CA2973585A1 - Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists - Google Patents

Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists Download PDF

Info

Publication number
CA2973585A1
CA2973585A1 CA2973585A CA2973585A CA2973585A1 CA 2973585 A1 CA2973585 A1 CA 2973585A1 CA 2973585 A CA2973585 A CA 2973585A CA 2973585 A CA2973585 A CA 2973585A CA 2973585 A1 CA2973585 A1 CA 2973585A1
Authority
CA
Canada
Prior art keywords
oxpapc
lps
caspase
composition
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2973585A
Other languages
English (en)
French (fr)
Inventor
Jonathan C. Kagan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Publication of CA2973585A1 publication Critical patent/CA2973585A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2973585A 2015-01-12 2016-01-12 Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists Pending CA2973585A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562102245P 2015-01-12 2015-01-12
US62/102,245 2015-01-12
PCT/US2016/012994 WO2016115097A2 (en) 2015-01-12 2016-01-12 Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists

Publications (1)

Publication Number Publication Date
CA2973585A1 true CA2973585A1 (en) 2016-07-21

Family

ID=56406560

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2973585A Pending CA2973585A1 (en) 2015-01-12 2016-01-12 Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists

Country Status (6)

Country Link
US (7) US20180318414A1 (enExample)
EP (1) EP3244923B1 (enExample)
JP (7) JP2018501322A (enExample)
AU (2) AU2021200638B2 (enExample)
CA (1) CA2973585A1 (enExample)
WO (1) WO2016115097A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018501322A (ja) * 2015-01-12 2018-01-18 チルドレンズ メディカル センター コーポレーション トール様受容体4アンタゴニストの炎症促進性およびアジュバント機能
EP3538138A1 (en) * 2016-11-14 2019-09-18 Dana Farber Cancer Institute, Inc. Compositions and methods of treating cancer
CA3135291A1 (en) * 2019-03-29 2020-10-08 The Brigham And Women's Hospital, Inc. Targeted synergistic cancer immunotherapy
KR20220098351A (ko) * 2019-10-07 2022-07-12 노쓰웨스트 바이오써라퓨틱스, 인크. 수지상 세포 및 T 세포의 활성화를 증진시키고 Th-1 면역 반응을 유도하기 위한 시험관내 방법 및 조성물
KR20220114556A (ko) * 2019-11-18 2022-08-17 칠드런'즈 메디컬 센터 코포레이션 암 면역요법을 위한 상주 수지상 세포를 과다활성화시키는 자극제
IL293034A (en) * 2019-11-18 2022-07-01 Childrens Medical Center Hyperactive dendritic cells enabling antitumor vaccination based on the transfer of resistant adoptive cells
CN114894910B (zh) * 2022-03-18 2023-10-20 重庆医科大学附属第一医院 1-棕榈酰-2-花生四烯酰-sn-甘油-3-磷酸胆碱检测试剂的新用途

