JP2018123152A - 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物 - Google Patents

新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物 Download PDF

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Publication number
JP2018123152A
JP2018123152A JP2018072746A JP2018072746A JP2018123152A JP 2018123152 A JP2018123152 A JP 2018123152A JP 2018072746 A JP2018072746 A JP 2018072746A JP 2018072746 A JP2018072746 A JP 2018072746A JP 2018123152 A JP2018123152 A JP 2018123152A
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Japan
Prior art keywords
alkyl
disease
compound
liver
fxr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018072746A
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English (en)
Japanese (ja)
Inventor
オーラフ キンツェル
Kinzel Olaf
オーラフ キンツェル
クリストフ シュティーネック
Christoph Steeneck
クリストフ シュティーネック
クラウス クレモザー
Kremoser Claus
クラウス クレモザー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11005722A external-priority patent/EP2545964A1/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of JP2018123152A publication Critical patent/JP2018123152A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2018072746A 2011-07-13 2018-04-04 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物 Pending JP2018123152A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161507153P 2011-07-13 2011-07-13
EP11005722A EP2545964A1 (en) 2011-07-13 2011-07-13 Novel FXR (NR1H4) binding and activity modulating compounds
US61/507,153 2011-07-13
EP11005722.1 2011-07-13

Related Parent Applications (1)

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JP2016154511A Division JP6321097B2 (ja) 2011-07-13 2016-08-05 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物

Related Child Applications (1)

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JP2019153457A Division JP6878526B2 (ja) 2011-07-13 2019-08-26 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物

Publications (1)

Publication Number Publication Date
JP2018123152A true JP2018123152A (ja) 2018-08-09

Family

ID=62454900

Family Applications (3)

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JP2018072746A Pending JP2018123152A (ja) 2011-07-13 2018-04-04 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物
JP2019153457A Active JP6878526B2 (ja) 2011-07-13 2019-08-26 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物
JP2021035272A Withdrawn JP2021091727A (ja) 2011-07-13 2021-03-05 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物

Family Applications After (2)

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JP2019153457A Active JP6878526B2 (ja) 2011-07-13 2019-08-26 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物
JP2021035272A Withdrawn JP2021091727A (ja) 2011-07-13 2021-03-05 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物

Country Status (4)

Country Link
JP (3) JP2018123152A (he)
HK (2) HK1244682A1 (he)
IL (3) IL253437A0 (he)
UY (1) UY39388A (he)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532729A (ja) * 1998-12-23 2002-10-02 グラクソ グループ リミテッド 核内受容体のリガンドのアッセイ
JP2009538333A (ja) * 2006-05-24 2009-11-05 イーライ リリー アンド カンパニー Ｆｘｒを調節する化合物及び方法
JP2010501610A (ja) * 2006-08-29 2010-01-21 フェネックス ファーマシューティカルス アーゲー 複素環式ｆｘｒ結合化合物
WO2011020615A1 (en) * 2009-08-19 2011-02-24 Phenex Pharmaceuticals Ag Novel fxr (nr1h4 ) binding and activity modulating compounds
JP5986633B2 (ja) * 2011-07-13 2016-09-06 フェネックス ファーマシューティカルス アーゲー 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532729A (ja) * 1998-12-23 2002-10-02 グラクソ グループ リミテッド 核内受容体のリガンドのアッセイ
JP2009538333A (ja) * 2006-05-24 2009-11-05 イーライ リリー アンド カンパニー Ｆｘｒを調節する化合物及び方法
JP2010501610A (ja) * 2006-08-29 2010-01-21 フェネックス ファーマシューティカルス アーゲー 複素環式ｆｘｒ結合化合物
WO2011020615A1 (en) * 2009-08-19 2011-02-24 Phenex Pharmaceuticals Ag Novel fxr (nr1h4 ) binding and activity modulating compounds
JP5986633B2 (ja) * 2011-07-13 2016-09-06 フェネックス ファーマシューティカルス アーゲー 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物
JP6321097B2 (ja) * 2011-07-13 2018-05-09 ギリアード サイエンシーズ， インコーポレイテッド 新規なｆｘｒ（ｎｒ１ｈ４）結合および活性調節化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GERNOT ZOLLNER ET AL: "Role of Nuclear Receptors in the Adaptive Response to Bile Acids and Cholestasis: Pathogenetic and T", MOLECULAR PHARMACEUTICS, vol. 3, no. 3, JPN6017030378, 2006, pages 231 - 251, ISSN: 0003982730 *
LAWSON, JOHN E. ET AL: "Diarylcyclobutane analogs of diethylstilbestrol", JOURNAL OF MEDICINAL CHEMISTRY, vol. 17, no. 4, JPN6016009504, 1974, pages 383 - 6, ISSN: 0003982731 *

Also Published As

Publication number Publication date
IL277570A (he) 2020-11-30
JP2021091727A (ja) 2021-06-17
JP2019214611A (ja) 2019-12-19
IL253437A0 (he) 2017-09-28
JP6878526B2 (ja) 2021-05-26
HK1246716A1 (zh) 2018-09-14
IL265973A (he) 2019-06-30
HK1244682A1 (zh) 2018-08-17
IL265973B (he) 2020-10-29
UY39388A (es) 2021-09-30

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