JP2018501322A5 - - Google Patents
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- JP2018501322A5 JP2018501322A5 JP2017555445A JP2017555445A JP2018501322A5 JP 2018501322 A5 JP2018501322 A5 JP 2018501322A5 JP 2017555445 A JP2017555445 A JP 2017555445A JP 2017555445 A JP2017555445 A JP 2017555445A JP 2018501322 A5 JP2018501322 A5 JP 2018501322A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antigen
- standard
- immune response
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 150000002632 lipids Chemical class 0.000 claims 12
- 108010034143 Inflammasomes Proteins 0.000 claims 10
- 230000028993 immune response Effects 0.000 claims 9
- 230000002163 immunogen Effects 0.000 claims 8
- 230000003213 activating effect Effects 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000028709 inflammatory response Effects 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- 241000224489 Amoeba Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000193403 Clostridium Species 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 208000009889 Herpes Simplex Diseases 0.000 claims 1
- 208000007514 Herpes zoster Diseases 0.000 claims 1
- 101000735376 Homo sapiens Protocadherin-8 Proteins 0.000 claims 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 claims 1
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims 1
- PEZXEQJZQAVYCZ-NLMPBQEBSA-N PKODiA-PC Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCC(=O)\C=C\C(O)=O PEZXEQJZQAVYCZ-NLMPBQEBSA-N 0.000 claims 1
- 102100034958 Protocadherin-8 Human genes 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000223109 Trypanosoma cruzi Species 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 230000028996 humoral immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020213210A JP7410845B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2020213211A JP7410846B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562102245P | 2015-01-12 | 2015-01-12 | |
| US62/102,245 | 2015-01-12 | ||
| PCT/US2016/012994 WO2016115097A2 (en) | 2015-01-12 | 2016-01-12 | Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020213210A Division JP7410845B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2020213211A Division JP7410846B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018501322A JP2018501322A (ja) | 2018-01-18 |
| JP2018501322A5 true JP2018501322A5 (enExample) | 2019-02-28 |
Family
ID=56406560
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555445A Pending JP2018501322A (ja) | 2015-01-12 | 2016-01-12 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2020213211A Active JP7410846B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2020213210A Active JP7410845B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2023015047A Active JP7719816B2 (ja) | 2015-01-12 | 2023-02-03 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2023015026A Active JP7719815B2 (ja) | 2015-01-12 | 2023-02-03 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2025041931A Pending JP2025094038A (ja) | 2015-01-12 | 2025-03-14 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2025041934A Pending JP2025090801A (ja) | 2015-01-12 | 2025-03-14 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020213211A Active JP7410846B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2020213210A Active JP7410845B2 (ja) | 2015-01-12 | 2020-12-23 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2023015047A Active JP7719816B2 (ja) | 2015-01-12 | 2023-02-03 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2023015026A Active JP7719815B2 (ja) | 2015-01-12 | 2023-02-03 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2025041931A Pending JP2025094038A (ja) | 2015-01-12 | 2025-03-14 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
| JP2025041934A Pending JP2025090801A (ja) | 2015-01-12 | 2025-03-14 | トール様受容体４アンタゴニストの炎症促進性およびアジュバント機能 |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US20180318414A1 (enExample) |
| EP (2) | EP4681782A3 (enExample) |
| JP (7) | JP2018501322A (enExample) |
| AU (2) | AU2021200638B2 (enExample) |
| CA (1) | CA2973585A1 (enExample) |
| ES (1) | ES3057334T3 (enExample) |
| WO (1) | WO2016115097A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4681782A3 (en) * | 2015-01-12 | 2026-04-15 | Children's Medical Center Corporation | Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists |
| CA3042944A1 (en) * | 2016-11-14 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods of treating cancer |
| CA3135291A1 (en) * | 2019-03-29 | 2020-10-08 | The Brigham And Women's Hospital, Inc. | Targeted synergistic cancer immunotherapy |
| CA3157004A1 (en) * | 2019-10-07 | 2021-04-15 | Northwest Biotherapeutics, Inc. | In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response |
| BR112022009560A2 (pt) * | 2019-11-18 | 2022-08-02 | Childrens Medical Center | Células dendríticas hiperativas possibilitam imunidade antitumoral baseada na transferência de células adotivas duráveis |
| WO2021102058A1 (en) * | 2019-11-18 | 2021-05-27 | Children's Medical Center Corporation | Stimuli that hyperactivate resident dendritic cells for cancer immunotherapy |