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5158939A (en) * 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
ES2166368T3 (es) 1993-12-24 2002-04-16 Merck Patent Gmbh Inmunoconjugados.
JP3595264B2 (ja) 1998-11-03 2004-12-02 デ・スタート・デル・ネーデルランデン・ベルテゲンボールディクト・ドール・デ・ミニステル・バン・ベルジーン・ボルクスゲツォントヘイト・エン・クルトゥール 遺伝的に修飾されたグラム陰性細菌由来の低毒性lps
AU2003243806A1 (en) 2002-07-15 2004-02-02 Bernd Binder Lipid oxidation products for inhibiting inflammation
US20060257359A1 (en) 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
US8961982B2 (en) 2005-12-16 2015-02-24 The Regents Of The University Of California Modulation of developmental immune programming and protection against cardiovascular disease, diabetes, infectious diseases, and cancer
EP2077821B1 (en) * 2006-10-12 2019-08-14 The University Of Queensland Compositions and methods for modulating immune responses
WO2011013682A1 (ja) 2009-07-27 2011-02-03 株式会社神戸製鋼所 配線構造およびその製造方法、並びに配線構造を備えた表示装置
US20130108661A1 (en) 2010-02-05 2013-05-02 Mount Sinai School Of Medicine Methods and compositions for cancer immunotherapy using flagellin-tumor associated antigen fusion protein expressing tumor cells
JP6042802B2 (ja) 2010-04-27 2016-12-14 ザ・ジョンズ・ホプキンス・ユニバーシティ 新生物(腫瘍)を治療するための免疫原性組成物及び方法。
CN103796680A (zh) 2011-06-21 2014-05-14 约翰霍普金斯大学 用于增强针对赘生物的基于免疫的治疗的聚焦放射
CA2858789C (en) 2011-12-12 2020-09-22 Vascular Biogenics Ltd. Treatment of inflammation
WO2014164699A1 (en) 2013-03-11 2014-10-09 The Regents Of The University Of California Herpes virus vaccines and treatments
EP3083945B1 (en) 2013-12-18 2020-03-18 Julius-Maximilians-Universität Würzburg Galactose oxidase treatment of dendritic cells to improve their immunogenicity
JP2018501322A (ja) 2015-01-12 2018-01-18 チルドレンズ メディカル センター コーポレーション トール様受容体4アンタゴニストの炎症促進性およびアジュバント機能
KR102873947B1 (ko) 2015-05-07 2025-10-22 베이롤 칼리지 오브 메드신 수지상 세포 면역요법
US10813988B2 (en) 2016-02-16 2020-10-27 President And Fellows Of Harvard College Pathogen vaccines and methods of producing and using the same
WO2018004747A1 (en) 2016-06-27 2018-01-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Therapeutic antitumor combination of a tlr4 ligand with other treatments
WO2018067302A2 (en) 2016-09-19 2018-04-12 North Western University Therapeutic effects of cellular delivery of small molecules and macromolecules with liposomal spherical nucleic acids
CN112236134B (zh) 2018-05-03 2024-09-13 L.E.A.F.控股集团公司 类胡萝卜素组合物及其用途
KR20220098351A (ko) 2019-10-07 2022-07-12 노쓰웨스트 바이오써라퓨틱스, 인크. 수지상 세포 및 T 세포의 활성화를 증진시키고 Th-1 면역 반응을 유도하기 위한 시험관내 방법 및 조성물
IL293034A (en) 2019-11-18 2022-07-01 Childrens Medical Center Hyperactive dendritic cells enabling antitumor vaccination based on the transfer of resistant adoptive cells
KR20220114556A (ko) 2019-11-18 2022-08-17 칠드런'즈 메디컬 센터 코포레이션 암 면역요법을 위한 상주 수지상 세포를 과다활성화시키는 자극제

Also Published As

Publication number Publication date
US11351250B2 (en) 2022-06-07
US11400153B2 (en) 2022-08-02
AU2024219454A1 (en) 2024-10-03
US20200405848A1 (en) 2020-12-31
EP3244923A4 (en) 2018-09-05
EP3244923A2 (en) 2017-11-22
AU2016206965B2 (en) 2021-03-04
WO2016115097A2 (en) 2016-07-21
JP7719816B2 (ja) 2025-08-06
US20180318414A1 (en) 2018-11-08
JP2025090801A (ja) 2025-06-17
JP2021059570A (ja) 2021-04-15
US20250025552A1 (en) 2025-01-23
US20240415957A1 (en) 2024-12-19
US12053522B2 (en) 2024-08-06
AU2016206965A1 (en) 2017-08-31
US12070499B2 (en) 2024-08-27
JP7719815B2 (ja) 2025-08-06
JP2018501322A (ja) 2018-01-18
US20230042429A1 (en) 2023-02-09
AU2021200638B2 (en) 2024-06-06
JP7410845B2 (ja) 2024-01-10
JP2021059571A (ja) 2021-04-15
JP2023055883A (ja) 2023-04-18
EP3244923C0 (en) 2025-10-01
EP3244923B1 (en) 2025-10-01
JP2025094038A (ja) 2025-06-24
AU2021200638A1 (en) 2021-03-04
US20200405847A1 (en) 2020-12-31
JP2023055880A (ja) 2023-04-18
JP7410846B2 (ja) 2024-01-10
US20230053338A1 (en) 2023-02-23
WO2016115097A3 (en) 2016-09-09

Similar Documents

Publication Publication Date Title
US12070499B2 (en) Pro-inflammatory and adjuvant functions of toll-like receptor 4 antagonists
Wu et al. CD14: Biology and role in the pathogenesis of disease
Chuang et al. Adjuvant effect of toll-like receptor 9 activation on cancer immunotherapy using checkpoint blockade
US20210340215A1 (en) T cell receptor constructs and uses thereof
US10780117B2 (en) Macrophages eat cancer cells using their own calreticulin as a guide
Gambuzza et al. Targeting Toll-like receptors: emerging therapeutics for multiple sclerosis management
US9061048B2 (en) Cyclic di-AMP induction of type I interferon
CA2978496A1 (en) Method
C Junquera et al. Recent advances in the development of anti-Infective prophylactic and/or therapeutic agents based on toll-like receptor (TLRs)
Lalor et al. An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM‐1. C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis
RU2785954C2 (ru) Конструкты т-клеточного рецептора и их применение
WO2023097237A2 (en) Cytosolic bacterial pathogens attenuated for spread from tumors and methods of use thereof
HK40053747A (en) T cell receptor constructs and uses thereof

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107

EEER Examination request

Effective date: 20210107