、ハロ、CN、ヒドロキシル、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4ヒドロキシアルキル、C1〜C4アルコキシ、C1〜C4ハロアルコキシ、−CORa1、−CO2Ra1、−SO2Ra1、−SO2NRa1Ra2および−CONRa1Ra2からなる群から独立して選択され、ここで、Ra1およびRa2はそれぞれ、HおよびC1〜C4アルキルからなる群から独立して選択されるか、または場合により、Ra1およびRa2は、窒素原子に結合している場合、一緒になって、4〜6員環を形成する;または場合により、隣接環員上の2つのRa置換基は、一緒になって、O、NおよびSから選択される、0、1または2環員を有する5員または6員の環を形成し;
Rbはそれぞれ、ハロ、CN、ヒドロキシル、C1〜C4アルキル、C1〜C4ジュウテロアルキル、C1〜C4ハロアルキル、C1〜C4アルコキシ、C1〜C4ハロアルコキシ、C3〜C6シクロアルキル、−NRb1Rb2、−CORb1、−CO2Rb1、−SO2Rb1、−SO2NRb1Rb2、−CONRb1Rb2、および5員または6員のヘテロアリールであって、C1〜C4アルキルにより場合により置換されているヘテロアリールからなる群から独立して選択され、Rb1およびRb2はそれぞれ、HおよびC1〜C4アルキルからなる群から独立して選択されるか、または場合によりRb1およびRb2は、窒素原子に結合している場合、4〜6員環を形成する;または場合により、隣接環員上の2つのRb置換基は、一緒になって、O、NおよびSから選択される、0、1または2環員を有する5員または6員の環を形成する、
前記化合物または薬学的に許容されるその塩。 - Ar1は、ピリジル、ピリダジニル、オキサゾリル、イソオキサゾリル、1,2,3−チアジアゾリル、イソチアゾリルおよびチアゾリルからなる群から選択され、それらのそれぞれは、1〜2つのRaにより場合により置換されている、請求項1に記載の化合物または薬学的に許容されるその塩。
- Ar2は、フェニル、ピリジルおよびピラゾリルからなる群から選択され、それらのそれぞれは、1〜3つのRbにより場合により置換されている、請求項1に記載の化合物。
- Rbは、ハロ、CN、C1〜C4アルキル、C1〜C4ハロアルキル、C1〜C4アルコキシおよびC1〜C4ハロアルコキシからなる群から選択される、請求項3に記載の化合物。
- R1は、H、FおよびCH3からなる群から選択される、請求項1に記載の化合物。
- R2は、H、FおよびCH3からなる群から選択される、請求項1に記載の化合物。
- R1およびR2は、各々が結合している炭素原子と一緒になって、シクロプロパン環またはシクロブタン環を形成する、請求項1に記載の化合物。
- R1およびR2は、同一ではなく、R1およびR2の少なくとも1つは、FおよびCH3から選択される、請求項1に記載の化合物。
- R1およびR2を有する炭素原子は、R立体配置を有する、請求項8に記載の化合物。
- R3は、HまたはFである、請求項1に記載の化合物。
- Ar1は、4−ピリジニルであり、Ar2は、1〜3つのRbにより場合により置換されているフェニルである、請求項1に記載の化合物。
- R3はHであり、R1およびR2のそれぞれは、Fである、請求項11に記載の化合物。
- R3はHであり、R1およびR2のそれぞれは、CH3である、請求項11に記載の化合物。
- R3はHであり、R1はCH3であり、R2はFである、請求項11に記載の化合物。
- R1およびR2を有する炭素原子は、立体化学的にR立体配置を有する、請求項14に記載の化合物。
- Ar1は、4−ピリダジニルであり、Ar2は、1〜3つのRbにより場合により置換されているフェニルである、請求項1に記載の化合物。
- R3はHであり、R1およびR2のそれぞれはFである、請求項16に記載の化合物。
- R3はHであり、R1およびR2のそれぞれはCH3である、請求項16に記載の化合物。
- R3はHであり、R1はCH3であり、R2はFである、請求項16に記載の化合物。
- R1およびR2を有する炭素原子は、立体化学的にR立体配置を有する、請求項19に記載の化合物。
- Ar1は、1,2,3−チアジアゾール−5−イル、イソチアゾール−5−イルおよびチアゾール−5−イルからなる群から選択され、それらのそれぞれは、1つのRaにより場合により置換されている、請求項1に記載の化合物。
- R3はHであり、R1およびR2のそれぞれはFである、請求項21に記載の化合物。
- R3はHであり、R1およびR2のそれぞれはCH3である、請求項21に記載の化合物。
- R3はHであり、R1はCH3であり、R2はFである、請求項21に記載の化合物。
- R1およびR2を有する炭素原子は、立体化学的にR立体配置を有する、請求項24に記載の化合物。
- 表2から選択され、++または+++の活性レベルを有する、請求項1に記載の化合物。
- 請求項1〜28のいずれか1項に記載の化合物および薬学的に許容される添加剤を含む、医薬組成物。
- 拡張型心筋症(DCM)、または収縮機能障害による障害もしくは収縮予備量の低下のような、DCMの病態生理学的特徴を有する心臓障害を処置する方法であって、それを必要とする対象に、有効量の請求項1〜28のいずれか1項に記載の化合物を投与するステップを含む、前記方法。
- 収縮機能障害、拡張機能障害、HFrEF、HFpEF、慢性心不全および急性心不全からなる群から選択される疾患または障害を処置する方法であって、それを必要とする対象に、有効量の請求項1〜28のいずれか1項に記載の化合物または薬学的に許容される塩を投与するステップを含む、前記方法。
- 前記化合物は、急性心不全の処置のためのIV製剤で投与される、請求項31に記載の方法。
- 心不全を処置することを目的とする治療と組み合わせた;左心室収縮機能障害もしくは症状、または収縮機能障害による運動能力の低下を特徴とする、疾患または障害を処置する方法であって、それを必要とする対象に、有効量の請求項1〜28のいずれか1項に記載の化合物または薬学的に許容されるそれらの塩を投与するステップを含む、前記方法。
- 拡張型心筋症(DCM)、またはDCMに関連する病態生理学的特徴を有する心臓障害を処置する方法であって、それを必要とする対象に、有効量の請求項1〜28のいずれか1項に記載の化合物または薬学的に許容されるそれらの塩を投与するステップを含み、心臓の神経ホルモン刺激を下方調節することにより心不全の進行を遅延させる、および心臓のリモデリングを防止しようとする治療(例えば、ACE阻害剤、アンジオテンシン受容体遮断薬(ARB)、β−遮断薬、アルドステロン受容体アンタゴニストまたは神経エンドペプチダーゼ阻害剤);心筋収縮を刺激するによって心臓機能を改善する治療(例えば、β−アドレナリンアゴニストであるドブタミンまたはホスホジエステラーゼ阻害剤であるミルリノンのような、陽性変力剤);および心前負荷(例えば、フロセミドのような利尿薬)または心後負荷(以下に限定されないが、カルシウムチャネル遮断薬、ホスホジエステラーゼ阻害剤、エンドセリン受容体アンタゴニスト、レニン阻害剤または平滑筋ミオシンモジュレーターを含めた任意のクラスの血管拡張薬)を低減する治療と組み合わされる、前記方法。
- 前記化合物が、ベータ遮断薬と組み合わせて投与される、請求項34に記載の方法。
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