| CN114894910B (zh) * | 2022-03-18 | 2023-10-20 | 重庆医科大学附属第一医院 | 1-棕榈酰-2-花生四烯酰-sn-甘油-3-磷酸胆碱检测试剂的新用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5158939A (en) * | 1989-07-21 | 1992-10-27 | Wisconsin Alumni Research Foundation | Method of stimulating the immune systems of animals and compositions useful therefor |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| DK0659439T3 (da) | 1993-12-24 | 2002-01-14 | Merck Patent Gmbh | Immunkonjugater |
| PT1127137E (pt) | 1998-11-03 | 2007-12-28 | Staat Nl Verteg Door Min Welzi | Lps com toxicidade reduzida a partir de bactérias gramnegativas modificadas geneticamente |
| WO2004006910A1 (de) | 2002-07-15 | 2004-01-22 | Norbert Leitinger | Lipidoxidationsprodukte zur hemmung von entzündungen |
| US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| US8961982B2 (en) | 2005-12-16 | 2015-02-24 | The Regents Of The University Of California | Modulation of developmental immune programming and protection against cardiovascular disease, diabetes, infectious diseases, and cancer |
| CA2702340C (en) * | 2006-10-12 | 2014-12-16 | The University Of Queensland | Compositions and methods for modulating immune responses |
| US20120119207A1 (en) | 2009-07-27 | 2012-05-17 | Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.) | Interconnection structure and method for manufacturing the same, and display device including interconnection structure |
| EP2531207B1 (en) | 2010-02-05 | 2019-10-30 | Cornell University | Methods and compositions for cancer immunotherapy using flagellin-tumor associated antigen fusion protein expressing tumor cells |
| BR112012027745A2 (pt) | 2010-04-27 | 2017-01-10 | Univ Johns Hopkins | método e composição imunogênica para tratamento de neoplásia |
| AU2012273182A1 (en) | 2011-06-21 | 2014-01-16 | The Johns Hopkins University | Focused radiation for augmenting immune-based therapies against neoplasms |
| WO2013088245A1 (en) | 2011-12-12 | 2013-06-20 | Vascular Biogenics Ltd. | Treatment of inflammation |
| WO2014164699A1 (en) * | 2013-03-11 | 2014-10-09 | The Regents Of The University Of California | Herpes virus vaccines and treatments |
| EP3083945B1 (en) | 2013-12-18 | 2020-03-18 | Julius-Maximilians-Universität Würzburg | Galactose oxidase treatment of dendritic cells to improve their immunogenicity |
| EP4681782A3 (en) * | 2015-01-12 | 2026-04-15 | Children's Medical Center Corporation | Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists |
| AU2016259020B2 (en) | 2015-05-07 | 2021-12-09 | Baylor College Of Medicine | Dendritic cell immunotherapy |
| US10813988B2 (en) | 2016-02-16 | 2020-10-27 | President And Fellows Of Harvard College | Pathogen vaccines and methods of producing and using the same |
| CA3028654A1 (en) | 2016-06-27 | 2018-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Therapeutic antitumor combination of a tlr4 ligand with other treatments |
| WO2018067302A2 (en) | 2016-09-19 | 2018-04-12 | North Western University | Therapeutic effects of cellular delivery of small molecules and macromolecules with liposomal spherical nucleic acids |
| JP7355394B2 (ja) | 2018-05-03 | 2023-10-03 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | カロテノイド組成物およびその使用 |
| CA3157004A1 (en) | 2019-10-07 | 2021-04-15 | Northwest Biotherapeutics, Inc. | In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response |
| WO2021102058A1 (en) | 2019-11-18 | 2021-05-27 | Children's Medical Center Corporation | Stimuli that hyperactivate resident dendritic cells for cancer immunotherapy |
| BR112022009560A2 (pt) | 2019-11-18 | 2022-08-02 | Childrens Medical Center | Células dendríticas hiperativas possibilitam imunidade antitumoral baseada na transferência de células adotivas duráveis |
-
2016
- 2016-01-12 EP EP25205526.4A patent/EP4681782A3/en active Pending
- 2016-01-12 CA CA2973585A patent/CA2973585A1/en active Pending
- 2016-01-12 ES ES16737709T patent/ES3057334T3/es active Active
- 2016-01-12 EP EP16737709.2A patent/EP3244923B1/en active Active
- 2016-01-12 WO PCT/US2016/012994 patent/WO2016115097A2/en not_active Ceased
- 2016-01-12 US US15/543,165 patent/US20180318414A1/en not_active Abandoned
- 2016-01-12 JP JP2017555445A patent/JP2018501322A/ja active Pending
-
2020
- 2020-09-11 US US17/018,045 patent/US11351250B2/en active Active
- 2020-09-11 US US17/018,038 patent/US11400153B2/en active Active
- 2020-12-23 JP JP2020213211A patent/JP7410846B2/ja active Active
- 2020-12-23 JP JP2020213210A patent/JP7410845B2/ja active Active
-
2021
- 2021-02-01 AU AU2021200638A patent/AU2021200638B2/en active Active
-
2022
- 2022-04-26 US US17/730,030 patent/US12070499B2/en active Active
- 2022-05-09 US US17/739,953 patent/US12053522B2/en active Active
-
2023
- 2023-02-03 JP JP2023015047A patent/JP7719816B2/ja active Active
- 2023-02-03 JP JP2023015026A patent/JP7719815B2/ja active Active
-
2024
- 2024-06-18 US US18/746,749 patent/US20240415957A1/en active Pending
- 2024-07-17 US US18/774,985 patent/US20250025552A1/en active Pending
- 2024-09-06 AU AU2024219454A patent/AU2024219454A1/en active Pending
-
2025
- 2025-03-14 JP JP2025041931A patent/JP2025094038A/ja active Pending
- 2025-03-14 JP JP2025041934A patent/JP2025090801A/ja active Pending
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